#=GF ID   P35
#=GF AC   PF02331.19
#=GF DE   Apoptosis preventing protein
#=GF AU   Mian N;0000-0003-4284-4749
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_13247 (release 5.2)
#=GF GA   20.80 20.80;
#=GF TC   20.90 20.90;
#=GF NC   20.30 20.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0672
#=GF RN   [1]
#=GF RM   10205157
#=GF RT   Crystal structure of baculovirus P35: role of a novel reactive
#=GF RT   site loop in apoptotic caspase inhibition. 
#=GF RA   Fisher AJ, Cruz Wd, Zoog SJ, Schneider CL, Friesen PD; 
#=GF RL   EMBO J 1999;18:2031-2039.
#=GF DR   INTERPRO; IPR003429;
#=GF DR   SCOP; 1p35; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This viral protein functions to block the host apoptotic
#=GF CC   response  caused by infection by the virus. The apoptosis
#=GF CC   preventing protein (or early 35kD protein, P35) acts by blocking
#=GF CC   caspase protease  activity.
#=GF SQ   7
#=GS Q0IL44_NPVLS/1-226        AC Q0IL44.1
#=GS A0A4S4MX46_9APHY/114-244  AC A0A4S4MX46.1
#=GS Q1A4T1_GVCF/4-210         AC Q1A4T1.1
#=GS Q8B9C7_NPVR1/1-296        AC Q8B9C7.1
#=GS A0A5A9N2L8_9TELE/317-463  AC A0A5A9N2L8.1
#=GS A0A3A9C296_9BACT/268-377  AC A0A3A9C296.1
#=GS P35_NPVAC/1-295           AC P08160.1
Q0IL44_NPVLS/1-226                   ............mcvtlstfhf-----------MDTILMDKpnIK.DANLRDLIYSNRL.VDGPT..NC..NVLFAFNLSGPLVAVNRTVFNtTLEMCRKKLDGAMEFYDCfSATDENRHNHkratE.TIgfeRYYEMDCYEVLC.LTHDDFKNNHEKYLRCVVGLERTVADAFKKECLDRLLNNN.DDddddggYqskpY.IVVCYARDAtAANIAQRSVSFVYKPEHGKVILPLMCVVHD------------------------------------------------------------------------------------------------------------gtrpnvigmnaivqgvr...............................................
A0A4S4MX46_9APHY/114-244             ................ttyeam--------IEGTVGVIVEC..LT.DNVTRTLHNIRDI.VTSRG..ARlaPVAFMFNRKGCVRVAVEKGED.FDSRLEQLIDSAFEAEAE.DFEQ------....-.--...------------.----------------------------------------.--......-....-.---------.------------------------------------------------------------------------------------------------------------------------------------------sdledsttaveveficpptvltkvtaavtasnlakellsseliyksa.................
Q1A4T1_GVCF/4-210                    ......................MCILMPG-FEAHQTVILDQ.pNLeNRNFRDIVYINNV.SHPDLvvNK..NAIMAFIVSGEVKQVKEVTTE.YAKFYKQKYDNVFSTMYE.NKC-MLDCSN....DiSA...DEFISNNYIVVA.FKLQYAEEKCVEYLNKWQ-CEEDEIVAFKNNCIPILMSEKlKS......A....Y.VVLCCLKPE.LLNEDCTV-CVTYEPVNNIVIIPLQHEISE--KYKYDVLAIVRGV---------------------------------------------------------------------------------------------gcyk............................................................
Q8B9C7_NPVR1/1-296                   ......................MCVIFPVEIDVSQTIIRDC..QV.DKQTRELVYINKI.MNTQL..TK..PVLMMFNISGPIRSVTRKNNN.LRDRIKSKIDEQFDQLER.DYSDQMDGLH....D.NI...KYFKDEYYSVSC.QKGSVLKSKFAKILKSHDYTDEKSIEAYEKYCLPKLVDER.KD......Y....Y.VAVCVLKPG.FENGSNQVLSFEYNPIGNKVIVPFAHEINDTGLYEYDVLAYVDNVQFDGEQFEEFVQSLILPSSFKNSEKVLYYNEASKNRSMIYKAVEFTTESNWSSRSEKYNWKIFCNGFIYDKKSKVLYTKLHNVTSALNKNVTL................................................................
A0A5A9N2L8_9TELE/317-463             ..sfqclskghlkvhvervhkk-------------------..--.-------------.-----..--..---------------------.------------------.----------....-.--...----IKQYCRFCkKKYSDVKNLLKHICESHDMTDEKVKESYDEYCLQTRAGKR.QL......L....YnCQICDRKF-.-K----------------------------------------------------------------------------------------------------------------------------------------nelerdrhmmvhgnkrpfgcelcdhgstkfqalqahirkhpfiyvcaicqqkfvssvrlrshlr
A0A3A9C296_9BACT/268-377             fkeesktsidsmgqevsnsqkh-------------------..--.------TALVNMVaLVTTV..VS..AVGMAVTVIGAFHDITITNTQ.RMDELRIEYESKYQALED.DYKDQVGMLQ....E.DI...RRLEDELSNLSE.QKGS------------------------------------.--......-....-.---------.------------------------------------------------------------------------------------------------------------------------------------------gedta...........................................................
P35_NPVAC/1-295                      ......................MCVIFPVEIDVSQTIIRDC..QV.DKQTRELVYINKI.MNTQL..TK..PVLMMFNISGPIRSVTRKNNN.LRDRIKSKVDEQFDQLER.DYSDQMDGFH....D.SI...KYFKDEHYSVSC.QNGSVLKSKFAKILKSHDYTDKKSIEAYEKYCLPKLVDER.ND......Y....Y.VAVCVLKPG.FENGSNQVLSFEYNPIGNKVIVPFAHEINDTGLYEYDVVAYVDSVQFDGEQFEEFVQSLILPSSFKNSEKVLYYNEASKNKSMIYKALEFTTESSWG-KSEKYNWKIFCNGFIYDKKSKVLYVKLHNVTSALNKNVIL................................................................
#=GC seq_cons                        ...................................sllh-p...h.st.hRplhhlNpl.hssph..sp..sVhhhFslpGsl+slscpspp.hhchh+pchDptapthtc.shpp..th.p....-.sh...c.h..c.Ypl.s..phs.hcp.h.chhpph..h-cp.h.uacp.Cl.hhhspp.p.......h....Y.h.lC.h+.............................................................................................................................................sp..............................................................
//