#=GF ID Ntox35
#=GF AC PF15534.10
#=GF DE Bacterial toxin 35
#=GF PI Toxin_56; Toxin_35;
#=GF AU Zhang D;0000-0001-8535-7620
#=GF AU de Souza RF;0000-0002-5284-4630
#=GF AU Anantharaman V;0000-0001-8395-0009
#=GF AU Iyer LM;0000-0002-4844-2022
#=GF AU Aravind L;0000-0003-0771-253X
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE [1]
#=GF GA 23.60 23.60;
#=GF TC 25.80 24.10;
#=GF NC 21.40 19.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF RN [1]
#=GF RM 22731697
#=GF RT Polymorphic toxin systems: comprehensive characterization of
#=GF RT trafficking modes, processing, mechanisms of action, immunity
#=GF RT and ecology using comparative genomics.
#=GF RA Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;
#=GF RL Biol Direct. 2012;7:18.
#=GF DR INTERPRO; IPR029109;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC A predicted RNase toxin found in bacterial polymorphic toxin
#=GF CC systems that is proposed to adopt the BECR
#=GF CC (Barnase-EndoU-ColicinE5/D-RelE) fold, and contains a conserved
#=GF CC histidine residue and a KH motif. In bacterial polymorphic toxin
#=GF CC systems, the toxin is usually exported by the type 2 secretion
#=GF CC system [1].
#=GF SQ 27
#=GS A0A0H4KCE7_9BACI/8-89 AC A0A0H4KCE7.1
#=GS A0A4R6S2C7_9MICO/158-234 AC A0A4R6S2C7.1
#=GS A0A0K8J6G5_9FIRM/162-239 AC A0A0K8J6G5.1
#=GS C0E858_9FIRM/75-153 AC C0E858.1
#=GS R5NI28_9FIRM/20-101 AC R5NI28.1
#=GS A0A1I4C5M9_9BACL/147-204 AC A0A1I4C5M9.1
#=GS A0A521BZY5_9BACL/2262-2341 AC A0A521BZY5.1
#=GS A0A1M4NFQ4_9CLOT/162-239 AC A0A1M4NFQ4.1
#=GS A0A075R1D7_BRELA/1201-1279 AC A0A075R1D7.1
#=GS A0A2U3AIU0_9BACL/58-135 AC A0A2U3AIU0.1
#=GS D3G211_ALKPO/192-267 AC D3G211.1
#=GS A0A8J2Y8M8_9BACL/21-99 AC A0A8J2Y8M8.1
#=GS D9TS74_THETC/158-235 AC D9TS74.1
#=GS A0A1H3F8X0_9FIRM/162-239 AC A0A1H3F8X0.1
#=GS A0A165X389_9BACI/17-92 AC A0A165X389.1
#=GS R1CQK4_9FIRM/1-71 AC R1CQK4.1
#=GS A0A235B4Q4_9BACL/92-139 AC A0A235B4Q4.1
#=GS A0A327Y8D0_9BACI/112-193 AC A0A327Y8D0.1
#=GS L8JMP6_9BACT/282-358 AC L8JMP6.1
#=GS A0A1I0ZM13_9FIRM/162-241 AC A0A1I0ZM13.1
#=GS F9Z8A0_ODOSD/942-999 AC F9Z8A0.1
#=GS A0A3A9HZR6_9FIRM/23-103 AC A0A3A9HZR6.1
#=GS D4MZ25_ANAHA/28-110 AC D4MZ25.1
#=GS A0A165WQ67_9BACI/13-94 AC A0A165WQ67.1
#=GS A0A7M4DGJ9_9MICO/199-266 AC A0A7M4DGJ9.1
#=GS M1MGK3_9CLOT/74-149 AC M1MGK3.1
#=GS B5CLB2_9FIRM/396-477 AC B5CLB2.1
A0A0H4KCE7_9BACI/8-89 ..........m-NENQIHHVIygsrRSNHYWERLVP.N....RN..WNEIDKIIRLVIQTGQDQ..KYK.KI.FKR......TKRIEGEPVEVVYLQlKDGSYKLSNAWI.........
A0A4R6S2C7_9MICO/158-234 ..........q-NAAKWSHIM....APKHKWSA-VG.A....RT..KTQVANVMAKTMSAGRHT..LYK.GN.PRVg...iaTMKYKGRSISVTYDI.KT--KRVGNG--wv.......
A0A0K8J6G5_9FIRM/162-239 .........qp---NKQRHIK....DPKHDWDKIIK.G....TI.tWEKVRDIIEKVMKKGTES..RYG.SA.YKR......VLKVGKETVTVTFQKiNDSIWKISDAWV.........
C0E858_9FIRM/75-153 .......isan---RMTNHIN....VPKHLWGKVLR.K....VT..NKGIENLIQQAIRKGSWN..IGK.NGiSTI......YYRYGGEIITVTGRI.INGVFNISDAWV.........
R5NI28_9FIRM/20-101 ..........l-SENKINHMIngskNSNHGWEKLVP.D....KN..WSDIKNIIVNVMDTGVEG..PYK.SV.FSK......KATISGFEVEVTYTKlSDGTIKISDTWV.........
A0A1I4C5M9_9BACL/147-204 ..........l-NINNVNKIL....NPKHAWNRIVE.N....PN.dWDTVSVIISKVMREGAEQ..TYM.KQ.NGG......---------------.------------kntafyk..
A0A521BZY5_9BACL/2262-2341 ........lke---DTKAHIF....SKKHLNDGIME.L....GN.dRRDIVEKFVKVIDDIDSQ..GLT.RN.GHNa....vYTTINGYKTQVNFFI.VKGEVKSIDGF-r........
A0A1M4NFQ4_9CLOT/162-239 .........qp---NKQRHIK....DPKHDWDKIIK.G....TI.tWEKVRDIIEKVMKKGTES..RYG.SA.YKR......VLKVGKETVTVTFQKiNDSIWKISDAWV.........
A0A075R1D7_BRELA/1201-1279 ........svi----KIEHIF....SKKHINNGIMDlG....KN..QNEILEKFINTVKTADSKgmLKE.GM.NQI......QTIINGHEAEIRVFV.SEGKVLNLDG--fk.......
A0A2U3AIU0_9BACL/58-135 ..........l-DANKKIHIL....KPKHDWHKVTK.N....PD.eFGSVSKIMMKVIKKGKHS..KYK.SV.NKA......TMKIQGQTVVVTYKR.VGDKLLISNAWV.........
D3G211_ALKPO/192-267 ...........IDANKRAHIL....ANKHDWHK-VT.K....NN..WTDVSKVMSHVMRYGKES..AYG.SA.RKK......TLSMSGQTVTVTFTR.VNGQVRISNGWV.........
A0A8J2Y8M8_9BACL/21-99 .........lg--SNKIHHIL....QDKHAWDLEVK.N....KN.sWEDVSKVISNVMRNGTES..AYK.TV.RMK......SMKVNGQTVDVTFVRlKDGTIKILDAWV.........
D9TS74_THETC/158-235 .........qp---NKQRHIK....DPKHNWDKIIK.G....AI.tWEKVRNTIEKVMKEGTES..RYG.SA.YKR......VLKVGKETVTVTFQKvSDNIWKISDAWV.........
A0A1H3F8X0_9FIRM/162-239 .........qp---NKQRHIK....DPKHDWDKIIK.G....TI.tWEKVRDIIEKVMKKGTES..RYG.SA.YKR......VLKVGKETVTVTFQKiNDSIWKISDAWV.........
A0A165X389_9BACI/17-92 ...........LDKNKIHYIM....QSKHNWHK-VT.K....NN..WNEVSKVISHVMRYGKES..SYK.SV.RKK......TLKMNGHTVTVTFTR.IRGQIKISDAWV.........
R1CQK4_9FIRM/1-71 ...........---------M....KAKHNWNKFKK.D....PK..WSDVAPILIKVLKDGAET..WEK.NN.QYI.....rTLTYKGETVVVRFIKdAEGLVKYIST--awc......
A0A235B4Q4_9BACL/92-139 ..........l-KNYKIHHFL....AEKHQWNRIVK.N....SD.dWDEISLIISKVMKK----..---.--.---......---------------.------------vwknftkrk
A0A327Y8D0_9BACI/112-193 ..........l-NSNQIKHIIngskKSNHQWEKLVP.D....KN..WGKIKEIIIDVMHNGADI..PYK.SV.SSR......VKMVNGQLVQVTYKKlPDGTIRISDAWV.........
L8JMP6_9BACT/282-358 ..........i-GANRISHIM....QTKHAWQKLMA.N....PT..WSKIQPLIDQTLVHGTLV..PYK.GV.SSR......VMYHNGFHIQVTFKE.LNGVINVSDAWV.........
A0A1I0ZM13_9FIRM/162-241 ..........v-NQNKIHHIM....ASKHNWNKFKK.N....PK..WNDIYPILLTVMKKGKET..HEKnSV.YIR......TYIYKGKTVVVRFIKdANGLVKAIST--awc......
F9Z8A0_ODOSD/942-999 ...........ANKTMIQHYF....PPKHSYRTLQG.G....HTncWKDVL-------------..---.--.---......GTRFQGDSIRGARII.SGGNGKSTATWR.........
A0A3A9HZR6_9FIRM/23-103 .........ka--KNKRIHIL....AEKHGWGKVVK.NpkdpKN..WNKIRGLIYLTMTKGGDE..AYK.SV.ASK......VYSYRGHIIQVTYRI.VDGVARISDAWV.........
D4MZ25_ANAHA/28-110 ...........SDQNKVRHIM....QSKHAWTKVTK.K....NQ..WKYVKPIVKKAMKSGKME..AIG.KT.KGKeivykfVYNYKGKIIEGTCIA.KKGVVKLSDAWV.........
A0A165WQ67_9BACI/13-94 ..........l-NSNQIKHIIngskKSNHQWEKLVP.D....KN..WGKIKEIIIDVMHNGADI..PYK.SV.SSR......VKMVNGQLVQVTYKKlPDGTIRISDAWV.........
A0A7M4DGJ9_9MICO/199-266 psderadavlh----------....-----------.E....PS..WNQVAALMYAAIQHGEQT..TYKvST.FQR......VHDFGGERIAVIFTV.IGGQPRVSDAWV.........
M1MGK3_9CLOT/74-149 ...........IKYER--HIF....SADHIKQGIEN.L....RN.sRKEIYDNFVNIINENKSK..LIQ.GN.NQL......RTVINGYEVEIKAFV.KDGKVASIDGQI.........
B5CLB2_9FIRM/396-477 ..........f-SENKIDHMVngskGSNHNWEKLVP.D....KN..WNDIKNIVNDVMENGEEG..PYK.SV.FSK......KKIIDGYEVEVTYNKlSDGTVRISDAWI.........
#=GC seq_cons ..............N+hpHIh....ssKHsWpKllp.s....ps..Wsclppll.pVM+pGpcp..hYp.us..p+......shphsGpplpVTaht..cGhh+lSDuWl.........
//
