#=GF ID   Noda_Vmethyltr
#=GF AC   PF19222.4
#=GF DE   Nodavirus Vmethyltransferase
#=GF PI   Nido_Vmethyltr;
#=GF AU   Karlin D;0000-0002-3033-7013
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   David Karlin
#=GF GA   30.00 30.00;
#=GF TC   30.20 46.70;
#=GF NC   29.90 28.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0696
#=GF RN   [1]
#=GF RM   25886938
#=GF RT   Sequence analysis reveals a conserved extension in the capping
#=GF RT   enzyme of the alphavirus supergroup, and a homologous domain in
#=GF RT   nodaviruses.
#=GF RA   Ahola T, Karlin DG;
#=GF RL   Biol Direct. 2015;10:16.
#=GF DR   INTERPRO; IPR043647;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This entry represents a family of nodavirus proteins that is
#=GF CC   homologous to Pfam:PF01660. These proteins are likely
#=GF CC   methytransferases involved in mRNA capping [1].
#=GF SQ   26
#=GS A0A1L3KGD1_9VIRU/86-234   AC A0A1L3KGD1.1
#=GS A0A1L3KFL2_9VIRU/78-228   AC A0A1L3KFL2.1
#=GS A0A1L3KFE9_9VIRU/125-274  AC A0A1L3KFE9.1
#=GS A0A1L3KFH3_9VIRU/77-223   AC A0A1L3KFH3.1
#=GS RDRP_SJNNV/67-213         AC Q9QAZ8.1
#=GS A0A1L3KH13_9VIRU/99-245   AC A0A1L3KH13.1
#=GS A0A1L3KG81_9VIRU/102-247  AC A0A1L3KG81.1
#=GS A0A1L3KFD9_9VIRU/86-232   AC A0A1L3KFD9.1
#=GS A0A1L3KFD8_9VIRU/104-250  AC A0A1L3KFD8.1
#=GS A0A1L3KGI3_9VIRU/137-293  AC A0A1L3KGI3.1
#=GS A0A1L3KFV2_9VIRU/3-148    AC A0A1L3KFV2.1
#=GS A0A1I7SRW5_BURXY/1-53     AC A0A1I7SRW5.1
#=GS A0A1L3KGR5_9VIRU/176-326  AC A0A1L3KGR5.1
#=GS A0A177B694_9BILA/5-135    AC A0A177B694.1
#=GS A0A1L3KFK8_9VIRU/85-237   AC A0A1L3KFK8.1
#=GS RDRP_NODAM/98-247         AC Q9IMM4.1
#=GS A0A1L3KGF7_9VIRU/74-220   AC A0A1L3KGF7.1
#=GS A0A1L3KFM4_9VIRU/216-365  AC A0A1L3KFM4.1
#=GS A0A1L3KFK3_9VIRU/99-244   AC A0A1L3KFK3.1
#=GS A0A1L3KFY0_9VIRU/143-291  AC A0A1L3KFY0.1
#=GS A0A1L3KGB6_9VIRU/87-237   AC A0A1L3KGB6.1
#=GS A0A1L3KFZ6_9VIRU/63-209   AC A0A1L3KFZ6.1
#=GS A0A1L3KGI6_9VIRU/146-294  AC A0A1L3KGI6.1
#=GS A0A1L3KGZ5_9VIRU/82-227   AC A0A1L3KGZ5.1
#=GS A0A1L3KG09_9VIRU/69-214   AC A0A1L3KG09.1
#=GS Q8BET0_9VIRU/62-213       AC Q8BET0.1
A0A1L3KGD1_9VIRU/86-234              ...llr---SSIGHTHPNCAGERTAVTLFMQELAKQ....CAYDPYTVSMSSPDQLNaEE..GSRYFFWAKDFAQEMRDDPIKANSLLIFTDVDFHVD.MNKY...L.KMFKPMLIYTIVPTSA..GHR....EEEFEYFFKDNKIHYKVSGGSDYCHQIWDYK..GDVVTVVD...
A0A1L3KFL2_9VIRU/78-228              .....e-VPRKSDNGHSVAGAARDAARRTIEATVHS....MGRRMYELSPGGHATDN.KG..GVLYHVAPGDLWDNVRNKQPEANDVIVCVDTDYYVEnLDEY...L.GTGLPHVLYTFAPLHV..SGN....DGDCRFRIENNEIIYEVSGGSSWKHKVWDWTafGEFVYS--ye.
A0A1L3KFE9_9VIRU/125-274             .....i-IPVNSMHSHPASAQFRSSANSYLNDCVVR....AGYRPYNISKSRRDI--.ED..GCRYFYHSKDLSIKYSNDKIEDQSVFIMTDVDYYVD.MPRW...L.KLFRPIVMYTLSPTKL..SCSgpndKAEYRFNIDGNVVHYHVSGGGEYTHQLWNYT..GDTVTCV-d..
A0A1L3KFH3_9VIRU/77-223              ....ey--KSPKGHSHGIAAGLRTAAQKSIMDFIEV....EGYEPYVISMSARDKM-.YD..GYHQVYMSKDVVHPSKSDPVHDRHVLVSIDADYYAN.VPQW...L.RYGRPALFYTFTPTQV..GGV....IDDGCFCIREDEVTYRVNGGGSYHHKIWDYS..RDSLRVD-y..
RDRP_SJNNV/67-213                    .....r-ISVRKGHSHQEAATERNSATDTMIGVVEK....CGYEPYIISPSPREKE-.YH..GSRQFYSLADFRQDYRRDEITDRHVIVMTDVDYYVD.MHEL...V.GLGVPILLYTFQPSTV..SGE....VKDGYFTITDDHVHYRVAGGKDVRHRIWNYN..QDTMFVR-s..
A0A1L3KH13_9VIRU/99-245              .....a-VFRNGQNPHARQAADRTNVTEEMKAFARR....VGMRPYIVSPSDREND-.EA..GWRDYYSIPDLRQKTRRDKIGAKDLLLFTDVDYYAD.MHYF...L.SLGRPCMMYSWVPFEV..SSS....GSPYAYTFVDDEVQYHCSGSSDYRHQLWDYN..TDYLVSV-d..
A0A1L3KG81_9VIRU/102-247             .....k-IPMASNHTHPNAASLRTSVAVELEKIVIN....AGFRPYSVSMSKRDQ--.YD..GCRYYFMDKDLDKAFRDDRVTEEHVLLMIDVDYYCD.INQY...L.QLGNPIMIYTFVPTEA..GGR....ALDASYTINNNVVSYCVKGGATYHHELWDYQ..GDNVVVKD...
A0A1L3KFD9_9VIRU/86-232              ....st--SVRKGHSHSTAASERNSATETMIDVITT....NGYEPYVISPSPRESD-.LD..GVRRFHSLADLRQDYRRSPITDRHIIVMTDVDYYVD.MHEI...I.SIGRPILLYTFQPRVV..SGP....VFDGFFTIKDNIIHYRVNGGKDVKHPTWNYN..QDTVFVRD...
A0A1L3KFD8_9VIRU/104-250             ...kcg---VRRGHSHQQAATERNSATETMLDFVTS....NGYIPYVISPSPREAG-.ID..GRRRFYSLADLRQNYLNDPLTDKHIIVMTDVDYYVN.MHEL...I.SLGRPILCYTFQPSTV..SGP....VKDGYFTIKDDVVHYHVNGGKDVQHRIWNYN..QDTIYVVD...
A0A1L3KGI3_9VIRU/137-293             .....r-VATNPANPHAAGAAIRLQVHKFVHAICAAwdtgATVVRYDLSYAKRDEMFgTSvlGRRWLRSAQDLSQPVRDDPRPIGVPVSAIDTAYYLR.PYDW...DeFCGELIVFNAQLPTAI..AWK...eSWTTAYFDAQSVLHEQIAGGKTYTHPLPEPG..LHELFLH-t..
A0A1L3KFV2_9VIRU/3-148               ....lf--TPRNNHSHPTAAMYRSGVNAFMTRLVTS....AGFIPYQVSMSATDK--.CD..GTRLFYGQKDLAIPYKHDSVKDQHVIIMTDVDYYTD.INKW...L.SYGRPILMYTMVPKTV..VGR....TQDYAYRIVNGRLEMHVAGGSTYTHELWDYQ..GDTVSIV-a..
A0A1I7SRW5_BURXY/1-53                ......------------------------------....-----------------.--..------------------------------------.----...-.-------MYTMSPTKV..STVg..eKSETAFYIEGDEVCNFVSGGATYKHPIWDYE..TDHLAVT-d..
A0A1L3KGR5_9VIRU/176-326             ....ir--RTMSNHSHPSSAAERSSVHAAIVNKIVE....AGYEPFDISMSKSAIEQgLS..GQRYFYWLKDYKCSVVEHPIRHSSVIVMVDVDYYLD.INEY...M.KYFRPIVIYTLQPLTL..RFV....GPEYSFRVDKGEVFYEVRGGAKYSHKIWNYSthGDTVSVR-d..
A0A177B694_9BILA/5-135               pyekai--------------------KELVRMRQQN....MNLIPYSISAENTET--.-I..GNRLYYNCKDLAMIFKNDLLTSKSVLVFIDVAYYVD.LNDD...L.LLGLPMILFTIYSEDL..TGN....VDDGTFYFEDNYFNRRIIGGANYRHQLWQHD..KGIVT---arg
A0A1L3KFK8_9VIRU/85-237              ....pe--ARKSDNGHPVAGSARDSARRGITAAIDA....LGCRKFEVNPAGRTLDD.TA..RDHDLLAPGDLTLDYKISRPVEGEVVTCIDTDYYVT.EGGWdrlL.GGGNLGILYTFSPVTV..AGS....DGECPFTIKDSTVEYTVSGGSVWRHRVWDWTagGEYVLL--yq.
RDRP_NODAM/98-247                    .....e-HARKADNGHPISGGTRDVARETISLAIRA....AGFRHYEISPARQSPA-.EA..ASHQHYAAADLVRAATEDKIQDGDVVVAIDIDYYLRdIDRY...L.GRGVPFMAYTFNPVEV..AGR....DGDSFFRITNNQVTFDVSGGGSWSHEVWDWCafGEFIET--rd.
A0A1L3KGF7_9VIRU/74-220              ....hs--SVRVGHSHQSAASERNSATETMLAVVRK....LGMIPYVISPSPREKD-.CD..GIRDYYTLADLRCQTKNDPITDNHVIIMTDVDYYVN.MDEI...L.SHGRPVLLYTFQPTKV..AGP....VKNGYFTIEHDTVTYHVKGGKDVKHKIWNYS..VDTIYT--pn.
A0A1L3KFM4_9VIRU/216-365             .fakvg-----GAHTHPEAASERNAMGPYFKRLAAM....MGRDLFMYSLSNADIKAdTR..GNKTMYWPKDLLVPHTAALPKETDMIGVVDCDWYLD.MNDL...LtRYVVTWAIYGLNPTEP..GGK....VKNGDFTFINNVLHYSITGGANYKHELWDWN..RETICA--sr.
A0A1L3KFK3_9VIRU/99-244              ....ps--TNKPGHSHPFSSAYRSFANKTIDETILR....YGYQPYSISSSIRDN--.GK..GNRFYYTEKDFGLPYQNDTLEEDSIITMVDVDYYCD.MNAY...L.SVGKPILLYTIIPESV..AFQ....GPDYAFTIKDDEIRHQVNGGAKYSHRLWDYE..RDTVSV--lt.
A0A1L3KFY0_9VIRU/143-291             ...yap---SLNGHSHGVCAAFRAAADDTINTFIQE....NGFEVYSVGMSAKDMDLgFE..GYRPMVEDKDMVMGFKCSPVRDNHIIKMVDVDYYVD.LLYW...L.SFGRPVIIYTFQPSAV..AGM....TDDASFTIKDDVVHFSVSGGARWQHRVWDYS..ADCVYVP-s..
A0A1L3KGB6_9VIRU/87-237              ....fq--RRVTDNGHPISGAVRDAARVLISDAIDS....TGLKRFEISPSSRTSAG.AR..CKHQHYAAGDLHLDLSNQIPQTGEVIVCIDTDYYLRdVSEA...F.GHVNPIIMHTFSPRRV..AGL....DGDSVYTIKNNQIRYQVSGGAAWSHEVWDWCgyGEFIR---lda
A0A1L3KFZ6_9VIRU/63-209              ....hi--GARAGHSHAEAATDRNSATQTMHTAARQ....LGMQPYVISPSRRESD-.AM..GWRCYFQSNDYGMQTKYDAIPEDACFIMTDVDYYAD.MPDW...L.SLARPILMYSFMPTRV..AGN....VDGSNFTIVNDYVRYRVNGGGDFKHQIWNWN..YDTLYVD-m..
A0A1L3KGI6_9VIRU/146-294             ....sf--KPSPHHTHGISAAERTGASRTIREAIMN....AGYKPYAVSAASMDQEMgLD..GNRSYYWAKDFKPKYQADEITSDHAIMMIDVDYYCD.LYYY...M.CQFRPILMYTLQPNFV..SYR....SKDYAYYIQNNKIHYDVSGGGKYSHEVWDYD..SDTISIV-d..
A0A1L3KGZ5_9VIRU/82-227              ....if--PCRTSHSHPTSAMYRTAVNNFMNTLATR....AGMEPFNVSKSPTDG--.GK..GTRYFYGAKDLATPYVDDKVGNNDVIIMCDVDYYTD.MTKW...L.SYFRPILMYTFVPTSA..AAR....RKDYAYRLIDDHVEFHVAGGSSYRHKLWNYK..GDYVSTV-d..
A0A1L3KG09_9VIRU/69-214              ....ta--PRDESHSHPESARNRTDAEYSIDLFARS....IGLEPYAVSTSARNT--.HD..GQRLYYTAKDACLPYKCDPVRDYHLLTFVDVDYYAD.MAKW...L.WTGRPALVYTFCPTSA..GGV....IPEGTFHIQDDELFVVYSGGARYNHKLWDYN..VDHLVVK-g..
Q8BET0_9VIRU/62-213                  ...pvv---AISGHTHASAASLRTAATRYAQNVAQY....CGTEVYVVGMSRSDQRKdMK..GSRQWYWTKDVNAANRNDRPGHRDIRFLCDVDYYVD.MPAM...LvAEAKPVLLYTVVPEEAtsSAN....DESAFYFEADGSLRTMVAGGGGYSHCIWDYA..ADSFLVV-k..
#=GC seq_cons                        .....t...spssHoHstuAu.RsuAspthpshlpp....sGhcPYslS.Ss+-p...hc..GpR.aYtspDlthsh+sD.lpcpclllhsDVDYYlD.hsca...L.shG+PllhYThtPspV..uGp....st-ssFpIpssplcYcVuGGusYpHclWDYs..sDslhl.....
//