#=GF ID Ntox30
#=GF AC PF15532.10
#=GF DE Bacterial toxin 30
#=GF PI Toxin_53; Toxin_30;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 25.00 25.00;
#=GF TC 25.70 25.90;
#=GF NC 24.10 24.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR029111;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted RNase toxin found in bacterial polymorphic toxin
#=GF CC systems. The toxin possesses an all-beta fold and two conserved
#=GF CC histidines present in an RxH and THIP motif. The domain
#=GF CC additionally has a highly conserved arginine residue. In
#=GF CC bacterial polymorphic toxin systems, the toxin is usually
#=GF CC exported by the type 2, type 6 or type 7 secretion systems [1].
#=GF SQ 30
#=GS A0A7W5JT51_9ACTN/1867-1969 AC A0A7W5JT51.1
#=GS D9VS65_9ACTN/1-78 AC D9VS65.1
#=GS A0A0X8GKQ8_9BURK/54-147 AC A0A0X8GKQ8.1
#=GS A0A6I5VDR0_9ACTN/223-325 AC A0A6I5VDR0.1
#=GS A0A2T7BMS2_9BACT/585-687 AC A0A2T7BMS2.1
#=GS A0A428X835_9ACTN/88-190 AC A0A428X835.1
#=GS B5HCD7_STRE2/1315-1417 AC B5HCD7.2
#=GS A0A6B3W0X4_9BACI/59-161 AC A0A6B3W0X4.1
#=GS C7Q9A7_CATAD/351-460 AC C7Q9A7.1
#=GS A0A6L3UZ84_9BACI/556-661 AC A0A6L3UZ84.1
#=GS A0A5R9G2M4_9BACL/278-380 AC A0A5R9G2M4.1
#=GS F2JHT4_CELLD/472-574 AC F2JHT4.1
#=GS A0A4U1H5E1_9DELT/1342-1438 AC A0A4U1H5E1.1
#=GS A0A1M7N2B1_9ACTN/1482-1584 AC A0A1M7N2B1.1
#=GS A0A109LQR9_9SPHN/423-510 AC A0A109LQR9.1
#=GS A0A6A9UP82_9ACTN/363-463 AC A0A6A9UP82.1
#=GS W7CDV5_9LIST/282-384 AC W7CDV5.1
#=GS A0A1C4JWI3_9ACTN/1448-1551 AC A0A1C4JWI3.1
#=GS A0A0Q4R3G4_9BACL/819-922 AC A0A0Q4R3G4.1
#=GS A0A4R2J9I1_9PSEU/2387-2489 AC A0A4R2J9I1.1
#=GS A0A1X7N0N1_9HYPH/261-348 AC A0A1X7N0N1.1
#=GS A0A3N6DFV8_9ACTN/1454-1557 AC A0A3N6DFV8.1
#=GS A0A090ZIW9_PAEMA/947-1054 AC A0A090ZIW9.1
#=GS A0A849C9C3_9NOCA/271-373 AC A0A849C9C3.1
#=GS A0A1E5KX71_9ENTE/1-101 AC A0A1E5KX71.1
#=GS F2NYM6_TRES6/415-516 AC F2NYM6.1
#=GS A0A523Q1U7_9BURK/143-245 AC A0A523Q1U7.1
#=GS A0A1K1SDJ2_9BACT/2795-2889 AC A0A1K1SDJ2.1
#=GS A0A4Q9DGF0_9BACL/3078-3178 AC A0A4Q9DGF0.1
#=GS S3B4W3_9ACTN/1412-1515 AC S3B4W3.1
A0A7W5JT51_9ACTN/1867-1969 .................DPMSVVPGHAEVRELTP.HPGaGSQYGLEFKWQH......eSGVTARMRIHGPDGTA..PPGSNSASGETYRV...Q....IGKQ.........YQD..--EAGNLHHAQSHNPNSPYY........DPSAANATHIPWP.........................
D9VS65_9ACTN/1-78 .................-----------------.---.-----MEYHWTDa.....vTGNSARLRIHDIDGTA..PAGSHAATGDSYRL...S....IGGK.........YQD..--EAGRLHHRNVHNERSPHY........DPDAANATHIPWP.........................
A0A0X8GKQ8_9BURK/54-147 .nilaaipagqqntfef-----------------.-EP.RSQYGFKFRWTD......aNGAQWQVHGHEPDAGA..VAGHVGAGAWTMRV...Q....CGNA.........FMM..--------------------........-------------srqlvsdfpaahanytpptfwsrcn
A0A6I5VDR0_9ACTN/223-325 .................DPMDIVPDNASVRELTPhPNG.GSQYGLEFKWVD......eSGVTMRMRIHGPDGTA..PPGSNSASGETYRV...Q....HGAR.........YQD..--EAGNLYHKNVHNPNSPHY........NPDAANATHIPWP.........................
A0A2T7BMS2_9BACT/585-687 silaralkrqglpklpg-----------------.---.----NFKEKWAE.......NGYDYEVRSRGADNKA..PAGSNSAHGQTFRV...A....RRLQ.........GKNenGQGNGWEYADDNNNWYSETQlk...sgnNPQAANDTHIPV-n........................
A0A428X835_9ACTN/88-190 .................DPMSIVPDNASVRELTPhPNG.GSQYGLEFKWTN......dAGKTVRLRIHGPDGTA..PAGSNSATGEAYRV...Q....IGRQ.........YQD..--EAGNLFHHQSHNPNSPNC........NPDAANATHIPWP.........................
B5HCD7_STRE2/1315-1417 .................NPLSIIPKDAVQEPWKP.IPG.GVEHGIKWKWTDd.....vTGKTVRMRVHGPDLGP..HAGPNASSGPIYRI...Q....IGHQ.........FQD..--EAGKLYHAQIGNVNSPNY........NEAAINDTHIPWP.........................
A0A6B3W0X4_9BACI/59-161 .................DILSRIPTDAKKRILTP.QSG.KVTEGFEYTWRN......sDGKKMTVRVHGPDASA..PVGSNASNGWIIRV...Q....EGKK.........YLD..-PVTGEYQPRGITNPNSPNY........SDDLANRTHIPIQ.........................
C7Q9A7_CATAD/351-460 .................DPSELVPPYARQRPWTPaAPGqGAEDGVEWIWKErdangdeIGPTIRLRVHSADPTA..PAGSNAANGPIYRI...Q....HGAK.........YQD..--ADGNLHPQGIHNKDSPNY........DEDAINDTHIPWP.........................
A0A6L3UZ84_9BACI/556-661 ...............df--RSRIPGNATQLPWKK.VPG.GAAEGEKYRWTD......sDGNVWNVRAHGIDPSA..PAGSNASKGWIYRV...EvktpSGKW.........TMD..--SQGNFYKKNVFNPNSPHY........DEAIANDSHIPF-t........................
A0A5R9G2M4_9BACL/278-380 khylnealkqqnltsvp-----------------.---.--ANGLKQKWSQ.......DGYDFEVRVHAADPNY..--GKTGDIYRVARR...Q....QGTNangqgygweYID..--HNGVWHHTSTLKPSSPNY........NAQAAADTHIQL-p........................
F2JHT4_CELLD/472-574 .................DILDRIPDDATLRELTP.VKG.GATEGFEFKWIQ.......DNQTYRVRVHNIDPGA..PVGSNASQGWIVRI...Q....RGRQ.........YYD..YTIEGFQPAKYTNNPNGEFF........DSTITNNTHIPIK.........................
A0A4U1H5E1_9DELT/1342-1438 ....elsksiptgtpns-----------WNPHGP.EAG.YSGPGFKYRWDDp.....aSGRSYRVWGHEAHPAA..PPGSNAATGPHVRV...K....IGNR.........YLT..TAGTTVKNAETVTNAN----........-------------lthipmd..................
A0A1M7N2B1_9ACTN/1482-1584 .................DPMSIVPDDAKIRELTP.HSGgGSQYGLEYSWKN......dAGQTVRLRIHGPDGTA..PVGSNSASGETYRI...Q....IGRQ.........YQD..--EAGNLYHHQSHNPNSPNY........NPNAANATHIPWP.........................
A0A109LQR9_9SPHN/423-510 .eiisrvpsdwtmlpqq-----------------.---.---RGMGIRFID.......DTGAERLRLHGPSARA..PEGSNAASGWTARV...Hv.pgTSNQ.........YYD..--NLGNIVG-----------........-------------arnndghipvygnan..........
A0A6A9UP82_9ACTN/363-463 ...............tp--LAGVPSNAQVRRLSP.SP-.HVSDGLEYEWVD......aQAKRVRLRVHDRDASA..PPGSNAASGPVYRV...Q....VGQR.........YQR..--ADGTLAPRSAHNPNSPNY........DPDVSNDTHIPWP.........................
W7CDV5_9LIST/282-384 .................DILSRIPKDANKRVLTP.QPG.KVTEGFEYTWKA......sDGTKMTVRVHGPDASA..PAGSNSADGWIVRV...Q....KGKK.........YLD..-PVAGEFQPPGISRPNSEFY........NEDLINSTHIPIQ.........................
A0A1C4JWI3_9ACTN/1448-1551 .................NPLDIVPGDAEKRVLTPdANG.GAQKGVEYKWKDp.....eTGNTVRLRVHDKDGTA..PAGSNAANGDVYRI...S....IGGK.........YQD..--EAGSLYHRQVHNPNSPHH........NPDAANGTHIPWP.........................
A0A0Q4R3G4_9BACL/819-922 .................EILSRIPTDAKRRELFP.IEG.KVMEGFEYKWVE.......DGQTIRVRVHGPDSSPdiPAGSNAANGWIVRI...Q....KGKK.........YFD.pVTGEYQPPG--ISNPASEFY........NEDLINRTHIPIK.........................
A0A4R2J9I1_9PSEU/2387-2489 .................DPMSIVPDDASVRGLKPdPNG.GAQYGIEFAWRN......aDGTRVRLRIHGPDGTA..PPGSNSASGETYRV...Q....IGAR.........YQD..--ISGTLYPRNVHNPLSPYY........DPVAANAAHIPWP.........................
A0A1X7N0N1_9HYPH/261-348 ........qirklipan------------RELPF.TKSqRIDEGYKYRFFL.......KGQRVEIKWHSPDRGA..PVGSNSRKMWTAQV...Q....IGGK.........YLG..--SDGKLYRNAKQNI-----........-------------thiplye..................
A0A3N6DFV8_9ACTN/1454-1557 .................NPLDIVPDDAKMRVLTPdANG.GAQKGVEYKWIDr.....eTGNTARLRVHDKDGTA..PAGSNAANGDVYRI...V....IGGK.........YQD..--EAGVLYHRQVHNANSPHY........NPDAANGTHIPWP.........................
A0A090ZIW9_PAEMA/947-1054 ................d-FITRIPANAKQIPWRQ.VPG.GAKDGVKFRWVD......gTGKTWDVRAHSIDPTA..PPGSNAAKGWIYRVevkQ....VNPK.........WKW.tMDSSGNFHKENVLRESSPYY........NESIANETHIPF-t........................
A0A849C9C3_9NOCA/271-373 .................DPLAAVPEGASVRTLRPdPNG.GAQVGVEFKWLN......eNGQTVRLRAHGPDGTA..PPGSNAASGPTYRI...Q....IGGR.........YLD..--AEGALYPRGVHNPNSPNY........DPAAANSTHIPWP.........................
A0A1E5KX71_9ENTE/1-101 ................m---SRIPKEANKRVLTP.QPG.KVTEGFEYTWKT......sEGAKMTVRVHGPDASA..PAGSNAANDWVVRV...Q....QGKK.........YLD..-PISGEFQPPGISRPNSEFY........NEELINNTNIPIQ.........................
F2NYM6_TRES6/415-516 .................EVLTRIPKNATRRELIP.EAG.KVTEGFEYKWIT.......NGKTYRARIHGIDGSA..PKGSNASKGWVLRI...Q....EGKK.........YLD.pITLEYQRPG--ITNIDSPYY........NEELANRTHIPIK.........................
A0A523Q1U7_9BURK/143-245 .................DIVKNIPPNASVRRLTP.AVG.GSQVGLEYKWVD......gNGVTNRLRMHDPDPSA..GVGSNSAEGWTARW...Q....VGKG.........YYD..-PINGDVRHPNVHNSASPFY........DPAAANNTHIPI-r........................
A0A1K1SDJ2_9BACT/2795-2889 .........rqglvylp-----------------.---.---EKFKEKWSE.......GGYDYEVRIHPKQENA..PEGSNSRNGTTYRV...A....RRLQ.........GSD..SNGQGFGWE-YVDDKNNWYKerdlktgdNKQAANDTHIPLK.........................
A0A4Q9DGF0_9BACL/3078-3178 .................DILSRIPSNAKGRILTP.IEG.GAQEGFEYKWDQ.......DGEKWTVRVHGPDASA..PAGSNSAEDWIVRV...L....KGKK.........SMD..--ADGVFHPRGIFSPDSPFY........DEKLINDVHIPI-t........................
S3B4W3_9ACTN/1412-1515 .................NPLDIVPPNAEMRHLTPdPNG.GAQVGVEYRWPDp.....eTGKTARLRVHGPDGKA..PAGSHAAEGDIYRV...Q....VGNQ.........YQD..--IDGNLYHRNVHKEASPHY........DPTAANRTHIPWP.........................
#=GC seq_cons .................p.hshlPtsAphR.LpP..sG.tsppGhEa+Wtc......tsGpshRlRlHusDuoA..PsGSNuAsG.shRV...Q....hGpp.........Y.D....tsGshatpslpNssSPhY........s.shANsTHIPh..........................
//
