#=GF ID PLCC
#=GF AC PF14466.10
#=GF DE PLAT/LH2 and C2-like Ca2+-binding lipoprotein
#=GF PI DUF4425;
#=GF AU Godzik A;0000-0002-2425-852X
#=GF SE BVU_3708 from Bacteroides vulgatus, JCSG target GS13500
#=GF GA 27.00 27.00;
#=GF TC 30.90 228.80;
#=GF NC 25.80 24.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 23681886
#=GF RT Structural representative of the protein family PF14466 has a
#=GF RT new fold and establishes links with the C2 and PLAT domains from
#=GF RT the widely distant Pfams PF00168 and PF01477.
#=GF RA Serrano P, Geralt M, Mohanty B, Wuthrich K;
#=GF RL Protein Sci. 2013;22:1000-1007.
#=GF DR INTERPRO; IPR025219;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC A small family of bacterial proteins, found in several
#=GF CC Bacteroides species. Structure determination (NMR and Xray)
#=GF CC shows an immunoglobulin beta-barrel fold. Multiple homologues
#=GF CC have been found in human gut metagenomics data sets. Structural
#=GF CC experimentation shows it to share features with two
#=GF CC well-established protein architectures in the SCOP database, ie,
#=GF CC C2 (calcium/lipid-binding domain) of the Pfam PF00168 and
#=GF CC PLAT/LH2 (lipase/lipooxigenase domain) of the Pfam PF01477. The
#=GF CC C2 and PLAT/LH2 domains bind Ca2+ in their functions of
#=GF CC targeting proteins to cell-membranes; this domain is also shown
#=GF CC to bind Ca2+ as well as to be a novel fold [1].
#=GF SQ 3
#=GS A6L6K5_PHOV8/9-132 AC A6L6K5.1
#=GS I9SB55_9BACE/9-132 AC I9SB55.1
#=GS R5NTY5_9BACT/10-136 AC R5NTY5.1
A6L6K5_PHOV8/9-132 SVVLLLAGFIFVGC--DNERTENASDFQTGIHKIVIQQSGDTDSFEVSVSIGGADKGGPAKLYNDKGEYIGDSYS-AQIRTATMSCCTNGNAFFMTCAGSVSSISE-AGKRLHITVIGYIDDKEVNRL
I9SB55_9BACE/9-132 SVVLFLAGFIFIGC--DNERTENASDFQTGIHKIVIQQSGDTDSFEVSVSIGGADKGGPAKLYNDKGEYIGDSYS-AQIRTATMSCRTNGNTFFMTCAGSVSSISE-AGKRLHITVIGYIDDKEVNRL
R5NTY5_9BACT/10-136 SIMVLCLSLALVSCGDDDHKNDHHG-MRTGIHKIVVEQSGNTEDFEVNLVFGATNVNGPARLYDENGEYLGDSYSVGKMKSNRVSCQTGQDGFFMTCSGSTTSTSEESGKRLKVTIIAYVNGEETNRL
#=GC seq_cons SVVLLLAGFIFVGC..DNERTENASDFQTGIHKIVIQQSGDTDSFEVSVSIGGADKGGPAKLYNDKGEYIGDSYS.AQIRTATMSCpTNGNuFFMTCAGSVSSISE.AGKRLHITVIGYIDDKEVNRL
//
