#=GF ID   Orthopox_C10L
#=GF AC   PF07020.15
#=GF DE   Orthopoxvirus C10L protein
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_12732 (release 10.0)
#=GF GA   25.00 25.00;
#=GF TC   27.00 41.30;
#=GF NC   22.60 24.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   12084512
#=GF RT   The immunosuppressive activity of peptide fragments of vaccinia
#=GF RT   virus C10L protein and a hypothesis on the role of this protein
#=GF RT   in the viral invasion. 
#=GF RA   Kluczyk A, Siemion IZ, Szewczuk Z, Wieczorek Z; 
#=GF RL   Peptides 2002;23:823-834.
#=GF DR   INTERPRO; IPR009748;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Orthopoxvirus C10L proteins.
#=GF CC   C10L viral protein can play an important role in vaccinia virus
#=GF CC   evasion of the host immune system. It may consist in the
#=GF CC   blockade of IL-1 receptors by the C10L protein, a homologue of
#=GF CC   the IL-1 Ra [1]. 
#=GF SQ   8
#=GS Q6TVW4_ORFSA/1-79      AC Q6TVW4.1
#=GS V018_VACCW/1-60        AC P17356.1
#=GS A0A7H0DN00_MONPV/1-64  AC A0A7H0DN00.1
#=GS Q0NPJ2_9POXV/1-62      AC Q0NPJ2.1
#=GS A0A097IVK2_9POXV/1-37  AC A0A097IVK2.1
#=GS Q0GP71_HSPV/1-63       AC Q0GP71.1
#=GS Q9JFG9_VACCT/1-59      AC Q9JFG9.1
#=GS H6TAH5_9POXV/1-37      AC H6TAH5.1
Q6TVW4_ORFSA/1-79                 MPGEGQYHIYSHSGTSKGFASTPGGAVKRP---SSGSG-IWGPLEKRMCVGGGSGGFWGGSKSLSGGVNGGVNGGVNGGCGKI..
V018_VACCW/1-60                   MSSKGG----SSGGMWSVFIHGHDGSNKGSKTYTSGGGGMWGG---------------GSSSGVKS----GVNGGVKSGTGKI..
A0A7H0DN00_MONPV/1-64             MSSKGG----SSGGMWSVFIHGHDGSNKGSKTYTSSGSGMWGG---------------GSSSGVKSGVNGGVNGGVKSGTGKI..
Q0NPJ2_9POXV/1-62                 MSSNGG-----SDGMWSVFIHGHDGSNKGSKTYTSGGGGMWGG----------------SSSGVKSGVNGGVNGGVKSGTGKI..
A0A097IVK2_9POXV/1-37             MSSKGG----SSGGMWSVFIHGHDGTVKGSKTYTSLGGG--------------------------------------------gv
Q0GP71_HSPV/1-63                  MSSKGG-----SGGMWSVFIHGHDGSNKGSKTYTSGGGGMWGG---------------GSSSGVKSGVNGGINGGVKSGTGKI..
Q9JFG9_VACCT/1-59                 MSSKGG-----SGGMWSVFIHGHDGSNKGTKTYTSGGGGMWGG---------------GSSSGVKS----GVNGGVKSGTGKI..
H6TAH5_9POXV/1-37                 MSSKGG----SSGGMWSVFIHGHDGTVKGSKTYTSLGGG--------------------------------------------gv
#=GC seq_cons                     MSSKGG....SSGGMWSVFIHGHDGSNKGSKTYTSGGGGMWGG...............GSSSGVKS....GVNGGVKSGTGKI..
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