#=GF ID Ntox10
#=GF AC PF15520.10
#=GF DE Novel toxin 10
#=GF PI Toxin_40; Toxin_10;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 26.80 26.80;
#=GF TC 26.80 26.80;
#=GF NC 26.50 26.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR029122;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted RNase toxin found in bacterial polymorphic toxin
#=GF CC systems. The toxin possesses an alpha+beta fold that is usually
#=GF CC exported by the type 2 secretion system [1].
#=GF SQ 17
#=GS A4ACT9_9GAMM/139-223 AC A4ACT9.1
#=GS W8IRS2_ENSAD/138-303 AC W8IRS2.1
#=GS A0A8A4TKT7_9BACT/288-374 AC A0A8A4TKT7.1
#=GS A0A820RJY3_9BILA/2-150 AC A0A820RJY3.1
#=GS A0A2V3U1J5_9HYPH/29-212 AC A0A2V3U1J5.1
#=GS A0A261GPE3_9GAMM/149-236 AC A0A261GPE3.1
#=GS A0A347UK94_9RHOB/1-51 AC A0A347UK94.1
#=GS A0A5Q0QDD0_9SPHI/1-25 AC A0A5Q0QDD0.1
#=GS A0A328ZEZ0_9BURK/132-228 AC A0A328ZEZ0.1
#=GS A0A848HM08_9BURK/17-123 AC A0A848HM08.1
#=GS A0A2R7KGX9_9SPHI/969-1169 AC A0A2R7KGX9.1
#=GS E5CAM8_9BACE/1256-1436 AC E5CAM8.2
#=GS Q8F5B9_LEPIN/2366-2453 AC Q8F5B9.2
#=GS A1WM30_VEREI/130-268 AC A1WM30.1
#=GS A0A432ZF62_9GAMM/438-649 AC A0A432ZF62.1
#=GS A0A1I6LYJ8_9GAMM/1394-1551 AC A0A1I6LYJ8.1
#=GS A0A2N1D1C0_9ALTE/26-162 AC A0A2N1D1C0.1
A4ACT9_9GAMM/139-223 .........................................ANGNPYKYVDPDGRAVET----AWDIFNVALGVRSLASNLV.aGNYGAAALDGVG-VLVDGVAAAFPFVPA.GASS...AIRG.ARD.....VTK---..--..---....----..-.-.---......----------------------.-----.---........---------.....------..----------------...--------------------------------ggerla.........................................................
W8IRS2_ENSAD/138-303 .....sgrmgvaqyeankaefekergrylsrigrtnqqiav-----------------------------------------..-----------------DAALELATLGSfGMGS...AARG.-IA.....GPAALP..GR..MAR....VVPA..EyA.NGS......RLAGPSASEAWVTAADDLAGIStSKGLA.ERL........ALVDESGNLlpgrrAIIEFD..TP-ASGVASPAFRSNP...GFVPGGYTAGGAREFVIPKH------------e..............................................................
A0A8A4TKT7_9BACT/288-374 .......................................th--QNPANAVDPDGQALET----VWDVANIGIGVASFVHNAR.eGNWLDATIDAGG-VVVDTLAAAVPVVPG.GAGT...AIKV.SRAg..kmVVN---..--..---....----..-.-.---......----------------------.-----.---........---------.....------..----------------...--------------------------------aatka..........................................................
A0A820RJY3_9BILA/2-150 .....................qgkavttktvatdivvglat-----------------------------------------..--------------------GGVGYGIG.KVAG...A-VG.SK-.....INNPVP..SR..VAR....VVPY..T.EeNIT......HIGRSSSNDVFVTNPSDIRGLN.SIQIA.EKL........TIPKSPTGF.....KVFEFR..TP--DGIASPINRTNL...GFVGQGKTAGGASEFVVPNQQIPKDVKTTIVK...............................................................
A0A2V3U1J5_9HYPH/29-212 tlnaleaiggflefvgeglqgagqaaapakavattgagvkt-----------------------------------------..-------------GVAALRAAGAAVRAE.KAAA...QVLG.KTTtl.dgLANPVP..ET..LAR....AVPEiyG.P.NPP......ALGPLSRGDVFVTDAEALRGLN.AKQIS.EAL........AIPEAE-AF.....NVFEFS..SRGL-DIASPYNRPDA...NFVNGGRTKAGLPEFVIPNGPFPEDTTRRTV-r..............................................................
A0A261GPE3_9GAMM/149-236 .........................................VNNNPYKYVDPDGRVLET----AWDALNIAIGVASFVSNVK.dGNYGAAAVDAGG-IIIDGLATAAPFIPG.GASS...AIKA.GR-.....------..--..---....----..-.-.---......----------------------.-----.---........---------.....------..----------------...--------------------------------ygdevvdvakgag..................................................
A0A347UK94_9RHOB/1-51 ...................................mrtpac-----------------------------------------..----------------------------.----...----.---.....------..--..---....----..-.-.---......----------------------.-----.---........---------.....------..---SAGVAPPVNQSNS...GFVGGGLTLGGAHEFVISNGPIPAGSTIRVVK...............................................................
A0A5Q0QDD0_9SPHI/1-25 .........................................-----------------------------------------..----------------------------.----...----.---.....------..--..---....----..-.-.---......----------------------.-----.---........---------.....------..----------MNRGNP...GFVGFGLTAGGAREFTIPN-------------...............................................................
A0A328ZEZ0_9BURK/132-228 ........................................g-NNNPYRYVDPDGKIAET----VWDAFNLSLGFQSLVGNVR.aGNWSGAAIDGVGIAV-DAAATALPGIPG.GMGAgiaAYRG.SAL.....A-----..--..---....----..-.-.---......----------------------.-----.---........---------.....------..----------------...--------------------------------akgaagearfingvkvt..............................................
A0A848HM08_9BURK/17-123 .........................atwrsrpftvrtavis-----------------------------------------..----------------------------.----...----.---.....------..--..---....----..-.-.---......-RGRPGAADVFVTAADDILGLN.AAQIA.ERL........TIPSSPTGF.....RVIEFP..TP-QSGMASPVFRSAP...GFIGGGRTLRGAREFVVPNQSLPLDSIIRTV-r..............................................................
A0A2R7KGX9_9SPHI/969-1169 ..........avqnpgataravvnnvksmsagelltspitk-----------------------------SPGVQLLKTEYAaaKAIVQGDGKALGSIIGRETANTATVLAT.AAAG...EAIGgAKAli.pkANNPVP..GE..LAR....VVPT..A.D.GIT......TLGRPGTPDVFVTAASDIKGLN.SSQIA.TKL........TIPESQTGF.....TIFTFP..TP-AEGIATPIYRSDP...GFVGFGRTMGGAREFTIPNQPIPANATKKVI-p..............................................................
E5CAM8_9BACE/1256-1436 .........................................VLRSPMSPLGSTFNQLDVAQAIAYDKAN---GTMTSAEVIG..NQWGDIAFDAVTTAVGAGV--------G.RGTG...LYKG.QTL.....VTNSIP..QK..VAR....VIPD..G.I.KTS......MLGAPNQSDVFVTAAKDIKGLN.AMQIA.NKL........TIPQSSSGF.....KVIEFR..TP-MNGLASPINRTNP...GFVGKGRTLGGAREFTIPNQQIPKDAIIKIVK...............................................................
Q8F5B9_LEPIN/2366-2453 ........................................t-LSAP-TPVNAVVNSVVATGKGAKELYDNRKEVYASAKDFA..GKLTSKDDKVRDYAVGQAKAYTMSAVLG.GAAS...KALG.SRL.....P-----..--..---....----..-.-.---......----------------------.-----.---........---------.....------..----------------...--------------------------------kpnvnvpg.......................................................
A1WM30_VEREI/130-268 .........................................ANNNPNKYVDPDGKIAET----VWDAFNLALGFQSLVDNAR.aGNWANAAIDLAG-ITLDAAATTVPGVPG.GAST...GIKA.YRE.....------..--..---....----..-.-.---......----------------------.-----.---........---------.....------..----------------...--------------------------------aaepkgaarafhaslrnlhhneriarirsklaevaknngwkknsrlsrmnkrdvydapdgiky
A0A432ZF62_9GAMM/438-649 .............................igsmleesyegl-------------------KAVVDDPTLLKKGLQKLEDDLT..GKNGEARQMLAWDNLNQSLQTAALTLPV.GGAF...ANSA.KTLdnvgdAVNALPdsNR..YSR....VMPE..E.F.AEKfkngngTLGSPDSDEIFVTSSDALKSTN.TSREAqEKLslytdyegTVPN-TAGD.....VVVEFTlkDPTKAEIRTPIETDPPrgfGFVQGGSTKGGAPEWNINNGT-----------adevgatdiiv....................................................
A0A1I6LYJ8_9GAMM/1394-1551 .........cvnngctgwgwglsaagvlpgigmvsgvarea-----------------------------------------..-----------------------RAV--.RAMC...QASGaARG.....VANPIS..ST..LAR....VVPR..N.I.NPT......TLGRAGDVDVFVTNASELRGLS.NAEIA.SKL........TIPEVPGGF.....RVIEFP..SSSVDGIASPVFRSNP...GFLQGGQTANGAAEFVIPNGPIPPGAT-----qwl............................................................
A0A2N1D1C0_9ALTE/26-162 ........................................v-ANDPVNMVDPTGKYLES----VWDAASLSVGLVSLGTNLS.qGNWGAAGLDALG-VVVDGVALALPVVPG.GASM...AISG.SRA.....GANALS..DSalVARgganITPQ..S.I.ENA......TSTHPSGVTGFSAQCNGGTCLN.-----.---........---------.....------..----------------...--------------------------------elganipngqmgv..................................................
#=GC seq_cons ........................................h.........................................................h.tththshshl.s.tuus...thhu.tp......h......................................................................................................................................................t..............................................................
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