#=GF ID   PB2_cap-binding
#=GF AC   PF21490.1
#=GF DE   Polymerase basic protein 2, cap-binding domain
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   ECOD:EF15851
#=GF GA   27.00 27.00;
#=GF TC   32.10 151.10;
#=GF NC   26.00 23.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RC   Paper describing PDB structure 4che
#=GF RN   [1]
#=GF RM   24454773
#=GF RT   Comparative structural and functional analysis of orthomyxovirus
#=GF RT   polymerase cap-snatching domains.
#=GF RA   Guilligay D, Kadlec J, Crepin T, Lunardi T, Bouvier D, Kochs G,
#=GF RA   Ruigrok RW, Cusack S;
#=GF RL   PLoS One. 2014;9:e84973.
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   Polymerase basic protein 2 (PB2) is a subunit of the
#=GF CC   RNA-dependent RNA polymerase of Orthomyxovirus Influenza A virus
#=GF CC   (IAV) which performs transcription of viral mRNAs by
#=GF CC   cap-snatching, a processes that generated capped primers by host
#=GF CC   pre-mRNA binding, mediated by PB2 [1]. This protein has two
#=GF CC   domains, the cap-binding and the so-called '627-domain'. This
#=GF CC   entry represents the cap-binding domain and includes PB2 from
#=GF CC   Thogoto (THOV) virus, which is similar to IAV [1].
#=GF SQ   4
#=GS A0A140H4W6_9ORTO/321-439  AC A0A140H4W6.1
#=GS PB2_THOGV/327-447         AC Q9YNA4.1
#=GS A0A2Z6BEV9_9ORTO/321-439  AC A0A2Z6BEV9.1
#=GS X2CUE5_9ORTO/326-446      AC X2CUE5.1
A0A140H4W6_9ORTO/321-439             ...VNQIRETRFVIMNREAERINVECIKKF-GNIQYLHKYQRFEGPYKVFFHWRHVKGIIIGSDMKISKILLHAEQGDFLLPLVLDILYYTASLEPGFERSYDQFVE-KKNLFSHFFAHHTSNP
PB2_THOGV/327-447                    ...TMKIRSTKFSILNSDHPRIEVKKVFSLSPDVQVTIPYRRFKGKAKVYFQNDQIQGYFSCTDRQIDEIKISAPKNAPLLEPLLDICYYGSFIEPGFEQTFGFYPAGKREFVDSFFMHHSKDH
A0A2Z6BEV9_9ORTO/321-439             ..i-LQIRETKFVIMNREAVRVCCEVQKSF-GVLSYTHRYQHFEGPFKVYFTWRHTRGVITGEKRKILAIQLHAEEGDMVLPLLLDICYYCSALEPGFEQSYDQFVE-KQNLFKHFFMHHETNP
X2CUE5_9ORTO/326-446                 sil---IRNTKFVIMSSDLPRKETKKIFELSPEVKTIIPYSHFQGFARVYFQAGAVHGYFTSTDRALHEIHLTAPDNAPLMDIILDICYYGAYIEPGFEYTFGYFPSNKRDFFDNFFLHHSKDH
#=GC seq_cons                        .....pIRpTKFVIMNp-tsRlpscplhph.sslphhh.Yp+FcG.hKVYFphcpl+GhhouoDRpIpcIpLpA.css.LLsllLDICYYsuhlEPGFEpoas.Fsp.K+shFcpFFhHHops.
//