#=GF ID   NtrZ
#=GF AC   PF20841.1
#=GF DE   NtrZ
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Crosson S
#=GF GA   27.70 27.70;
#=GF TC   27.80 47.10;
#=GF NC   27.50 20.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   34124942
#=GF RT   The ChvG-ChvI and NtrY-NtrX Two-Component Systems Coordinately
#=GF RT   Regulate Growth of Caulobacter crescentus.
#=GF RA   Stein BJ, Fiebig A, Crosson S;
#=GF RL   J Bacteriol. 2021;203:e0019921.
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family represents the periplasmic protein NtrZ which
#=GF CC   functions to regulate the activity of the NtrY-NtrX
#=GF CC   two-component system [1]. NtrZ inhibits NtrY phosphatase
#=GF CC   activity.
#=GF SQ   56
#=GS A0A4Y9RGM2_9CAUL/62-138   AC A0A4Y9RGM2.1
#=GS V4PTJ3_9CAUL/58-136       AC V4PTJ3.1
#=GS A0A4Q3SBM9_9CAUL/58-134   AC A0A4Q3SBM9.1
#=GS A0A4S2HAK8_9PROT/110-185  AC A0A4S2HAK8.1
#=GS A0A8E0KJX4_9CAUL/47-123   AC A0A8E0KJX4.1
#=GS A0A4S2H1F2_9PROT/34-110   AC A0A4S2H1F2.1
#=GS A0A519J085_9CAUL/57-133   AC A0A519J085.1
#=GS A0A399RPI1_9PROT/69-145   AC A0A399RPI1.1
#=GS A0A5M6ZJI5_9PROT/134-211  AC A0A5M6ZJI5.1
#=GS F4QK00_9CAUL/51-128       AC F4QK00.1
#=GS A0A328BL61_9CAUL/52-128   AC A0A328BL61.1
#=GS A0A1I6P185_9CAUL/54-130   AC A0A1I6P185.1
#=GS A0A2D2ASM8_9CAUL/70-152   AC A0A2D2ASM8.1
#=GS C6XKB4_HIRBI/72-151       AC C6XKB4.1
#=GS A0A318AN05_9CAUL/55-132   AC A0A318AN05.1
#=GS A0A7W9A3D2_9CAUL/72-148   AC A0A7W9A3D2.1
#=GS A0A257J8U9_9PROT/36-113   AC A0A257J8U9.1
#=GS A0A0Q5V7J4_9CAUL/56-132   AC A0A0Q5V7J4.1
#=GS B4RCZ2_PHEZH/54-130       AC B4RCZ2.1
#=GS A0A1V1V2K8_9CAUL/51-127   AC A0A1V1V2K8.1
#=GS A0A7G8ZMQ6_9PROT/65-139   AC A0A7G8ZMQ6.1
#=GS Q0AKF8_MARMM/66-143       AC Q0AKF8.1
#=GS A0A2Z3HUM5_9CAUL/60-138   AC A0A2Z3HUM5.1
#=GS A0A0Q7QEQ8_9CAUL/54-130   AC A0A0Q7QEQ8.1
#=GS Q9A219_CAUVC/73-150       AC Q9A219.1
#=GS A0A1G9R3G7_9PROT/82-158   AC A0A1G9R3G7.1
#=GS A0A514BXC9_9CAUL/56-131   AC A0A514BXC9.1
#=GS A0A2P2E6J3_9PROT/95-177   AC A0A2P2E6J3.1
#=GS A0A399RK55_9PROT/69-146   AC A0A399RK55.1
#=GS A0A0Q7CXD5_9CAUL/46-122   AC A0A0Q7CXD5.1
#=GS A0A0H3CE94_CAUVN/59-136   AC A0A0H3CE94.1
#=GS A0A6B3UFP6_9CAUL/57-132   AC A0A6B3UFP6.1
#=GS E8RNK2_ASTEC/50-126       AC E8RNK2.1
#=GS A0A3T0E607_9PROT/113-188  AC A0A3T0E607.1
#=GS A0A328AXM7_9CAUL/51-128   AC A0A328AXM7.1
#=GS A0A7W9CGM4_9CAUL/57-133   AC A0A7W9CGM4.1
#=GS A0A328ARW9_9CAUL/36-113   AC A0A328ARW9.1
#=GS D9QJU1_BRESC/55-131       AC D9QJU1.1
#=GS A0A062U071_9PROT/74-150   AC A0A062U071.1
#=GS A0A0Q7ER24_9CAUL/56-133   AC A0A0Q7ER24.1
#=GS A0A059FMK1_9PROT/74-150   AC A0A059FMK1.1
#=GS A3UIE2_9PROT/110-187      AC A3UIE2.1
#=GS A0A0Q7T483_9CAUL/54-130   AC A0A0Q7T483.1
#=GS A0A328AJP1_9CAUL/44-121   AC A0A328AJP1.1
#=GS A0A257JTP7_9PROT/65-147   AC A0A257JTP7.1
#=GS A0A4Q5XZW9_9PROT/77-160   AC A0A4Q5XZW9.1
#=GS A0A0Q7UAH1_9CAUL/61-138   AC A0A0Q7UAH1.1
#=GS A0A1B1AID3_9PROT/61-144   AC A0A1B1AID3.1
#=GS A0A2U2BWE9_9PROT/133-209  AC A0A2U2BWE9.1
#=GS A0A0N1BRK8_9CAUL/55-131   AC A0A0N1BRK8.1
#=GS A0A2S8W0Q1_9CAUL/53-131   AC A0A2S8W0Q1.1
#=GS A0A1V1PL61_9PROT/1-73     AC A0A1V1PL61.1
#=GS Q0BWB8_HYPNA/74-150       AC Q0BWB8.1
#=GS A0A1G4T0V4_9CAUL/46-126   AC A0A1G4T0V4.1
#=GS A0A6I6MND7_9CAUL/58-140   AC A0A6I6MND7.1
#=GS A0A059FDB8_9PROT/74-152   AC A0A059FDB8.1
A0A4Y9RGM2_9CAUL/62-138              ............l-RWY-DPGRWGLNFN.LN.QPV.G......RE.....AD......L...GDVEAGAYYRLNRRLSVGAAADLG.AR..EVD..P......A.RPAETDRRGQPRVRLETIFKF
V4PTJ3_9CAUL/58-136                  ............y-QFNL-DGKWGVKFD.VN.QPE.T......AQ.....SG......L...NDIDAGAFYKLTPSVRVGGTVGFG.EK..SDPlkP......E.SRRLSQDKKQPRVRLETTFKF
A0A4Q3SBM9_9CAUL/58-134              .............MQFDAKTGKWGLKLG.LG.SPI.G......RE.....AD......A...KDLEAGAYFKVTPSLRVGGAVGLA.SE..RDN..P......-.VRRNGEKDEAPRVRLETTFKF
A0A4S2HAK8_9PROT/110-185             ............f-RFSA-GERWGFTLG.FTeQER.G......PQ.....FQ......L...DDMSAGAFYELSDRFRVGTNLRFS.SP..TED..V......F.GE--QGEERAPELKFESAFRF
A0A8E0KJX4_9CAUL/47-123              .............LRWN-EDGRWGLDLN.LS.QPV.G......RE.....AD......W...SDVQAGAYYRLNPRLRVGAAASLS.DP..QTD..P......A.RPVETDRRSLPRVRLETIFKF
A0A4S2H1F2_9PROT/34-110              ...........fs--FT-AGERWGFTLG.IA.EQE.Hg....pQQ.....FE......L...EDVRAGAFYELSSRFRVGTNLRFS.SP..TAD..V......F.GQ--EGEDSVPELKFESAFRF
A0A519J085_9CAUL/57-133              ............l-RFN-ENGRWGLNLN.FS.QPV.G......RE.....TE......L...GDVEAGAYYRLSPRLRVGAAAGLA.AP..ETD..P......A.RAPETDRRTQPRLRLESIFKF
A0A399RPI1_9PROT/69-145              ............l-AW-IKGDRWQLSVD.MTsRPD.G......SP.....LA......R...EEMRAGAEFRITPRISVGGELTLG.AT..ELD..E......-.FEQLQNETIETGIRLRSAFKF
A0A5M6ZJI5_9PROT/134-211             .......efqiqa------GQRWAVTLG.YA.DSD.R......RE.....QS......Fg.lQDFSAGAFFSVNERFRFGGQLRFT.SP..EDE..M......F.GEE--GEERTPEIRFESAFRF
F4QK00_9CAUL/51-128                  ............y-QFDL-KGKWGVKFD.IN.QPE.T......AP.....SG......L...NDVDAGAFYKLSPSLRVGGTVGFG.EK..SDP..L......KpEPKTVKDKQQPRVRLETTFKF
A0A328BL61_9CAUL/52-128              .............MKYDASKGRFGFTLN.IQ.QPT.E......RP.....TT......G...NDVQAGAYFRLTPSLRVGGSVALG.EQ..ELA..P......R.ANQARPAD-TPKVRLESTFKF
A0A1I6P185_9CAUL/54-130              ............l-RFT-ERGRWGLDLN.LS.QPV.G......RE.....SN......L...GDVEAGAYYRVNPRLRVGAAAGLA.EP..DAD..P......A.RAPQSDRRAAPRFRLESIFRF
A0A2D2ASM8_9CAUL/70-152              ............i-TWDAKKGRWGLSLD.IK.PRN.EidpttsRD.....LQ......G...RDVEAGAFFKVTPQLRVGGSVGVG.PN..NPA..P......-.LRKNDGREEAPRVRLETAFKF
C6XKB4_HIRBI/72-151                  ............l-AWS-GNGRWGLTLD.MT.RRS.G......DD.....VH......VlpeEEITAGAFYQFSPRFRIGGGISIG.GE..RLS..Q......D.TSSWVDQENETGVRIESAFSF
A0A318AN05_9CAUL/55-132              .............LEFDARKGKWGLKLD.LD.QPV.G......RD.....ME......L...KDVQAGAYFKVTPSIRVGGAVALG.EN..NPA..V......A.ARKNETREPAPRVKLETAFKF
A0A7W9A3D2_9CAUL/72-148              ..........lrv---N-ESGRWGLDFN.LS.PPV.G......RE.....AE......W...GDVEAGAYYRVNPSLRVGASAGLA.VA..DPD..P......A.RVRESDARAQPRVRLESIFRF
A0A257J8U9_9PROT/36-113              ............i-KWDARRGRWGMTLN.LD.QSV.D......RG.....AV......L...NDVQAGAYFRLTPSLRIGGAVGLG.DQ..PAL..P......V.YKKTQPQDSAPRVRLETAFKF
A0A0Q5V7J4_9CAUL/56-132              .........mrln-----PSGRWGLDFN.LN.QPV.G......RE.....SN......W...GDVEAGAYYRLSPRLRVGAAAAVG.SP..ETD..P......A.RAPETDRRAQSRFRLETIFKF
B4RCZ2_PHEZH/54-130                  ...........qv--YDASKGRFGVTLG.VR.QSD.V......RE.....ST......L...NDVQAGAYFRITPSLRVGGSVALG.DQ..ELT..P......R.ANQARPAD-APKVRLESTFKF
A0A1V1V2K8_9CAUL/51-127              ..........lrl---N-DRGRWGLDFN.LN.QPV.G......RE.....TD......W...GDVEAGAYYRLNDRLRVGAAAAVA.TP..EAD..P......A.RAAETNGRAQPRVRLETIFKF
A0A7G8ZMQ6_9PROT/65-139              ...........ve--FQ-SGDGWGFTLG.ID.RND.E......QR.....RE......F...DSIDAGVYVDLNQRFRFGGSIRFS.NP..DNL..V......-.-TGPQIDNRAPEVKFETGWRF
Q0AKF8_MARMM/66-143                  ......ttfdlel------GEHWGVTLG.YQ.DRS.D......SR.....LN......-...DDLSAGAFVTFGDRIRLGGQVRFA.SP..DDS..F......F.VRNSDDEERQPEIKFESALRF
A0A2Z3HUM5_9CAUL/60-138              .............LTWDARKGRWGMTFN.VE.SPQ.T......RE.....TE......W...TDVKAGAYYRVSPSLRIGGAVSMG.DQ..AAQ.pE......A.WRKAAPQQPAPRVRLETAFKF
A0A0Q7QEQ8_9CAUL/54-130              ............l-RFT-ERGRWGLDLN.LS.QPE.T......RD.....SN......V...GDVEAGAYYRVNPRLRVGAAAGLA.ET..DTD..P......A.RGPQTERRSAPRFRLESIFRF
Q9A219_CAUVC/73-150                  .............LRWDAKKGRWGLKLD.LD.QPS.S......RE.....ME......L...QDVKAGAYFKVTPSIRVGGAVSLG.ET..NPA..L......A.ARKAQQADPAPRVRLETAFKF
A0A1G9R3G7_9PROT/82-158              ............v-DWESPGGRWGVRVG.IQ.EGP.D......VR.....ND......L...NDLSAGAFINLGDRFRLGGQVRLI.SP..EDP..M......-.FRLMESDARQPEIKFESALRF
A0A514BXC9_9CAUL/56-131              ............l-RFT-ERGRWGLDLN.LN.QPV.G......RE.....NN......L...GDVEAGAYYSVNPRLRVGASAGLA.EQ..ERD..P......-.ARAPQGERPAARFRLESIFRF
A0A2P2E6J3_9PROT/95-177              ..........vkv---D-PRSRWGVTLG.VQ.QDP.V......TP.....FTprngqaS...GRTSAGAFYQVSPKFRVGGEVVVP.NE..QLG..V......S.QNRDRSQRREPGVKVESAFRF
A0A399RK55_9PROT/69-146              ............l-AW-VKGDKWQLSVD.LTsRPD.D......SP.....LA......R...EEMRAGAEFRITPRISVGGSVSVG.AN..ELN..G......A.FDQLQDEAVETGIRLRSAFKF
A0A0Q7CXD5_9CAUL/46-122              .............LKWDTRKGRWGVTLN.LE.QRG.E......RD.....TQ......W...NDVEAGAYFRVTPSLRVGGAVALG.EK..EAP..-......A.YKKTEPQESAPRVRLETAFKF
A0A0H3CE94_CAUVN/59-136              .............LRWDAKKGRWGLKLD.LD.QPS.S......RE.....ME......L...QDVKAGAYFKVTPSIRVGGAVSLG.ET..NPA..L......A.ARKAQQADPAPRVRLETAFKF
A0A6B3UFP6_9CAUL/57-132              .............LQWA-GGGRWALNLD.VD.QPS.T......RD.....VE......W...KDVEAGASIRITPSLRLGGSVGLG.AS..NED..P......-.RRVTPDEKPQPRVRLETTFRF
E8RNK2_ASTEC/50-126                  ............y-QWSV-KGRWGLKLD.LN.QDE.A......RP.....SG......W...NDVDAGAFYKISPSVRVGGTVGFG.EK..TKS..L......Q.PRDPAAEKDQPRVRLETTFKF
A0A3T0E607_9PROT/113-188             ............f-RFSA-GERWGISLG.IS.QRMrG......QA.....FE......L...QDVSAGAFYSLTDRVRIGGEFRFT.SP..EED..V......F.GEEADR--RTPQLRFESAFRF
A0A328AXM7_9CAUL/51-128              .............LKWDARKGRWGLTLN.MD.QPD.A......RP.....ST......W...NDVAAGAYYRITPSLQVGGAVALG.DQ..QLM..Q......G.PKKLTPDEGQPRVRLESSFKF
A0A7W9CGM4_9CAUL/57-133              .............LRWN-ENGRWGLNFN.AN.EPV.G......RD.....AD......W...GDVEAGAYYRLNPRLSVGAAAGLG.RV..EQD..P......A.RAPETERRAQPRIRLESIFKF
A0A328ARW9_9CAUL/36-113              .............VKWDARKGRWGLTLN.LD.QPD.A......RP.....SN......L...NDIQAGAYYRITPSLRVGGAVALG.DQ..QVG..P......G.PKKITPNEGQPRVRLESSFKF
D9QJU1_BRESC/55-131                  .............LRWN-SNGRWGLDFN.LN.QPV.G......RE.....TR......W...GDVEAGAYYRLSPSVRVGAAAGLA.PA..EQD..P......A.RAPETDRRAQPRVRLETLFRF
A0A062U071_9PROT/74-150              ........mqfgg------DKRLRFSLDkVS.RPG.L......TP.....LP......R...EEMQAGATFLITPRFSVGGEVSVG.AD..KLD..D......-.KSTWESREVEAGIRLKSAFKF
A0A0Q7ER24_9CAUL/56-133              ............l-RFT-ERGRWGLDLN.LS.QPV.G......RE.....SN......L...GDVEAGAYYRVNPRLRVGATAGLA.EP..DQD..P......AaPSSQNDRRAAPRFRLESIFRF
A0A059FMK1_9PROT/74-150              .........vqfg-----GNTRWQLNLDmLT.RPN.S......SP.....LP......R...EQMQAGATFRVTPRFSVGGEVSVG.AD..RLN..D......-.TSEWEDRQVETGIRLKSAFKF
A3UIE2_9PROT/110-187                 .......efhlqa------GDRWGVTLG.YV.APA.Rg....aQG.....VD......L...EDFSAGAFYEFSEHFRFGGEVRFT.SP..EEQ..V......F.GEDG--QDKAPEIRFESAFRF
A0A0Q7T483_9CAUL/54-130              ............l-RFT-ERGRWGLDLN.LS.QPE.T......RD.....RG......V...GDVEAGAYYRVNPRLRVGAAAGLA.ET..DTD..P......A.TGPQTERRSAPRFRLESIFRF
A0A328AJP1_9CAUL/44-121              ............v-NLDARRGRWGVTLN.MQ.QPD.T......RQ.....ST......L...NDVAAGAYFRITPSLRVGGAVALG.DQ..QLQ..P......G.ARTPTPDEGLPRVRLETKFKF
A0A257JTP7_9PROT/65-147              ..........vkv---D-PRSRWGMTFG.VQ.QDP.T......TA.....LTprngqnS...GRTLAGAFYQVSPKFRVGGEVVVP.NE..QLG..V......S.QSRERSQRREPGVKVESAFKF
A0A4Q5XZW9_9PROT/77-160              ............l-TWQ-PASKWGLTLD.LT.SRApN......EI.....FP......Q...EEVTAGVTYQVTPRFRFGGGVTVR.GD..SLA..QslsspnT.NFSNSKDGADATVRIESAFSF
A0A0Q7UAH1_9CAUL/61-138              .............LKWDDKKGKWGLKLD.LE.QPV.G......RE.....ME......A...KDVQAGAYYSVTPSIRVGGAVALG.DQ..NPA..L......A.ARRNEIQEPAPRVKLETAFKF
A0A1B1AID3_9PROT/61-144              ............p-AWTL-SQRWGVTVD.VR.EAQ.R......IE.....RApd.gghG...DQTSVGAYYQFTPNISVGGQFNLE.TT.pAPG..V.....aP.VARANEDEPRADVRIESAFRF
A0A2U2BWE9_9PROT/133-209             .......efeipa------GERWGFTLG.IS.EPTqG......PQ.....FE......I...EDMRAGAFFELNERLRLGGQFRFS.SP..ERD..F......F.GEQ--GDEQAPEIKFESAFRF
A0A0N1BRK8_9CAUL/55-131              .............LRWN-ENGRWGLDFN.LN.QPV.G......RE.....AE......W...GDVEAGAYYRLSPSLRVGAAAGLA.AP..EQD..P......A.RAAETNRRAQPRVRLESIFRF
A0A2S8W0Q1_9CAUL/53-131              .............LRWN-DSGRWGLNFN.LN.QPV.G......RE.....TD......W...GDVEAGAYYRLSPRLRVGAAANLA.SPeiDPA..R......A.PESAADRRAAPRVRLETIFKF
A0A1V1PL61_9PROT/1-73                mdvreaarierdp---------------.--.---.-......QG.....SR......G...DETSVGAFYQFTPAVRVGGQVSVEtAP..APG..Va....aP.ARRREEDGPAAGVRLESAFRF
Q0BWB8_HYPNA/74-150                  .........vqig-----KDSRWQLNLDkVT.RPG.E......TY.....LP......R...EEVQAGATFRITPRFSVGGEVRIG.AE..ELD..S......-.STRWENQEVEAGIRLKSAFKF
A0A1G4T0V4_9CAUL/46-126              ............y-QFNL-DGKWGVKFD.VN.QPE.S......SA.....PR......S...SDIDAGAFYRLTPSLRVGGTLGFG.EK..SDP..Mkp..epA.RSAAQGDKKQPRVRLETTFKF
A0A6I6MND7_9CAUL/58-140              ............p-AWTL-NQRWGVTLD.VR.EAE.R......IErlpevSR......G...DQASVGAYYQFTPSMRVGGQLSVE.TP..DTA..P.....iT.AQPQEHEEPNAGVRIESAFRF
A0A059FDB8_9PROT/74-152              ............m-QFS-GSDRWEFRIDkLS.RPS.A......NI.....SP......Lp.rQEMQAGATFKITPRFSVGGEVSVG.AD..DLN..-......A.VSTWEDRDVETGVRLKSAFKF
#=GC seq_cons                        ............h.pas.tpGRWGlsLs.ls.pPs.s......cp.....ss......h...sDVpAGAaY+loPplRVGGslulu.ss..p.s..s......s.tpptpsccstP+VRLESsF+F
//