#=GF ID NgoMIV_restric
#=GF AC PF09015.14
#=GF DE NgoMIV restriction enzyme
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Sammut SJ;0000-0003-4472-904X
#=GF SE pdb_1fiu
#=GF GA 23.20 23.20;
#=GF TC 24.90 23.40;
#=GF NC 22.90 22.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0236
#=GF RN [1]
#=GF RM 10966652
#=GF RT Structure of the tetrameric restriction endonuclease NgoMIV in
#=GF RT complex with cleaved DNA.
#=GF RA Deibert M, Grazulis S, Sasnauskas G, Siksnys V, Huber R;
#=GF RL Nat Struct Biol. 2000;7:792-799.
#=GF RN [2]
#=GF RM 22638584
#=GF RT Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT phosphodiesterase superfamily.
#=GF RA Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA K;
#=GF RL Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR INTERPRO; IPR015105;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Members of this family are prokaryotic DNA restriction enzymes,
#=GF CC exhibiting an alpha/beta structure, with a central region
#=GF CC comprising a mixed six-stranded beta-sheet with alpha-helices on
#=GF CC each side. A long 'arm' protrudes out of the core of the domain
#=GF CC between strands beta2 and beta3 and is mainly involved in the
#=GF CC tetramerisation interface of the protein. These restriction
#=GF CC enzymes recognise the double-stranded sequence GCCGGC and cleave
#=GF CC after G-1 [1].
#=GF SQ 138
#=GS A0A8H9IUF4_9PSEU/12-140 AC A0A8H9IUF4.1
#=GS A0A512PII2_9CELL/92-223 AC A0A512PII2.1
#=GS A0A841FRK7_9ACTN/19-150 AC A0A841FRK7.1
#=GS A0A2V1GS93_9GAMM/11-302 AC A0A2V1GS93.1
#=GS A0A3A8URI5_9BACT/8-153 AC A0A3A8URI5.1
#=GS A0A101JQW7_9ACTN/125-256 AC A0A101JQW7.1
#=GS A0A433GXX9_9MICC/95-378 AC A0A433GXX9.1
#=GS L1MCZ4_9CORY/15-303 AC L1MCZ4.1
#=GS A0A3A8YH68_9BACT/12-291 AC A0A3A8YH68.1
#=GS A0A5N6MHY9_9MICC/145-264 AC A0A5N6MHY9.1
#=GS A0A1H9RYU4_9CORY/13-296 AC A0A1H9RYU4.1
#=GS A0A418KM37_9ACTN/101-176 AC A0A418KM37.1
#=GS A0A447IGZ0_9HYPH/15-286 AC A0A447IGZ0.1
#=GS A0A6I5C1J8_9ACTN/132-250 AC A0A6I5C1J8.1
#=GS A0A2H5WEH4_9BACT/6-130 AC A0A2H5WEH4.1
#=GS A0A5N5V7B3_MYCPH/150-273 AC A0A5N5V7B3.1
#=GS A0A4R6PU91_NOCIG/160-276 AC A0A4R6PU91.1
#=GS D1A869_THECD/10-134 AC D1A869.1
#=GS A0A6L5FAJ7_9ACTN/132-247 AC A0A6L5FAJ7.1
#=GS A0A085LEN8_9MICO/41-176 AC A0A085LEN8.1
#=GS A0A1Y5SBN1_9RHOB/11-278 AC A0A1Y5SBN1.1
#=GS A0A2N3XTU4_SACSN/138-251 AC A0A2N3XTU4.1
#=GS A0A2R4XP43_9BURK/14-287 AC A0A2R4XP43.1
#=GS A0A2H5WEH4_9BACT/127-241 AC A0A2H5WEH4.1
#=GS U5E4V7_NOCAS/142-257 AC U5E4V7.1
#=GS C7H4D8_FAEPA/15-288 AC C7H4D8.1
#=GS A0A3N4YJV0_9MICO/37-311 AC A0A3N4YJV0.1
#=GS A0A543IQ98_9ACTN/5-136 AC A0A543IQ98.1
#=GS A0A4R6PU91_NOCIG/34-163 AC A0A4R6PU91.1
#=GS A0A841GXK2_9BACT/10-286 AC A0A841GXK2.1
#=GS A0A431VNE1_9PROT/11-284 AC A0A431VNE1.1
#=GS A0A101NKA2_9ACTN/73-190 AC A0A101NKA2.1
#=GS A0A4P7GNS9_9ACTN/9-149 AC A0A4P7GNS9.1
#=GS A0A0P6XFJ3_9CHLR/10-286 AC A0A0P6XFJ3.1
#=GS A0A7X0HFZ8_9ACTN/119-257 AC A0A7X0HFZ8.1
#=GS E6KRH9_9ACTO/12-286 AC E6KRH9.1
#=GS A0A4Q7J4P1_9PSEU/158-280 AC A0A4Q7J4P1.1
#=GS H2JNF6_STRHJ/65-187 AC H2JNF6.1
#=GS A0A7H8JQQ4_9ACTN/143-262 AC A0A7H8JQQ4.1
#=GS R6Y7P9_9FIRM/12-291 AC R6Y7P9.1
#=GS A0A3P3DAD3_9RHOB/14-287 AC A0A3P3DAD3.1
#=GS A0A2H5WZS4_9BACT/1-260 AC A0A2H5WZS4.1
#=GS Q4JT21_CORJK/15-294 AC Q4JT21.1
#=GS A0A6L5FAJ7_9ACTN/13-138 AC A0A6L5FAJ7.1
#=GS A0A7K2FIM0_9ACTN/11-138 AC A0A7K2FIM0.1
#=GS A0A5N6MHY9_9MICC/25-152 AC A0A5N6MHY9.1
#=GS R4YXJ7_9ACTN/124-240 AC R4YXJ7.1
#=GS A0A8H9IUF4_9PSEU/137-251 AC A0A8H9IUF4.1
#=GS A0A6I5C1J8_9ACTN/5-141 AC A0A6I5C1J8.1
#=GS A0A1I6MGK5_9RHOB/12-279 AC A0A1I6MGK5.1
#=GS A0A6N7ZR53_9HYPH/90-351 AC A0A6N7ZR53.1
#=GS A0A1H6E8S2_9ACTN/130-249 AC A0A1H6E8S2.1
#=GS A0A3A9YWV4_9ACTN/12-287 AC A0A3A9YWV4.1
#=GS A0A6B8JR30_9GAMM/14-286 AC A0A6B8JR30.1
#=GS A0A2V2L6H8_9RHOB/13-281 AC A0A2V2L6H8.1
#=GS A0A285J0D1_9ACTN/17-291 AC A0A285J0D1.1
#=GS A0A2S8VY21_9CAUL/17-295 AC A0A2S8VY21.1
#=GS R4YXJ7_9ACTN/12-128 AC R4YXJ7.1
#=GS A0A1G8M612_9NOCA/27-281 AC A0A1G8M612.1
#=GS A0A2P7THW8_9SPHI/10-279 AC A0A2P7THW8.1
#=GS A0A1X7FMI3_CELCE/1-78 AC A0A1X7FMI3.1
#=GS A0A1H6E8S2_9ACTN/16-136 AC A0A1H6E8S2.1
#=GS B0TCH8_HELMI/1-128 AC B0TCH8.1
#=GS A0A1M6BA57_9ACTN/12-287 AC A0A1M6BA57.1
#=GS A0A3N6WMG4_9ACTN/129-251 AC A0A3N6WMG4.1
#=GS A0A3G6J2M3_9CORY/16-296 AC A0A3G6J2M3.1
#=GS A0A2N5H2V4_9BACI/17-289 AC A0A2N5H2V4.1
#=GS D1A869_THECD/131-252 AC D1A869.1
#=GS A0A0C5BD22_9MICO/16-292 AC A0A0C5BD22.1
#=GS A0A3P1SBN6_9ACTO/18-293 AC A0A3P1SBN6.1
#=GS D4YMD3_9MICO/15-290 AC D4YMD3.1
#=GS A0A7W7VWR2_KITKI/138-286 AC A0A7W7VWR2.1
#=GS E1IE54_9CHLR/62-335 AC E1IE54.1
#=GS A0A199NTB8_9MICC/132-415 AC A0A199NTB8.1
#=GS A0A6V8MPX0_9DELT/13-290 AC A0A6V8MPX0.1
#=GS A0A8J6IYH4_9FIRM/12-285 AC A0A8J6IYH4.1
#=GS A0A0P6X781_9CHLR/11-299 AC A0A0P6X781.1
#=GS A0A3D9HVM7_9PROT/13-309 AC A0A3D9HVM7.1
#=GS A0A2U3A104_9ACTN/12-287 AC A0A2U3A104.1
#=GS A0A5Q0LHX9_9ACTN/133-251 AC A0A5Q0LHX9.1
#=GS A0A4R6TVE4_9BURK/14-287 AC A0A4R6TVE4.1
#=GS A0A7H8JQQ4_9ACTN/13-146 AC A0A7H8JQQ4.1
#=GS A0A418ZPD4_9RHOB/14-287 AC A0A418ZPD4.1
#=GS S2ZCC8_9CORY/13-299 AC S2ZCC8.1
#=GS A0A5C5USN1_9CORY/12-287 AC A0A5C5USN1.1
#=GS A0A1N6QNI4_9GAMM/14-293 AC A0A1N6QNI4.1
#=GS A0A369AFQ9_9BURK/14-287 AC A0A369AFQ9.1
#=GS A0A0B8NG68_9NOCA/19-145 AC A0A0B8NG68.1
#=GS A0A7G1KGK3_9NOCA/142-256 AC A0A7G1KGK3.1
#=GS A0A5N5V7B3_MYCPH/21-156 AC A0A5N5V7B3.1
#=GS A0A1T1CA67_9SYNE/11-288 AC A0A1T1CA67.1
#=GS A0A076NID6_9CORY/15-294 AC A0A076NID6.1
#=GS A0A1A9BU78_9ACTN/12-287 AC A0A1A9BU78.1
#=GS Q5F8B2_NEIG1/12-286 AC Q5F8B2.1
#=GS A0A5Q3RVA4_9NEIS/12-284 AC A0A5Q3RVA4.1
#=GS A0A1W6YZ28_9BORD/13-286 AC A0A1W6YZ28.1
#=GS A0A841FRK7_9ACTN/145-259 AC A0A841FRK7.1
#=GS A0A4P7GNS9_9ACTN/148-259 AC A0A4P7GNS9.1
#=GS R6R3N2_9FIRM/12-291 AC R6R3N2.1
#=GS A0A6B1UB08_9FIRM/12-291 AC A0A6B1UB08.1
#=GS A0A161JNN6_9MICO/17-292 AC A0A161JNN6.1
#=GS A0A3S0C338_9ACTO/12-287 AC A0A3S0C338.1
#=GS A0A6V8M2E3_9BACL/14-286 AC A0A6V8M2E3.1
#=GS A0A4P6EPI1_9MICO/8-156 AC A0A4P6EPI1.1
#=GS A0A8J6Z0H7_9RHOB/11-279 AC A0A8J6Z0H7.1
#=GS A0A098S0R1_9BACT/13-286 AC A0A098S0R1.1
#=GS A0A401FTZ0_9DELT/10-287 AC A0A401FTZ0.1
#=GS E8N1W7_ANATU/10-282 AC E8N1W7.1
#=GS K0F3N5_NOCBR/142-255 AC K0F3N5.1
#=GS A0A7G1KGK3_9NOCA/16-139 AC A0A7G1KGK3.1
#=GS A0A4Q6IMP5_9ACTN/133-245 AC A0A4Q6IMP5.1
#=GS A0A543IQ98_9ACTN/130-241 AC A0A543IQ98.1
#=GS K0F3N5_NOCBR/16-139 AC K0F3N5.1
#=GS A0A5Q0LHX9_9ACTN/5-144 AC A0A5Q0LHX9.1
#=GS A0A231HEL9_9NOCA/137-255 AC A0A231HEL9.1
#=GS A0A8J3C1A0_9ACTN/151-284 AC A0A8J3C1A0.1
#=GS A0A2U0H997_9MICO/17-292 AC A0A2U0H997.1
#=GS A0A7K2FIM0_9ACTN/134-249 AC A0A7K2FIM0.1
#=GS A0A1I3JIE3_9RHOB/11-279 AC A0A1I3JIE3.1
#=GS A0A0B8NG68_9NOCA/142-260 AC A0A0B8NG68.1
#=GS A0A165B3G9_9SYNE/11-290 AC A0A165B3G9.1
#=GS A0A3N6WMG4_9ACTN/8-138 AC A0A3N6WMG4.1
#=GS A0A7L5ZT24_9BACL/12-279 AC A0A7L5ZT24.1
#=GS U5E4V7_NOCAS/17-139 AC U5E4V7.1
#=GS A0A511XR27_9PROT/14-287 AC A0A511XR27.1
#=GS A0A2N3XTU4_SACSN/5-139 AC A0A2N3XTU4.1
#=GS A0A292YLC2_9BACL/12-284 AC A0A292YLC2.1
#=GS A0A0S2KAW6_9GAMM/14-287 AC A0A0S2KAW6.1
#=GS R6HMW5_9FIRM/12-291 AC R6HMW5.1
#=GS A0A1Y3X3C2_9FIRM/12-291 AC A0A1Y3X3C2.1
#=GS A0A1Y4T813_9FIRM/12-291 AC A0A1Y4T813.1
#=GS A0A1E3X2W6_9BACT/11-281 AC A0A1E3X2W6.1
#=GS A0A0J9YH32_NOCSI/95-305 AC A0A0J9YH32.1
#=GS A0A7W7I584_9ACTN/15-289 AC A0A7W7I584.1
#=GS A0A418KM37_9ACTN/172-295 AC A0A418KM37.1
#=GS A0A4Q6IMP5_9ACTN/5-141 AC A0A4Q6IMP5.1
#=GS A0A2A6RM68_9CHLR/16-289 AC A0A2A6RM68.1
#=GS A0A231HEL9_9NOCA/16-143 AC A0A231HEL9.1
A0A8H9IUF4_9PSEU/12-140 ...........................................wkrskknkl--------------..NWA......LVPNsADADSAESLRLAASVLDAL.......GVP.SG....TPS.....AVPANPGAPLEQLVQEDLQAQLPCLDS..RR--.H.WQV----.....-R.N.....GG.LITEFVQYAHLKEVDA.......LVR..AN..P......E.LR......V....T.......IGRDY.L.IKPDVTV..A-..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------lldlnvl.............................
A0A512PII2_9CELL/92-223 .......................................eesllgidltvas--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.-AG.G..A....G...K...P.........RLE..VALSAKWSLRTDRAQDCVSQGAKLVSQRRGRMPHFAVVTMEPRPAMLRILADGSGAVDCVYHLDLPALEHAVRL...E..A..A......A...........A.Taar..wppL.......ETFERLCAQRRLRDYDEL------lnev................................
A0A841FRK7_9ACTN/19-150 ................................................aqrq--------RMLAIT..GHP......AAPSiADIGSDTSLEIAHRVLRELg....vtHGTdGH....IDA.....PSGQKAGSDFEAAVKTDLRQSLSTTAS..YR--.T.WQI---G.....--.-.....AE.DVKHFEQYKHLGGLEE.......LLA..DQ..P......T.LR......V....T.......LGTDY.Q.IKPDVTV..G-..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------ieddrg..............................
A0A2V1GS93_9GAMM/11-302 ....................................................FHRLLIKNEILTFS..AFSkygaekICSN.ADSGQKHSVLTANLLTDKIaqn.lgiTVT.TR....SQK.....KKGQTLGNEFEQACTEYLQKTFLQLGN..LRPG.N.WQVEKIN.....SR.R.....QS.VLGQYEQYTHLSELGL.......LAD..KH..A......E.LR......N....F.......LGDGY.T.VAPDIVI..SR..SPET....DDMLNS.N......TLIV...D..D.H.S.C..KQSA.L.RIK.N..H....KtleA...Pn.......lILH..ASISCKFTMRSDRAQNTRTEALNLMRARKGRSPHIISLTAEPTVSRIASLALGTGDLDCVYHIALYELLEALKE...L..D..A......S...........E.P........L.......EQLEQMVVGKRIKDISDLPLDLAI....................................
A0A3A8URI5_9BACT/8-153 .................................................dgc--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..-LYD....DEELNR.D......NIFI...N..D.D.V.C..KMAA.L.RKK.N..G....G...K...P.........ILH..ASVSAKWTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTGEPLPSRLASLALGTGDLDCVYHFALYELMEAVQE...Y..G..Sh...grE...........D.I........V.......ETLENLVEGKRLKDISDLPLDLSV....................................
A0A101JQW7_9ACTN/125-256 ..................................sllgldvtisdnstagpa--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........ELR..TALSLKWSLRTDRAQDCLSQGAKLASQRRGRMPHYGVVTMEPRPYMLAILCDGSGAVDFVYHLHLDAVREAVAR...L..A..S......Erg.......dsD.Rw.....qgV.......RTLERLVGQGRLRDYDDL------vdeit...............................
A0A433GXX9_9MICC/95-378 ....................................................FHRALLDERVLVVD.pNSG......VPSN.ADKDSASSIRYAQAMTDGI.......GGV.PE....ARR.....APGHGVRRNFERAVAAYLKSVMRALDV..VRPG.E.WTVRRLGdvadgQG.A.....QD.ASTVFEQYEHVSGLRE.......AIA..AH..R......D.LR......A....L.......IGHDS.SiIAPDVVV..AR..APVA....DSELNA.T......ARLV...DplG.P.L.A..SASP.L.RSA.V..Q....E...K...S.........LLH..AVVACKWTLRSDRAEQVRSEARHLIRNRRGRVPHLVLVTGEPMPSRLAAVALGTGDIDCVYHVGLHELLDAIDP...A..T..D......P...........A.G........A.......DLLHTMVQGRRLKDISDLPLDLAL....................................
L1MCZ4_9CORY/15-303 ....................................................FHKRLVEQKVLAII..TTGkt..pgIASN.ADRSQDYSRQLAIHIANNL.......EAH.TV....DRK.....LPAQTAGTLFEELVAEFLITTLPIISL..GHPT.G.WHVENVG....nSR.K.....RD.HLAQYWPYRHLDELQT.......KVQ..AD..R......T.LE......A....V.......LGNLY.S.VNPDVLV..LR..SALE....DSVFNQ.H......EKLV...D..D.V.T.G..QRSH.I.RAT.K..E....Q...Q...HsdnnkstsaIVH..AVVSCKWTMRSDRAQNSRSEALSLIRNRKGRTPHIVAVTAEPTPSRIASLALGTGDLDMIYHFALDELITAVEA...G..R..N......D...........E.G........K.......AQLETLLNGDRLRDISDLPLDL--vt..................................
A0A3A8YH68_9BACT/12-291 ....................................................FHERLFETNTLTLT..KAG......VASN.ADTSSRGSKAIAGKIVDILvd..ehhHTV.NT....VDK.....ISGQTLGKQFELLTMEFLQETFPHLQN..LRPG.Q.WSILQLG.....NN.N.....RL.KTSDFEQYEHLAYLSA.......LTA..EN..A......Q.LA......A....A.......LGNDY.L.VAPDVVI..YR..NLYE....DEEINA.K......QYIV...D..D.E.I.S..RMAD.I.RKS.N..G....G...K...P.........LLH..ASVSAKYTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTAEPMPIRLASLALGTGDIDCVYHFALYELIRAVKE...V..G..S......E...........D.A........V.......ETLETLVQGKRLKDISDLPLDLAV....................................
A0A5N6MHY9_9MICC/145-264 ............................................lparhewe--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...P........rFLH..AAVSCKWTIRSDRVQNIRHENNQMIRHRRERLPHLVTVTAEPLPTRLAAIARGTGEVDAVYHVAYDALDGAIAE...A..GflT......R...........D.Q........K.......DAWEEVTEQGRVRPYSDLAKTLA-f...................................
A0A1H9RYU4_9CORY/13-296 ....................................................FHQSLIDNGTLAFT..STGkh..gkVASN.ADKSQRQSVEIAEHLGNQL.......-GV.QD....ADK.....LTGQTQGKNFEEAVEKFLAQVLEHVGH..LRPG.T.WHVVNVG....gSR.S.....ID.HLANFEPYRHLAQLEE.......AIE..KT..P......E.LL......S....V.......LGNSY.A.ISPDLLV..TL..DAFS....DEQLNA.V......TTLV...D..K.D.N.S..HFCP.I.RAI.N..H....P...N...Slt....ttaFVH..AVISCKWTMRSDRSQNTRSETLNLIRNRKGRAPHMVAVTAEPTPSRISSLALGTGDIDMVYHFALDELIVAVTA...C..G..D......R...........K.A........T.......ELLKTLVNGNRLRDISDLPLDLL-v...................................
A0A418KM37_9ACTN/101-176 ...........................................gialevgle--------------..---......----.-------------------.......---.--....---.....------------------QDIYTSLKE..LAPG.RaWKVTRRG.....S-.-.....--.-ANQFAQYRHLAHLQE.......LLK..SD..P......T.LK......T....T.......VGRDY.T.VSSDVMV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------glpnp...............................
A0A447IGZ0_9HYPH/15-286 ....................................................FHAALLE-SILYAN..ADG......VPTI.ADGSSKTSVRISLDLLHRL.......GSK.LV....NER.....LAGQMAGSKFEVIVGEYLEATLPRLSH..LRPG.R.FIFT-KG.....-S.S.....RL.AIADSDQYQHLSSLSA.......AME..AS..P......E.LA......V....A.......IGMDY.L.IKPDVMI..LR..KPEP....DEFINS.G......EQIV...D..E.T.S.A..TLTS.M.RSS.N..G....G...L...P.........MLH..ASVSCKWTIRSDRAQNARSEALNLIRNRKGRLPHIVIVTGEPTPGRLASLAFGTGDIDCVYHIALPELKAAVAA...V..G..S......D...........D.A........K.......EMLDTMIEGRRLRDIADLPLDLT-a...................................
A0A6I5C1J8_9ACTN/132-250 .............................................vensqes--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..G....I...A...P.........FLH..AAVSCKWTIRSDRVQNIRHEFLQMIRHRRGRLPHLVTVTAEPMPSRIASIARGTGEVDAVYHIAFDALRAAVEE...A..G..S......Q...........Q.Q........K.......NDLDEIISQGRLRPYEELA-----stlat...............................
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A0A6I5C1J8_9ACTN/5-141 ........................................fatrllgwkklk------------SS..GKP......VPNS.ADSHSAPSRELAAKILDSL......gAEP.GF....ILP.....ETPANPGPELERAVHIDLAAALAVADP..SRP-.-.WQV----.....-D.H.....QK.VIADFSQYTHLGKLKQ.......AVR..KN..P......V.LS......A....D.......LGLDY.L.IKPDVTV..GV..ENSQ....E-----.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------sgia................................
A0A1I6MGK5_9RHOB/12-279 ........................................fhsaclagpisi--------------..TKS......VPSI.ADVSNKASREISSALVGKI......gTTQ.HK....AEK.....PAGQTAGHMFESVCQGFLQESIVQLSH..LRPG.H.FSV----.....-E.R.....GK.AISLFDQYAHLDELRI.......LSD..AS..R......E.LK......T....H.......LGTDY.L.IKPDVVV..IR..EPET....DESINA.G......NFIV...D..D.S.V.A..KQTS.I.RQA.N..G....A...Y...A.........TLH..ASVSCKLTIRSDRVQNTRSEALNLVRNRKGRLPHIAAITAEPVPSRIAAIALGTGDIDCVYHFALNELVEVLVE...Q..E..R......-...........E.T........L.......ELVETMIDGKRLRDISDLPLDLVI....................................
A0A6N7ZR53_9HYPH/90-351 ............................eihaklpksyrnqcrslgarnpps--------------..---......----.-------------------.......---.--....---.....--RNTKGSEFEKAIRLFLEESFLELVApvYRPG.D.YLI---R.....SK.Q.....NN.RLEEFSQYVHLAWHSKeldlisrLSKdsRA..G......D.LA......DearrIldecphgLPNSY.Q.TSPDVTI..AR..KPKK....M-PANP.-......----...-..S.G.I.G..PDNH.L.FTS.F..D....P...H...P.........VLF..AICSAKWTLRSDRAQNSRSEVSYLERERRGPKCRFVAVTAETNASIISSIAIGS-EVDCTYHVALPELLEVTRS...V..HpaG......D...........D.K........L.......DKLENLIATKRLKDISDLPFDLAV....................................
A0A1H6E8S2_9ACTN/130-249 ............................................givdlavl--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..G....S...E...P.........FLH..GAVSCKWTIRSDRVQNIRHECNQMIRHRRGRQPHLVTVTAEPLPSRLASIARGTGEVDAVYHIAFDALDASVRV...H..G..N......S...........A.Q........K.......DAWEECVEQRRLLSYKELPETLA-q...................................
A0A3A9YWV4_9ACTN/12-287 ....................................................FHGALAARHTLSLS..PDG......VASN.ADSNQKTSTAIAAAIAKAL.......GAQ.IV....PKK.....LDGQRAGKQFEQAVEEFLAAVFPLFRS..LRPG.K.WRIENVG....sSR.G.....EY.QISKYEPYAHLGELAH.......VIE..SN..R......T.LA......S....V.......LGNSY.E.ISPDILV..LR..APEP....DGLINQ.E......RELV...D..E.E.S.G..RYSI.L.REV.N..Q....E...R...A.........IVH..AIVSCKWTLRSDRAQNARSEALNVIRNRKGRTPHIVVVTGEPTPSRLASLALGTGDIDTVYHFALPELIQAVEK...T..G..N......D...........E.A........I.......SMLSTLVNGKRLRDISDLPLDLAV....................................
A0A6B8JR30_9GAMM/14-286 ....................................................FHAALLS-SVLRTD..DKG......VPSN.ADKDSAASKRIAAGIMKKL.......GAE.AV....GAR.....LSGQMAGSKFEEICKEYLEETFPALNH..LRPG.K.WNI-SKG.....VG.G.....RS.AIAQFDQYEHLAALDH.......ASK..SN..P......E.LA......A....A.......LGSDY.L.IKPDVVV..VR..FPED....DDTINS.E......DNLV...D..L.T.T.A..RHTP.I.RKT.N..S....E...R...P.........ILH..ASVSCKWTMRSDRAQNARSEGLNLVRNRKGKLPHVVVLTGEPTPNRIASIALGTGDIDCVYHFALPELVDTVKE...L..N..M......M...........D.A........H.......ELLQTMIHGKRLRDIGDLPLDLI-i...................................
A0A2V2L6H8_9RHOB/13-281 ....................................................FHATLLA-GILTRS..DNG......VPSN.ADRSSRPSIAIASAILEQL.......GPA.QT....ASK.....LAGQTAGADFEGVCAEFLALCFARLGH..LRPG.R.FEV----.....-R.K.....GG.GIAQFDQYAHLDDLEA.......IAR..AN..R......E.IA......T....A.......LGSDY.L.IKPDILI..SR..HPVP....DTVLNA.H......ERLV...D..D.G.A.G..RLSS.L.RSR.N..N....A...M...S.........TLH..ASISCKWTLRSDRAQNARSEGLNLVRNRKGRLPHIAVITAEPAPARLASLALGTGDIDCIYHFALYELRAALEA...Q..H..R......D...........D.T........L.......DLLDMMVDGKRLRDISDLPLDL--vt..................................
A0A285J0D1_9ACTN/17-291 ....................................................FHAGLVAEGTLTVD..ARG......VASI.ADRANRLSVAVGAEIATSL.......LVD.TE....AER.....AAGQTLGGSFEEATANYLGATFPAFWM..LRPG.K.WEVRKIG.....NT.R.....RS.AIAAYEPYQHLADLAE.......AIE..RD..P......T.LI......S....V.......LGNAY.A.ISPDIVV..TR..QPEP....DDHINE.G......SLLV...D..D.Q.F.A..RLTA.I.RAD.M..Q....G...L...P.........ILH..AVVSCKWTLRSDRAQNARSEALNLIRNRKGRLPHIVVVTAEPTPSRLSSLALGTGDVDCVYHIALPELLDAMEK...H..G..N......D...........D.N........L.......ELLETMIKGRRLKDISDLPLDLTI....................................
A0A2S8VY21_9CAUL/17-295 ....................................................FHAELLKSNVLHFR..DNG......NANV.ADGSNTTSIALGNGYLNAL.......KAE.VW....LEK.....IAPQTGGSKFEVVVEDFVLRTLELL-D..IFGG.R.S----FS.....TR.R.....RK.DITDYHQYRPIAPENL.......TLP..EL..D......A.LR......H....A.......FGGDY.V.VTPDILV..ER..RALS....REELNA.K......GLVV...D..D.A.Y.G..DLST.I.RAA.K..G....-...-...L.........ILH..ASISCKQTIRSDRSQNSRLEALNLLRMRTGRAPHIVVVTSEPLPSRIGSVAIGTGDLDCTYHVALTELRAAMAE...H..E..K......SgegqpghkaraK.Q........K.......RDLELMVKNGRLKDIADLPLDL--ll..................................
R4YXJ7_9ACTN/12-128 ...............................................fvgdk--------------..---......--PNtADIANHGSTDIARGVLEVL.......-GI.S-....HQA.....PNAQTAGMNLEDGVKEYLAAELPRLDQ..RRP-.-.WEV----.....-R.R.....GG.AISEFRQYAHLARLNE.......LVG..AD..P......T.LK......V....E.......LGQDY.M.ISPDVTV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------gfmhgdv.............................
A0A1G8M612_9NOCA/27-281 vnsirwgramfdalgvahatpeisdvgtalevavvedlrarrpdlivdrsri--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.-ATDFDQYRHLSQLKN.......YMS..SF..HddldriE.MA......I....A.......ETKQL.D.TSKSVTA..LR..RQLNtirnHAASNR.G......FFCA..lK..E.N.L.A..EESM.L.RTD.I..A...vT...S...Prs.....gqRLL..VALSSKWSLRTDRAQDCVSQGSKLVSLRRGHMPHFAVITMEPRPSMLRLLTDGSGSVDCVYHVAFGALKTAANS...L..S..K......Qsip.....rmpE.Q........L.......DLLDRMIKQNRIRPFSAL------ldein...............................
A0A2P7THW8_9SPHI/10-279 ...................................................y-HAAIFA-ELLTID..NKG......IPSN.ADKHSNISVKIAQSIVEQI.......NLH.VQ....ANV.....VSGQTAGKTFEKLTANYLEQAFSELNH..LRPG.K.YAF-FIG.....--.-.....-K.SIETFEQYEHLAILTE.......ALK..NN..R......A.LR......V....L.......IG-DY.I.ICPDIIV..GR..KPIT....DSEINE.T......KSLL..hT..G.DlS.A..QFTP.L.RIK.N..S....S...K...L.........ILH..ASISCKWTIRSDRSQNSRTEALNLLRNRKGNAPHIAIVTAEPYPQRIASLALGTGDLDCVYHFALPELLNAVNC...L..N..N......E...........S.V........A.......DSVETLVSGKRLRDISDLPFDMAI....................................
A0A1X7FMI3_CELCE/1-78 ....................................................--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..-------------------------------MPHFGVVTMEPRPYMPNLLAGGSGDVDCVYHLDLPALTAAVDH...V..Y..V......G...........S.K........Qlv..kgrDLLHRLIDQRRIRDYDDLI-----aeiq................................
A0A1H6E8S2_9ACTN/16-136 ..............................................rggkrp--------------..---......-VPNcADSDSAQSVILAEGMLREL.......GLV.PN....DDR.....KVPTDPGPVLEEHVRRHLTEALPHLNS..HR--.A.WQV----.....-R.R.....GT.LITDFAQYAHLRRVDE.......LVR..DS..A......E.LR......I....T.......IGQDY.L.IKPDVTV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------givdlav.............................
B0TCH8_HELMI/1-128 ....................................................--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......--MV...D..D.S.V.C..LKTV.L.RKS.N..G....G...K...D.........ILH..ASISSKWTIRSDRSQNSRTEALNLIRNRKGHLPHIVVVTGEPLPSRIASISLGTGDIDCVYHFALYELIQAVNE...F..G..N......D...........D.S........I.......VLMQTMINGKRLKDISDLPLDLAV....................................
A0A1M6BA57_9ACTN/12-287 ....................................................FHRQLVEDRTLMLD..EAG......IASN.ADGSQRTSREIAAFIARGL.......GAR.QG....PKK.....LPGQQAGRQFEVAVQSFLEQTFPLMQS..LRPG.K.WHVENVG....gQR.G.....EY.HLARYEPYSHLDELAR.......AIE..KS..P......T.LI......S....V.......LGNSY.E.ISPDVLI..TR..EPET....DEVINR.Q......LELV...D..R.F.S.A..RHAV.I.RRA.N..Q....D...R...A.........IVH..AVVSCKWTLRSDRAQNARSEALNLIRNRKGRTPHIAVVTGEPSPSRLASLALGTGDLDVIYHFALPELIDGVEA...T..G..N......D...........E.G........I.......SMLGHLVDGKRLRDIADLPLDLAV....................................
A0A3N6WMG4_9ACTN/129-251 ...........................................isrhrlmdr--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.--A.A..D....P...A...P.........FLH..AVISCKWTIRSDRVQNIRHEFGQMIRHRRGRQPHLVTLTAEPLPTRLASIARGTGEVDATYHVAFDALAEAVRS...A..G..N......Q...........E.Q........R.......NAWNECVAQGRLKPYDEL------aptlaa..............................
A0A3G6J2M3_9CORY/16-296 ....................................................FHRFLIESGTLSIA..ETAq...grVASN.ADKSQASSKNVALHIAEQL.......-EV.PV....GTK.....SAGQTAGTKFELATNNFLAATFPLLQA..VRPG.T.WEVMNLG.....NR.R.....RHdHFADYEPYRHLADLAD.......AIA..LD..S......S.LA......A....A.......LGNSY.V.ISPDVIV..VR..SAVA....DVEINA.D......QYIV...D..E.F.A.G..RLSP.L.RAD.N.fA....G...D...Pt.......kFIH..AVVSCKWTMRSDRAQNTRAEALNLLKNRKGRAPHIVAVTGEPSLSRIASLALGTGEIDMVYHAFLPELRTAIEQ...V..G..T......E...........D.A........Q.......ELFHILVDGNRLRDIADLPLDLAV....................................
A0A2N5H2V4_9BACI/17-289 ....................................................YHAELLN-SVLTIN..SDG......VPSN.ADKGNRLSVLIAAGIADLL.......-ES.ST....GER.....LAGQTSGSKFETINTEFIINTFKMMGH..IRPG.E.WEVRKIG.....NN.S.....RM.GIAEFEQYSHLADLTV.......IAK..EN..P......V.LA......A....A.......IGRDY.T.ITPDTII..SR..KPLT....DAEINT.Y......SQIV...D..S.S.I.A..KYTP.L.REV.N..N....Q...H...P.........ILH..ASISSKWTIRSDRSQNSRSEALNLIRNRKGKLPHIVVITGEPLPSRLASIALGTGDIDCVYHFALHELMQAVAN...C..G..A......L...........D.A........L.......EMLNIMINGKRLKDISDLPLDLSI....................................
D1A869_THECD/131-252 ..............................................lpgrsp--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..S....D...P...P.........FLH..AAVSCKWTIRSDRVQNIRHENNQMIRHRRERLPHLVTVTAEPLPSRLLAIARGTGEVDAVYHIAYAALDSAIRD...L..A..D......A...........G.K........I.......E-----------------------sdqldawregtelgrirpfadlaptia.........
A0A0C5BD22_9MICO/16-292 ....................................................FHASLLAHKVLSFN..DTR......VPSN.ADGSNGTSIAYARAIADAL.......QVE.TV....SER.....LAGQTSGGQFEQAIADFLASTFPKLDM..LRPG.D.WEIRKVS....gRG.A.....SA.QASMFEQYAHLTALDQ.......AVK..AN..P......Q.LQ......A....V.......LGNGY.T.IAPDIVV..SR..APVT....DSVINR.R......EHLV...D..D.T.I.G..GHAP.I.RASvN..P....T...L...Q.........ILH..AVVSCKWTIRSDRAQNSRSEALNLIRNRKGRLPHISVVTAEPLPSRIASVALGTGDIDCVYHFALPELIQAIDA...E..G..H......G...........D.A........T.......ESLHMMIDGKRLKDISDLPLDLAV....................................
A0A3P1SBN6_9ACTO/18-293 ....................................................FHQHLILHEVLSVA..RDG......IASN.ADKSQKTSRDIALHMATSL.......GAH.IE....VQK.....LAGQRSGANFERIVADFLSETFPHFLS..LRPG.N.WTLANVG....sSR.K.....NE.HLSRFEPYRHLSLLSD.......AVE..AD..P......A.LQ......A....I.......LGNSY.S.ISPDVVV..LR..SPES....DETINA.G......TYLV...D..E.D.S.G..RYSV.I.RQA.N..Q....T...H...D.........IVH..AVISCKWTLRSDRAQNARAEALSILRNRKGRAPHIVVVTGEPTPSRLASLALGTGDLDMVYHFALPELIDAVEA...C..G..N......D...........E.A........Q.......AMLAALVEGQRLRDISDLPLDLSV....................................
D4YMD3_9MICO/15-290 ....................................................FHALLIANGTLAIN..KAG......VPSN.ADKSQKSSIKFASEIARLL.......KVE.TV....GER.....LAGQTVGGQFEAAVMSFLERTFPLLNT..LRPG.S.WRFTNLG....gKR.R.....GA.GMSDYVPFRHLDELAR.......AIE..AS..P......T.LQ......S....V.......LGNAY.V.ISPDVLV..SR..LPEP....DERIEQ.G......GLLM...S..D.D.V.G..RYTP.V.REA.N..Q....P...H...P.........ILH..AVVSCKWTLRSDRAQNARSEALNLVRNRKGRLPHIVVVTGEPTPSRISSLALGTGDIDCVYHFALPEMIEAVTK...S..G..N......D...........E.A........L.......NLLMSMVNGERLRDIADLPLDLAV....................................
A0A7W7VWR2_KITKI/138-286 ......................srnrrrplldalgdeslpkldisvhrdlgp--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.-AA.Q..A....G...K...P.........HLV..AGLSLKWSLRTDRLQDPRTHGAKMAALRRGRMPHFAAVTMEPRPYFLARLGQGTGDLDCVYHLHLPALAAAVND...Y..Y..T......G...........T.Ksr...lriR.......DTFHRMVDQRRLRDYDDL------vsylg...............................
E1IE54_9CHLR/62-335 ....................................................FHAALLS-AVLRID..AAG......IPTN.ADKDSRVSVAIARGIIDIL.......GKR.GP....GTR.....MAGQIAGNHFEMICKEYLDTVFPHLQH..LRPG.T.WTISKGV.....GA.G.....RL.AIAQFDQYAHLAALDN.......AAR..SN..P......E.LA......A....A.......LGSDY.L.IKPDVVI..IR..HPEM....DATINS.Q......EMLV...D..E.T.C.A..RLTS.L.RKC.N..N....T...Q...P.........ILH..ASISCKWTLRSDRAQNARSEGLNLVRNRKGRLPHIAVITGEPTPSRIASIALGTGDIDCVYHFALTELLSTVNT...L..G..Y......V...........D.A........E.......DLLHTMIDGKRLRDIADLPLDLI-i...................................
A0A199NTB8_9MICC/132-415 ....................................................FHRALIDERVLVTR.pGSG......VPSN.ADTGSGSSLRYARAIAEGI.......GAV.EA....HPR.....SPGHSAGRSFERAVAAYLQAVLQALDG..IRPG.E.WTVRRLG.....DR.GadgtiRD.ASEIFEQYEHLAALRE.......IVE..GS..R......D.LR......A....V.......LGAEAeL.LAPDVVV..MR..SPLS....DRDLNA.V......TRLV...DplG.P.L.A..SASP.L.RSA.V..Q....P...K...P.........LLH..AVVSCRWTLRSDRAQQAKAEAQQLIRNRRGRAPHLVMVTGEPMPSRLAAVALGTGELDCVYHFALHELMDAIDP...A..V..D......P...........A.G........A.......ELMHTMVQGRRLRDISDLPLDLAI....................................
A0A6V8MPX0_9DELT/13-290 ....................................................YHRKICCDIFGHRG..GTV......IFSN.ADNSSKASVDLARGMADRI.......CQP.IC....GNP.....PSGQLAGSLFTRYTKEFLDESFKLIQH..IRPG.E.WSF--ST.....SQ.S.....RI.GIASFHQYEHLAELKS.......VLD..TH..T......E.LK......A....A.......LGGDY.L.ITPDIIV..SR..SPVN....DNDINGhG......GQVVs.eN..E.S.I.A..TLTP.L.RSS.N..Y....E...K...Sc.......eILH..ASISCKWTMRSDRAQNTRTEALNLVRNRKGRTPCILAVTFEPLPSRIASIALGTGDIDCTYHGALYELVDAAKS...S..S..H......S...........D.S........Y.......EMLQLLIQGRRLRDISDIPFDLAI....................................
A0A8J6IYH4_9FIRM/12-285 ....................................................YHSELLHRGVLAIN..AQG......IATN.ADKDSVASVSIARGIADRL.......-LA.ET....DER.....IAGQTSGKAFEEITMMFIKSTFPKLQH..LRPG.K.WEIKKLG.....NR.S.....KI.KTSAFAQYEHLAYLTE.......LTK..AN..R......K.LS......A....M.......IGNDY.M.VAPDIVI..YR..GLCT....DEEINT.P......MLVV...D..D.T.L.S..RMAD.L.REA.N..G....G...K...A.........ILH..ASISAKWTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTGEPLPSRISSLALGTGDIDCVYHFALNELIAAVND...Y..D..H......D...........D.I........K.......EMLKTLVEGKRLKDISDLPLDLSV....................................
A0A0P6X781_9CHLR/11-299 ....................................................YHQEILQKIVRLNThpDKGs....rYPSF.ADSSSKNSIAIAWKLIEKI.......NTE.SItfveDQS.....ITAQTAGGRFEEITRNFLQNALDLLTH..LRVG.E.WLY----.....-Y.T.....SI.PISRFDQYEHLAALEK.......LSR..EN..P......Q.IA......A....T.......LGGDY.I.IKPDIVV..AK..KPVY....PSNINR.P......QREVisdD..E.E.I.A..AFSPfIfRSN.A..P....E...K...L.........ILH..ASISCKWTLRSDRGQNSRTEALNLIRNRKGSVPKIVAVTGEPLPMRIASLALGTGDLDCVYHFALPELQKAIEE...L..I..EntgsslE...........D.Q........K.......DMLNTLIEGRRLRDISDLPFDL--ll..................................
A0A3D9HVM7_9PROT/13-309 .......................lhkkliqdetlayspvpeknhkklggite--------------..---......IASF.GDVGQKLSAEVSNRLAEVIadk.vdlPLV.RR....SKK.....KDGQTLGNEFEDACADFVRETFLELSH..LRPG.K.WIVEKVS.....SR.K.....ES.LIGRYAQYSHLSELNG.......LMD..KY..T......E.LR......S....F.......LGEGY.A.IAPDVII..AR..LPEE....DAEINL.R......TELV...D..G.S.S.A..KQAV.L.RKE.N..QysetE...T...S.........ILH..ASISCKYTMRSDRAQNTRTEALNLIRARKGRTPHIVAVTAEPIPNRIVSLALGTGDLDCTYHFALYELRETLLQ...L..G..K......E...........E.S........L.......DTLDMMIEGKRLKDISDLPLDLAV....................................
A0A2U3A104_9ACTN/12-287 ....................................................FHKNLVDRHTLSLS..PGN......VASN.ADSSQKTSVGIALRIAKEL.......SAQ.VI....PEK.....IKGQRAGKQFEEAVEIFLRETFPLFHS..LRPG.S.WSIENVG....gSR.A.....EY.QISKYEPYAHLAALAN.......AIE..ND..R......T.LA......S....V.......LGNSY.E.ISPDVLI..LR..SPEP....DEVINR.D......QELV...D..E.D.F.G..KYSV.V.RMA.N..Q....D...R...P.........IVH..AIVSCKWTLRSDRAQNARSEALNVIRNRKGRTPHIAVVTGEPSPSRLASLALGTGDIDTVYHFALPELIRAVDS...V..Q..N......D...........E.A........V.......SMLHTLLEGKRLRDISDLPLDLAV....................................
A0A5Q0LHX9_9ACTN/133-251 ..........................................tspaadaasr--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...R.........HLH..AAVSCKWTIRSDRVQNVRHEFLQMIRHRRGRLPHLVVVTAEPMPSRIASIARGTGEADAIYHVALDALKAAVAA...V..G..S......S...........K.Q........K.......DDLDEIIEQGRLLPYGTLP-----ptlst...............................
A0A4R6TVE4_9BURK/14-287 ....................................................FHAALL-EATLTIN..AAG......VPSN.ADKDSKASVAIAKGIAELL.......KAE.TI....GER.....IAGQTSGSQFEEICSKFVRETFLKLGH..LRPG.S.WDVHQVG.....GR.N.....RL.EIARYEQYAHLIALDR.......AAK..AD..A......E.LA......A....A.......LGSDY.T.ITPDIVV..VR..GTED....DSVINA.P......AYLV...D..D.S.V.T..TLAS.L.RKK.N..G....G...R...P.........LLH..ASISCKWTIRSDRAQNARSEALNLVRNRKGRLPHVVVVTAEPTPSRLASIALGTGDIDCVYHFALYELQETVKA...L..G..M......D...........D.A........A.......DLLAVMVNGHRLKDISDLPLDLAV....................................
A0A7H8JQQ4_9ACTN/13-146 ...............................................wknss------NKKVLEAC..GKA......FAPNiADVDNKRSLLIARSVFDDL.......QVT.RL....INA.....NSSEAKEENRGTALENAVTEEIEAQLS..LKAP.H.TSY-N--.....VA.R.....GV.DVWTYEQYKHLSELRK.......ILS..DT..P......S.LR......V....T.......LGTDY.Q.ITPDITV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------gigip...............................
A0A418ZPD4_9RHOB/14-287 ....................................................FHAALLE-ATLTTN..AAG......VVSN.ADGSNTTSKAIAKGIADLL.......KAE.TI....GER.....IAGQTSGNQFEGICAKFVRETFLKLGH..LRPG.I.WDIHQVS.....GR.N.....RL.EIARYEQYAHLVALDR.......AAK..AD..A......E.LA......A....A.......LGSDY.T.ITPDIVV..VR..DTED....DAAINA.P......ALLV...D..S.S.V.T..TLAS.L.RKQ.N..G....G...L...P.........LLH..ASISCKWTIRSDRAQNARSEALNLVRNRKGRLPHIVVVTAEPTPSRLASIALGTGDIDCVYHFALYELQATVAA...L..G..M......N...........D.A........A.......DMLAVMVDGKRLKDISDLPLDLAV....................................
S2ZCC8_9CORY/13-299 ...............................fhatlvsesgplcllsengel--------------..--C......MASN.ADRSQATSRAISLAIAEEL.......GAV.ER....KQK.....PSGQTMGSNFENAVHGFLAECLPHLDV..IRPG.P.WKFLNVG....gSR.R.....SD.QLADYFPYRHLGDLAH.......EIS..NH..P......E.LL......S....V.......LGNLY.A.VSPDVLV..IR..EALS....DSAINE.F......ETVV...D..G.Q.S.A..LLTP.V.RAV.N..T....A...SeslPt......paFIH..AVISCKWTMRSDRSQNTRAEALNLIRNRKGRTPHIVAVTAEPSLSRIASIALGTGDIDMTYHFALPELERAVEK...V..G..N......D...........E.S........Q.......TLLKTLVEGDRLRDITDLPLDLAV....................................
A0A5C5USN1_9CORY/12-287 ....................................................FHADIVDQQLLVID..SNG......VASN.ADSSQRFSRETALDIANRL.......GAH.KV....QKK.....ISGQSAGRIFESAVQSFLESSFLALHS..IRPG.D.WKVENFG....nSR.S.....EY.HLGRYVPYRHLIALAN.......AIE..KD..P......T.LT......A....A.......LGNSY.D.ISPDVLV..LR..NPVL....DDTINK.R......DLIV...D..A.L.A.G..NRSP.I.RMS.N..Q....K...S...P.........IVH..AVISCKWTLRSDRAQNARSEALNIIRNRKGRTPHIAVVTGEPSPSRIASLALGTGDLDTVYHFALEELLEATIK...S..D..N......S...........E.A........I.......QTLHNLVDGERLRDISDLPLDLAV....................................
A0A1N6QNI4_9GAMM/14-293 ....................................................FHKRLLA-SILQID..DSG......VPGN.ADRSSASSCNIASGIAQKL.......LAE.NG....VRT.....-VAQTSGNKFEEVVALFISNTFPNLSN..LRPG.T.WDVRQIK.....SR.G.....GS.EISKYSQYEHLAALTE.......AAK..GN..L......E.LS......A....A.......LGNDY.T.ITPDVVI..TR..QPET....DAVINS.I......GHIV...D..S.E.V.A..LRSD.L.RDR.S..L....G...R...P........pLLH..ASISTKWTLRSDRAQNARSEALNLIRNRKGRQPHIVVVTGEPTPSRLASLALGTGDIDCVYHFALHELIETVSE...L..S..DspgtkiS...........D.S........D.......DLLRIMVEGKRLKDISDLPLDLAV....................................
A0A369AFQ9_9BURK/14-287 ....................................................FHASLLQ-STLTIN..SAG......VVSN.ADSSNTTSKAIAKGIADLL.......KAE.TI....GER.....IAGQTSGNQFEGICAAFVQETFLKLGH..LRPG.T.WDVHQVS.....GR.N.....RL.EIARYEQYAHLVALDR.......AAK..AD..A......E.LA......A....A.......LGSDY.T.ITPDIVV..VR..DTED....DGTINA.P......ACLV...D..D.T.V.T..TLAS.L.RKK.N..G....G...L...P.........LLH..ASISCKWTIRSDRAQNARSEALNLVRNRKGRLPHVVVVTAEPTPSRLASIALGTGDIDCVYHFALYELQATVKA...L..G..M......D...........D.A........A.......DLLAVMVDGKRLKDISDLPLDLAV....................................
A0A0B8NG68_9NOCA/19-145 ..........................................kknklgwrwv--------------..---......--PNtADVDSVTSLTLAGHALEQLgka.npnLNP.GL....NSA.....VPPKDPGGLLEQRVLEDLTDRLPTLDS..TR--.K.WAL----.....-A.R.....GQ.SIAGYAQYQHLAGVKA.......AIG..KD..P......N.LL......V....T.......LGTDY.L.IKPDVLV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------gllg................................
A0A7G1KGK3_9NOCA/142-256 .................................................tpt--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.S..T....N...H...P.........WLH..AAIACKWTIRSDRVQNIRHENGNMIRHRRGRLPHLVTVTAEPLPTRLASIARGTGEVDATYHIAYDELAEAVAT...H..G..S......L...........E.Q........R.......DAWEEVTKQGRLLDYKDLA-----rslv................................
A0A5N5V7B3_MYCPH/21-156 ..........................................srrvceelfg--------------..-ED......AAPNlADVGSRASLHLAGYAYETLgvpksrvRAD.SL....DDD.....SAQTASGTALERAIEADLA---TQLRA..RDPDrT.WLVT---.....--.R.....TG.TVANYAQFTHLNDLQE.......LLE..AT..P......V.LR......S....T.......FAGDY.Q.VKTDVYV..GV..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------ensanl..............................
A0A1T1CA67_9SYNE/11-288 ....................................................YHAKLGQQVIRFST..RAG.....iTYPNfADCGSRSSTLIANGIAEAL......gVPR.QT....ARQ.....IPAQRAGALFENLTCEFIEHTLTAISH..MRPG.K.WKY--L-.....-T.S.....QT.QISRFAQYRHLKALDD.......LVR..DD..R......D.LS......T....A.......LGRDY.L.VTPDIVV..SR..SAVS....HDDING.Q......AMFL...D..HpG.I.A..TLTP.F.LES.N..C....Sp.aL...P.........FLH..ASVSCKWTIRSDRSQNTRTEALNLIRNRKGRLPHIVAVTAEPLPMRIASLALGTGDLDCVYHIALDELKTVCGA...L..P..S.....cE...........D.Q........A.......EMLFTMIDGDRLRDISDLPFDIAV....................................
A0A076NID6_9CORY/15-294 ....................................................LHQELVDTKTLSIA..ENSd...grIASN.ADKKQKASCVLALHVAEQL.......HA-.GT....AKK.....KPAQKLGADFERIVAKFLQATFPQMQS..VRPG.D.WSILNVG....sAR.R.....KD.HLAAHEPYTHLASLAE.......AIW..LN..P......D.LG......A....S.......LGNNY.V.ISPDILV..LR..DAIS....DEVLNR.D......RIIV...D..G.Q.A.G..SLSP.V.RAA.N..R....E...S...Pa.......tHVH..AVISCKWTMRSDRSQNTRAEALNLIRNRKGRSPHIVAVTNEPTMSRIASLALGTGDVDMVYHVALKELMAAIDE...K..G..S......D...........D.A........K.......ELMHTLVTGDRLRDIADLPLDLSI....................................
A0A1A9BU78_9ACTN/12-287 ....................................................FHQGLVDRKTLSLS..PDD......VASN.ADKSQRTSVSIALSIARAL.......SAE.CI....PKK.....LDGQRAGKQFEEAVEQFLKDTFPLLQS..LRPG.Q.WSIENVG....gSR.A.....EY.QIARYEPYSHLAELAR.......AIE..GD..R......N.LA......S....V.......LGNSY.E.ISPDVLV..LR..NPEP....DEVINR.D......QELV...D..E.D.S.G..QRAI.I.RKS.N..Q....E...R...S.........IVH..AIVSCKWTLRSDRAQNARSEALNVIRNRKGRTPHIAVVTGEPSPSRLASLALGTGDIDTVYHFALPELIDAVNA...T..D..N......D...........E.A........V.......SMLSTLIDGKRLRDISDLPLDLAI....................................
Q5F8B2_NEIG1/12-286 ....................................................FHKKLLDGNILATN..NRG......VVSN.ADGSNTRSFNIAKGIADLL.......HSE.TV....SER.....LPGQTSGNAFEAICSEFVQSAFEKLQH..IRPG.D.WNVKQVG.....SR.N.....RL.EIARYQQYAHLTALAK.......AAE..EN..P......E.LA......A....A.......LGSDY.T.ITPDIIV..TR..NLIA....DAEINR.N......EFLV...D..E.N.I.A..TYAS.L.RAG.N..G....N...M...P.........LLH..ASISCKWTIRSDRAQNARSEGLNLVRNRKGRLPHIVVVTAEPTPSRISSIALGTGEIDCVYHFALYELEQILQS...L..N..Y......E...........D.A........L.......DLFYIMVNGIRLKDISDLPLDLAF....................................
A0A5Q3RVA4_9NEIS/12-284 ....................................................FHRKLLG-SILTTN..AKG......IVSN.ADGNNGRSCTIAKGIAELL.......EAE.TV....TER.....AAGQTSGNAFEAICSQFVESAFKKLNH..LRPG.D.WNVRQIG.....SR.N.....RL.EIANYQQYAHLVALAH.......AAE..NN..P......E.LA......A....A.......LGSDY.T.ITPDIIV..TR..DLVD....DEEINR.H......EFLV...D..N.N.I.A..KLAS.L.RKN.N..-....V...L...P.........LLH..ASISCKWTIRSDRAQNARSEGLNLVRNRKGRLPHVVVVTAEPTPSRISSIALGTGEIDCVYHFALYELEKTLQT...S..G..Y......E...........D.A........L.......DLFYIMVNGKRLKDISDLPLDLAI....................................
A0A1W6YZ28_9BORD/13-286 ....................................................FHASLLQT-TLTTN..AAG......IVSN.ADTGNGPSRAIAKGIADLL.......KAE.TI....AER.....IAGQTSGNQFESICAAFVRETFLKLSH..LRPG.S.WDIHQVS.....GR.N.....RL.EIARYEQYAHLIALDK.......AAK..AD..A......E.LA......A....A.......LGSDY.T.ITPDIVV..VR..GTEE....DDAINA.P......GLLV...D..D.T.V.T..RLAS.L.RKK.N..G....G...L...P.........LLH..ASISCKWTIRSDRAQNARSEGLNLVRNRKGRLPHVVVVTAEPTPSRLASIALGTGDIDCVYHFALYELQATVKA...L..G..M......D...........D.A........A.......ELLDVMVNGNRLKDISDLPLDLTV....................................
A0A841FRK7_9ACTN/145-259 .............................................ieddrgr--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........YLH..AVVSCKWTLRSDRAQNVRHEFKPLIASRRGRTPHLIAVTAEPLPTRLASLARGTGEIDAVYHVAFEEMHAAVAA...S..E..H......P...........E.Q........Q.......DAWNEIVGQERLRDYRHLAADL--tr..................................
A0A4P7GNS9_9ACTN/148-259 ...............................................tptvt--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....A...H...P.........WMH..AAVSCKWTIRSDRVQNIRHEFGQMIRHRRGRQPHLVTVTAEPLPTRLASIARGTGEVDATYHVAFDELAAAVAA...S..S..N......Q...........G.Q........Q.......DAWAEVVGQGRLRN----------ynllad..............................
R6R3N2_9FIRM/12-291 ....................................................FHKRLFETNTLTLT..SAG......VASN.ADTSSRGSKAISRKIVDILve..eqhHAV.AT....VDK.....ISGQTLGKQFETLTMEFLRATFPYLQN..LRPG.N.WTILQLG.....NN.N.....RL.KTSDFAQYEHLAYLNA.......LTA..EN..A......Q.LA......A....A.......LGNDY.L.VAPDVVV..YR..DLYE....DAGINA.E......QEIV...D..D.T.V.C..KMAD.I.RKA.N..G....G...K...P.........ILH..ASVSAKYTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTAEPMPNRLASLALGTGDIDCVYHFALYELLCAVKE...V..G..S......E...........D.A........V.......EILETLVQGKRLKDISDLPLDLSV....................................
A0A6B1UB08_9FIRM/12-291 ....................................................FHKQLFETNTLTLT..SAG......VASN.ADTSSRGSKAIARRIVDILvd..eqhHAV.ST....VDK.....ISGQTLGKQFETLTMDFLRETFPNLQN..LRPG.R.WTILQLG.....NN.N.....KL.KTSDFAQYEHLAYLNE.......LTT..QN..A......Q.LA......A....A.......LGNDY.L.VAPDVVI..YR..DLYE....DSEINA.A......QCIV...D..G.D.V.S..KMAD.I.RKA.N..G....G...K...P.........LLH..ASVSAKYTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTAEPMPNRLASLALGTGDIDCVYHFALYELIRAVKE...V..G..S......E...........D.A........V.......ETLETLVQGKRLKDISDLPLDLAV....................................
A0A161JNN6_9MICO/17-292 ....................................................FHAGLLMGSILTLS..DNG......VPSN.ADRNNTTSVKYAKRMAESL.......RVE.TI....AER.....RAGQTSGNEFESATAAFLNATFPALQA..LRPG.D.WEIRKVG.....GRgA.....AA.QASVFEQYAHLVELNA.......AVR..AN..P......Q.LQ......A....V.......LGNGY.T.IAPDIVV..SR..APVD....DRVINA.Q......EVLV...D..E.T.V.A..LHTA.M.RSS.N..Q....T...R...R.........ILH..AVVSCKWTIRSDRAQNSRSEALNLIRNRKGRLPHIAVVTAEPLPSRIASVALGTGDIDCVYHFALPELVEAVEH...E..G..H......G...........D.A........T.......ESLHMMIEGKRLKDIADLPLDLAV....................................
A0A3S0C338_9ACTO/12-287 ....................................................FHQTLVDSGTLIID..NNG......IASN.ADRSQETSRKIALSIARKL.......RAR.EV....ARR.....LNGQTTGGNFENAVSEFLRSSFPRFAP..LRPG.A.WRIENVG.....AR.R....gEY.HLARFEPYTHLDDLAN.......AIE..KD..N......T.LR......A....V.......LGNSY.A.ISPDVLV..IR..DPEP....DDHINI.D......EHLV...D..E.D.S.G..LHAP.I.RAM.N..N....T...H...G.........ILH..AVVSCKWTLRSDRAQNARSEALSLIRNRKGRTPHIAVVTAEPTPSRLASLALGTGDVDCVYHFALPELIAAVEQ...S..G..N......D...........E.A........Q.......SMLNSLLDGKRLRDISDLVLDLTV....................................
A0A6V8M2E3_9BACL/14-286 ....................................................YHASLLRT-ILTVN..ASG......VPSN.ADKDSKLSVRIAKGIADIL.......-QS.ET....GER.....LAGQTSGSEFEAINAEFLRKTFMSLEH..IRPG.N.WEIKKIG.....NR.N.....RS.AIAEFEQYAHLTALNN.......AAK..LN..P......D.LA......A....A.......MGNDY.T.ITPDVII..FQ..KLLS....DEIINF.E......KAIV...D..D.T.I.G..RRAS.I.RER.N..G....G...K...P.........LLH..ASISSKWTIRSDRSQNSRAEALNLIRNRKGHLPHIVVVTAEPLPSRLASISLGTGDIDCVYHFALEELKTAVEN...C..G..E......E...........D.A........L.......AMLNIMIDGKRLKDISDLPLDLA-t...................................
A0A4P6EPI1_9MICO/8-156 .................svdaadavlrklldeigdesllgldltvarqgrld--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....R...L...P.........TLE..VGLSLKWSLRTDRAQDCRSQGAKMSALRRGRMPHFAVVTMEPRPYMLNLLGGGSGDVDCVYHLDLPALTTAVDA...V..Y..S......T...........P.Arv....rgR.......DQFRRLVDQRRIRDYDEL------vaeiq...............................
A0A8J6Z0H7_9RHOB/11-279 .................................................fha---ALLAG-PLTVS..DRG......IPSN.ADSSSAPSRRIALGILDRL.......GPS.RT....AVK.....LPGQTAGANFETLCAAFLEEILPALAH..LRPG.R.FEI----.....-A.K.....GG.GIARFEQYAHLDELEA.......IAR..SN..R......D.IA......T....A.......LGSDY.L.IKPDIVI..AR..RPEP....DAAINA.R......ETLV...D..A.T.V.A..RHAS.I.RAW.A..Q....P...L...D.........LLH..ASISCKWTLRSDRAQNARSEGLNLVRNRKGRLPHVAVVTGEPLPSRIASLALGTGDIDCVYHFALPELRATLDG...T..G..D......E...........G.Y........L.......DTLDMMVEGKRLKDISDLPLDL--va..................................
A0A098S0R1_9BACT/13-286 ....................................................FHQRLLDELIFT-N..KEG......VPNF.ADNSQVFSREVASHIYTAI.......GGE.SK....EGR.....LSGQTLGNQFEVFTSAYLEATFLKLSH..LRPG.K.WTIEQVR.....SR.A.....SE.SIARFEQYAHLIDLKA.......LAT..NN..Q......V.LA......A....A.......LGNDY.S.ISPDIVI..LR..DPEG....DDHINL.Y......DTLV...D..G.N.A.N..RQSS.L.RKS.A..N....S...A...P.........ILH..ASISCKWTLRSDRAQNARSEALNLLRNRKGRSPHIVIVTAEPTPSRISSIALGTGDIDCVYHFALYELQQAVQD...I..G..N......D...........D.N........Q.......QLLNIMIEGKRLKDISDLPLDLAV....................................
A0A401FTZ0_9DELT/10-287 ....................................................YHRQLCKEIIRIKQ..NKAk....gDYPNfADGDSKSSREIAWGIVRQL.......GCP.EK....NGN.....LKAQTVGKLFENVTKIFLENAFKQLAH..LRPG.E.WRY----.....ST.E.....KT.EISGFDQYEHLSYIKD.......LVR..ND..S......I.LA......S....A.......LGGNY.I.VRPDIVI..SR..SPVS....DEEINR.R......QTVIg.tD..D.I.S.A..RYTP.L.RQV.N..H....T...E...Pc.......qILH..ASISCKWTIRNDRAQNTRTEALNLIRNRKGNQPHIVAVTAEPLPMRIAALALGTGDLDCVYHFALPELKSAAEE...A..K..N......Q...........D.Q........S.......EMLDMMVSGKRLRDISDLPFDLAI....................................
E8N1W7_ANATU/10-282 ....................................................YHQRICREIVRIQQ..GES......AYPNfADKSSKASREIAWRILEKI......gYQT.SQ....EQS.....LPGQTAGGRFEDVTRDFLEKAFQELQH..IRPG.K.WLY----.....-K.T.....GM.NISLFDQYEHLARLQK.......LTI..KN..S......D.LS......S....I.......FGTEY.L.ITPDITV..SR..EPLN....DEEINR.S......MTIV..eD..S.R.L.A..GLTP.L.RKT.N..S....S...V...P.........ILH..ASISCKWTLRSDRSQNARAEALNLIRQRKGNTPHIVVVVAEPLPTRIASLALGTGDIDCVYHFALPELQQAILE...I..H..N......E...........D.Q........H.......DMLQTLIEGRRLRDISDLPFDLAI....................................
K0F3N5_NOCBR/142-255 ................................................tpts--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..T....M...H...P.........WLH..AAIACKWTIRSDRVQNIRHENGNMIRHRRGRLPHLVAVTAEPLPSRLASIARGTGEVDATYHIAYDELSNAVAA...Y..G..S......S...........E.Q........Q.......GAWEEVTKQGRLLDYRNL------akal................................
A0A7G1KGK3_9NOCA/16-139 ...........................................kknklgwsw--------------..---......-VPNsADTDSVSSLRLAAHVLERIne..pnpNST.GV....KPI.....VPPDNPGGLLETQVLADLDT---QLRV..LDPRrE.WCF----.....-A.R.....GR.GIDEYAQYQHLAGVEA.......AIA..KN..P......N.LR......V....T.......LGTDY.L.IKPDVLV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------gi..................................
A0A4Q6IMP5_9ACTN/133-245 .............................................trppaet--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..A....A...R...P.........HLH..AAVSCKWTIRSDRVQNVRHEFLQMIRHRRGRLPHLVVVTAEPMPSRIASIARGTGEADAIYHVAFDALKTAVAD...V..G..N......S...........K.Q........R.......DDLSEIIEQGRL------------lpygml..............................
A0A543IQ98_9ACTN/130-241 ..............................................giaspd--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..A....G...F...P.........FLH..AAISCKWTIRSDRVQNIRHEFNQLIRHRRGRLPHLVTVTAEPLPSRLQAIARGTGEVDAVYHIAYDALAAAVEK...V..G..N......A...........T.Q........R.......AAWHECTQQRR-------------vlsyehl.............................
K0F3N5_NOCBR/16-139 ...........................................kknklgwkw--------------..---......-VPNsADVDNPTSLRLAAHVLEQLga..pnpNST.DT....TPD.....VPPPNPGGLLETMVLA---NLVSELPL..LDPGrK.WDF----.....-A.R.....GQ.SIVGYAQYQHLAGVDA.......AIA..HD..P......N.LR......V....T.......LGTDY.L.IKPDVLV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------gl..................................
A0A5Q0LHX9_9ACTN/5-144 ......................................fatrllgwkklert--------------..GK-......LVPNtADSDSNASKLLAGHMLEAL......gVEP.GA....VLP.....DTPESLGPALEHAVCDHLKTAQPLLDP..ER--.S.WHV----.....-D.H.....KQ.KVAAFAQYEHLHRVAE.......AVR..KN..A......T.LR......V....D.......LGRDY.L.IKPDVTI..G-..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------vtspaadaasrrh.......................
A0A231HEL9_9NOCA/137-255 ............................................girgtpts--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..T....P...H...P.........WLH..AAIACKWTIRSDRVQNIRHENGNMIRHRRGRLPHLVTVTAEPLPTRLASIARGTGEVDATYHIAYEELAKAVAV...H..G..S......S...........E.Q........H.......NAWEEVTKQGRLLDYKNL------arslv...............................
A0A8J3C1A0_9ACTN/151-284 ...................................eallnidvtvadlrpgs--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...P........sRLH..IALSSKWSLRTDRAQDCVSQGAKLVAQRRGRMPHFAVVTMEPRPSMLKILGDGSGSVDCIYHLDLPALEQAMET...L..V..-......-...........-.-........-.......------------------------dlprrrgrkwapmqtfrrliaqrrlldydelleela
A0A2U0H997_9MICO/17-292 ....................................................FHAALLASGVLTVN..DKG......VASN.ADGSQRSSVAYAKRIAESL.......LVE.TI....GER.....LAGQTSGGEFETACADFVRTTFLRLGM..LRPG.D.WSVTKVA....gRK.S.....TE.YIAKYDQYSHLFDLDV.......AVK..QN..P......E.LR......A....I.......LGNAY.V.IAPDVVV..VR..QPVE....DDVINE.N......ELIV...D..A.S.V.G..RLAS.I.RRA.N..Q....E...R...G.........ILH..AVISCKWTLRSDRAQNARSESLNLIRNRKGRLPHIAVVTAEPSPSRLASLALGTGDIDTLYHFALPELIEAVHA...E..D..N......D...........E.A........I.......SMLDTMVSGKRLKDIADLPLDLAI....................................
A0A7K2FIM0_9ACTN/134-249 ..............................................dpsldp--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...V...P.........FLH..AAVSCKWTIRSDRVQNVRHEFLQMIRHRRGRLPHLVVVTAEPMPSRIAAIARGTGEVDAVYHIAFDALTEAVKD...V..G..S......K...........Q.Q........Q.......NDLAEFIGQGRLRPYEELAATL--at..................................
A0A1I3JIE3_9RHOB/11-279 ....................................................FHATLLA-EVLTLS..GTG......VASN.ADKSSKWSRMFAAGIIERI.......GHA.AV....APK.....LAGQTSGARFEVICAQFLTATQAHLTH..LRPG.R.FEV-EVG.....--.-.....-G.HIARFRQYAHLDELEA.......IAR..SN..R......E.IA......T....A.......LGSDY.L.IKPDILI..SR..QPEG....DRVINA.H......AALV...D..W.D.V.A..GLSD.L.RAG.M..T....A...M...P.........LLH..ASVSCKWTLRSDRAQNARSEGLNLVRNRKGPLPHIVVVTGEPLPSRIASLALGTGDIDCVYHFALPELRDVLTT...P..G..N......A...........A.Y........L.......ETLDMMVEGGRLKDISDLPLDL--vs..................................
A0A0B8NG68_9NOCA/142-260 ............................................gllgtstg--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..T....M...H...P.........WLH..AAVACKWTIRSDRVQNIRHENSNMIRHRRGRLPHLVTVTAEPLPTRLAAIARGTGEVDATYHIAYEELSVAVAE...Y..G..N......D...........E.Q........R.......SAWDEVTKQGRLLDYSTLA-----rslv................................
A0A165B3G9_9SYNE/11-290 ....................................................YHAKLGQQVVRFSA..RAGt...gvIYPNfADCGSRSSVLIANGIAEAL......gISR.QT....SEP.....IPAQRAGALFESLTCEFIEHTFTAISH..MRPG.K.WKY--L-.....-T.S.....QT.QISRFAQYRHLKALDD.......LVR..DD..R......N.LS......T....A.......LGHDY.L.VTPDIVI..AR..STVS....HDDVNG.Q......AVVL...D..RpG.L.A..TLTP.F.LES.N..R....Sp.aL...P.........FLH..ASISCKWTIRSDRSQNTRTEALNLIRNRKGRLPHIVAVTAEPLPMRIASLALGTGDLDCVYHIALDELKRVCGA...L..A..S.....cE...........D.Q........A.......EMLFTMIDGDRLRDISDLPFDLAV....................................
A0A3N6WMG4_9ACTN/8-138 .........................................allgwktskgr--------------..---......LVPNtADTASSMSMRLAAAVLENL.......GVE.AA....ESP.....LLPKDPGSALEQMTRKDLQQELLELAP..ER--.A.WDV----.....-H.C.....GV.LISRFQQYRHLDALDQ.......LVR..NQ..P......A.LR......V....T.......IGTDY.M.IKPDVTVgiSR..HRL-....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------mdra................................
A0A7L5ZT24_9BACL/12-279 .......................................fhasclagpitvt--------------..-GD......VASI.ADSSSPHSRDIAIGVVNMI......gASR.VT....AAK.....PPGQTSGSMFESVCQTFLTETLATLQH..LRPG.V.HRV----.....-E.R.....GS.TIAQFDQYAHLAELQV.......LAD..AS..R......E.LK......T....L.......LGTDY.L.IKPDVVV..IR..DPET....DANINR.N......MHLV...D..D.M.V.A..RRTS.L.RVA.N..G....A...K...A.........TLH..ASISCKLTIRSDRVQNTRSEALNLMRNRKGRLPHIAAVTAEPMPSRIAAIALGTGDIDCVYHFALPELVAVLTA...Q..G..R......-...........E.S........L.......DLVETMIEGQRLRDIADLPLDLVI....................................
U5E4V7_NOCAS/17-139 ........................................knklgwqwvpnt--------------..---......----.ADTDSVSSLRLSAAVLEYLaa..pnpNGG.AS....DPV.....EPPDNPGGLLETQVATDLATELPRLDP..ER--.K.WEV----.....-R.K.....GQ.SIVNYAQYQHLAAIDR.......AIA..ND..P......N.LR......V....T.......LGTDY.L.IKPDVLV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------gl..................................
A0A511XR27_9PROT/14-287 ....................................................FHAALLK-STLTTN..AAG......VVSN.ADSSNRTSKSIAKGIADLL.......KAE.TI....GER.....IAGQTSGNQFESCCADFVHETFLKLRH..LRPG.S.WDVHQVS.....GR.N.....RL.EIARYEQYAHLVALDR.......AAK..AD..A......E.LA......A....A.......LGSDY.T.ITPDIVV..VR..DTED....DAVINA.N......ELLV...D..D.N.V.T..TLAS.L.RKK.N..G....G...L...P.........LLH..ASISCKWTIRSDRAQNARSEALNLVRNRKGRLPHVMVVTAEPTPSRLASIALGTGDIDCVYHFALYELQATVKM...L..G..M......D...........D.A........A.......DMLAIMVEGKRLKDISDLPLDLAV....................................
A0A2N3XTU4_SACSN/5-139 ..................................fakqllgwkasrknklgw--------------..--S......LVPNsADVDSAESLRLAAGVLDAL.......GVM.SG....VPS.....KVPASPGSPLEQCVETDLKHELPRLDV..GR--.H.WEV----.....-R.N.....GA.LITEFAQYTHLKAVDA.......LVQ..EN..P......E.LR......I....T.......IGRDY.L.IRPDVTV..AL..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------qdldv...............................
A0A292YLC2_9BACL/12-284 ....................................................FHKNLLK-SVLTIN..SNG......IPSN.ADKDSKLSVRIATGIAEIL.......-QF.VT....GER.....LAGQTSGSEFETITSEFIREAFLPLQH..IRPG.N.WEIKKIG.....NR.N.....RL.AIAQFEQYSHLVELDK.......AAK..IN..P......E.LA......A....A.......LGNDY.T.ITPDIII..IR..HLLS....DDEINT.P......KQIV...D..N.S.V.S..LRTA.L.RAS.N..N....G...K...P.........LLH..ASISSKWTIRSDRSQNSRAEALNLIRNRKGHLPHIVVVTAEPLPSRLASIALGTGDIDCVYHFALDELLAAVQA...T..N..A......E...........D.S........L.......ELLNIMIDGKRLKDISDLPLDLAI....................................
A0A0S2KAW6_9GAMM/14-287 ....................................................FHAALLE-TTLTIN..SAG......VVSN.ADSSNTTSKKIARGIADRL.......KAE.TV....GER.....IAGQTSGNQFESVCADFVKATFIQLEH..LRPG.P.WDVHQVA.....GR.N.....RL.EIAKYEQYAHLVALDK.......AAR..ND..A......E.LA......A....A.......LGSDY.T.ITPDIVV..VR..ETLS....DQQINQ.P......VLIV...D..D.T.I.A..RLAS.L.RKK.N..G....G...L...P.........LLH..ASISCKWTIRSDRAQNARSEALNLVRNRKGRLPHIVVVTAEPTPSRLASIALGTGDIDCVYHFALTELQETVRD...L..G..M......S...........D.A........E.......DMLAIMVDGKRLKDIADLPLDLAI....................................
R6HMW5_9FIRM/12-291 ....................................................FHANLFNTNTLTLD..AKG......VASN.ADSSSRASIAISKKIIDILqn..ehkHLV.NT....GTK.....VSGQTLGKQFESICMNFLRDTFPKMQN..LRPG.K.WTILQLG.....NN.N.....RL.KTSDFAQYEHLAYLSA.......LTA..QN..A......Q.LA......A....S.......LGNDY.L.VAPDVVI..YR..DLYE....DDEINS.D......EIIV...N..D.S.V.S..KMAD.I.RKS.N..G....G...K...P.........LLH..ASVSAKFTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTAEPMPNRLASLALGTGDIDCVYHFALYELIRAVAE...E..G..S......E...........D.A........I.......ETLETLVQGKRLKDISDLPLDLAV....................................
A0A1Y3X3C2_9FIRM/12-291 ....................................................FHKQLFETNTLTLT..SAG......VASN.ADTSSRGSKAIARRIVDILvd..eqhHAV.ST....VDK.....ISGQTLGKQFETLTMDFLRETFPNLQN..LRPG.H.WTILQLG.....NN.N.....KL.KTSDFAQYEHLAYLNE.......LTA..QN..A......Q.LA......A....A.......LGNDY.L.VAPDVVI..YR..DLYE....DSEINA.A......QCIV...D..G.D.V.S..KMAD.I.RKA.N..G....G...K...P.........LLH..ASVSAKYTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTAEPMPNRLASLALGTGDIDCVYHFALYELIRAVKE...V..G..S......E...........D.A........A.......ETLETLVQGKRLKDISDLPLDLAV....................................
A0A1Y4T813_9FIRM/12-291 ....................................................FHERLFETNTLTLT..SAG......IASN.ADTSSRGSKAISRKIIDILvd..ehhHAV.NT....VDK.....ISGQTLGKQFEILTMDFLRETFPHLQN..LRPG.C.WTILQLG.....NN.N.....KL.KTSDFAQYEHLAYLNA.......LTT..QN..A......Q.LA......A....A.......LGNDY.L.VAPDVVV..YR..DLYE....DDEINA.V......QCIV...D..E.D.V.S..KMAD.I.RKA.N..G....G...K...P.........ILH..ASVSAKFTMRSDRAQNSRTEALNLIRNRKGHLPHIVVVTAEPMPNRLASLALGTGDIDCVYHFALYELIRAVNE...V..G..S......E...........D.A........V.......ETLETLVKGKRLKDISDLPLDLTV....................................
A0A1E3X2W6_9BACT/11-281 .......................................fqkqvcsrsmfrk--------------..SGN......TPSI.ADASSKISTALSKKVIVKL.......GHP.LA....SSR.....ISSQTAGRRFEEAVCNYVEAALTLLSH..LRPA.K.FVY----.....-N.I.....HV.DISSFHQYSHLADLKQ.......LMK..GN..K......Q.LQ......T....T.......LGS-Y.V.VKPDVIV..GR..KPIT....DEEINV.S......DNVV..nT..E.S.Y.P..KLTQ.I.RES.N..Q....E...Q...At.......eILH..ASISCKLTLRSDRSQNARTEGLNLIRHRKGHSPHIVVVTAEPMPTRISSLALGTGDIDCVYHFSLHELVEATKE...L..G..K......E...........T.A........T.......ELLDMMISGNRLRDISDLPFDL--va..................................
A0A0J9YH32_NOCSI/95-305 ...............................................pegvv--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.--NTFQQYRHVGALAD.......IAV..EP..S......AaYEkawrrlT....A.......EARKR.V.IAPPAAV..TRleQLIE....DVERAT.SaevearQTALaeiG..T.E.S.L..LKLD.V.AVA.Q..D....Q...R...Pr......lpELE..IGLSLNWSLRTDRAQDCRSQGAKLSALRRGRMPHFAAVTMEPRPYMLNLLGGGSGDVDCVYHLHLPALQAAVDD...VygR..K......T...........D.Rts...qriV.......AVFNRLVEQRRVRDYDEL------vah.................................
A0A7W7I584_9ACTN/15-289 ....................................................FHAGLVAEGTLTVN..ARG......VASI.ADGANRLSVAVGSEIATAL.......LVD.TE....AER.....AAGQTLGGSFEEATANYLRATFPAFWM..LRPG.Q.WDVRKIG.....NT.R.....RS.AIAAFEPYQHLADLAE.......AIE..RD..P......T.LV......S....V.......LGNAY.A.ISPDIVV..TR..QPEP....DGYINQ.Q......SWLV...D..D.Q.F.A..QLTA.I.RAD.M..Q....G...P...P.........ILH..AVVSCKWTLRSDRAQNARSEALNLIRNRKGRLPHIVVVTAEPTPSRLSSLALGTGDVDCVYHIALPELLAAMKK...H..G..N......D...........D.N........L.......ESLETMIGGRRLKDISDLPLDLT-m...................................
A0A418KM37_9ACTN/172-295 ..........................................glpnprsanl--------------..---......----.-------------------.......---.--....---.....---------------------------..----.-.-------.....--.-.....--.----------------.......---..--..-......-.--......-....-.......-----.-.-------..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...T...H.........VLH..AAVSCKLTIRSDRVQNVRVEFGTLVRNRRGRLPHLVVVTAEPLPSRLVSIGRGTGEIDTIYHLLFEQIDEALES...L..R..N......H...........D.R........Fmn..tqwQGWRELVEMERIRPYSELS-----sala................................
A0A4Q6IMP5_9ACTN/5-141 ..........................................fatnllgwkk----------LEKT..SKL......VPNN.ADSDSDTSKLIAKHVLEAL......gVEP.DV....VLP.....DAPDSLGPALEHAVCDHLKTALPA---..EAPGcV.WHV----.....-D.H.....KK.TVADFAQYEHLDRVAK.......AVR..EN..A......T.LR......V....D.......LGRDY.L.IKPDVTI..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------gitrppaetaa.........................
A0A2A6RM68_9CHLR/16-289 ....................................................FHAALLA-TVLRTD..SAG......IPTN.ADKDSRVSVAIAQGIIEIL.......GAQ.ST....GAR.....LAGQMAGSQFETICKGYLEEVFPHLYH..LRPG.S.WTISKGL.....GS.G.....RL.AIAKFDQYAHLEALDA.......ASK..AN..P......Q.LA......A....A.......LGSDY.I.IKPDVVV..IR..HPEL....DTTINA.H......ESLV...G..D.D.S.A..RLSS.L.RAT.N..N....V...L...P.........ILH..ASILCKWTLRSDRAQNARSEGLNLVRNRKGRLPHVAVVIGEPTPSRIASIALGTGDIDCVYHFALPELLTTVKA...L..G..Y......S...........D.A........E.......ELLNTMIDGKRLRDIADLPLDLVI....................................
A0A231HEL9_9NOCA/16-143 ...........................................kknklgwkw--------------..---......-VPNsADTDNVTSLLMAAHILEQIrq...pnPNP.GS....EPV.....TAPNNPGALLETLVLTDLASQLPDLDP..RR--.Q.WDF----.....-D.R.....GK.SIVGYAQYQHLAGIEA.......AIS..KD..P......N.LR......V....T.......LGTDY.L.IKPDVLV..--..----....------.-......----...-..-.-.-.-..----.-.---.-..-....-...-...-.........---..--------------------------------------------------------------------------...-..-..-......-...........-.-........-.......------------------------girgtpt.............................
#=GC seq_cons .............................................................................hsss.ADtspt.Sh.lu.tlhp.l..........................sspp.Gt.hEthstt.lttth..ht...hR...p.Wph..........p.t.....t...hspatQYtHLstltt.......hht..ts.........p.Lt......s....h.......lGpsY.h.ltPDlhl.............................................................t....t...h...s.........hLH..AulSCKWTlRSDRuQNsRsEuhpllRpR+GRhPHllsVTuEPhPoRlASlAhGTG-lDsVYHhAL.EL.tAlpt...h..s..p......p...........-.t........h.......phhpthlptpRL+DhsDLs.sh......................................
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