#=GF ID Noggin
#=GF AC PF05806.16
#=GF DE Noggin
#=GF AU Moxon SJ;0000-0003-4644-1816
#=GF SE Pfam-B_7925 (release 8.0)
#=GF GA 24.10 24.10;
#=GF TC 24.10 24.10;
#=GF NC 23.80 23.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF CL CL0079
#=GF RN [1]
#=GF RM 12633782
#=GF RT Noggin arrests stromal cell differentiation in vitro( small
#=GF RT star, filled ).
#=GF RA Gazzerro E, Du Z, Devlin RD, Rydziel S, Priest L, Economides AN,
#=GF RA Canalis E;
#=GF RL Bone 2003;32:111-119.
#=GF DR SCOP; 1m4u; fa;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC This family consists of the eukaryotic Noggin proteins. Noggin
#=GF CC is a glycoprotein that binds bone morphogenetic proteins (BMPs)
#=GF CC selectively and, when added to osteoblasts, it opposes the
#=GF CC effects of BMPs. It has been found that noggin arrests the
#=GF CC differentiation of stromal cells, preventing cellular maturation
#=GF CC [1].
#=GF SQ 1290
#=GS A0A7K9T7M4_9AVES/1-193 AC A0A7K9T7M4.1
#=GS NOGG_HUMAN/12-232 AC Q13253.1
#=GS A0A852DNX0_PASAF/4-209 AC A0A852DNX0.1
#=GS T1HGP4_RHOPR/1-188 AC T1HGP4.1
#=GS A0A6F9C8G8_9TELE/2-89 AC A0A6F9C8G8.1
#=GS A0A7K6M3L8_PANBI/4-216 AC A0A7K6M3L8.1
#=GS B7PHR4_IXOSC/7-231 AC B7PHR4.1
#=GS A0A4E0RDF4_FASHE/202-336 AC A0A4E0RDF4.1
#=GS A0A7L4CUM7_9AVES/31-222 AC A0A7L4CUM7.1
#=GS A0A267EDN3_9PLAT/68-269 AC A0A267EDN3.1
#=GS A0A087RI86_APTFO/4-216 AC A0A087RI86.1
#=GS A0A6P9CSV3_PANGU/7-215 AC A0A6P9CSV3.1
#=GS A0A670IBQ3_PODMU/11-224 AC A0A670IBQ3.1
#=GS A0A7K6K0V4_9PASE/4-224 AC A0A7K6K0V4.1
#=GS A0A4W6F5R9_LATCA/28-178 AC A0A4W6F5R9.1
#=GS A0A5A9N7Q3_9TELE/7-213 AC A0A5A9N7Q3.1
#=GS T1IET5_RHOPR/14-188 AC T1IET5.1
#=GS A0A7L4CBW1_9AVES/4-216 AC A0A7L4CBW1.1
#=GS A0A6J1V1G4_9SAUR/11-224 AC A0A6J1V1G4.1
#=GS A0A0Q3M172_AMAAE/40-254 AC A0A0Q3M172.1
#=GS A0A7K8M0L3_9CORV/4-216 AC A0A7K8M0L3.1
#=GS A0A091FIQ6_CORBR/94-148 AC A0A091FIQ6.1
#=GS A0A7K7QR29_POEAT/4-216 AC A0A7K7QR29.1
#=GS A0A3M0KYP6_HIRRU/16-213 AC A0A3M0KYP6.1
#=GS A0A2K6S1M7_SAIBB/12-232 AC A0A2K6S1M7.1
#=GS A0A851YCD5_9AVES/3-210 AC A0A851YCD5.1
#=GS A0A669PNW9_PHACC/11-223 AC A0A669PNW9.1
#=GS A0A7M4DX69_CROPO/15-223 AC A0A7M4DX69.1
#=GS A0A8C6ZMW0_NOTPE/44-256 AC A0A8C6ZMW0.1
#=GS A0A6G0T7K2_APHGL/8-250 AC A0A6G0T7K2.1
#=GS R7UCW7_CAPTE/26-238 AC R7UCW7.1
#=GS A0A8R2NP03_ACYPI/8-253 AC A0A8R2NP03.1
#=GS A0A093EZP1_GAVST/86-195 AC A0A093EZP1.1
#=GS A0A8C8BM93_9STRI/11-223 AC A0A8C8BM93.1
#=GS A0A5E4MN83_9HEMI/51-260 AC A0A5E4MN83.1
#=GS A0A8C4QH81_EPTBU/8-218 AC A0A8C4QH81.1
#=GS A0A4U1EJ85_MONMO/12-232 AC A0A4U1EJ85.1
#=GS H2KU47_CLOSI/256-399 AC H2KU47.1
#=GS A0A183VQ77_TRIRE/266-435 AC A0A183VQ77.1
#=GS A0A1W0WUG2_HYPDU/2-140 AC A0A1W0WUG2.1
#=GS A0A183PAN6_9TREM/192-352 AC A0A183PAN6.1
#=GS A0A093J9G1_EURHL/4-216 AC A0A093J9G1.1
#=GS A0A6P6NZJ9_CARAU/7-211 AC A0A6P6NZJ9.1
#=GS S4S1S8_PETMA/12-221 AC S4S1S8.1
#=GS A0A210PLX7_MIZYE/42-268 AC A0A210PLX7.1
#=GS A0A8C9NNW1_SERCA/11-223 AC A0A8C9NNW1.1
#=GS A0A315UXK2_GAMAF/11-220 AC A0A315UXK2.1
#=GS A0A6P8WDG8_DROAB/167-250 AC A0A6P8WDG8.1
#=GS A0A672N8N8_SINGR/11-221 AC A0A672N8N8.1
#=GS A0A7K7R369_POEAT/4-209 AC A0A7K7R369.1
#=GS A0A4D9DZD8_9SAUR/11-223 AC A0A4D9DZD8.1
#=GS A0A672LD20_SINGR/11-221 AC A0A672LD20.1
#=GS A0A8V5GQ59_MELUD/6-212 AC A0A8V5GQ59.1
#=GS A0A8C0AEL0_BOSMU/12-232 AC A0A8C0AEL0.1
#=GS G5BPB0_HETGA/1-85 AC G5BPB0.1
#=GS A0A7K6QGV4_9PASS/4-216 AC A0A7K6QGV4.1
#=GS A0A1S3Q225_SALSA/142-301 AC A0A1S3Q225.1
#=GS A0A7K5JL66_9TYRA/4-216 AC A0A7K5JL66.1
#=GS A0A2T7PYS3_POMCA/1-116 AC A0A2T7PYS3.1
#=GS A0A3N0XSN6_ANAGA/5-214 AC A0A3N0XSN6.1
#=GS A0A3L8Q5M2_CHLGU/11-223 AC A0A3L8Q5M2.1
#=GS A0A4W5R6D2_9TELE/5-211 AC A0A4W5R6D2.1
#=GS A0A8I6RBV6_CIMLE/91-234 AC A0A8I6RBV6.1
#=GS A0A218UV37_9PASE/11-203 AC A0A218UV37.1
#=GS A0A8C7YPB0_9TELE/6-214 AC A0A8C7YPB0.1
#=GS A0A8D2JG67_VARKO/12-220 AC A0A8D2JG67.1
#=GS A0A8B7XHE1_ACAPL/10-229 AC A0A8B7XHE1.1
#=GS A0A8C8HNA1_ONCTS/11-220 AC A0A8C8HNA1.1
#=GS A0A8C6VUU5_NOTFU/6-209 AC A0A8C6VUU5.1
#=GS A0A7K9WJI1_9PASS/4-216 AC A0A7K9WJI1.1
#=GS A0A4U5VPN9_COLLU/28-235 AC A0A4U5VPN9.1
#=GS M7B4H0_CHEMY/117-338 AC M7B4H0.1
#=GS A0A0R3UM17_MESCO/127-287 AC A0A0R3UM17.1
#=GS A7SH36_NEMVE/1-112 AC A7SH36.1
#=GS A0A8C0BFP0_9AVES/11-223 AC A0A8C0BFP0.1
#=GS A0A8C4MKJ8_EQUAS/12-232 AC A0A8C4MKJ8.1
#=GS A0A8B9IQ61_ANSCY/51-260 AC A0A8B9IQ61.1
#=GS A0A8C9Y4V8_SANLU/5-211 AC A0A8C9Y4V8.1
#=GS A0A6P8WTK3_DROAB/169-248 AC A0A6P8WTK3.1
#=GS A0A8C3J3Y9_9CHAR/11-223 AC A0A8C3J3Y9.1
#=GS A0A6P8QQ35_GEOSA/24-246 AC A0A6P8QQ35.1
#=GS A0A6A5E4D6_PERFL/5-211 AC A0A6A5E4D6.1
#=GS A0A093E024_9AVES/1-173 AC A0A093E024.1
#=GS H3AT22_LATCH/8-216 AC H3AT22.1
#=GS A0A3Q1EUH4_9TELE/11-229 AC A0A3Q1EUH4.1
#=GS A0A074ZMP3_9TREM/141-332 AC A0A074ZMP3.1
#=GS A0A7L1ZNW6_LEILU/4-216 AC A0A7L1ZNW6.1
#=GS Q2NNA9_XENTR/40-245 AC Q2NNA9.1
#=GS A0A3Q7MIS0_CALUR/12-232 AC A0A3Q7MIS0.1
#=GS A0A4W3H9B1_CALMI/34-232 AC A0A4W3H9B1.1
#=GS A0A852AV00_9CORV/4-216 AC A0A852AV00.1
#=GS A0A674I6M9_TERCA/2-210 AC A0A674I6M9.1
#=GS A0A0P7UQ03_SCLFO/11-221 AC A0A0P7UQ03.1
#=GS A0A8C5JC46_JUNHY/11-223 AC A0A8C5JC46.1
#=GS A0A7L1SDN6_ARAGA/4-216 AC A0A7L1SDN6.1
#=GS A0A8C3XPS0_CHESE/11-223 AC A0A8C3XPS0.1
#=GS A0A8C9ZWY3_SANLU/38-290 AC A0A8C9ZWY3.1
#=GS A0A7K7IZL9_LOXCU/4-216 AC A0A7K7IZL9.1
#=GS A0A6J2V2M2_CHACN/14-226 AC A0A6J2V2M2.1
#=GS A0A7L2LW16_9SYLV/4-216 AC A0A7L2LW16.1
#=GS A0A7K6GSI7_9PASS/4-216 AC A0A7K6GSI7.1
#=GS A0A3P9C4N8_9CICH/7-92 AC A0A3P9C4N8.1
#=GS A0A4Y1ZT78_ARAVE/34-272 AC A0A4Y1ZT78.1
#=GS A0A452HE38_9SAUR/4-212 AC A0A452HE38.1
#=GS A0A7K5CQ92_9TYRA/4-216 AC A0A7K5CQ92.1
#=GS A0A671XT39_SPAAU/18-192 AC A0A671XT39.1
#=GS A0A667XS27_9TELE/4-202 AC A0A667XS27.1
#=GS A0A0R3WCQ3_TAEAS/24-226 AC A0A0R3WCQ3.1
#=GS A0A7L0TPV6_CHOAC/4-216 AC A0A7L0TPV6.1
#=GS A0A4Z2DF20_SCHJA/195-371 AC A0A4Z2DF20.1
#=GS A0A493TUJ3_ANAPP/6-216 AC A0A493TUJ3.1
#=GS A0A8C4WPC1_9SAUR/11-223 AC A0A8C4WPC1.1
#=GS A0A851D1T1_TODME/4-211 AC A0A851D1T1.1
#=GS A0A7L0FDY4_CORCN/3-209 AC A0A7L0FDY4.1
#=GS A0A3Q2WUH1_HAPBU/40-282 AC A0A3Q2WUH1.1
#=GS A0A8J4WJD8_9TREM/159-401 AC A0A8J4WJD8.1
#=GS A0A4W5M3A5_9TELE/26-198 AC A0A4W5M3A5.1
#=GS A0A4W4GTH7_ELEEL/6-209 AC A0A4W4GTH7.1
#=GS A0A1S3JUK8_LINUN/58-260 AC A0A1S3JUK8.1
#=GS A0A1V4JA26_PATFA/41-253 AC A0A1V4JA26.1
#=GS A0A6I9PTG2_9TELE/11-220 AC A0A6I9PTG2.1
#=GS A0A8D2HE06_UROPR/12-232 AC A0A8D2HE06.1
#=GS A0A7L4DPH0_9AVES/4-216 AC A0A7L4DPH0.1
#=GS A0A851NDX5_9GALL/4-216 AC A0A851NDX5.1
#=GS A0A852P212_9PASS/4-216 AC A0A852P212.1
#=GS A0A7N5JWM8_AILME/12-232 AC A0A7N5JWM8.1
#=GS A0A2I3HGL4_NOMLE/12-232 AC A0A2I3HGL4.1
#=GS A0A8K1GLZ9_9PASS/11-223 AC A0A8K1GLZ9.1
#=GS A0A851KDW3_VIDCH/4-216 AC A0A851KDW3.1
#=GS A0A850W314_FREMA/4-216 AC A0A850W314.1
#=GS A0A8J2P1D6_9HEXA/73-191 AC A0A8J2P1D6.1
#=GS A0A851W5L6_CORMO/4-209 AC A0A851W5L6.1
#=GS A0A8C6QPR0_NANGA/12-232 AC A0A8C6QPR0.1
#=GS A0A6H5GUS6_9HEMI/14-84 AC A0A6H5GUS6.1
#=GS A0A7M7REB8_STRPU/7-236 AC A0A7M7REB8.1
#=GS A0A8C6YZN9_NOTPE/11-223 AC A0A8C6YZN9.1
#=GS A0A0P8XGG4_DROAN/28-226 AC A0A0P8XGG4.1
#=GS A0A7K8IPV2_9PASS/4-209 AC A0A7K8IPV2.1
#=GS A0A1U7QKI5_MESAU/12-232 AC A0A1U7QKI5.1
#=GS A0A8D0F1A0_STROC/11-223 AC A0A8D0F1A0.1
#=GS A0A8C5EL03_9TELE/6-212 AC A0A8C5EL03.1
#=GS A0A8B9MXK2_9AVES/11-223 AC A0A8B9MXK2.1
#=GS A0A7K7M137_9PASS/4-216 AC A0A7K7M137.1
#=GS L5JQJ4_PTEAL/12-232 AC L5JQJ4.1
#=GS A0A7L2HVR2_SAGSE/4-216 AC A0A7L2HVR2.1
#=GS A0A8C3T432_CHESE/25-246 AC A0A8C3T432.1
#=GS A0A8C4UAR2_FALTI/11-223 AC A0A8C4UAR2.1
#=GS A0A7L3FJ80_9GRUI/4-216 AC A0A7L3FJ80.1
#=GS A0A850YK52_AEGCA/4-216 AC A0A850YK52.1
#=GS A0A672N8U7_SINGR/5-215 AC A0A672N8U7.1
#=GS A0A672VCC4_STRHB/11-223 AC A0A672VCC4.1
#=GS A0A8D0EXW3_STROC/6-212 AC A0A8D0EXW3.1
#=GS A0A5A9NCI6_9TELE/5-206 AC A0A5A9NCI6.1
#=GS A0A6J3CC06_GALME/19-195 AC A0A6J3CC06.1
#=GS A0A4W5N254_9TELE/11-220 AC A0A4W5N254.1
#=GS A0A7K6WST6_STECA/6-81 AC A0A7K6WST6.1
#=GS A0A498L6T8_LABRO/7-211 AC A0A498L6T8.1
#=GS A0A7K8XWE7_9PICI/1-205 AC A0A7K8XWE7.1
#=GS A0A6J1T410_FRAOC/206-293 AC A0A6J1T410.1
#=GS A0A4W6CN49_LATCA/11-220 AC A0A4W6CN49.1
#=GS A0A1A8APY2_NOTFU/5-209 AC A0A1A8APY2.1
#=GS A0A7J7EJX4_DICBM/12-232 AC A0A7J7EJX4.1
#=GS A0A3Q1IHK0_ANATE/10-209 AC A0A3Q1IHK0.2
#=GS A0A067R583_ZOONE/35-285 AC A0A067R583.1
#=GS A0A7K5N4G9_CHRMC/4-216 AC A0A7K5N4G9.1
#=GS A0A8C4G7U3_9TELE/134-283 AC A0A8C4G7U3.1
#=GS A0A448WDX9_9PLAT/223-351 AC A0A448WDX9.1
#=GS A0A8C3Y6M3_CATUS/5-210 AC A0A8C3Y6M3.1
#=GS A0A8C8XMJ6_PANLE/12-232 AC A0A8C8XMJ6.1
#=GS A0A7K5UNA1_CEPOR/4-216 AC A0A7K5UNA1.1
#=GS A0A8C5T9V3_9PASS/40-254 AC A0A8C5T9V3.1
#=GS A0A7L0G7E8_HERCA/4-216 AC A0A7L0G7E8.1
#=GS A0A850U407_GRUAM/4-216 AC A0A850U407.1
#=GS A0A3Q3LQY4_9TELE/32-262 AC A0A3Q3LQY4.1
#=GS A0A2I0TMC1_LIMLA/11-223 AC A0A2I0TMC1.1
#=GS W6UXG6_ECHGR/135-331 AC W6UXG6.1
#=GS A0A7K8EZ62_9CORV/4-216 AC A0A7K8EZ62.1
#=GS A0A671XX36_SPAAU/9-190 AC A0A671XX36.1
#=GS A0A482X151_LAOST/12-253 AC A0A482X151.1
#=GS A0A852MCT4_9PASS/4-216 AC A0A852MCT4.1
#=GS A0A1X7V5G2_AMPQE/67-231 AC A0A1X7V5G2.1
#=GS A0A2U3XEL8_LEPWE/12-232 AC A0A2U3XEL8.1
#=GS A0A183LAN2_9TREM/113-392 AC A0A183LAN2.1
#=GS A0A2K5PNH2_CEBIM/12-232 AC A0A2K5PNH2.1
#=GS A0A851PEC9_ANHAN/4-216 AC A0A851PEC9.1
#=GS A0A7L2JHE4_CINMU/4-216 AC A0A7L2JHE4.1
#=GS A0A8C6L0Z9_NOTFU/11-217 AC A0A8C6L0Z9.1
#=GS A0A7L2SQN8_9PASS/4-216 AC A0A7L2SQN8.1
#=GS A0A654GSD2_9CEST/193-344 AC A0A654GSD2.1
#=GS A0A437D5R3_ORYJA/11-221 AC A0A437D5R3.1
#=GS A0A6J0UZX7_9SAUR/7-215 AC A0A6J0UZX7.1
#=GS A0A8C4I185_DICLA/11-220 AC A0A8C4I185.1
#=GS A0A7L4HEX0_PODST/3-209 AC A0A7L4HEX0.1
#=GS A0A8B6EMF1_MYTGA/27-234 AC A0A8B6EMF1.1
#=GS A0A7K7LAC2_9AVES/4-216 AC A0A7K7LAC2.1
#=GS A0A803YL44_MELGA/36-238 AC A0A803YL44.1
#=GS A0A7K8RYF7_9PASS/4-209 AC A0A7K8RYF7.1
#=GS A0A8D2NH64_ZONAL/11-223 AC A0A8D2NH64.1
#=GS A0A6A5EZG5_PERFL/11-220 AC A0A6A5EZG5.1
#=GS A0A286XBA2_CAVPO/6-210 AC A0A286XBA2.1
#=GS A0A7K8H649_9CORV/4-216 AC A0A7K8H649.1
#=GS A0A7L1CQQ9_9PASS/4-216 AC A0A7L1CQQ9.1
#=GS A0A7L2PTZ5_9PASS/4-216 AC A0A7L2PTZ5.1
#=GS A0A7K4K505_9AVES/4-216 AC A0A7K4K505.1
#=GS A0A6I9NT38_9TELE/5-199 AC A0A6I9NT38.1
#=GS A0A093NPZ8_PYGAD/4-216 AC A0A093NPZ8.1
#=GS A0A8C2W835_CHILA/12-232 AC A0A8C2W835.1
#=GS A0A8C4BDT6_9TELE/5-208 AC A0A8C4BDT6.1
#=GS A0A1U7RMD7_ALLSI/44-278 AC A0A1U7RMD7.1
#=GS A0A556UF33_BAGYA/12-231 AC A0A556UF33.1
#=GS A0A6P7SEA0_OCTVU/40-250 AC A0A6P7SEA0.1
#=GS A0A7L2R443_9PASS/4-216 AC A0A7L2R443.1
#=GS A0A6P6J7T8_CARAU/7-210 AC A0A6P6J7T8.1
#=GS A0A851EFG1_9CORV/4-216 AC A0A851EFG1.1
#=GS A0A3M6TXY1_POCDA/14-220 AC A0A3M6TXY1.1
#=GS A0A8U8C1G5_GEOPR/5-210 AC A0A8U8C1G5.1
#=GS A0A430Q8X2_SCHBO/184-367 AC A0A430Q8X2.1
#=GS A0A674IL06_TERCA/18-238 AC A0A674IL06.1
#=GS A0A851XB43_EOLRO/3-209 AC A0A851XB43.1
#=GS A0A6P8T9V3_GYMAC/5-193 AC A0A6P8T9V3.1
#=GS A0A4W5KZD1_9TELE/28-224 AC A0A4W5KZD1.1
#=GS A0A8C7CWR8_ONCKI/64-272 AC A0A8C7CWR8.1
#=GS A0A4S2M4R3_OPIFE/169-403 AC A0A4S2M4R3.1
#=GS A0A6J2RS60_COTGO/5-211 AC A0A6J2RS60.1
#=GS V8P9N1_OPHHA/11-224 AC V8P9N1.1
#=GS A0A4E0RS04_FASHE/213-450 AC A0A4E0RS04.1
#=GS A0A852DNU7_PASAF/4-216 AC A0A852DNU7.1
#=GS A0A7L0Z3S9_9PASE/4-216 AC A0A7L0Z3S9.1
#=GS A0A7K6SFH6_9GRUI/2-214 AC A0A7K6SFH6.1
#=GS A0A7K9AMT0_DRONO/4-216 AC A0A7K9AMT0.1
#=GS A0A267GEB1_9PLAT/94-270 AC A0A267GEB1.1
#=GS A0A484GHN8_SOUCH/12-232 AC A0A484GHN8.1
#=GS A0A8C6X8H9_NAJNA/33-233 AC A0A8C6X8H9.1
#=GS B4NQF6_DROWI/21-226 AC B4NQF6.1
#=GS A0A087TFK6_STEMI/1-68 AC A0A087TFK6.1
#=GS A0A6P3QDQ3_PTEVA/12-232 AC A0A6P3QDQ3.1
#=GS H2S1L5_TAKRU/11-221 AC H2S1L5.3
#=GS A0A7I8VJU6_9ANNE/19-194 AC A0A7I8VJU6.1
#=GS A0A091VN43_NIPNI/4-216 AC A0A091VN43.1
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#=GC seq_cons .............................................................................................................................hh.h.h.ht..uhsQ.....ahh.lR..P.t...P.SDs.....L.P.l...h..-...L.h.E..cP.DP..h...a.D..PKE+D.LsEshLR...plLGuc.FD......PsFMuls...P.........ps.p........................h....u..s.-.s.hs...............p.........pt+s....sG....s..h..P....s....E...l...+.....s...L.-...h........-.....s.........G................p+..t.......+.....l..u....K............K...l............R........R........+.......L........p.....WL....Wu..t..Ta.....CPVlYsWpDLGsRF.....WPRYlKh..GsCh............u...c...R.......S..........CS..lPEG.M.sCKP..uKS...splTlLR...W+...C.....p..t..c..........................................................................................u..t..p+...C.sWIPlQYPlIoECKCSC........................................................................
//
