#=GF ID   NotI
#=GF AC   PF12183.12
#=GF DE   Restriction endonuclease NotI
#=GF AU   Mistry J;0000-0003-2479-5322
#=GF AU   Gavin OL;
#=GF SE   pdb_3bvq
#=GF GA   22.00 22.00;
#=GF TC   22.00 23.10;
#=GF NC   21.70 21.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   18400177
#=GF RT   Structures of the rare-cutting restriction endonuclease NotI
#=GF RT   reveal a unique metal binding fold involved in DNA binding.
#=GF RA   Lambert AR, Sussman D, Shen B, Maunus R, Nix J, Samuelson J, Xu
#=GF RA   SY, Stoddard BL;
#=GF RL   Structure. 2008;16:558-569.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR022009;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This family of proteins is found in bacteria. Proteins in this
#=GF CC   family are typically between 270 and 341 amino acids in length.
#=GF CC   There is a conserved CPF sequence motif. The type IIP
#=GF CC   restriction enzyme, NotI, is a homodimer that recognises the 8
#=GF CC   bp DNA sequence 5'-GC/GGCCGC-3' and cleaves both strands of DNA
#=GF CC   to create 5', 4 base cohesive overhangs.
#=GF SQ   94
#=GS A0A2H3NLF6_9BACT/9-238    AC A0A2H3NLF6.1
#=GS A0A7C9J2X7_9RHOB/40-275   AC A0A7C9J2X7.1
#=GS A1BHQ3_CHLPD/10-67        AC A1BHQ3.1
#=GS A0A0X1T2K1_PSEAA/23-235   AC A0A0X1T2K1.1
#=GS A0A1X3P8B5_9MICC/15-227   AC A0A1X3P8B5.1
#=GS A0A4Y8SQ91_9SPHI/15-242   AC A0A4Y8SQ91.1
#=GS A0A0C2UQT8_9BACL/16-239   AC A0A0C2UQT8.1
#=GS A0A7T8ADD6_9SPHN/66-303   AC A0A7T8ADD6.1
#=GS A0A316JC50_9HYPH/30-147   AC A0A316JC50.1
#=GS B7KLG6_GLOC7/22-220       AC B7KLG6.1
#=GS A0A1Q2SLH7_9GAMM/13-239   AC A0A1Q2SLH7.1
#=GS A0A0W1R7X6_9EURY/18-234   AC A0A0W1R7X6.1
#=GS A0A1M6KH37_9RHOB/177-412  AC A0A1M6KH37.1
#=GS A0A2S8SQA3_9BACT/8-236    AC A0A2S8SQA3.1
#=GS A0A401UDE0_9BACT/13-240   AC A0A401UDE0.1
#=GS A0A1I4EWA8_9PROT/15-225   AC A0A1I4EWA8.1
#=GS U5QCS6_9CYAN/27-253       AC U5QCS6.1
#=GS A0A0Q8LCD3_9HYPH/19-216   AC A0A0Q8LCD3.1
#=GS A0A840MQ82_9PROT/21-235   AC A0A840MQ82.1
#=GS A0A6H1U097_9CYAN/15-235   AC A0A6H1U097.1
#=GS A0A1I1MED5_9RHOB/72-310   AC A0A1I1MED5.1
#=GS A0A328VKP2_9CHLR/18-239   AC A0A328VKP2.1
#=GS A0A1H2BU38_9SPHI/38-235   AC A0A1H2BU38.1
#=GS A0A498CMT8_9FIRM/9-208    AC A0A498CMT8.1
#=GS A0A069P5A5_9BURK/2-194    AC A0A069P5A5.1
#=GS A0A256A6R0_9FLAO/13-239   AC A0A256A6R0.1
#=GS W0PKF7_ADVMD/15-211       AC W0PKF7.1
#=GS A0A8J8FFB5_9BACT/13-239   AC A0A8J8FFB5.1
#=GS A0A4V1RVC0_9BACT/48-230   AC A0A4V1RVC0.1
#=GS A0A150XEP2_ROSEK/13-239   AC A0A150XEP2.1
#=GS A0A318UB79_9SPHI/13-239   AC A0A318UB79.1
#=GS A0A1I1QV69_9RHOB/13-226   AC A0A1I1QV69.1
#=GS H1WMW5_9CYAN/19-228       AC H1WMW5.1
#=GS A0A0A0HSR4_9RHOB/14-227   AC A0A0A0HSR4.1
#=GS A0A316JC50_9HYPH/150-299  AC A0A316JC50.1
#=GS A0A257FJQ7_9BURK/133-377  AC A0A257FJQ7.1
#=GS A0A1I6LIV5_9BACT/16-255   AC A0A1I6LIV5.1
#=GS A0A1T4VRW8_9GAMM/26-234   AC A0A1T4VRW8.1
#=GS C5AJ73_BURGB/19-234       AC C5AJ73.1
#=GS A0A1J0ABJ1_9CYAN/15-237   AC A0A1J0ABJ1.1
#=GS A0A1U7IMQ1_9CYAN/9-236    AC A0A1U7IMQ1.1
#=GS A0A1H6FJ68_9GAMM/30-254   AC A0A1H6FJ68.1
#=GS R6ZGA1_9CLOT/9-208        AC R6ZGA1.1
#=GS A0A1E5Q458_9PROT/124-239  AC A0A1E5Q458.1
#=GS A3VJB0_9RHOB/15-226       AC A3VJB0.1
#=GS A0A0F3GJW6_9BACT/18-247   AC A0A0F3GJW6.1
#=GS A0A4R5D8J0_9BACT/12-220   AC A0A4R5D8J0.1
#=GS A0A5C7EFZ9_9PROT/21-236   AC A0A5C7EFZ9.1
#=GS A0A7Y9MBN3_9MICO/15-209   AC A0A7Y9MBN3.1
#=GS A0A1Y4WH83_9FIRM/13-209   AC A0A1Y4WH83.1
#=GS A0A133UCM8_9EURY/21-236   AC A0A133UCM8.1
#=GS A0A1Z4C521_9GAMM/16-218   AC A0A1Z4C521.1
#=GS T0J8E2_9SPHN/32-173       AC T0J8E2.1
#=GS A0A6P2G184_9BURK/32-277   AC A0A6P2G184.1
#=GS A0A6I4U0Q5_9SPHN/18-226   AC A0A6I4U0Q5.1
#=GS A0A1I0GVG8_9CLOT/19-237   AC A0A1I0GVG8.1
#=GS A0A7U7GAT5_9GAMM/6-153    AC A0A7U7GAT5.1
#=GS A0A109CY13_9BURK/12-227   AC A0A109CY13.1
#=GS Q28NA7_JANSC/66-303       AC Q28NA7.1
#=GS A0A0B6WUM2_9BACT/10-242   AC A0A0B6WUM2.1
#=GS A0A6L9SD70_9ACTN/14-227   AC A0A6L9SD70.1
#=GS A1BHQ4_CHLPD/1-167        AC A1BHQ4.1
#=GS A0A377R524_9NEIS/9-224    AC A0A377R524.1
#=GS A0A1I4XIB7_9PROT/12-214   AC A0A1I4XIB7.1
#=GS A0A1M6HID9_9FLAO/25-234   AC A0A1M6HID9.1
#=GS A0A5R8KIB1_9BACT/27-211   AC A0A5R8KIB1.1
#=GS A0A0F7PPU1_9HYPH/66-221   AC A0A0F7PPU1.1
#=GS A9WI40_CHLAA/15-247       AC A9WI40.1
#=GS A0A399EW61_9DEIN/15-235   AC A0A399EW61.1
#=GS A0A0G3XL25_9SPHN/23-227   AC A0A0G3XL25.1
#=GS A0A256FYH0_9HYPH/3-118    AC A0A256FYH0.1
#=GS A0A0A6P6G9_9GAMM/14-219   AC A0A0A6P6G9.1
#=GS A0A542ZRF5_9ACTN/33-275   AC A0A542ZRF5.1
#=GS A0A4R5DBZ9_9BACT/1-117    AC A0A4R5DBZ9.1
#=GS A0A369QCI6_9BACT/1-125    AC A0A369QCI6.1
#=GS I3IGR9_9BACT/22-241       AC I3IGR9.1
#=GS Q0AZL8_SYNWW/2-165        AC Q0AZL8.1
#=GS A0A2R7J5Z2_9SPHN/15-216   AC A0A2R7J5Z2.1
#=GS A0A7C8EB87_9BACT/9-236    AC A0A7C8EB87.1
#=GS A0A0L1JJF5_9RHOB/15-229   AC A0A0L1JJF5.1
#=GS A0A4Y3TXG5_9PROT/11-239   AC A0A4Y3TXG5.1
#=GS A0A5C7EHL5_9PROT/30-276   AC A0A5C7EHL5.1
#=GS A0A1G5KM06_9FLAO/16-250   AC A0A1G5KM06.1
#=GS A0A1T4MZU5_9SPIR/16-234   AC A0A1T4MZU5.1
#=GS Q5LUK6_RUEPO/66-303       AC Q5LUK6.1
#=GS A0A3A9FFP3_9BACT/19-210   AC A0A3A9FFP3.1
#=GS A0A4Q3Y5M6_9RHOB/114-230  AC A0A4Q3Y5M6.1
#=GS A0A2P8NAF5_9HYPH/106-248  AC A0A2P8NAF5.1
#=GS A0A285TMW1_9HYPH/66-303   AC A0A285TMW1.1
#=GS A0A1H7S6J4_9RHOB/7-229    AC A0A1H7S6J4.1
#=GS A0A180FVT6_9BACT/23-216   AC A0A180FVT6.1
#=GS A0A7L5YVI2_9CHLR/11-209   AC A0A7L5YVI2.1
#=GS Q9PFL7_XYLFA/20-233       AC Q9PFL7.1
#=GS A0A2M9EC12_9GAMM/20-234   AC A0A2M9EC12.1
A0A2H3NLF6_9BACT/9-238               ..............................................e-VFGYAIddfseeaVQH.REEKL-CPF.--N..NK.......SQYCTKDKks...dplGACNV-----.-......-.-.--...-.---..HQRGN.A.VIT...CPQ...R.F.T.E.....D.W.T......I.V..RDS......A.......AFFFE-.........-....---.......-.N..G.........S...T.Y..........H............VL.......R.................E.Y...Q....MRDAD.NE........V..V..G.........N...ID.FVLVKVED--DSI..VDFGTIEVQSVYIS..GN..MRRPFE...HY..MD....DP.E-Q..A..SR..DW..R.SRVserggyyptP..DW...R...SS-......H......KRLFRQINSKGTLLAELGKKQ.AVVIQQPFY.D...SMP...D..L.T..R....VP-..IED..............ANMVWLIYDLVREDE....------rhrlt...............................................
A0A7C9J2X7_9RHOB/40-275              ............................................hdl---TLKL.......DEQ.QRNERPCPF.RTD..MR.......HPTCTKPG........GVCSLQLLSD.D......N.G.QI...R.AAE..GERGM.L.RAL...CPY...R.F.H.Q.....D.D.T......V.F..RHI......G.......EHLLDD.........P....APK.......Q.V..G.........E...V.G..........F............LE.......S.................T.G...N....LDSAP.GE........N..V..G.........R...ID.MILYSPASAMGAP..AKWAAVEIQAVYFS..GR..EMGLEF...RH..LD....KT.AGR..L..SM..AQ..A.KRR.........P..DY...R...SSG......P......KRLMPQLQIKVPTLRRWGKKM.GIVVDIPFF.M...SMG...N..M.R..T....VEN..VSN..............ADIVWYLVDFRS---....------vpgedir.............................................
A1BHQ3_CHLPD/10-67                   .................................evfgfrvndhsara-------.......KRY.RAHRL-CPF.--N..NK.......IPNCTKDKak...nplGVCSI--FHN.N......N.T.VI...-.---..-----.-.---...---...-.-.-.-.....-.-.-......-.-..---......-.......------.........-....---.......-.-..-.........-...-.-..........-............--.......-.................-.-...-....-----.--........-..-..-.........-...--.-------------..--------------..--..------...--..--....--.---..-..--..--..-.---.........-..--...-...---......-......---------------------.---------.-...---...-..-.-..-....---..---..............---------------....------tcpi................................................
A0A0X1T2K1_PSEAA/23-235              ...................inhqrcsytnkrcykvrksnpeisigtc-------.......---.---------.---..--.......--------........----------.-......-.-.--...S.VLY..GKASE.P.VII...CPV...R.L.I.E.....R.R.Q......I.F..TDC......F.......HLLTT-.........-....--H.......E.P..G.........N...E.L..........H............IV.......P.................E.V...S....IP---.--........-..G..G.........S...VD.YFLVSVKD--GKV..KDFVGIELQTLDTT..GT..VWPERQ...RM..LK....ELgLPR..I..DG..AE..D.STKt.......fG..MN...W...KMT......A......KTILVQMHHKVQTFEHINKKL.VLVVQDKLL.S...YMT...R..E.F..K....FDH..---..............---------------....------lkapalisdsmhlhaykmdnagagdyk.........................
A0A1X3P8B5_9MICC/15-227              .......................................ddsqeaie-------.......---.AAQRARCPF.---..-M.......DDTCTKTLrdg..tiaGVCTL-----.-......-.-.--...-.--K..PATNS.P.VIC...CPI...RlY.A.D.....D.Y.R......I.L..RDV......A.......DRAFAP.........G....LPL.......K.A..G.........A...S.A..........V............VE.......ArhrnsevvavfgkrwggE.L...H....LPQRQ.GT........G..A..Y.........F...VD.WILARVDS-GGNL..VEFVAIEVQSIDTT..GN..YQDARR...K-..LL....DP.ARR..V..EK..AT..A.GFN.........W..--...-...ENV......N......KRILPQLIYKGNVLQR-----.---------.-...---...-..-.-..-....---..---..............---------------....------eqlclkglffvtptpvfdkvmsrl............................
A0A4Y8SQ91_9SPHI/15-242              ...................................lgekaykgidps-------.......---.-SNNFECPF.---..-I.......KSRCTKRStnlpnepyPVCSI--WRK.G......D.G.NA...D.P--..--KQD.L.IFV...CPK...R.F.Y.A.....V.D.F......L.T..DVI......D.......HCWPG-.........E....KP-.......-.-..-.........K...N.A..........R............FA.......-.................-.-...-....-PEVK.MA........D..F..G.........N...VD.FVIADVQD-DGEV..GNFLSVELQAIDIT..G-..--SVFK...AY..QA....LR.EGK..D..-L..DR..S.PTF.........G..LN...W...DNV......Y......KRYVTQLIRKGYFHHHWKSKI.VAVIPDQVY.KyitSRA...D..F.M..R....STD..VKNn...........pqINIIFMTYRLEIDP-....------nhsgkyk.............................................
A0A0C2UQT8_9BACL/16-239              ......................................demhepvna-------.......---.--DYI-CPF.I--..--.......SERCVKRGhnt.rdpfPVCTL--WKQ.S......G.S.G-...-.-VN..RVPSR.P.VIV...CPK...R.F.F.T.....A.D.I......V.-..GDI......L.......EHVWVG.........P....---.......-.-..Y.........D...R.E..........K............IE.......A.................V.R...E....I--KM.G-........K..I..G.........N...VD.MVVCDTST-LPVL..DKFVSVELQAIDIT..GS..VSDAYT...DH..IS....--.--Q..V..VM..ER..P.PKY.........N..FN...T...ANV......H......KRYLTQLIKKGYFHSTWRKKI.VAVVQDFLL.E...SIR...E..R.V..RfaatNPK..DEN..............TSIVFMSYSLDTSEK....------deegyyrl............................................
A0A7T8ADD6_9SPHN/66-303              ...............................................DVLREKL.......SKQ.NEDELPCPF.KAG..RD.......HPVCTKKG........GVCSIRLYED.S......G.N.QI...E.PVK..GDQGK.I.RSL...CPW...R.F.H.Q.....G.H.V......A.F..AEI......G.......KSLLGT.........S....DPV.......E.V..G.........E...V.G..........F............LE.......S.................T.G...S....LDSEE.GK........D..V..G.........R...ID.MVLLKLDKDDQSL..LDWVAVEVQAVYFS..GK..RMAVEF...DD..IA....NR.QGK..L..AM..PV..L.GRR.........P..DY...R...SSG......V......KRLMPQLLTKIPTLRRWGKKM.AIVVDWAFY.H...SMG...Q..M.E..Q....TKH..ISN..............ADIAWFIADFVEDPV....SGRYQL....................................................
A0A316JC50_9HYPH/30-147              ............................................aer----KML.......ADT.KNTTMNCPF.FEQ..VPalgpksgKLHCNKKG........GVCSLRNFHE.P......L.P.PA...D.DIT..F--GP.I.TAT...CPN...R.F.L.E.....N.G.T......I.V..KHI......G.......QYVLGT.........E....EPL.......F.A..K.........E...I.A..........F............LM.......-.................-.-...-....-----.--........-..-..-.........-...--.-------------..--------------..--..------...--..--....--.---..-..--..--..-.---.........-..--...-...---......-......---------------------.---------.-...---...-..-.-..-....---..---..............---------------....------rpragevgaaeadaaaeed.................................
B7KLG6_GLOC7/22-220                  ..........................................ivanq-------.......---.-----PCPY.-LQ..KR.......CIKIRKSQ........PEISI-----.-......-.G.TC...S.VIY..GKKAI.P.III...CPH...R.M.L.E.....R.K.Q......V.F..IDC......L.......HLLTT-.........-....--H.......Q.P..G.........N...E.L..........H............II.......S.................E.V...A....IP---.--........-..G..G.........N...VD.YFLISVNG--SKV..KDFVGIELQTLDTT..GT..VWPERQ...RL..LE....EL.GVP..V..DA..PK..S.KDSks.....fgM..N-...W...KMT......A......KTILVQLHHKIETFENINKKL.VLVIQDCFL.H...YIQ...R..-.-..-....---..---..............---------------....------efnfshvshqaqlgdslh..................................
A0A1Q2SLH7_9GAMM/13-239              .................................evfgfpidnqskra-------.......VRY.RENKL-CPF.--N..NI.......VSNCTKNSie...fplGVCSL-----.-......-.-.--...-.---..NHKGK.P.III...CPI...R.F.R.E.....D.W.R......I.I..SDV......A.......AFIFD-.........-....---.......-.A..K.........T...T.W..........T............HV.......G.................E.V...R....LKDKF.GK........S..A..G.........N...ID.YVLVAYDD-KGQV..LDFGSLEVQSVYIS..GN..LTGPFS...AF..LE....NP.IPE..F..NW..THalK.YPK.........P..DY...L...SSS......R......KRLVPQIIAKGSILNQWGKKQ.AVALQTAFY.N...TLP...P..L.P..E....VD-..KAE..............SDFAFFLYDLVPVKK....EKRL--el..................................................
A0A0W1R7X6_9EURY/18-234              .....................................anreeakkgm-------.......---.--EDDHCPF.-VD..GT.......CKKRRKSEge....siGTCAV-GYRG.Q......G.-.--...-.---..QAEYK.P.HCI...CPH...R.F.E.T.....P.-.E......V.L..NEI......E.......SLFVN-.........-....---.......-.E..G.........E...Y.-..........F............AT.......P.................E.V...P....LQG--.--........-..-..T.........S...ID.YVAGKRAD-DGTV..IDFAGVEIQALDTT..GS..VWNHRE...AY..FD....DD.AD-..M..ED..VS..K.NYG.........I..NW...A...MSL......T......KTMMQQAYKKGQTFGEWGENL.IFLVQ----.-...---...-..-.-..-....---..---..............---------------....------dvsidyirdnydasglrsarkddpvhfysyrmdynhetdny...........
A0A1M6KH37_9RHOB/177-412             ......................................leqdyldlt-------.......---.-ATRKVCPF.RTD..SP.......FPLCTKAG........GVCSIRLVEE.V......G.G.KV...Q.PVA..GERAP.I.RAT...CPY...R.F.Q.E.....G.N.R......V.F..QAI......G.......KDLLGD.........P....EPH.......Q.A..G.........E...V.G..........F............LE.......S.................T.G...N....LDSAP.GQ........D..V..G.........R...ID.MVLVKTNAPEGHP..LEWVAAEIQAVYFS..GD..EMPMEF...KQ..LR....EN.GGR..L..TM..PA..G.KRR.........P..DY...R...SSG......P......KRLMPQLQIKVPTLRRWGRKM.VCIVDTPFY.D...SMG...K..M.E..E....VED..VSN..............GDIVWYLVDFVAGDP....GEPHQL....................................................
A0A2S8SQA3_9BACT/8-236               ................................evfgfpidnnspqae-------.......-RH.RRLKL-CPF.--N..NK.......VPNCTKDKak...dplGVCSI-----.-......-.-.--...-.---..LQNDA.P.VIT...CPV...R.F.R.E.....E.W.L......I.A..EDA......A.......AFFFG-.........P....D--.......-.-..-.........V...Q.W..........T............SL.......T.................E.V...R....LPDKH.GK........S..A..G.........N...ID.VVLVAYDQ-NGQV..TDFGSLEVQAVYIS..GN..VSLPFK...YF..MQ....AP.AER..A..DM..DW..S.KQPly.....prA..DF...L...SSS......R......KRLAPQLIFKGGILRAWQKKM.AVALDSAFW.A...TLP...A..I.P..Q....VP-..ATE..............ADMAWLIYDLERDES....EKRFHL....................................................
A0A401UDE0_9BACT/13-240              .................................evfgfpinnesara-------.......KRY.RENKL-CPY.--N..NI.......VSNCTKNSie...fplGVCSL-----.-......-.-.--...-.---..NHKEK.P.VII...CPI...R.F.R.E.....D.W.S......I.I..SDA......A.......SFIFD-.........-....---.......-.K..K.........A...T.W..........T............HV.......G.................E.V...R....LKDKH.GK........S..A..G.........N...ID.YVLVSYDD-KGRV..VDFGSLEVQAVYIS..GN..LTGPFT...AY..LE....EP.SPS..F..TW..TQ..A.FKFp.......kP..DY...L...SSS......R......KRLIPQIIAKGSILKQWKKKQ.VVALQTSFY.K...TLP...D..L.P..E....VD-..KAE..............SDFAFFLYDLVPTKS....------ktlelkl.............................................
A0A1I4EWA8_9PROT/15-225              ...........................................ddse------V.......AQE.AAKTETCPV.-TG..TK.......CEKTFNDGi.....isGVCTL-----.-......-.-.--...K.PIT..---SE.P.VIC...CPI...R.LyA.D.....D.Y.Q......I.R..KDV......S.......LKAFEQ.........E....LPL.......V.P..G.........R...E.A..........Vayaqd..rgqacIAvfgkgwgG.................E.L...R....LPQKS.GS........G..G..Y.........F...VD.WVLGKIDA-DGSL..LEFTAIEVQTIDTT..GN..YRNG-F...SA..LK....DS.RT-..-..-V..EK..T.SAG.........L..NW...-...ENV......S......KRILPQLIYKGQVLQRE----.---------.-...---...-..-.-..-....---..---..............---------------....------elckrglffvcpeqvferiakr..............................
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A0A4R5DBZ9_9BACT/1-117               ...............................................-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.---..-----.-.---...---...-.-.-.-.....-.-.-......-.-..---......-.......------.........-....---.......-.-..-.........-...-.-..........-............--.......-.................-.-...-....-----.--........-..-..-.........-...--.----------GRI..LDFASLEVQAVYIS..GT..IRGAFR...TY..ME....TQ.SPD..FewRG..VT..K.YPR.........P..DY...L...SSS......N......KRLIPQMLTKGGIFKQWAKKQ.AVAVQTAFF.N...TLP...E..L.I..E....VS-..PEE..............ADLAWLLYDLIPSED....GLRYDL....................................................
A0A369QCI6_9BACT/1-125               ...............................................-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.---..-----.-.---...---...-.-.-.-.....-.-.-......-.-..---......-.......------.........-....---.......-.-..-.........-...-.-..........-............--.......-.................-.-...-....-----.--........-..-..-.........-...MD.MVLAEMDE-WGEI..HKFVSVELQAVDIT..G-..--SYFP...AY..NA....LT.NSE..M..--..--..L.ERA.........P..TY...SfnwKNV......Y......KRYVTQLIDKGFQHSMWKTII.VSVMQDTVL.ErilQIG...N..I.A..S....SP-..INE..............SNVVFLGYKFVEDEF....NGRF--tp..................................................
I3IGR9_9BACT/22-241                  .......................................adwkalaa-------.......---.---AQQCPF.---..-L.......NRKCLKNRksdpeitiGT--------.-......-.-.-C...T.VVY..GRQPQ.P.VII...CPF...R.L.L.D.....R.R.Q......V.F..TDC......V......hLRKLH-.........-....---.......E.P..G.........N...E.L..........R............IV.......A.................E.L...A....VP---.--........-..G..G.........S...IG.YCLVSVRD--GKP..RDFIGIELQTLDTT..GT..VWPERQ...RF..LR....QH.KVY..V..NR..EH..A.TSDk......pfG..MN...W...KMT......A......KTILVQLNHKITTFEHLHKRL.VLVLQDCLL.D...YMR...-..-.-..-....---..---..............---------------....------refafdhikgirdgdpmqfhayelrkesaayrlkl.................
Q0AZL8_SYNWW/2-165                   ......................................vtidaasff-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.---..-----.-.---...---...-.-.-.-.....-.-.-......-.-..---......-.......---FS-.........-....---.......-.P..G.........T...K.W..........T............TL.......T.................E.V...R....LNDIN.GH........T..A..G.........N...ID.IVLVAYDD-YGKI..TDFGALEIQSVYIS..GN..IRRPFE...AY..IQ....EP.ELM..Y..NM..DW..L.SKPny.....prP..DY...L...SSS......R......KRLVPQLIYKGKILNVWSKKI.AVALHSGFF.S...TLP...Q..L.P..R....VS-..ADK..............AEIAWLIYDIELKQE....TNRYNL....................................................
A0A2R7J5Z2_9SPHN/15-216              ...................................qreaspfvtdrq-------.......---.------CPF.---..-T.......RGDCIKPD.......hGACSVKQVNS.G......I.I.IC...C.PNR..LYADD.Y.RAL...SEVgheV.F.G.Q.....G.T.E......L.ItaSDArl..rkA.......QGTLTG.........N....QAV.......L.F..G.........K...R.W..........G............GE.......L.................PlP...R....PPRAD.GG........K..A..G.........Sy.yVD.WIVAKIDQ-NGEL..LEFTALEVQSIDTT..GN..YGDQAE...AY..FE....GK.PFP..G..MG..GR..G.YSD.........A..DM...N..wENV......N......KRILPQLIYKGHVLRREAK--.---------.-...---...-..-.-..-....---..---..............---------------....------cskgl...............................................
A0A7C8EB87_9BACT/9-236               ...................................vfgfpitnftke------A.......KRF.RRNKL-CPF.--N..NK.......VPSCTKDKak...nplGVCSI-----.-......-.-.--...-.---..FDDGN.P.VIT...CPV...R.F.R.Q.....S.W.V......I.A..EKA......A.......RFCFE-.........-....---.......-.K..S.........A...S.W..........T............SI.......A.................E.V...R....LTDKN.GK........S..A..G.........N...ID.LVLVAYDD-RGHV..TDFCSLEIQAVYIS..GN..IRSPFE...YY..MG....SP.NTR..K..GM..IW..K.RKPny.....pkP..DF...L...SSS......R......KRLIPQVLYKGGILKAWGKKQ.TVALQKSFF.E...TLP...E..I.P..Q....VN-..AEQ..............ADIAWFLYDLKKDSK....ANLFNL....................................................
A0A0L1JJF5_9RHOB/15-229              ..............................................d---RSDL.......AKH.AADTEVCPI.SRE..--.......--TCQKSFndg..vvsGVCAI-----.-......-.-.--...K.PIT..S---E.P.VIC...CPI...RlY.A.D.....D.Y.R......I.L..SDI......A.......DRVFGP.........N....LKL.......V.A..G.........RdavN.Y..........S............ID.......Nrepcvav...fgkgwggE.L...R....LPQKS.KK........G..G..Y.........F...VD.WVLAKISE-EGDL..VEFVAVEVQTIDTT..GT..YRPG-Y...DA..LK....Q-.DGL..V..EK..TT..A.GLN.........-..--...W...ENV......A......KRILPQLIYKGQILQR-----.---------.-...---...-..-.-..-....---..---..............---------------....------eelcksglffvcpepvfkrimerlggq.........................
A0A4Y3TXG5_9PROT/11-239              ........evlgrravkgrdpaalafecpfikarcpkrstqlpnepy-------.......---.---------.---..--.......--------........PVCTL--WRR.A......D.G.EA...D.PA-..---KD.L.IFV...CPK...R.F.Y.A.....V.D.F......L.T..EVV......G.......HCWSG-.........-....---.......E.K..P.........E...N.P..........Q............VA.......A.................E.V...K....MA---.--........G..F..G.........N...VD.LVIADVKG-DGEI..GQFLSVELQAIDIT..GS..V---FP...AY..QA....LR.AG-..-..-M..D-..L.DKR.........P..TYglnW...DNV......Y......KRYITQLIRKGYFHHHWKSKI.VAVIPEQVY.Q...YITgraD..F.I..R....SSD..VTNp............qVNIIFMTYRLEAD--....------parageyr............................................
A0A5C7EHL5_9PROT/30-276              ........................................fahkakl-------.......T-H.KVANLECPY.RTRlfGR.......PMMCNKNG........GVCSIALYTQ.S......T.D.DN...L.P--..NVSQD.I.VSL...CPS...R.L.L.-.....E.P.E......V.F..KRI......G.......KAILGS.........D....EVY.......L.V..R.........E...V.P..........F............LQ.......N.................A.A...A....NSQFI.GA........K..A..G.........R...LD.FVLVDNID----R..KRWCAVETQSVYFS..GR..NMKIEF...DA..II....SA.GGE..L..TM..PV..A.RRR.........P..DY...R...SSV......P......KRLSPQLMLKAPYLGS-GKYL.AVIVDTYVR.S...QMA...E..L.E..E....VSV..NCDgmndeelrleklalSQIVWFVVDLRPG--....------ecakvvnehy..........................................
A0A1G5KM06_9FLAO/16-250              ..................................gslqaneaaavyn-------.......---.------CPI.---..--.......------LK........STCEKRLSDG.K......I.A.GV...C.SLK..PIKSG.P.VIC...CPI...RlY.A.D.....D.Y.K......I.L..TDV......V.......SQAFGE.........D....FPL.......L.P..G.........R...E.AlakvkatgkpS............IAvfgkkwgG.................E.L...R....LPKRS.GS........G..G..Y.........F...VD.WVLAKLNG-SGEL..EEFVAVEVQTIDTT..GN..YRNGIN...-A..LE....NN.--R..L..--..-Q..E.KTT.........A..GL..nW...ENV......S......KRILPQLIYKGQLLQRE----.---------.-...---...-..-.-..-....---..---..............---------------....------efckkglffvcpepvytrimerlggesglvkyalqpasisflaynfd.....
A0A1T4MZU5_9SPIR/16-234              ......................................enidkrasy-------.......--Y.RENRL-CPF.--F..NR.......FPNCTKDKad...dplGVCSI-----.-......-.-.--...-.---..NHQGS.K.IIT...CPS...R.F.R.E.....D.W.M......I.L..RNA......A.......AFVWP-.........-....---.......-.K..G.........T...K.W..........T............SL.......P.................E.I...R....LSDAN.GQ........S..A..G.........N...ID.YVLVSYDT-DGKI..LDFASIEVQGVYIS..GN..LRNSFK...EY..MT....NP.SPD..F..SW..DG..K.NYP........hP..DY...L...SSS......R......KRLIPQMLYKGGIFKAWGKKQ.CFVIQKSFF.E...TLP...S..L.P..Q....VS-..KEQ..............ADIAWFLYDLDYSK-....------tdnqnhl.............................................
Q5LUK6_RUEPO/66-303                  ...............................................SVLRDKL.......TRQ.QAEEIPCPF.RPD..TP.......NATCTKPG........GVCSIRVYRG.E......K.N.RV...E.PIT..GERGR.L.RAL...CPW...R.F.H.Q.....D.G.K......A.F..SEV......G.......KRLLND.........P....DPI.......K.A..G.........E...V.G..........F............LE.......S.................S.G...N....LDSDP.GE........D..V..G.........R...ID.MILVKSNGVEGAP..MDWVAVEVQAVYFS..GK..KMSIEF...DH..LI....KT.QGK..I..SM..AR..E.KRR.........P..DY...R...SSG......V......KRLMPQLQTKVPTLRRWGKKM.AVVVDAPFF.Y...SMG...E..M.A..R....ERD..VSN..............ADIIWFLADFKEDLN....GGGFKL....................................................
A0A3A9FFP3_9BACT/19-210              ......................................ealivvaqk-------.......---.-----RCPF.LGT..QC.......TKILSRDRv.....vsGVCAIRQKTD.G......SpN.VI..cC.PIR..IYAED.Y.KML...RTI...A.N.N.A.....F.G.M......N.L..NLY......A.......GRAAVD.........K....SKS.......E.G..G.........A...I.A..........V............FGhg...wgG.................E.L...R....LPQRE.GT........G..S..Y.........F...VD.WVLARLDA-NGEL..VEFTAIEVQTIDTT..GN..YRDAR-...QA..LE....DS.R-E..I..VP..CT..V.GLN.........W..EN...-...--V......S......KRIIPQLIYKGQVLQR-----.---------.-...---...-..-.-..-....---..---..............---------------....------edlcrt..............................................
A0A4Q3Y5M6_9RHOB/114-230             .................................elplprpkgkgakt-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.---..-----.-.---...---...-.-.-.-.....-.-.-......-.-..---......-.......------.........-....---.......-.-..-.........-...-.-..........-............--.......-.................-.-...-....-----.-A........S..A..Y.........Y...VD.WVLARLDA-AGDL..SEIIAVEVQTIDTT..GS..YRDQSE...TF..F-....--.QGR..A..YA..DA..S.GRI.........P..GF...S...NAG......MnwenvnKRILPQLIYKGHVLRR-----.---------.-...---...-..-.-..-....---..---..............---------------....------eelcrkglffvcpkqvy...................................
A0A2P8NAF5_9HYPH/106-248             ...................................spqvapevkmtg-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.---..-----.-.---...---...-.-.-.-.....-.-.-......-.-..---......-.......------.........-....---.......-.-..-.........-...-.-..........-............--.......-.................-.-...-....-----.--........-..F..G.........N...VD.FVIADVQD-DGEI..GQFLSVELQAIDIT..GS..AF---K...AY..EA....LR.---..-..AG..ED..L.DER.........P..TYgfnW...DNV......Y......KRYITQLIRKGYFHHHWKSKI.VAVIPEQVYrY...IVG...RadF.M..R....SSD..VKEt............qVNIIFMTYRLEND--....------psrpgeyr............................................
A0A285TMW1_9HYPH/66-303              ..............................................d-ALRDKL.......TRQ.QAEELPCPF.RTD..SP.......HPTCTKPG........GVCSIRIYRE.E......A.G.TI...E.PID..GKRGR.L.RAL...CPW...R.F.H.Q.....D.G.T......A.F..DKI......G.......ESILSD.........P....APL.......R.A..G.........E...V.G..........F............LE.......S.................T.G...N....LDSDP.GE........D..V..G.........R...ID.MILVKSNGPGGSP..MEWVAVEVQAVYFS..GK..KMSIEF...DH..LK....LT.QGK..L..SM..AQ..E.KRR.........P..DY...R...SSG......V......KRLMPQLLTKVPTLRRWGKKM.AVVVDAPFF.Y...SMG...K..M.E..R....VPH..LSN..............ADIVWFLVDFKQAAP....GEPYRL....................................................
A0A1H7S6J4_9RHOB/7-229               ..................................nsiaeilgepari-------.......---.-------GF.DPA..SK.......NYQCPYIG........QTCTKRSTAS.E......Y.PyPV...C.TLK..KRDGA.P.VCV...CPK...R.F.Y.E.....-.I.D......F.L..QEV......V.......QHAWPG.........Q....KPV.......N.P..-.........-...-.-..........R............IA.......R.................E.V...Q....-----.MK........D..F..G.........N...VD.FVIADTAD-GKNI..GQFLSVELQAIDIT..GS..VRDAYD...AI..L-....--.AGQ..M..LD..TK..K.SYG.........F..NW...-...KNV......Y......KRYINQLISKGYYHHHWGTKIvAVIQDEVYN.Y...VCN...DadF.M..R....TADisSQN..............VNIIFMSYRFEDNG-....------aggyk...............................................
A0A180FVT6_9BACT/23-216              ..................cskqhcsylnrkclknrksqadisigtct-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.-VK..YGAEC.N.VII...CPY...R.L.L.E.....R.K.Q......I.F..MDC......L.......HLLTA-.........-....--H.......E.P..G.........N...E.L..........H............LL.......S.................E.I...S....IP---.--........-..G..G.........N...VD.YFIVSTDS-DRNV..KDFIGIELQTLDTT..GT..VWPERQ...RF..LK....KQ.GIK..V..NN..ED..S.DSVk......sfG..MN...W...KMT......A......KTILVQLHHKIDTFECLNKHL.VLIVQDCFL.D...YI-...-..-.-..-....---..---..............---------------....------kknfhllifpkmqnle....................................
A0A7L5YVI2_9CHLR/11-209              ...........................eifgypvsnrsaeaedirrr-------.......---.----HWCPF.---..-T.......DRLCSKQSrll.eypfGVCSV-QYH-.-......-.-.--...-.---..---GE.V.CAI...CPR...R.F.E.E.....R.G.SlrntpiV.L..EQV......A.......RHYFGD.........V....NNI.......V.A..-.........-...-.-..........-............-F.......S.................E.V...G....LP---.--........H..I..G.........T...ID.YVLVLHPPMQPEV..IDFVTVEFQTDSTT..GT..GA-IVQ...GL..RD....FV.DGQ..D..VQ..AQ..V.YRF.........G..MN...T...YDT......F......KRSVTQLLNKGIVYEAWXVKC.YWVIGEY--.-...---...-..-.-..-....---..---..............---------------....------ihanlvkry...........................................
Q9PFL7_XYLFA/20-233                  ..............qneiadqqcpflgkrcynvrksnpeisigsctv-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.-LY..GREPE.P.III...CPT...R.L.I.Q.....R.G.Q......I.F..TDC......L.......H-LLTS.........H....E--.......-.P..G.........N...E.L..........H............LV.......S.................E.V...T....VP---.--........-..G..G.........S...ID.YVLVSAKE--GKV..RDFVGIELQTLDTT..GT..VWP-ER...QR..LL....KE.LGV..A..RG..DN..G.EESdk.....sfG..MN...W...KMT......A......KTILVQMHHKVQTFEHVNRKL.VLVVQDKFL.A...YMT...K..E.F..K....FDH..MKN..............---------------....------paavgdsmhlhsyrmaraddgn..............................
A0A2M9EC12_9GAMM/20-234              ...............qneiadqqcpflgkrcykvrksnpeisigsct-------.......---.---------.---..--.......--------........----------.-......-.-.--...-.VLY..GREPE.P.III...CPT...R.L.I.Q.....R.G.Q......I.F..TDC......L.......H-LLTS.........H....E--.......-.P..G.........N...E.L..........H............LV.......S.................E.V...T....VP---.--........-..G..G.........S...ID.YVLVSTKE--GKV..RDFVGIELQTLDTT..GT..VWPE-R...QR..LL....KE.LGV..A..RG..DN..G.EESnk.....sfG..MN...W...KMT......A......KTILVQMHHKVQTFEHVNRKL.VLVVQDKFL.A...YMT...K..E.F..K....FDH..MKN..............---------------....------paavgdsmhlhsyrmaraddgnf.............................
#=GC seq_cons                        ............................................ttt........................CPa..................h.+.t........GsCsl...............................tsp...hlh...CPh...R.h.h.p.....s.h.t......l.h..pcs......u.......phhhs...........................s..s.........p...p.h..........h............hh.......s.................E.l...p....lspt..up........s..u..G.........p...lD.aVLsphcs.tGpl..h-FsulElQul.ho..Gs..hhs.hp...th..hp....p..tst..h..sh..sp..s.tpp.........s..sh...h...pss......t......KRllPQLlhKGthhcphtc+..shhlpt.hh......h................................................................tt.h................................................
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