#=GF ID NrfD_2
#=GF AC PF14589.10
#=GF DE Polysulfide reductase
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE CATH:2vpzC00, Pfam-B_200168
#=GF GA 27.00 27.00;
#=GF TC 27.10 27.00;
#=GF NC 26.80 26.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF CL CL0308
#=GF RN [1]
#=GF RM 18536726
#=GF RT Molecular mechanism of energy conservation in polysulfide
#=GF RT respiration.
#=GF RA Jormakka M, Yokoyama K, Yano T, Tamakoshi M, Akimoto S,
#=GF RA Shimamura T, Curmi P, Iwata S;
#=GF RL Nat Struct Mol Biol. 2008;15:730-737.
#=GF DR INTERPRO; IPR032796;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Bacterial polysulfide reductase is an integral membrane protein
#=GF CC complex responsible for quinone-coupled reduction of
#=GF CC polysulfide, a process important in extreme environments such as
#=GF CC deep-sea vents and hot springs. Polysulfides are a class of
#=GF CC compounds composed of chains of sulfur atoms, which in their
#=GF CC simplest form are present as an anion with general formula
#=GF CC Sn(2-). In nature, polysulfides are found in particularly high
#=GF CC concentrations in extreme volcanic or geothermically active
#=GF CC environments. Here, the reduction and oxidation of polysulfides
#=GF CC are vital processes for many bacteria and are essential steps in
#=GF CC the global sulfur cycle. In particular, the reduction of
#=GF CC polysulfide to hydrogen sulfide in these environments is usually
#=GF CC linked to energy-generating respiratory processes, supporting
#=GF CC growth of many microorganisms, particularly hyperthermophiles.
#=GF SQ 21
#=GS A0A1H7RX85_9ACTN/48-321 AC A0A1H7RX85.1
#=GS A0A6V8MGP5_9DELT/61-333 AC A0A6V8MGP5.1
#=GS B9L6C2_NAUPA/85-369 AC B9L6C2.1
#=GS R4YWL4_9ACTN/76-348 AC R4YWL4.1
#=GS A0A8J3UME8_9ACTN/19-293 AC A0A8J3UME8.1
#=GS U5W3Q5_9ACTN/7-280 AC U5W3Q5.1
#=GS A0A1G8XZK0_9ACTN/25-298 AC A0A1G8XZK0.1
#=GS A0A3N6CTK0_9ACTN/17-290 AC A0A3N6CTK0.1
#=GS A0A848LPC8_9DELT/69-348 AC A0A848LPC8.1
#=GS A0A1I4LD46_9ACTN/44-317 AC A0A1I4LD46.1
#=GS A0A0G2ZIM4_9DELT/61-340 AC A0A0G2ZIM4.1
#=GS E4U7V7_OCEP5/1-254 AC E4U7V7.1
#=GS E4U7K8_OCEP5/1-265 AC E4U7K8.1
#=GS A0A6I2H1E7_9DELT/65-346 AC A0A6I2H1E7.1
#=GS A0A8J3UZZ0_9ACTN/7-283 AC A0A8J3UZZ0.1
#=GS A0A4Q7YCV8_9ACTN/48-321 AC A0A4Q7YCV8.1
#=GS A0A7Y6PV43_9DELT/60-338 AC A0A7Y6PV43.1
#=GS A0A1M5D2Y4_9ACTN/47-320 AC A0A1M5D2Y4.1
#=GS A0A4Q7Y4Y6_9ACTN/7-281 AC A0A4Q7Y4Y6.1
#=GS A0A8J7IP02_9DELT/46-317 AC A0A8J7IP02.1
#=GS B5EDJ5_CITBB/58-328 AC B5EDJ5.1
A0A1H7RX85_9ACTN/48-321 .........................................................................f-TSYYG..RQ.I.V.K..T.pV.WKSP.DV.P..L.Y.LFLgG.A.A.GS..S...A.......I...L.....G...A....L.............A.......D.....L.....T........D.........R..........P.....T.........lT..........R.....V........S....R.....L....T....A..G..G...G.SILSV....A.YLI..H.D....LG.....R....P...ER..F.LH..-.......-.........M.......L.......R......V.......L....K.P..T....S.P.L.S....V.....G....T.Y.......IL..........A................pF...........S..........A......A.......Ag........atA.............A...............V.............E............L..............L..............G..................W........F........P..............rL.................K...............R.............F.................G...............G...............-..................-..............-............V.............V...............G.............A..............V.................F......G...........G..................P.......LA.......T.........YTGVLLA.-.N.TAVPS.W.H.......M.......A.......H.tQ.LP.Y.V.FGGSAMAA..G..G..G......I.....T............M.......A.......F...........T.........P........V.......E.......E.......A.......G.....P.......A.....R..K..M.....A...-....-..........-.......I.......A....G.....A....A....I.E....L.......A..A......M.....H...K.....V...E....T....D........H.....-.........G.....L........L.....S........E......P........F......H.....E......G.......R.........P.......G......A.......L......M........R.......A.......A.Q......V.......C......T.A.....A......G....A....T..L........-............T.....V......V.....A.............G........-..........-.............R..........R.........R........W.............G.........A.........V.....A.......S.......G..T.........L..L.AaGS.LLT.RFG.VFEAGI--------astk..................................................................................
A0A6V8MGP5_9DELT/61-333 .................................................................dyyrlpllk------..--.-.-.E..P..V.WIWS.VP.A..Y.F.YLG.G.V.A.GG..S...A.......L...L.....A...T....L.............A......hG.....K.....R........G.........L..........K.....K..........L..........A.....A........L....C....rG....L....A..F..A...G.TTVGP....A.LLT..Y.D....LG.....K....M...GR..F.LN..-.......-.........M.......L.......R......V.......F....R.P..S....S.P.M.S....V.....G....S.W.......SL..........A.................G...........S..........G.....aL.......A...........T.............L...............A.............L............V..............Q..............G..................D........H........P...............A.................A...............K.............-.................P...............T...............T..................R..............A............L.............A...............G.............G..............G.................-......-...........L..................V.......VS.......G.........YTGVLLG.N.-.SANPL.W.Q.......G.......T.......R..LtLP.L.L.FTASAIAS..T..S..A......L.....L............E.......Lf.....tL...........N.........R........R.......E.......E.......R.......-.....-.......V.....V..R..R.....F...G....T..........I.......G.......K....I.....Ae.agS....M.A....L.......F..E......-.....L...E.....A...A....Q....N........P.....-.........-.....E........A.....A........R......A........L......D.....R......G.......K.........A.......G......V.......L......W........K.......G.......A.K......G.......F......L.A.....A......G....I....A..L........S............L.....L......P.....G.............D........S..........V............gK..........R.........R........A.............-.........-.........-.....A.......G.......T..L.........T..T.I.GA.LCL.RFG.LLEAGKEA------vrd...................................................................................
B9L6C2_NAUPA/85-369 .................................................................ieevnkaep------..--.-.-.-..-..-.--WG.IF.V..S.Q.YTY.L.L.Y.GG..S...Al.....iF...L.....T...A....L.............A.......E.....L.....F........Hv.......kI..........A.....P..........K..........V.....A........A....A.....F....I....T..F.gI...S.MVFGG....L.VSI..AtD....LA.....N....Q...IN..I.Y-..-.......W.........M.......F.......L......N.......P....Q.P..Q....S.G.M.W....L.....MlplyT.V.......YI..........P.................F...........T..........F......I.......E...........I............yF...............L.............L............T..............N..............N..................R........E........M...............A.................R...............K.............I.................A...............G...............V..................L..............V............I.............L...............G.............L..............V.................I......D...........A..................A.......EF.......Y.........IQGLLFN.L.N.DPRHL.W.T.......D.......I.......P..Q.LW.I.Y.FLITGALT..G..V..Ag...amL.....Y............S.......F.......L...........G.........L........K.......D.......-.......-.......K.....P.......Y.....Y..E..D.....T...-....M..........N.......-.......L....L.....I....K....A.G....L.......V..I......A.....V...L.....T...G....L....Y........E.....V.........-.....V........N.....Y........M......T........V......D.....P......K.......W.........T.......SlivsgsP.......V......A........T.......M.......F.W......T.......W......I.V.....L......G....L....V..I........P............I.....I......L.....W.............A........T..........K.............N..........K.........T........L.............A.........V.........V.....G.......A.......I..S.........A..I.I.GT.FFM.RQA.FIYGGN--------vypmt.................................................................................
R4YWL4_9ACTN/76-348 ....................................................................vtkqsr------..--.-.-.-..-..-.WTWE.VP.A..Y.F.AVG.G.M.A.GA..A...A.......T...LaagalL...A....G.............L.......G.....G.....D........E.........Q..........R.....L..........V..........R.....S........G....R.....V....I....A..L..G...G.TAVGS....V.LLV..A.D....LG.....R....P...ER..F.WH..-.......-.........M.......L.......R......V.......W....R.P..S....S.P.M.N....V.....G....S.W.......VL..........A.................G...........F..........G......T.......A...........S.............A...............V.............A............A..............V..............-..................L........Grs...rnrR...............L.................R...............F.............V.................G...............D...............V..................A..............G............L.............T...............A.............G..............V.................L......G...........L..................P.......MA.......G.........YTGVLLG.A.-.TAQPAwW.H.......A.......R.......R..W.LP.R.L.FVASAASA..G..A..G......Al...eL............I.......P.......M...........S.........P........D.......E.......E.......R.......A.....V.......R.....I..F..A.....I...G....A..........R.......A.......A....D.....L....A....V.S....K.......A..M......V.....H...D.....L...A....D....T........P....eV.........A.....A........A.....Y........G......N........G......Q.....A......G.......R.........R.......K......K.......L......A........E.......R.......L.T......-.......-......-.-.....-......A....G....A..L........A............A.....A......L.....V.............S........S..........K.............V..........R.........A........A.............R.........P.........L.....A.......G.......A..L.........G..L.A.GS.FAT.RFA.VMQA----------tvkp..................................................................................
A0A8J3UME8_9ACTN/19-293 ..............................................................rsyygqpvlkpp------..--.-.-.-..-..V.WHEP.HM.P..V.Y.LYL.G.G.L.SG..A...S.......S...V.....V...A....-.............A.......A.....A.....Rf.....sgH.........D..........R.....L..........A..........F.....A........A....R.....M....T....A..F..A...G.AGLGS....G.LLV..A.E....LG.....R....P...ER..F.LN..-.......-.........M.......L.......R......V.......F....K.V..T....S.P.M.S....V.....G....S.W.......TL..........A.................V...........H.........gG......L.......T...........A.............A...............G.............A............A..............S..............A..................L........T........G...............L.................L...............P.............L.................A...............G...............D..................A.............aV............M.............A...............S.............A..............L.................T......G...........P..................V.......MA.......T.........YTGVLLA.D.-.TAVPA.W.H.......A......aR.......R..E.MP.F.L.FAGSALAS..A..G..A......A.....G............M.......L.......T...........T.........P........R.......A.......E.......A.......A.....P.......A.....R..V..A.....A...-....-..........-.......-.......A....L.....G....A....V.M....E.......T..T......A.....A...A.....I...I....E....R........R.....L.........G.....L........E.....G........E......P........Y......H.....Q......G.......R.........A.......G......L.......L......I........K.......A.......S.R......A.......L......T.L.....A......G....-....G..L........-............L.....A......T.....V.............A........G..........R.............S..........R.........T........L.............T.........A.........M.....S.......G.......L..A.........I..T.A.GA.LCT.RFG.MLAAGKAS------aldp..................................................................................
U5W3Q5_9ACTN/7-280 ........................................................................fr--SYYG..RP.I.V.K..A.aV.WRHD.IP.A..Y.L.FTG.G.L.A.AG..S...A.......L...L.....A...A....-.............G.......Gd...aT.....G........R.........P..........A.....L..........R..........R.....A........G....R.....F....A....A..L..G...A.VAASG....Y.FLI..N.D....LG.....R....P...MR..F.LH..-.......-.........M.......L.......R......V.......A....K.P..T....S.P.M.S....M.....G....T.W.......VF.........sA.................F...........S..........A......A.......A...........G.............V...............A.............A............A..............A..............E.................vV........P........P...............L.................A...............P.............F.................G...............T...............V..................G..............Q............Y.............G...............A.............A..............L.................T......A...........P..................A.......LA.......T.........YTAVLLA.D.-.TATPS.W.H.......A......aY.......P..E.LP.F.V.FAGSALAS..G..A..G......I.....G............L.......I.......A...........A.........P........A.......D.......Q.......A.......G.....P.......A.....R..R..M.....A...A....L..........G.......-.......-....-.....A....A....L.E....L.......Y..G......A.....H...R.....V...E....T....T........K.....-.........G.....L........L.....S........E......P........Y......Q.....Q......G.......K.........A.......G......R.......Y......L........R.......A.......A.R......T.......L......T.A.....L......G....A....A..G........A............V.....L......G.....R.............-........-..........R.............S..........R.........V........A.............S.........A.........L.....A.......G.......V..S.........L..L.T.GS.LLT.RFG.IFEGGQAS------ard...................................................................................
A0A1G8XZK0_9ACTN/25-298 .......................................................................frs---YYG..RP.I.IkE..P..T.WKVP.DV.P..A.Y.LYL.G.G.M.AG..A..sS.......V...M.....G...A....L.............A.......Q.....L.....R........G.........Y..........S.....R..........L..........R.....R........V....G.....L....L....C..V..A...GgSGASV....L.ALI..H.D....LG.....R....P...LR..F.LN..-.......-.........M.......L.......R......V.......F....K.P..T....S.P.L.S....V.....G....S.W.......IL..........A................pF...........S..........A......L.......S...........G.............A...............A.............A............V..............F..............E..................F........T.......eV...............A.................R...............P.............L.................G...............N...............A..................A..............A............W.............C...............A.............A..............L.................L......A...........P..................A.......MT.......T.........YTAVLLA.D.-.TAVPG.W.H.......E......tR.......R..E.LP.F.V.FAFSSVSA..A..G..S......L.....G............T.......M.......L...........A.........P........R.......A.......E.......A.......G.....P.......A.....R..R..M.....A...-....L..........V.......G.......S....L.....G....E....L.V....A.......S..R......-.....-...V.....L...E....H....R........A.....G.........R.....I........A.....E........V......Y........R......S.....G......R.......A.........G.......S......T.......-......-........L.......R.......A.A......R.......I......M.A.....T......G....C....A..V........-............-.....-......-.....G.............A........V..........F.............A..........R.........Rg.....tsA.............A.........I.........L.....A.......G.......L..C.........G..T.A.AS.IAT.RYG.VFEAGRES------ar....................................................................................
A0A3N6CTK0_9ACTN/17-290 .......................................................................vsy----YG..RP.V.I.K..A.pS.WSAQ.DI.A.gY.F.FLG.G.L.A.GA..G...S.......V...F.....A...A....G.............A.......Q.....L.....T.......gR.........A..........T.....T..........A..........K.....A........L....K.....V....S....S..L..A...A.VSLSA....A.ALV..H.D....LG.....R....P...SR..F.SH..-.......-.........M.......L.......R......V.......F....K.P..T....S.P.M.S....M.....G....S.W.......LL..........S.................V...........Y..........G......P.......A...........A.............G...............A.............A............A..............L..............T..................A........V........T...............G.................R...............L............pR.................T...............G...............V..................A..............A............T.............T...............A.............A..............A.................V......L...........G..................P.......AL.......A.........TYTAVLA.A.D.TAVPA.W.H.......G.......A.......H..ReLP.Y.L.FAASATAA..A..A..G......M.....A............L.......A.......T...........G.........P........P.......H.......E.......N.......T.....P.......A.....R..Y..A.....C...-....-..........-.......-.......V....L.....A....A....V.A....D.......G..A......A.....T...H.....A...M....E....R........R.....-.........-.....L........G.....T........V......A........V......T.....C......Re.....gR.........A.......G......A.......L......L........R.......T.......A.R......G.......L......T.A.....A......G....A....A..A........A............L.....L......L.....G.............H........-..........R.............S..........R.........P........V.............A.........V.........G.....A.......G.......L..A.........L..L.A.GS.VCT.RFG.IFAAGIA-------sae...................................................................................
A0A848LPC8_9DELT/69-348 ........................................................................ps---YYG..LP.A.V.K.eP..V.WIWS.IP.T..Y.-.LYV.G.G.V.AG..A...A.......S...L.....Lg.lAa..dV.............M......gG.....P.....R........L.........A..........K.....L..........G..........R.....R........C....L.....W....V....G..T..A...G.DMIST....V.LLI..H.D....LG.....R....P...ER..F.LN..-.......-.........M.......L.......R......V.......F....R.P..T....S.P.M.S....I.....G....S.W.......VL..........A.................G...........S..........G......G.......-...........L.............N...............T.............L............G..............V..............L..................L........A........H...............R.................P...............G.............W.................M...............G...............V..................Vgr..........saA............A.............G...............A.............A..............V.................L......G...........M..................P.......LA.......G.........YTAVLLC.N.-.TSVPI.W.Q.......A.......T.......H.rA.LP.L.F.FMSSATAA..A..G..S......L.....L............S.......L.......L...........P.........H........A.......P.......H.......E.......A.....R.......V.....L..R..P.....Y...R....L..........A.......G.......K....V.....A....E....L.V....T.......G..V......A.....V...A.....R...D....A....A........R.....V.........S.....E........V.....A........R......P........L......K.....E......G.......V.........S.......G......A.......L......W........K.......T.......-.-......-.......-......S.R.....V......C....S....A..A........G............L.....L......L.....D.............V........L..........Pg...........rS..........R.........W........K.............H.........V.........A.....A.......D.......V..L.........T..T.A.GA.LAA.RFA.IFHAGKAS------ar....................................................................................
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A0A0G2ZIM4_9DELT/61-340 .......................................................................psy----YG..QP.A.LkE..P..V.WIWS.IP.L..Y.F.YVG.G.A.S.GA..A...S.......L...L.....G...A....V.............Aeav.ggeG.....L.....R........K.........L..........G.....-..........-..........H.....R........C....R.....W....V....G..A..A...G.DIVSS....G.LLI..H.D....LG.....R....P...ER..F.LN..-.......-.........M.......L.......R......V.......F....R.P..T....S.P.M.S....V.....G....S.W.......VL..........V.................G...........S..........G......A.......M...........N.............T...............A.............S............V..............L..............-..................F........A........G...............R.................R...............G.............W.................R...............G...............R..................V..............G............D.............G...............A.............A..............Vaa.............glL......G...........L..................P.......LA.......G.........YTAVLL-.A.N.TAVPV.W.Q.......A......tR.......K..S.LP.L.L.FMSSAVAG..A..G..S......L.....L............E.......L.......L...........P.........H........A.......S.......H.......E.......A.....K.......V.....L..H..L.....F...S....T..........M.......G.......K....V.....G....E....L.M....A.......G..V......A.....V...Q.....H...E....A....S........G.....L.........E.....V........L.....E........R......P........L......K.....Q......G.......V.........S.......G......T.......L......W........K.......A.......A.R......V.......C......A.A.....A......S....L....A..L........G............L.....W......P.....G.............R........-..........-.............-..........R.........K........W.............M.........K.........V.....A.......G.......A.lL.........G..T.A.GA.IAT.RFA.VFRAGK--------asak..................................................................................
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