#=GF ID   Orf78
#=GF AC   PF06024.16
#=GF DE   Orf78 (ac78)
#=GF PI   DUF912;
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_8809 (release 9.0)
#=GF GA   29.40 29.40;
#=GF TC   29.70 29.70;
#=GF NC   29.30 29.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   23698311
#=GF RT   The Autographa californica multiple nucleopolyhedrovirus Orf78
#=GF RT   is essential for budded virus production and general occlusion
#=GF RT   body formation.
#=GF RA   Tao XY, Choi JY, Kim WJ, Lee JH, Liu Q, Kim SE, An SB, Lee SH,
#=GF RA   Woo SD, Jin BR, Je YH;
#=GF RL   J Virol. 2013;87:8441-8450.
#=GF RN   [2]
#=GF RM   25087880
#=GF RT   Disruption of the baculovirus core gene ac78 results in
#=GF RT   decreased production of multiple nucleocapsid-enveloped
#=GF RT   occlusion-derived virions and the failure of primary infection
#=GF RT   in vivo.
#=GF RA   Li SN, Wang JY, Yuan MJ, Yang K;
#=GF RL   Virus Res. 2014;191:70-82.
#=GF DR   INTERPRO; IPR009261;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Family members include Autographa californica nuclear
#=GF CC   polyhedrosis virus (AcMNPV), AC78 or Orf78. AC78 is a late gene
#=GF CC   in the viral life cycle and encodes an envelope structural
#=GF CC   protein that plays an essential role in embedding the
#=GF CC   occlusion-derived virus (ODV) in the occlusion body [1].
#=GF CC   Although AC78 is not essential for budding virus formation or
#=GF CC   nucleocapsid assembly and ODV formation, number are
#=GF CC   significantly reduced if the gene is knocked-out [2].
#=GF SQ   16
#=GS A5IZU8_9BBAC/6-90         AC A5IZU8.1
#=GS A0A024WFD9_PLAFA/4-94     AC A0A024WFD9.1
#=GS A0A0M3WNH0_9ABAC/3-116    AC A0A0M3WNH0.1
#=GS A0A2H4UZU8_9ABAC/1-100    AC A0A2H4UZU8.1
#=GS Q0IL29_NPVLS/3-98         AC Q0IL29.1
#=GS AC78_NPVAC/3-104          AC Q06693.1
#=GS Q8B9H6_NPVR1/3-104        AC Q8B9H6.1
#=GS Q7TLS4_NPVCF/3-101        AC Q7TLS4.1
#=GS Q77K68_9ABAC/3-110        AC Q77K68.1
#=GS Q461Z4_9ABAC/3-123        AC Q461Z4.1
#=GS Q9J856_9ABAC/3-126        AC Q9J856.1
#=GS A0A346TQ24_9ABAC/3-119    AC A0A346TQ24.1
#=GS I3XMB3_NPVMB/42-149       AC I3XMB3.1
#=GS A0A836B0G5_9CHLO/400-479  AC A0A836B0G5.1
#=GS A0A183MAX1_9TREM/5-80     AC A0A183MAX1.1
#=GS A0A0E3Z7F1_9ABAC/3-133    AC A0A0E3Z7F1.1
A5IZU8_9BBAC/6-90                    ..............v-QVPFEKLSNTD.ALDAIPLKLAYTK...............----NDAP------QSFYANESSDSPNAD............................-------NNIWIVIICSITILALIIIISYYIITTLYDYYSV...E.-DE--feye......
A0A024WFD9_PLAFA/4-94                ............pdf------------.--QAIPLKAQ-EI...............VTQGTKAADAKTAEVSSRIAADITTKQTTa..........................iNSTYASYEITIIASIVAIVVIVLIMVIIYLILRYRRKTKMK...K.KLQ--yi........
A0A0M3WNH0_9ABAC/3-116               ...............FDIPYERFNNKN.KVEYIPLKLALND...............ENTDNEKGDQHSSSPSLSSTSLFNNGELQnqqmnv................gdhqynYFEKRMVDILMLSLLTFFCVLVLLYAVYYFVILRDRQDTLM...SvQPNF-f.........
A0A2H4UZU8_9ABAC/1-100               ...............MELPYERLSTNT.NIDHIPLKLAYLD...............AEPKSFYKNNVTDVDNSVDNSSEYP--YH............................VPYNPIFQYILIGIICIFIVAVFVFIIYYFLIRDRRGR---...-.-----drsrtrtnlf
Q0IL29_NPVLS/3-98                    ...............LDIPYDRLGTSD.KVDYIPMKLAVND...............AANNDKS-----KTNALITSDDQQQQQQD............................EQPALKMNCFLMAFVLIVLIVAILYILYYFFILRDRRYHRR...G.RSSY-r.........
AC78_NPVAC/3-104                     ...............LDVPYYRLGNHE.KVEYIPLKLALND...............--DTASEPQQFSEPVHKMPINDMVGYDNT............................TSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQQYSD...-.-----sidtdspfv.
Q8B9H6_NPVR1/3-104                   ...............LDVPYYRLGNHE.KVEYIPLKLALND...............--DIASEPQQFSEPVHKMPINDMVGYDNT............................TSNVSAGIIILISVVAFIALFLLLYVIYYFVILREQQQYSD...-.-----sidtdspfv.
Q7TLS4_NPVCF/3-101                   ...............LDVPYYRLGNHE.RVDYIPLKLALSD...............DAPAPSAHEAEP-----AAYKVAGEMDAP............................ANQMSAGLIVLISLIAFVALFLLLYVIYYFVILRDRPEYSNdidD.DPSF-v.........
Q77K68_9ABAC/3-110                   ...............LDIPYDRLGVND.KVDYIPLKLAISDf............nvDAADLSNNTDDSSTKSILGHNDLTSYRSNyq........................krNNSTWIGNILLISLLAVFCVMVLLYALYYFVILRERRKSIV...R.QPYYV..........
Q461Z4_9ABAC/3-123                   ...............LEVPYERMSLNQkKVEYIPLKLAVNDidengyrkpkqkandDSDDNDNIINKSQTSPSLLANDFGNTNYIay........................anATQGGILNVVLMALLSIFCVLVILYAIYYFVIIREREKRIV...K.PPYF-i.........
Q9J856_9ABAC/3-126                   ...............LDVPYERLGTAT.KVDYIPLKLALTDlpennisssssssvdDYDNNDKNKTLSTAKNQRPKVDIDLTDRNlqlr...................qpsadLSKQQFYNSLVLGLLTFFCVLVLLYAIFYFVILRDRQKSIV...-.KPSYM..........
A0A346TQ24_9ABAC/3-119               ...............LDVPYERLGTST.KVDYIPLKLALTDlpetngg.gggenegK----NNDATKNDQPKIDITDRAKSQQTTttt.....................ttsvQSKQQFYDALVLGLLTFFCILVLLYAIYYFVILRDRQKSTI...-.KPSYM..........
I3XMB3_NPVMB/42-149                  ...............LDIPYERLSPTL.TVKYIPLKLALNDi............pdTSNGETANNKNSNDSATAPKVNITVPEKRnyd......................tnvASPKQMYDVLVLGMLTVFCILVLLYAIYYFVILRDRQKPT-...-.-----epril.....
A0A836B0G5_9CHLO/400-479             lmaaaadgagagagq------------.-------------...............QQQQQQQQQQQQQQQQQQQQQQMQQQQQQ............................QQQQQQQPVVVVVVVVVVVVVVVVVVVVV------------...-.-----vmvmagr...
A0A183MAX1_9TREM/5-80                ......rehllesnv------------.-------------...............---------TKATNNNNNHSNYLQNDEIE............................FEMFHLTNNLLIILLSVLCIIIILLLLIYIVYRRLRHHQHH...H.DSQY-f.........
A0A0E3Z7F1_9ABAC/3-133               ...............LDIPYELLGANNqNVEYIPLKFALKD...............ENNRSNVQQAQN-KNNGNNNDGVYNYDADhvddvaaqaynffnkfqdnnvrnaanfvSRNDKSLNCIIVAMLSVFCAIVLLYAIYFFVILRDTKYNTF...N.R----qqtkff....
#=GC seq_cons                        ...............LDlPY-RLuspp.pV-YIPLKLAlsD...............ttstssttpppspsssthspsshss.pts............................tsptphhshlllullshhsllVLLYsIYYFVILR-Rpp.hh....................
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