#=GF ID   Ntox23
#=GF AC   PF15528.10
#=GF DE   Bacterial toxin 23
#=GF PI   Toxin_48; Toxin_23;
#=GF AU   Zhang D;0000-0001-8535-7620
#=GF AU   de Souza RF;0000-0002-5284-4630
#=GF AU   Anantharaman V;0000-0001-8395-0009
#=GF AU   Iyer LM;0000-0002-4844-2022
#=GF AU   Aravind L;0000-0003-0771-253X
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF SE   [1]
#=GF GA   26.20 26.20;
#=GF TC   26.30 26.30;
#=GF NC   24.50 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   22731697
#=GF RT   Polymorphic toxin systems: comprehensive characterization of
#=GF RT   trafficking modes, processing, mechanisms of action, immunity
#=GF RT   and ecology using comparative genomics.
#=GF RA   Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL   Biol Direct. 2012;7:18.
#=GF DR   INTERPRO; IPR029115;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   A predicted RNase toxin found in bacterial polymorphic toxin
#=GF CC   systems.  The toxin possesses an all-beta fold and conserved ND
#=GF CC   and DxxR motifs and a histidine residue. In bacterial
#=GF CC   polymorphic toxin systems, the toxin is exported by the type 2
#=GF CC   or TcdB/TcaC secretion system [1].
#=GF SQ   54
#=GS A0A3L7ZZ78_9BACT/155-336    AC A0A3L7ZZ78.1
#=GS A0A7L4ZP74_9FLAO/1993-2199  AC A0A7L4ZP74.1
#=GS A0A4Q7EEJ1_9CYAN/67-272     AC A0A4Q7EEJ1.1
#=GS A0A2I0R6X5_9FLAO/157-348    AC A0A2I0R6X5.1
#=GS A0A1M4W7T2_9BACT/1840-2030  AC A0A1M4W7T2.1
#=GS A0A3L7ZYK1_9BACT/2011-2196  AC A0A3L7ZYK1.1
#=GS A0A4Y8KVL1_9BACT/42-235     AC A0A4Y8KVL1.1
#=GS A0A5B0FSA5_9BACT/1832-2018  AC A0A5B0FSA5.1
#=GS A0A2S8AEF1_9FLAO/27-215     AC A0A2S8AEF1.1
#=GS A0A4S4GQE7_9BACT/12-214     AC A0A4S4GQE7.1
#=GS A0A2I0R3C3_9FLAO/60-256     AC A0A2I0R3C3.1
#=GS M1PME9_DESSD/64-261         AC M1PME9.1
#=GS A0A7L4ZRE4_9FLAO/128-229    AC A0A7L4ZRE4.1
#=GS A0A1M4TCL3_9BACT/43-236     AC A0A1M4TCL3.1
#=GS A0A8J8GD38_9FLAO/330-519    AC A0A8J8GD38.1
#=GS A0A4Q8RVK6_9BACT/65-261     AC A0A4Q8RVK6.1
#=GS E4TTK0_MARTH/79-275         AC E4TTK0.1
#=GS A0A0M9DV54_9BACT/68-264     AC A0A0M9DV54.1
#=GS A0A553EAU5_9FLAO/74-294     AC A0A553EAU5.1
#=GS A0A3B0BV70_9FLAO/160-326    AC A0A3B0BV70.1
#=GS A0A0Q5UQ51_9FLAO/39-254     AC A0A0Q5UQ51.1
#=GS A0A2W1MZ71_9FLAO/55-253     AC A0A2W1MZ71.1
#=GS A0A4Q2ZIK6_9SPHI/177-391    AC A0A4Q2ZIK6.1
#=GS A0A086F4R2_CHRP1/6-61       AC A0A086F4R2.1
#=GS A0A086F4R3_CHRP1/2-63       AC A0A086F4R3.1
#=GS A0A1T5A6S4_9BACT/1-166      AC A0A1T5A6S4.1
#=GS A0A0D6TLZ7_9FLAO/2102-2302  AC A0A0D6TLZ7.1
#=GS A0A162DJL6_9FLAO/1982-2195  AC A0A162DJL6.1
#=GS A0A2U2X1F1_9FLAO/60-256     AC A0A2U2X1F1.1
#=GS A0A4S4G2T5_9BACT/12-144     AC A0A4S4G2T5.1
#=GS A0A653V7I8_9FLAO/38-239     AC A0A653V7I8.1
#=GS A0A4S4G4M6_9BACT/1-79       AC A0A4S4G4M6.1
#=GS A0A5J5IFE5_9BACT/32-221     AC A0A5J5IFE5.1
#=GS A0A2V3PKV4_9BACT/51-237     AC A0A2V3PKV4.1
#=GS A0A2H1E6L5_9FLAO/701-888    AC A0A2H1E6L5.1
#=GS L8M1F9_9CYAN/1-140          AC L8M1F9.1
#=GS A0A4R3VQL5_9SPHI/131-215    AC A0A4R3VQL5.1
#=GS L8MB27_9CYAN/1-140          AC L8MB27.1
#=GS A0A1V9FDF2_9BACT/1358-1535  AC A0A1V9FDF2.1
#=GS A0A2S1LJZ1_9FLAO/38-221     AC A0A2S1LJZ1.1
#=GS A0A3P3W990_9FLAO/38-255     AC A0A3P3W990.1
#=GS A0A1M5CG36_9FLAO/1973-2172  AC A0A1M5CG36.1
#=GS C7M525_CAPOD/1952-2136      AC C7M525.1
#=GS A0A2K9PSL6_9FLAO/1310-1513  AC A0A2K9PSL6.1
#=GS F2ID63_FLUTR/57-253         AC F2ID63.1
#=GS A0A0D6TN67_9FLAO/38-249     AC A0A0D6TN67.1
#=GS A0A1Q3GWP9_9BACT/69-267     AC A0A1Q3GWP9.1
#=GS A0A8J6PHM0_9FLAO/60-257     AC A0A8J6PHM0.1
#=GS H6L1Z5_SAPGL/58-270         AC H6L1Z5.1
#=GS A1ZJH5_9BACT/69-268         AC A1ZJH5.1
#=GS D3IMK5_9BACT/1392-1585      AC D3IMK5.1
#=GS R6KF61_9BACE/2091-2277      AC R6KF61.1
#=GS F8X4S1_9BACT/1867-2044      AC F8X4S1.1
#=GS A0A2A3U594_9SPHI/72-261     AC A0A2A3U594.1
A0A3L7ZZ78_9BACT/155-336               .......................................................................................LTAGVSAMASMQF.G...........DWGFSLS..AGAGN................KYVGGDF.AF....--....SYDGW.GAG.Y.....----.....GLTHY.....Y.SETVQGNR.......LGS.....QNVGTISLLL.RGVSIRVSND..................LF..G..NKDHDRWRSSA..VEIGFK--..--DFT.IGTYVTTND.GKL..ESE.Y.NNSQKI.DHN...............QILE.SG.QEK.PDVWSNG.......AVY...-.SAPFWIGFKSgn................qiQRIGFSDKC.IQNITQN-AVHK............................................................
A0A7L4ZP74_9FLAO/1993-2199             ......................................................................................a-GIGASLSVGYSD.G...........NWSFSAG..IGYMNy..............gNYNGFGN.GV....-E....IRKSI.LAA.Y.....--DD.....GKTGF.....S.LGTNWWSGnlgggndNFH.....QQTGMLGIRS.GDFRLRYENDgkp............fsgLS..G..D-GNDQYRTAA..LELGVG--..--EYS.VGFNLFTGK.RNK..ESY.K.AEKSGQ.WDGnlgei.....gpyksGKYG.EH.YKN.GLVKEVG.......TKY...R.LGALTFGYKG....................YKLGVNSEW.VRHAIQNVAIH-g...........................................................
A0A4Q7EEJ1_9CYAN/67-272                ................................................................ietaesgwesqvtvglthgfggv-------------.-...........-------..-----................-------.RS....LP....EDYDW.SLA.An...nTQRT.....NSVSL.....Y.ATFYDDTY.......NTS.....QGNIGLGLNV.GAFNLRFENDfd.............pigIL..G..E-YGDRFRTGA..LEVGYRAA.dGTNFV.AGFNTFTGD.IGD..GYI.I.RPEDGG.AGP..............hGEYS.RT.ERN.GRPIEAG.......DRS...-.IGNAYVGIRNldltqanddtwhalgfdnlqVRVGWSDEA.IRDGVQNR-LH-d...........................................................
A0A2I0R6X5_9FLAO/157-348               ...............................................fnassngtsigidasfgvpqklliharaeggisyhfsdnk-------------.-...........-------..-----................----NNY.QG....WE....FRYGF.EVG.I....gPIKS.....ANTNY.....A.FQ----DK.......KYN.....QSTNVITIGG.PKINFKYEND.................fMF..GlpADGGDRYRTAA..GKFSLY--..--NLN.VGFNLYTGD.PGL..TDE.E.RNPQYV.N--...............GQLT.YL.KNE.YGDD--P.......DEY...R.SGVAYIGFAG....................LKLGRNSEK.IRHAIQNRFAHD............................................................
A0A1M4W7T2_9BACT/1840-2030             ............................................................ltagvgsvalgggfrigaavsvsqkig-------------.-...........-------..----Dwtl.........mangSMFGGGA.GN....N-....LKNTL.SGG.Fay.ddGKRG.....FSYMF.....N.RYNYSNEP.......GGK.....QSTGTIGVRY.KDLSIKHEND..................LF..A..R-SGDKQRTAA..LEVGYK--..--GYS.AGFNIYTTD.P--..-SR.D.EYGVKM.TEE...............H---.-A.QNR.KGVYDGG.......YQL...-.ASPFYIGVRQgn................stTKIGMNIPQ.V-GWFQN-AMHR............................................................
A0A3L7ZYK1_9BACT/2011-2196             .......................................................................................LTAGVSAMASMQF.G...........DWGFSLS..AGAGN................KYVGGDF.AF....--....SYDGW.GAG.Y.....----.....GLTHY.....Y.SETVQGNR.......LGS.....QNVGTISLLL.RGVSIRVSND..................LF..G..NKKHDRWRSSA..VEIGFK--..--DFT.IGTYVTTNN.GKK..ESN.N.NVNSKA.EAPiw...........geNNDD.KN.GDS.LGAWEKG.......EVF...-.SAPFWIGFKSgn................qiQRIGFSHKV.VQNITQN-GVHK............................................................
A0A4Y8KVL1_9BACT/42-235                ..............................................................fkisaslvavfttgaadrngfrigg-------------.-...........GLSASKT..IGNWT................FSAGLDA.YK....AL....SRFGL.GTT.YagiiyDTPK.....TAASY.....Y.LNKY--HQ.......GEK.....QMSGIVGVRI.RDFEIKFEDDil.............slpFT..G..FRVYDRYRTAA..LELRYR--..--QFL.LGMNVYTSE.PD-..--G.L.TDASLY.NRK...............GVYK.EG.NQ-.-------.......--I...-.SSPLYLGYTDkn................lmVRYGWN---.------------snlggyigqnswhr..............................................
A0A5B0FSA5_9BACT/1832-2018             ..............................................................................vnvgvnisg-TFSVNGSTSISA.G...........NWNFSVG..GGGGN................NHSAYGG.SI....--....SYKGY.GAG.Y.....----.....YQTRY.....G.GATGPDGM.......SNS.....QVVGGASLSL.GKVSIRIEND..................FF..A..FNHQDRWRSNA..LEIGIG--..--DFV.VGTRLYNND.PKG..GKQ.G.IKNLPD.L-M...............GNFN.KH.DNQ.--AWENG.......QTY...-.NAPFWVGYRFgn................tvERIGYSHPI.FQDRTQN-FIH-l...........................................................
A0A2S8AEF1_9FLAO/27-215                ........................................................................tfgvgvtykfsphlq--TGVNLGFKVYN.Gglgs..ipgsdK------..---LNldfv........gtgaFTTGIGK.GNpmdlNP....LTIEH.GTG.M....qDRYK.....KSITI.....G.TNYIFNNF.......GRN.....QQVGFLQTRF.NDFTFQNYNDfn.............kfgRL..S..D-GHDRWYTGG..GNVTMGSNssNYQVI.LSSDVFTSD.TNN..AAF.T.R-----.---...............----.--.---.-------.......---...-.----------....................---------.------------pdyvdydlleknnplpgnfrdrftyt..................................
A0A4S4GQE7_9BACT/12-214                ..................................................................................feyfl-----NASLCLDFgG...........GWRANLS..FGATN................QYSGWYA.RM....AFr..gLKIGY.GET.Y.....YREQ.....YIASY.....K.ELPSGETI.......KTSyllgeQTVGTITAQV.DGWQLRVSND..................CL..G..D-GHDRWRTSA..VEITKG--..--NLT.LGTSVTTNN.GSL..ESY.AmDTEKPC.IKNgad........ynpfSEEN.AK.IRD.KGTWKNG.......RAY...-.SAPIWIGLKNgn................tiYRFGYSHPE.VQDKTQN-YVHK............................................................
A0A2I0R3C3_9FLAO/60-256                ......................................................................................f-NLGNHIRFNNTHlG...........KRKNFVT..QRINT...............gVVLKAGK.KS....IA....PQLIFdGLN.H....qSKSS.....LAIAY.....N.YLWYFDNI.......GTS.....QRSGGWGIHI.QQFSFLIEND..................IF..A..GSGRDRYRTSY..AGIAYHDD..LYNIS.LNTQLWTGD.TRG..TPL.L.NTPDSI.YQK...............GYKD.LS.STH.YGKTSHGil..sigIDY...-.-EIIYG---Nh.................asLVVGIDGEK.IRNGLQNKFMHD............................................................
M1PME9_DESSD/64-261                    .......................................................................................LNLHARWYYNFTSlGp.........sQSGSEAV..VSLG-................GLLAWGEeQK....WE....NRFVT.SVG.N....qTGKK.....YSLAY.....A.YNYYVDQI.......STS.....QPTGTIAAQI.DTFHIITEND..................AL..G..FQGGDKFRTGA..VLLAIQNK..KEQFG.LNTILWTGN.ASK..QIEkI.KESSYP.GRY...............GYKD.LQ.QAP.YGNLSHGi....lsLQY..dK.VLDGFQTIQG....................-RLGIDAEQ.VRHFLQNKVMHD............................................................
A0A7L4ZRE4_9FLAO/128-229               ..............................................................................adftanplq-------------.-...........-------..-----................-------.--....--....-----.-NP.Y.....---K.....TSVSY.....G.LNWIFVQD.......KKQ.....QRTGFFNLNVmGRAQISYYNDggp............ilgWA..G..D-NRDRYYTGG..VTISYHGD..ITD--.---------.---..---.-.------.---...............----.--.---.-------.......---...-.----------....................---------.------------lidlvelsyhkytgyqkhafd.......................................
A0A1M4TCL3_9BACT/43-236                .........................................................feikaslvavftsgaadrngfrlgagvsas-------------.-...........-------..KTVGNwtfv........tgldSYKATGK.FG....--....LGMIY.AGT.Vy...dTPKA.....GASYY.....L.-TKY--LQ.......GDK.....QVSGIIGAKI.HDFEVKFEDDil.............smpFT..G..FRIYDRYRTAA..LEVKYK--..--HFL.LGMNVYTTE.PNG.lTDA.S.LKNRK-.---...............----.--.---.-GVFKEG.......YQI...-.SSPIYLGYTDkn................lmIRYGFNNHI.GGD---------vgqnswhr....................................................
A0A8J8GD38_9FLAO/330-519               ................................................................sgtpsltlgyktgnsmnmnlfnd-------------.-...........----FSG..SGVNNp.............yeYAFTLGQ.VG....VL....SSGRV.TSE.Y.....DIDG.....NRIKD.....P.-YNSHDRP.......NRN.....QILGAASIKI.GNFMISSYNDiyk............lplFL..G..M-DSDQYWSAG..VNMKARIS.dNIDMA.YAFDLYYGK.SNN..-KN.T.YNLDKN.IGG...............QNYD.TQ.RLF.DVLLNRG.......QE-...-.----------....................---------.------------sfsftdangnfnkttkvgygt.......................................
A0A4Q8RVK6_9BACT/65-261                ......................................................................................v-NAGTYAYYNFRGpG...........--TDMPS..WEVQMn.............agGHFVWGS.ES....-T....RYNRF.NGS.Ld..lqAPVS.....CGIGY.....I.YKYYWDNK.......GTR.....QPAGVFALRT.KAFRLVIEND..................VF..S..GQGEDKYRTAG..VTLSYSEY..DTEIS.LVSWHWTGN.THE..GKL.I.KDSDYP.SRF...............GYKD.LS.EAC.YGKTSHGi....laLRW...R.QNLGWGQVGM....................VEGGLDSEW.IRHALQNKLIHD............................................................
E4TTK0_MARTH/79-275                    .......................................................................................VSFQYNFFYTFKDfGyy.......enSFQHIAG..IKLAT................---AFDR.RP....II....FRAIS.NSP.F....sSRAF.....YQFHY.....F.YRYYFNNW.......NTS.....QPTGEIGLNF.GHFFLLHEND..................LL..A..AETVDKFRTAA..LRIGYQDS..LQSIA.SSFLFWTGN.KDD..PDT.K.RVNSSD.FSR..............yGYFD.LS.DTP.YGKYSHGi....laIDY..tR.QLPFGNQLRI....................-SSGYDHEK.IRNLIQNKFMHD............................................................
A0A0M9DV54_9BACT/68-264                ..................................................................................qfnge----VTGLYHYKH.-...........-YSGKKG..IGFRTs.............lgALYGFGK.TD....-I....SNKNF.LSV.In..hqMSNA.....YALGY.....A.FHYYGNNF.......QTS.....QCSGSVTAHF.KNWLISLEND..................VF..G..GGGKDRFRTSA..LSTTFQKD..NFQYS.FQNILWTGD.TQG..AMR.V.KDSLYP.ARF...............GYLD.ME.NQP.FGKTSAG......iIAF...K.VNYAWNFGQTf..................qTSVGIDSEK.IRNFFQNALLHD............................................................
A0A553EAU5_9FLAO/74-294                ...............................................................paygvqvgdwsfsispsiafgnta-GIGASLSVTYSA.G...........DFSFSGG..VGIMSn..............sNYNGLGK.NG....ME....IRKSI.LAS.Y.....--DD.....GKNGF.....S.LGTNIWSGtd..gmkEFS.....QTTGVVGLHF.GDFRAMYENDggpv..........lkqtGL..G..G-GTDSYRTAA..LNLSIG--..--EFS.AGFNLFTGA.RDQ..SKD.P.EKWAVT.NSV...............DGYS.RK.YTR.GYVNETG.......TKY...R.LGALTVGYGG....................YRVGVNSEH.LRHAIQDRVIH-g...........................................................
A0A3B0BV70_9FLAO/160-326               .......................................................................ettnskevsylsglls-------------.-...........-------..-----................-------.--....--....-----.---.-.....----.....-----.....V.ESKVYNSG.......ETS.....QTTGTVTIGS.PIINAKYENDwfdpglvdkldpfdilpaEL..G..D-GGDRFRTAR..VDINLG--..--PFS.TGFKLGTGD.PGL..DKF.E.RRKNID.FESpds.........gpfGTYR.LN.PDT.------Gd....npDNI...R.LGIGYFGIGP....................FKVGTDSEK.LRDLIQNKIVHD............................................................
A0A0Q5UQ51_9FLAO/39-254                ....................................................................................vdp---GVNIAINAYN.G...........GMGALSG..SNAMNfdvv........mtgkLTVGGGR.TNpmsvYP....LHMDS.GTG.M....eDTYK.....YSGTL.....G.TSMVLNNN.......DRN.....QQVGFVQLRA.DNFSFQFYNDfgg...........fkkiGI..A..D-GHDRWWTGG..GKVILGNNrsNYQMI.IASDVFTAD.TDS..ESV.T.DSEAAK.RSLadfeq.....rhigsS---.--.---.-------.......---...-.----------....................---------.------------gfekfkdkafnytpttatevgqdflnfkrdgvawnpnahsfdlnq...............
A0A2W1MZ71_9FLAO/55-253                .................................................................................lnsnlg------CYYNFKSfGvq.......ekTPELQFG..LG---................SSFGFGT.KG....EI....PEYFF.DSK.Ln...nSSYP.....YALSY.....H.YQIYLDKQ.......NTS.....QTTGTIGLHI.KHFSILTEND..................LLgaG..KGWRDRFRTGA..LAINYRYK..AYFFS.IKNIMYTGD.FAS..ATK.V.LDSDYP.ARF...............GYRS.AD.KAI.HADRSVGll..sftFSY...-.ALPYHQIVGL....................-SVGLDSEK.IRHQLQNEWMHD............................................................
A0A4Q2ZIK6_9SPHI/177-391               ......................................................................................l-NVGVDVQFSGRS.Gn.........tSFGGSIG..VGITGfyagasvsqqignwqvGISGS-S.NG....DM....YSIGG.GGG.Y.....NDGKtalgyYQTYY.....G.GGTSTTGE.......NMS.....QWVGGISFRS.GDFSLSYEND..................FL..A..FRHGDAWRTHG..IQIGAG--..--DFV.LGSYIYTND.GAA..A-S.Q.NNRNPR.ATSplw.........kenGRPD.GK.GGK.YSAWTNG.......QTF...-.RAPVYAGYKNgn................nvSRTGYSAKG.VQDFQQN-WMHQ............................................................
A0A086F4R2_CHRP1/6-61                  ...................................................................................fsll----ATISAAFRV.G...........DFALSAG..FGIMNy..............gAHAGSGE.SG....WG....FRKSA.MVS.Y.....NSR-.....-----.....-.--------.......---.....----------.----------..................--..-..-----------..--------..-----.---------.---..---.-.------.---...............----.--.---.-------.......---...-.----------....................---------.------------dfgis.......................................................
A0A086F4R3_CHRP1/2-63                  .............................................................................dyvkkngplk-------------.-...........-------..-----................-------.--....--....-----.---.-.....----.....-----.....-.--------.......---.....----------.----------..................--..-..-----------..--------..-----.---------.---..---.-.------.---...............GVAG.AR.YPQ.GFAYEQG.......PAY...R.LGAAYVGYKN....................MRIGINSDRyIRHPIQNIVAH-g...........................................................
A0A1T5A6S4_9BACT/1-166                 ...................................................................................mefg-------------.-...........-----FG..FGRGS................GYSEFSM.GG....SV....KYKGW.GLG.M.....----.....YSTQY.....T.-------G.......VHA.....QRVGGVQAFA.PGGSLRIENDf...............wpVL..G..D-KYDRLRTSA..AELEIG--..--GLL.IGKSVYTNS.PDR..NAD.R.DESYFS.RFY...............RKFGlLA.RPE.AGTYADG.......RVY...-.SSPAWVGVRHgk...............hfvSRAGINHPA.VQDIFQN-GVH-l...........................................................
A0A0D6TLZ7_9FLAO/2102-2302             ......................................................................................g-GAGVSYGVTFSD.G...........DFSISGG..YGIMEy..............sNYNGFGA.NS....RE....FRYSA.LVS.Y.....--DD.....GKTGF.....S.LGTNFWRG.......DFK.....QRTTYLGFRN.GDFRFGYENDgspf.........syagkVL..S..N-NTDMYRTAA..ASVGIG--..--GFD.LQLNMFTGR.SGN..DTG.K.GRKNER.NSEfv..........dldNGRF.KK.DRR.LGLWKNSe.....aDAY...R.LGALSVGYKG....................YKVGVNSEY.VRDVFQNWFAHK............................................................
A0A162DJL6_9FLAO/1982-2195             ......................................................................................v-SLGANFRVGYRD.G...........SFNASVG..FGVSYa..............gSAQGTGD.SG....WE....YRGSY.SVG.Y.....DDGK.....FRVSV.....Y.-STSFASG.......ETS.....QRVAGINIGH.GDFNLRYENDgspfdrl...nklglgkpLV..G..E-DSDRYRTAA..MSLSYK--..--DYS.VGFNLFTGD.P-N..GDK.D.KGITKD.VPGhgd........ftkyKWKG.DK.LKK.IGEFTGGqysgesaSKY...R.LGAAYVSYKG....................FRFGRNSEG.IRHTIQNKVAHT............................................................
A0A2U2X1F1_9FLAO/60-256                ......................................................................................i-NLGNQIRFNSTNlGgrk.....dyvTQRISTG..IALLT................---GAKN.ST....-P....QLILD.GLN.H....qSKHD.....YAIAY.....N.YLWYFDNI.......GTS.....QRSGGFGIHL.QQISLYIEND..................FF..A..GSGRDRYRTNH..ASISYHDG..LYNVS.LNTQLWTGD.TRG..TRL.M.NTADSM.YVV...............GYKD.LS.ETH.YGRFSHGil..slgFDY...-.QLFYGNQFSA....................-LAGVDSER.IRHGLQNQFMHN............................................................
A0A4S4G2T5_9BACT/12-144                ..................................................................................feyfl-----NASLCLDFgG...........GWRANLS..FGATN................QYSGWYA.RM....AFr..gLKIGY.GET.Y.....YNEQ.....YIASYkelpsG.ETINTGYS.......LGE.....QTVGTITVQI.DGWQLRVSND..................CL..G..D-RQDRWRTSA..VEITKG--..--NLT.LGTSVTTNN.VSL..ES-.-.------.---...............----.--.---.-------.......---...-.----------....................---------.------------kd..........................................................
A0A653V7I8_9FLAO/38-239                ......................................................................................f-NPGVNLAVNFYN.Gg........igSLSNNSS..FNIDTvl...........takLTVGDGK.GKpmdiYP....LHLNS.GTG.L....eDKYK.....YSATI.....G.TNFIFNNH.......ERN.....QHVGFVQLRA.SDFSFQTYNDfgg...........fkkiGI..S..D-GYDRWWTGG..GNITLGAKnsDYQFV.IASDVFTAD.TDS..END.T.DRYNAN.KNL...............ETFL.NN.NQ-.-------.......---...-.----------....................---------.------------nnsklerlknrvtgytpatasqvdqsfldvnrng..........................
A0A4S4G4M6_9BACT/1-79                  .......................................................................................-------------.-...........-------..-----................-------.--....--....-----.---.-.....----.....-----.....-.--------.......---.....----------.----------..................--..-..-----------..--------..----T.LGTSVTTNN.VSL..ESK.D.FHNLDP.QNN..............pETIP.DS.SNK.-GIWSKG.......KAY...-.SGLLWVGIKNgn................qiYRFGFSHPE.VQDRTQN-HVH-r...........................................................
A0A5J5IFE5_9BACT/32-221                fnfgcninftygkaqtfpglrlfaafiangiyknnfsvnygpsvsvytktlganlnpltgdiqidftntfsigstwgkelsytkffk-------------.-...........-------..-----................-------.--....--....---TL.NTGsFyn.iaTNKK.....YAAYL.....S.TNFILNNR.......RRN.....QVVGSVSFSA.PDFSINYYNDgavp..........ftflPL..A..D-NFDRWWTGG..FGIYIHNH.kNYNIAeLSFDQFTG-.---..---.-.------.---...............----.--.---.-------.......---...-.----------....................---------.------------yspllye.....................................................
A0A2V3PKV4_9BACT/51-237                ...........................................................................iamftagsadrn---------GFRLgG...........SLTVSKN..IGDWT................LCTGLDA.YK....AK....ERFGL.GTT.FagveyDDGK.....YGASY.....F.VNKY--YQ.......GGK.....QVSGILGLRL.DDFSLKFEDDil.............alpFT..G..FTIYDRYRTAA..LELQYK--..--HFI.IGTNVYTTGiNGL..TDT.S.PYNRKG.TYM...............GGKQ.I-.---.-------.......---...-.SSPMYIGYTNkd................liLRYGMNNQT.------------ggylgqnlwhr.................................................
A0A2H1E6L5_9FLAO/701-888               ......................................................................................t-GFGVNVSVSYQD.G...........DFTFSAG..YGVTFy..............gTAHGTGK.KG....WE....HRFSG.SIG.S.....---N.....GKVKF.....SaYTTYFSSG.......KTS.....QQVGGFSLGH.GDWNIRYENDfiekp.......lkyvgkYL..A..D-GKDRFRTTA..LQLSYK--..--DYS.VGLKFFTGD.PLK..GEK.R.DKSNPN.AKY...............GIYS.N-.---.----PEA.......DEY...R.LGSVLLGYKG....................YQVGYHNEA.IRGAIQNKFVHN............................................................
L8M1F9_9CYAN/1-140                     .....................................................................................fg-------------.-...........-------..-----................-------.--....--....-----.---.-.....----.....-----.....-.--------.......---.....-------INV.EKFNFHFENDyd.............plkLL..G..D-YGDRYRTGA..IEIGYRIY.kTSNLV.AGFNIFTGD.PEQ..GGI.I.-PNSQG.ASGkhgdys...llkpdgSPVD.SR.DRS.-------.......---...-.IGNIYLGLRGlnlkdgdvs..silgfdnmqFRVGWSSEE.IRNAIQN-NFHD............................................................
A0A4R3VQL5_9SPHI/131-215               ............................................................................hpikhfnqmta-------------.-...........-------..-----................-------.--....--....-----.YSN.Y.....DLKH.....YSVSY.....G.TNFIINSH.......NRN.....QQVGFVGFNT.PWLSFGFYNDgt.............lgkLV..G..D-NYDRFWTGG..GHLRIH--..-----.---------.---..---.-.------.---...............----.--.---.-------.......---...-.----------....................---------.------------stptt.......................................................
L8MB27_9CYAN/1-140                     .....................................................................................fg-------------.-...........-------..-----................-------.--....--....-----.---.-.....----.....-----.....-.--------.......---.....-------INV.EKFNFHFENDyd.............plkLL..G..D-YGDRYRTSA..IEIDYRVY.kTNNLV.VVFNIFTGD.SEQ..GGI.I.PN-SQG.ASGk.............hG-DY.SL.LKP.NGSPVNS.......RDR...S.IGNIYLGLRElnlkdgdas..filgfdnmqFRMGWSSEE.IRNAIQN-NFHD............................................................
A0A1V9FDF2_9BACT/1358-1535             ......................................................................................i-TAGGNFGAAYDD.G...........KWNISAG..IGTTN................NSVSAGG.G-....-V....TYNGY.GGS.Y.....----.....YRTHY.....G.NAIGPDGA.......SNS.....QIVGGVKLSF.RDVSFRLEND..................FF..A..G-NGDRWRTNA..WELGVG--..--NFV.VGSSVYTNE.RKE..GSP.V.ANNPS-.---...............PTYG.YN.QRPgFSAWEKG.......MVY...-.SSPLWIGYRNgs................nvSRFGYSHWI.FQDVQQN-GIHQ............................................................
A0A2S1LJZ1_9FLAO/38-221                ....................................................................................vqp---GANLAVNFYN.GgigarsdsnmmHFDTVLT..GKITT...............gAGHGNPM.TV....YP....LHVDS.GSG.L....eDRYQ.....YSATM.....G.TNLILNNS.......GRN.....QHVGFVQLRA.GDFSFQTYNDfga...........fkkiGI..S..D-GHDRWWTGG..GNFTFGAKnsDYQVI.VASDVFTAD.TDS..ESE.R.DRLNAE.KSL...............EEFT.QT.N--.-------.......---...-.----------....................---------.------------qgswlertrnralnytp...........................................
A0A3P3W990_9FLAO/38-255                ....................................................................................vep---GVNLAVNFYN.GgmgarsdsnamNFDTVFT..GKVTA................---GTGR.ANpmsiYP....LHMDS.GTG.M....nDTYK.....YSATL.....G.TSMILNNN.......DRN.....QQVGFLQLRS.DNFGFQFYNDfgg...........fkkiGI..A..D-GHDRWWTGGgkVILGNNNS..NYQLL.IGSDVFTAD.TDS..QSL.V.DEENAK.RSLaefektntgnffertANRA.FN.YTP.TQATEVG.......QEF...-.----------....................---------.------------ldakrngvlwnenahsfdlnmgqt....................................
A0A1M5CG36_9FLAO/1973-2172             .......................................................................................FGVGANVSVSYND.G...........NFNMSAG..FGVTYf..............gSAHGTGH.KG....WE....YRTSY.AIG.Y.....NSGK.....FNISV.....-.YSTYFKSG.......ETT.....QRVAGLSLGY.AEWNIRYENDgspfs........ylgniFT..G..E-NSDRYRTAA..MSLSYK--..--DYS.IGFNLFTGD.PRE..GLQ.K.REIAST.ESVv.............gHPTL.SA.NKK.GGQYNGGn.....aDKY...R.LGAAYFSYKG....................FRFGRNSEG.IRHAIQNKVAHT............................................................
C7M525_CAPOD/1952-2136                 .......................................................................................LGVGVNGTFGYQT.-...........NFGLNIG..LNFGAty............ylSAIGTGE.SG....WE....KRIGY.GIG.Y.....KGKS.....FQAGI.....G.-STYFFSG.......ETS.....QQTGSIYMGG.GNWRLTYENDtwap..........vpglFT.pG..TYEKDKYRTAA..LRFDITGG.kLKGLN.AGLNIFTGK.A--..---.-.------.---...............EGYD.SE.NIY.GGGT--A.......DKY...R.MGVIYIGYNQ....................YRIGYNSERnIRGPIQN-GFHD............................................................
A0A2K9PSL6_9FLAO/1310-1513             ......................................................................................n-SIGLNLTANYEI.G...........DFTLSASatGSFTN................KAVGTGK.SG....FG....GVFSG.GGS.Y.....--DD.....GNTGF.....SlYSTYYTNVg.....gVGK.....QRVGGLGFRS.GDFRFRYENDgfp............fggTL..G..D-GNDSYRSAA..AGIGVG--..--NYS.VGFNLFTGS.RSK..SSY.E.GDKDEK.KRAraid......rygdtGFYG.ER.YPN.GFVNETG.......TAY...R.LGALYFGFKN....................YRIGIDSDRyVRHPIQNRFAH-g...........................................................
F2ID63_FLUTR/57-253                    .......................................................................................LNAGVTTRYFLTNfGnrs.....nfgELRLSAG..GGVM-................----FGK.GN....NP....LNMDW.EGT.Lh...qSKSE.....YSIGY.....A.HYWYLDRI.......GTA.....QRSGAWNIGI.QRFDILMEND..................VF..G..GQAKDRFRTGG..LIVSYRDS..LYKAS.IGLAIWTGE.TGN..TTW.D.RTPRPG.APN...............GIRD.LT.NNP.FGKLNHG.......ILY..gE.IKHRFVGVQTv..................gGRIGWDSEQ.IRHVFQNKISHD............................................................
A0A0D6TN67_9FLAO/38-249                ....................................................................................vtp---GINLGVNFYN.Gglg....slpnSSNFNID..TVITA...............kLTAGGGK.GN....PMtiypLHLNS.GSG.L....eDHYK.....YSATL.....G.TNFIFNNN.......NRN.....QQVGFLQVRA.YDFSFQTYNDfqg...........fkkiGI..S..D-GYDRWWTGG..GNLTFGAKnsDYQFV.IASDVFTAD.TDV..EPR.S.K-----.---...............----.--.---.-------.......---...-.----------....................---------.------------fmrdgklvnsdemkldvfdknvaapegssfyhkyfvhkpniaseltqdylndyrdgvtwn
A0A1Q3GWP9_9BACT/69-267                .......................................................................................FNFQTLWRYNFSAyG...........-PSNTSG..KEVQTs.............igLMFGWGK.QT....KK....FDQQF.LLP.Fg..nqMQRL.....NSLGY.....A.FNIYQDDI.......GTS.....QTSGTIAFQA.NRFWLVTEND..................AL..G..DIAVDKFRTGT..VWMAYRVE..NTLLA.LNTRLWTGN.SNN..TPI.I.TNQGYP.SQY...............GYRD.MS.KTT.YGNYSHGvl...tfQVL...Q.ALPFGQTAMA....................-EIGLDAER.VRHFLQNQLMHD............................................................
A0A8J6PHM0_9FLAO/60-257                .................................................................lnlgntfswkvyslgnrkrffe-------------.-...........-NRAYAG..AALM-................--VGKNN.SI....VD....FELDG.LS-.H....qTRKD.....VGVAF.....N.YLVYTDNA.......GTS.....QLSGGFALHI.KNVSVRFEND..................VF..G..GQARDRFRTGI..LAVSYRQE..WYKIN.AGLYIWTGE.TRG..SFW.D.KSIRTNeMPG...............GFRS.LE.DLP.YGKTSHG.......IYYggvQfLLPYGNIVH-....................LKIGADSEH.FRHFFQNRLIHD............................................................
H6L1Z5_SAPGL/58-270                    .................................lnlqwhqhynwsargtdqrawesqiklgaqgswgpkyqqveqihpfltaagqqt-------------.-...........-------..-----................-------.--....--....-----.---.-.....-ARP.....YALGY.....A.YIFYLDQW.......KTS.....QRSGIFSAQI.KDFRFFFEND..................FL..A..FQSLDRYRTGA..MGLHYRYK..DWQFG.FSNITYTGD.AYSpySPW.I.SNPNFP.SAS...............GYID.MA.SAP.YGDKSLGvl..alkI--...D.WRPHFEALSHdflvh.........lqpqlsLRLGVDAEQ.IRNLVQNKWIHD............................................................
A1ZJH5_9BACT/69-268                    .......................................................................................FNFQTRWQYNVTTyG...........PPRLLPG..IEVQTn.............ygLMFGWGK.QT....EV....QAYAF.LLP.Fg..nqMKRL.....NALGY.....V.FNVYHDKI.......KTS.....QTTGTIAFQA.NRFWLVTEND..................AL..G..DMAVDKFRTGG..VWIAYQVQ..NTMIA.LNTRFWTGN.SGR..TPV.I.ENANYP.AQY...............GYRD.MS.NAM.YGRFSHGi....ltMQV..lQ.ALPYRQIIGA....................-EVGLDAEI.IRHFLQNKLIHD............................................................
D3IMK5_9BACT/1392-1585                 .......................................................................................LTAGMLASLSYTD.G...........DFSASVS..GGITN................NYVGWNA.EA....--....SYGGW.GAG.F.....----.....GKTYY.....G.EQTVRGNV.......LGK.....QIVGAITLLApGDVSFRLYND..................MF..G..QSGHDRWRTSA..AELTIG--..--DFS.VGTYVTTND.GKE..ESG.I.YGYDPN.IVDpylga....nperviHVNG.RE.QKV.GGGWPNG.......KVY...-.SAPFWVGIKSgs................qiYRFGVSARI.VQSLTQN-LVHR............................................................
R6KF61_9BACE/2091-2277                 .......................................................................................FTAGINAGIGYSD.G...........DFSIGAG..VGVGD................NHWGWNA.SA....--....TYNGV.GVG.Y.....----.....GLTYY.....G.KTQGPDGK.......SNA.....QRVANITAYW.KGGSFALQND..................MIslG..G-DGDRWRTNA..FELSVG--..--DFS.FGSYIYTND.GKA..DSG.G.KDNESR.TVDr............nsPIWG.KNrNKG.FSTWKNG.......QVF...-.SAPVWIGYRRgn................qiTRIGYSHKV.FQDLQQN-GIH-g...........................................................
F8X4S1_9BACT/1867-2044                 .......................................................................................LTVGLNYGAHYLA.G...........DFEFGAG..VGVGN................NHEGWNA.SG....--....TYKGW.GLG.Y.....----.....GRTSY.....L.ESEVMGQK.......FGA.....QTVGSLTTYF.NHNSFTFAND..................AL..G..D-GKDRWRSSA..VELNIG--..--KYS.LGTYLYTND.GRT..ESE.R.ETIDLA.A--...............PLWR.KN.KKE.--AWTKG.......QVY...-.FAPAWIGYKSkn...............gqiNRIGFSHPT.VQNLSQN-FIHK............................................................
A0A2A3U594_9SPHI/72-261                ............................................yfnfkglgpklrypelvlaqgivfsagrekdyfnpfissvsnq-------------.-...........-------..-----................-------.--....--....-----.---.-.....TKYE.....NAIAY.....S.YNAWFNKI.......KTT.....QQTGIIAIQV.QNFSLITEND..................IL..A..RQMLDRFRTAA..ALIQYQYK.dQFQAA.VSCAMWTGS.MGR..RHE.I.RRSEFN.Y-E...............CYMD.TA.GAV.YGNTSHGll..saqI--...-.--KYNLGYSQn.................aqLNLGIDAEQ.VRNGVQNKFIHD............................................................
#=GC seq_cons                          .............................................................................................h.hth...G...........t.t..hs..hshhs.................h.uhst.ts...........thsh.sss.h........t.....hthsa.....s.hphhhssh.......tps.....QpsGslslph.tsashphEND..................hh..u..s.stDRaRTuu..hplsht......phs.luhplaTuc.spt..ts..h.pp.p.....................shhs..p.tt.....hptG.........h......tshhhshpt.....................chGhstc..lpphhQN.hhH.............................................................
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