#=GF ID PAZ_3
#=GF AC PF18309.5
#=GF DE Argonaute PAZ domain
#=GF PI Ago_PAZ;
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE PDB:3dlb
#=GF GA 27.00 27.00;
#=GF TC 39.30 38.30;
#=GF NC 26.70 25.70;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0010
#=GF RN [1]
#=GF RM 18754009
#=GF RT Structure of the guide-strand-containing argonaute silencing
#=GF RT complex.
#=GF RA Wang Y, Sheng G, Juranek S, Tuschl T, Patel DJ;
#=GF RL Nature. 2008;456:209-213.
#=GF DR INTERPRO; IPR040895;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is a PAZ domain is found in argonaute present in Thermus
#=GF CC thermophiles. Argonaute has a central role in the RNA
#=GF CC interference pathway by mediating the maturation of small
#=GF CC interfering RNA (siRNA) through initial degradation of the
#=GF CC passenger strand, followed by guide-strand-mediated
#=GF CC sequence-specific cleavage of target mRNA. The
#=GF CC nucleic-acid-binding channel is thought to be positioned between
#=GF CC the PAZ and PIWI domain [1].
#=GF SQ 15
#=GS Q53W94_THET8/181-263 AC Q53W94.1
#=GS A0A0X8DAA3_9DEIN/181-263 AC A0A0X8DAA3.1
#=GS A0A2Z6E0R7_HYDTE/208-308 AC A0A2Z6E0R7.1
#=GS B1XJG0_SYNP2/54-141 AC B1XJG0.1
#=GS A0A2Z6E1D5_HYDTE/199-296 AC A0A2Z6E1D5.1
#=GS Q5P0R2_AROAE/174-273 AC Q5P0R2.1
#=GS A0A0H3K5Y6_SYNP6/185-276 AC A0A0H3K5Y6.1
#=GS A0A5A9W0K3_9GAMM/201-296 AC A0A5A9W0K3.1
#=GS Q8DKB1_THEVB/210-297 AC Q8DKB1.1
#=GS K9XZC6_STAC7/180-264 AC K9XZC6.1
#=GS A0A2T1EKT1_9CHRO/184-275 AC A0A2T1EKT1.1
#=GS Q2JI93_SYNJB/194-290 AC Q2JI93.1
#=GS A0A563W180_9CYAN/180-263 AC A0A563W180.1
#=GS A0A0F4NXW8_PSEO7/186-281 AC A0A0F4NXW8.1
#=GS E0UCX3_GLOV7/180-267 AC E0UCX3.1
Q53W94_THET8/181-263 AWL.aQGHP.-LP...-KRVRNAYD....-RR....TWELLRL..GEE.DPKELPLPG...-.GLSLLDYHAFKGR.L-..-QGRE...GGRVAWVAD.P....KDPRKPIPHLTGLLVP
A0A0X8DAA3_9DEIN/181-263 AWL.aQGHP.-LP...-KRVRNAYD....-RR....TWELLRL..GEE.DPKELPLPG...-.GLSLLDYHASKGR.L-..-QGRE...GGRVAWVAD.P....KDPRKPIPHLTGLLVP
A0A2Z6E0R7_HYDTE/208-308 DWV.iRRRPqWLEingIRRVKHRYElpgkGYL....TAEWLGVaeGMT.PMSTFHTAE...G.ETTYFDYHRKAGN.IP..KDEEE...LARKTWVVT.Vr..yDTRTPPRHHLASLLQP
B1XJG0_SYNP2/54-141 QWL..EWYP.DFS...AKILRNTYD....-GR....TWKLQKI..TNE.DPNNIDSGT...-.GQTLATYHKNHQKpAT..DQEIN...SSKVIYVKPyN....SKKEESYPHLSSRVKP
A0A2Z6E1D5_HYDTE/199-296 QWM.lAQRP.NWC...IEKLRHRYTtadgKIK....TCTFDGI..AETlTPQSTFCDNqsgK.TYSYLEYHRERGH.IK..EAELDaarCSQVVWVIY.P....--NGKRLAHLAQLLQP
Q5P0R2_AROAE/174-273 DWV.iRKRPeWME..gIRRVRHRYVs.ngQYG....TAELIGIatGRT.ALSTFPTPK...G.EVSLLGYHESKGN.LP..EGEREavaASHVVQVRYgR....DTRAKPMEHLAALLQP
A0A0H3K5Y6_SYNP6/185-276 QWL..EQYP.EIP...LSYVRNNYL....DERhgfiNWQYGRF..TQE.RPQDILLDC...L.GMSLAEYHLNKGA.T-..EEEVQ...QSYVVYVKPiS....WRKGKLTAHLSRRLSP
A0A5A9W0K3_9GAMM/201-296 DWV.iKKRPqWMK..dIQRVRHRYTdqgkAAA....VADLHGV..AEG.KTADSLVPG...T.VQSIYEYHKARGR.VP..PVESNsirNSQVVRVSY.G....--NKVQYEHLAGLLEP
Q8DKB1_THEVB/210-297 WWL..SEYP.NIQ...IKYVRNTYK....DKK....KWILENF..ADK.SPNEIQIEA...L.GISLAEYHRQEGA.T-..QQEID...ESRVVIVKKiS....DYKAKPVYHLSQRLSP
K9XZC6_STAC7/180-264 QWL..QTYP.DLS...INWVRNTYN....-DR....SWKFERI..SDE.NPETVMIPS...-.-GSLADYHRNLEN.NQakETEIS...NAKVVYVSS.K....--GNQEIPHLSTRLQP
A0A2T1EKT1_9CHRO/184-275 EWQ..DKYP.DIP...ISYVRNTYKdknnNYI....TWQYEDV..SEQ.TPEQILIEG...L.GITLAAYHRQIGA.S-..DAEIE...NSRVVYVKK.A...nDWKAQLTTHLSRRLSP
Q2JI93_SYNJB/194-290 EWL..ENYP.DVS...IEIVRNTYRtknnKYP....TWEYRGI.iSNQ.SPREVWLAE...L.NTSLADYHVQKYG.AT..PEEVD...GSLVVQVVS.RernfRQKAEPILHLSRRLSP
A0A563W180_9CYAN/180-263 EWN..QQYP.NIP...IKWVRNTYD....-DR....SWELVRI..SKE.KPEDLIIEN...L.GISLADYHRSKQA.T-..VAEIN...SARTIYVKK.R....--KGQEIPHISTRVRP
A0A0F4NXW8_PSEO7/186-281 QWVitQRNA.WLG..sLRRVRNRYKs..nDDM....TMSFDFV.aVEP.NLNAQSTPD...GmAMSLLEYHVSQGN.IN..KNELAaaeQSAVVKVRT.A....--KGQTLLHLAYLLEP
E0UCX3_GLOV7/180-267 KWL.nSGYK.NLP...IEYVRNTYD....-DQ....TWKYARV..SDE.KPETVMIPG...L.GMSLADYHRNHKK.YPatQEEIK...NSHVVYVKN.N....--NGQEIAHLSSRLRP
#=GC seq_cons pWl..ppaP.pls...IchVRNsYc....ttp....TWchtpl..u-p.sPpslhlss...h.uhSLh-YH+s+Gs.h...ppElc...sS+VVaVps.s......+up.lsHLoshLpP
//
