#=GF ID   Nop5_N
#=GF AC   PF21667.1
#=GF DE   Nop5, N-terminal domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   ECOD:EF16500
#=GF GA   27.00 27.00;
#=GF TC   27.40 36.10;
#=GF NC   24.50 22.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0759
#=GF RC   Paper describing PDB structure 3t7z
#=GF RN   [1]
#=GF RM   22496443
#=GF RT   Structurally conserved Nop56/58 N-terminal domain facilitates
#=GF RT   archaeal box C/D ribonucleoprotein-guided methyltransferase
#=GF RT   activity.
#=GF RA   Gagnon KT, Biswas S, Zhang X, Brown BA 2nd, Wollenzien P, Mattos
#=GF RA   C, Maxwell ES;
#=GF RL   J Biol Chem. 2012;287:19418-19428.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This entry represents the N-terminal domain of archaeal Nop5, a
#=GF CC   Nop56/58 homologue which are pre-RNA processing
#=GF CC   ribonucleoproteins (RNP). This domain is very well conserved and
#=GF CC   mediates a stable interaction with fibrillarin, playing a role
#=GF CC   in both RNP assembly and methyltransferase activity [1].
#=GF SQ   6
#=GS D7DTQ2_METV3/1-81    AC D7DTQ2.1
#=GS A6UV21_META3/1-122   AC A6UV21.1
#=GS F6BE65_METIK/1-120   AC F6BE65.1
#=GS D7DTQ2_METV3/89-163  AC D7DTQ2.1
#=GS Q6LZM8_METMP/1-121   AC Q6LZM8.1
#=GS Y694_METJA/1-117     AC Q58105.1
D7DTQ2_METV3/1-81               .....................MLSAILVPYGIFIVKKDDET.QN..FEDITnnivYFKKFDEEEIPSIMYELRQ.DANEKKEELKNALI...EEIKE-------------------------..-----.----------------------lketnenkedle
A6UV21_META3/1-122              .....................MINLTFTIFGAFATEKDGEI.NS..IDDID....YYKIFDNNNRIKISYDLKN.GDYTIIEELKEQWNletDDIKVELAGNTPLPIGIFVRRNLYEIGLKYgeGLFNN.YEEFLEKMNLWSSELTKMNMKQ............
F6BE65_METIK/1-120              .....................MLFIAFSPFGAFALKEKESYtYT..IDDIE....YYKIFNEEEIPKILYDLKRgNVQGIIEDLKKEWNv.dDEVDVEVFG-KPNVAGEIVRANLYELGRKF..GVFED.YNDFINKMNFWALELTKLSMKS............
D7DTQ2_METV3/89-163             kdeeianleslkilnleeles--------------------.--..-----....-------------------.--------------...--ITFE--GSKIKAENDAIRNVMYELGVQY..GVFEDlEDDFLNKMNEWTVQYTKMMMKR............
Q6LZM8_METMP/1-121              .....................MLFIAFAPFGAFALEANSKN.DGysLDDIK....YYKIFENEDIPKIMYALRQ.GDFEIIAELKNEWEieeEDVSFE-YTTSKNPLGELIRDNLYELGQKY..EVFED.ESDFVSKMNVWATAFTKSMMKK............
Y694_METJA/1-117                .....................MIYVTFTPYGAFGVKDNKEV.SG..LEDIE....YKKLFNEEEIPDIMFKLKT.QPNKIADELKEEWG...DEIKLETLSTEPFNIGEFLRNNLFKVGKEL..GYFNN.YDEFRKKMHYWSTELTKKVIKS............
#=GC seq_cons                   .....................Ml.lsFsPaGAFulccspch.ps..l-DIc....YaKlFspE-IPcIhYcL+p.ss.pIh-ELKppWt...--IchE.husp..shG-hlRsNLYElGhca..GlFps..s-FlpKMNhWusphTKh.MKp............
//