#=GF ID   PM0188
#=GF AC   PF11477.12
#=GF DE   Sialyltransferase PMO188
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2c83
#=GF GA   25.00 25.00;
#=GF TC   25.00 28.80;
#=GF NC   23.90 24.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0113
#=GF RN   [1]
#=GF RM   18304450
#=GF RT   Structural analysis of sialyltransferase PM0188 from Pasteurella
#=GF RT   multocida complexed with donor analogue and acceptor sugar. 
#=GF RA   Kim DU, Yoo JH, Lee YJ, Kim KS, Cho HS; 
#=GF RL   BMB Rep. 2008;41:48-54.
#=GF DR   INTERPRO; IPR021574;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   PMO188 is a sialyltransferase from P.multocida. It transfers
#=GF CC   sialic acid from cytidine 5'-monophosphonuraminic acid to an
#=GF CC   acceptor sugar [1]. It has important catalytic residues such as
#=GF CC   Asp141, His311, Glu338, Ser355 and Ser356 [1].
#=GF SQ   20
#=GS A0A448QYN9_ACTEU/1-152   AC A0A448QYN9.1
#=GS A0A377I1L9_HAEPH/9-391   AC A0A377I1L9.1
#=GS A0A0U2L6Z3_9BACL/44-405  AC A0A0U2L6Z3.1
#=GS A0A448QYT2_ACTEU/1-58    AC A0A448QYT2.1
#=GS A0A0F5EVQ9_AVIPA/67-205  AC A0A0F5EVQ9.1
#=GS A0A4R6E6Q7_9ENTR/4-377   AC A0A4R6E6Q7.1
#=GS A0A3S4VRV6_ACTEU/1-58    AC A0A3S4VRV6.1
#=GS A0A1T0AV48_9PAST/7-385   AC A0A1T0AV48.1
#=GS M4R454_BIBTR/12-393      AC M4R454.1
#=GS J5L2V4_PASMD/1-324       AC J5L2V4.1
#=GS A0A3S4XZ65_ACTEU/10-66   AC A0A3S4XZ65.1
#=GS A0A0F5EUE5_AVIPA/1-347   AC A0A0F5EUE5.1
#=GS A0A4P7J2L7_9ENTR/4-369   AC A0A4P7J2L7.1
#=GS Q9CP67_PASMU/28-399      AC Q9CP67.1
#=GS Q7VPL1_HAEDU/7-388       AC Q7VPL1.1
#=GS A0A1I1D4F5_9SPIR/14-344  AC A0A1I1D4F5.1
#=GS D0YWU3_PHODD/114-490     AC D0YWU3.1
#=GS A0A1V3TSQ6_9PAST/9-392   AC A0A1V3TSQ6.1
#=GS A0A3N4VZ51_9PAST/9-392   AC A0A3N4VZ51.1
#=GS A0A257CGA0_9BURK/6-353   AC A0A257CGA0.1
A0A448QYN9_ACTEU/1-152              ........................................................................................................m--------------------------.--------------------------------..----------------...------------------------FLNLSPTYTKYKD..KVSKVVLHLYDDGSEGVMSQYQLQ..QS...N.SLA..QDLASTKASLV..SLFE....I.GEGS.FTH......ID.L..IRYVWNAVFETHYYLLS.DHFLV.HEK.LQPLKA..ELG....NYQLLNFAA.YRNLSGEDLLWLKQILKID.VE..LEALM.QK...LTAQPVY----------------------.------------...-------...---------.-------------.-..-......-----------------------------------....-----------.-------.----.------------------fsav.................
A0A377I1L9_HAEPH/9-391              .........................................................................................................VEVYLDYATIPTLNYFYHFTENKDDI.ETIRLFGLGRFNISKSIIESYPEGIIRYCSII..S-EDQTAFQQLFITLL..tEDSFFQYRFNFHINLFHSWKMLIPLLH---IIGQFKN..KVLDIKLNFYDDGSEGLVMLSKIE..QN...-.-YS..TEILQKIIDID.sQSFY....A.EKLS.FLD......AD.I..ARYLWNSLFESHYYLLN.DFLLK.NEK.LSLLKN..SIK....YCHIMELER.YLQFTQEEKDFFNELLGISiQS..LEDKI.KI...FQQEKTFIFTGTTIFDLPKEEEEALYHLH.LNAILNYIHPNG...KYFIGDG...FTLIIKGHP.HQKEMNLRLEKSF.E..K......AVMLPDNIPFEILYLIGFKPDKIGGFVSTSYFSCD....KKNIADLLFIS.ATQEEVRkNDYL.FNIQYQLRDMMIKTGFI-q....................
A0A0U2L6Z3_9BACL/44-405             diyatlgtlptlyaglnafhsdhesymwfhrkatfnpsalpenvnliafehtynrtvmdeligkvadiyfenpnaqfnfyvddlrvqfilqmfvanglpesqykv--------------------------.--------------------------------..----------------...-------------------------------------..-------YLLSDGTGSYSIFKSLF..EQ...E.NSF..VNWETYKNEYEnrKMLIqageT.DVIN.TDN......NTeLhkSMYFVSQQPNTQYWMQF.PELLS.SND.PQVAEEikKMN....VVKKMPYDM.FASLSDEKKKEFAKAVGIDkDK..FDRLF.HS...--DKPSLIISGTSLA-GEQNGFEKVVKQI.V-----------...RDF-GDT...YKLFFKPHP.AFDPVSHSELIKL.KrkEfldslgITLLPAQLPMEALMW-AYPEVKIGGYSSTLYMSTA....KEQTVFFIANS.P------.----.------------------edltaplndlyqmg.......
A0A448QYT2_ACTEU/1-58               ........................................................................................................m--------------------------.--------------------------------..----------------...-------------------------------------..------------------------..--...-.---..-----------..----....-.----.---......--.-..-----------------.-----.---.------..---....---------.-------------------.--..-----.--...-------------------------ADIH.AILIREHLDPNS...QLFIGKP...YLFVFKGHP.NSPEINQALREYY.S..D......VIF--------------------------------....-----------.-------.----.------------------yltifrl..............
A0A0F5EVQ9_AVIPA/67-205             ...........................................................................................rliykvirkfkflr--------------------------.--------------------------------..----------------...-------------------------------------..------------------------..--...-.---..-----------..----....-.KYFH.FT-......-Y.L..NKYTWHTLFPTKYIVLC.PEYFE.TDKkMSYINK..ELE...kHFTKMNFQQ.FHTLTSENKSLFLHFINIDsQQ..LHTLA.RT...LKQKNTLILTGTTTWK---DERLEFAKLQ.ANLLKDLID---...-------...---------.-------------.-..-......-----------------------------------....-----------.-------.----.------------------tnfknyhi.............
A0A4R6E6Q7_9ENTR/4-377              .........................................................................................................LKVYLSSVSVPVIPQMIDFAKCGNDK.NVVKVIGWYRNEISEQKLKGT---QAKYYRQI..SRISPEFVTYILKLIG...EFKPDK--ISLHVNIYWCLVELFPLVS-YVARLVPRD..---KIHIHVYDDGSAGVVERNAMH..QL...S.EVDflHQKRNCTKKLM..GLLR....E.NVRP.FDHgdrsqwPA.M..MNYTWHEFFNTTYHLIN.EFELR.CHD.NSPLFN..YLA...sNMVSLNNNN.FYTLTKPQQAFCLSLLNVD.TAllLEVAA.KI...-MRPNSLLYLGSGRFGKSED--DTLTEQQ.IIKIRA---LKS...QGVIKDN...DQIIFKAHPiNHKENREKIKDELgP..N......TYMIPNALPFEALQLAGIPLCEIISTFTTLIYTLP....KAQFRHVIGEG.-------.----.------------------dtrsevlnkpviqqliennq.
A0A3S4VRV6_ACTEU/1-58               .........................................................................................................--------------------------.--------------------------------..----------------...-------------------------------------..------------------------..--...-.---..-----------..----....-.----.---......--.-..-----------------.-----.---.------..---....---------.-------------------.--..-----.--...-----------------------------.------------...-------...---------.-------------.-..-......------------------MPEKIGGFASTLHVNSE....KRKLANLFFLT.SAEEQER.NRSDgYIKQYALAQTMIEMQLV-s....................
A0A1T0AV48_9PAST/7-385              .........................................................................................................VEIYLDYATIPSLNYFLHFAENYQDT.TTIRLFGLGRFTIPQTIIDRYPAGIIRFCEAKagDQTQFEQLFTEL---L...EQSTQPLNLCFHLNLFHSQQM---FLPLHHLIQGYRT..KIANVSLHFYDDGAEGVAKLNDLS..EK...P.K--..----YLADQLA..QQQL....KgQNII.ISD......YS.I..FRYQWGMIYPTTYHLLN.TDILT.QNA.LLPLKE..YLK....NHSLIDFSR.FQKLSKLQQDIILEIIGLIrEN..VEKLI.KA...SYQYAFFIFIGSAIFDDDKQRLIEFERLH.FNLLEQYLFPTG...KFYIGQE...YVACYKGHP.HSSQINEKIKEHY.Q.gK......LIYLPDNIPLEVLLLLGLDVKLIGGFASTIHFQFS....SEKIADLIFMTtNNYQLNK.TNDL.YQTQLNFLNVMIKLGY--ti...................
M4R454_BIBTR/12-393                 .........................................................................................................ICVYLDYATIPSLNYILHFAQHFEDQ.ETIRLFGLSRFHIPESVIQRYPKGVVQFYPNQ..E-KDFSALLLALKNILievKQQQRKCEIELHLNLFHYQLLLLPFLSLYLDTQDYCH..----LTLKFYDDGSEAISALQELA..LA...P.DLA..AQIQFEKQQFD..ELVV....K.KSFK.LS-......-L.L..SRYFWGKLFESEYIWFN.QAILQ.KAE.LQILKQ..EIS....SSRQMDFAI.YQQMSDEQKQLVLEILNIDlNK..VAYLK.QL...MENQPSFLFLGTTLFNITQETKTWLMQMH.VDLIQQYCLPSG...QFF--NNkagYLCFYKGHP.NEKEMNQMILSQF.K..N......LIALPDDIPLEILLLLGVIPSKVGGFASSALFNFT....PAQIENIIFFT.PRYFE-K.DNRL.HATQYRLMQGLIELGYLD.....................
J5L2V4_PASMD/1-324                  .........................................................................................................-----------------------EDK.THPRIFGLSRFKIPDNIITQY--QNIHFVELK..DNRPTEALFTIL----...DQYPGNIELDIHLNIAHSVQLIRPILA-----YRFKHldRVSIQQLNLYDDCSMEYVDLEK-E..EN...K.DIS..AEIKQAEKQLS..HYLL....T.GKIK.FDN......PT.I..ARYVWQSAFPVKYHFLS.TDYFE.KAEfLQPLKE..YLA....EIIKMDWTA.YQQLTPEQQAFYLTLVGFN.DE..VKQSL.EV...--QQAKFIFTGTTTWEGNTDVREYYAQQQ.LNLLNHFTQAEG...DFFIGDH...YKIYFKGHP.RGGEINDYILNNA.K..N......ITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLP....KEKLAILF---.-------.----.------------------shrin................
A0A3S4XZ65_ACTEU/10-66              .........................................................................................................IDIYIDFATVPSLSYFLHFLKHKHDH.QRLRLFSLARFEIPETIIERYEEGIIQFL---..----------------...-------------------------------------..------------------------..--...-.---..-----------..----....-.----.---......--.-..-----------------.-----.---.------..---....---------.-------------------.--..-----.--...-----------------------------.------------...-------...---------.-------------.-..-......-----------------------------------....-----------.-------.----.------------------vm...................
A0A0F5EUE5_AVIPA/1-347              .........................................................................................................--------------------------.---------RFDFNKEILNSFSKERIEFSKVSilDIKEFS---DKLYLNI...EKSDTPVDLIIHTNLDHSVRS---LLSIFKTLSPLFH..KINIEKLYLYDDGSGNYVDLYQ-H..RQ...E.NIS..AILIEAQKKLK..DALE....N.RETD.ADK.....lHS.L..TRYTWHKIFPTEYILLR.PDYLD.IDEkMQPLKH..FLS...dTIVSMDLSR.FSHFSKKQKELFLKITHFD.QN..IFNEL.NIgtkNKEYKTFIFTGTTTWEKDKKKRLNNAKLQ.TEILESFIKPNG...KFYLGND...IKIFFKGHP.KGDDINDYIINKT.-..G......AEKVPANIPFEVLMMTNSLPDYVGGIMSTVYFSLP....PKNIDKVIFLG.SEKIKNE.NDAK.SQTLSKLMLML-------nvit.................
A0A4P7J2L7_9ENTR/4-369              ........................................................................................................v-KLYIEPASLPLTQQLLNYIRSYEDD.SVINIVAFQRLKLNMDYINKK---NTAFIDNI..N-IGLSEKLIKIAEFI...NG-VKPLLIEIHTNIHRERDILFPLMKLLAVSFSLVD..----IKLHLYDDGSGSLIERAAIEslDS...R.ELD..RLMLKRREQLL..GVLT....R.GSKKeYEW......NV.V..DNYIWHYILDVTYYFIP.PRL-R.IST.NEFYKK..LEQ....HVIYSNFNI.QEQYSVKEKALLLKLVSFP.VE..LYKKL.EK...IKKEPDVLLFIT-SYCPDPLKVLTYHQRL.ITLISIL-KSSG...K--IPDS...SKVIFKGHP.ENRKLNHEICLAIgS..D......VIRVPDEIPVEFLSSFDLLPRKIGGEFSSTFFCME....DINAEFIILKG.EESDK--.----.------------------aneifcniankykaf......
Q9CP67_PASMU/28-399                 .........................................................................................................ITLYLDPASLPALNQLMDFTQNNEDK.THPRIFGLSRFKIPDNIITQY--QNIHFVELK..DNRPTEALFTIL----...DQYPGNIELDIHLNIAHSVQLIRPILA-----YRFKHldRVSIQRLNLYDDGSMEYVDLEK-E..EN...K.DIS..AEIKQAEKQLS..HYLL....T.GKIK.FDN......PT.I..ARYVWQSAFPVKYHFLS.TDYFE.KAEfLQPLKE..YLA...eNYQKMDWTA.YQQLTPEQQAFYLTLVGFN.DE..VKQSL.EV...--QQAKFIFTGTTTWEGNTDVREYYAQQQ.LNLLNHFTQAGG...DLFIGDH...YKIYFKGHP.RGGEINDYILNNA.K..N......ITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLP....KEKISHIIFTS.NKQVKSK.EDAL.NNPYVKVMRRL---GII-d....................
Q7VPL1_HAEDU/7-388                  .........................................................................................................LEIYLDYATIPSLACFMHFIQHKDDV.DSIRLFGLARFDIPQSIIDRYPANHL-FYHNI..DNRDLTAVLNQLADIL...AQENKRFQINLHLNLFHSIDL---FFAIYPIYQQYQH..KISTIQLQLYDDGSEGIVTQHSLC..KI...A.DLE..QLILQHKNVLL..ELLT....K.GTAN.VPN......PT.L..LRYLWNNIIDSQFHLIS.DHFLQ.HPK.LQPLKR..LLK....RYTILDFTC.YPRFNAEQKQLLKEILHIS.NE..LENLL.KL...LKQHNTFLFTGTTAFNLDQEKLDLLTQLH.ILLLNEHQNPHS...THYIGNN...YLLLIKGHA.NSPALNHTLALHF.P..D......AIFLPANIPFEIFAMLGFTPNKMGGFASTSYINYP....TENINHLFFLT.SDQPSIR.TKWLdYEKQFGLMYSLLAMQKIN.....................
A0A1I1D4F5_9SPIR/14-344             ......................................................................................lkliytprftnnfnaidni--------------------------.-----------------------------RKH..D--NIDSLLLNIKQIL...KKYP-SVKIELHTQI-HPFKMYSDVLRA-IPTNRLFH..------VYVYDDGSEDYVNFYI-N..KK...T.GRQ..KEVLKASDEAW..QKFF....S.GESN.LI-......--.G..HRNMIAKYLPVTHYMLR.PDYLD.HSD.MKIVKD..AMTqnnaQIKKIDFDNlRMQLSELEKKRYFKYIGFNyKK..IKKIL.CQ...-SSNFSFVFTGSAVYDDPQRAQKF-VEEQ.INMIKNVIQPEGilhKYLNGKT...YDFFLKLHP.HGGDSNKKTKNAF.P..D......FPNIPNFIGYEALIVSGLIPDRTGGFLSSLYFNLP....KEKIAFLVA--.-------.----.------------------svdktewddplvqvmielgii
D0YWU3_PHODD/114-490                .........................................................................................................LEVYIDHASLPSLQQLIHIIQAKDEYpSNQRFVSWKRVTVDADNANKL---NIHTYPLK..GNNTSPEMVAAI-DEY...AQSKNRLNIEFYTNTAHVFNNLPPIIQ--PLYNNE--..KVKISHISLYDDGSSEYVSLYQWK..DT...P.NKI..ETLEGEVSLLA..NYLA....G.TSPD.APK......GM.G..NRYNWHKLYDTDYYFLR.EDYLDvEAN.LHDLRD..YLG...sSAKQMPWDE.FAKLSDSQQTLFLDIVGFD.KE..QLQQQ.YS...QSPLPNFIFTGTTTWAG-GETKEYYAQQQ.VNVINNAINETS...PYYLGKD...YDLFFKGHP.AGGVINDIILGSF.P..D......MINIPAKISFEVLMMTDMLPDTVAGIASSLYFTIP....ADKVNFIVFTS.SDTITDR.EEAL.KSPLVQVMLTL-------givke................
A0A1V3TSQ6_9PAST/9-392              .........................................................................................................IEVFLDYATLPSLNYLINFASHKEDR.ETIRLFGLARFNISDEIIDSYPQGKLHFVPVN..V-SKLEDFKSKFKQILe.dNIPHKKVKLNFHFNLFHSLEMLTNMLG---VLTNYLS..DIVEVKLNFYDDGSEGIVSLYKLA..NTiskD.ELI..YHIEHQKEQIN..QFLS....S.GKLE.FSN......SI.V..LRYLWGNLFSSHYHLIR.SDYIK.EEK.LAPLQN..AIS....SYQELEIDS.FQRLSNEAKHFMFQLLQLDfNE..ISPLL.SN...--KGKSFLFLGTTVNTDNLEITNFANKLH.LDYLQQFISPDG...KFYIGEY...DNIYFKAHP.NSKQVNKLISDNF.K..N......IVILPNNIPMEILLFLGLNITMIGGFSSTLFFYLH....PENIHHVIFMT.EDKNKDK.AYSL.-EIHYWLKQSLIGLGNIN.....................
A0A3N4VZ51_9PAST/9-392              .........................................................................................................VEVYLDYATIPSLNYFLHFVKNKDDM.ETIRLFGLSRFTIPDSIVNAYPEGIIQYYPVK..T-GDQDKFNQAFACLI...SESSTKLKFNIHLNLFHSLMMFVPLLQ---ICNQYSD..KVEEIKLNFYDDGAEGISYLYSLS..KM...DiDLI..KEVDFHYSILS..KLNE....T.REIK.FNF......LN.I..LRYLWNANFSSHYYLMQ.SNYLD.IAQ.LSPLKE..KLN...gSYSEMDLTR.YSSLSVEQWQMILAILNLPlDL..VNSYI.KL...SSEYKVFVFTGTTIFDGNET---VLEKLH.IKLLLQYLDPKS...KYYIGDN...YLIFYKGHP.NSPEINKKVDDIF.K..S......VIRLPDNIPLEILFLLGFKAKKLGGFASSLYLSLDlkkrEAEIESLAFLT.SNEDK-T.KHSL.FETQYNLAQLMIDLGYV-t....................
A0A257CGA0_9BURK/6-353              .........................................................................................................LKLYIDSTSLPLVHQMADFVRCADDP.GITKLITWLRLPLSEAQLAGT--GAL-YLPQM..A-AISSAFVGQVCNLV...KQGHR--DIEIHSNQFHAWRGVAPLLQALAPVLRSG-..-AVRVRLHLYDDGSVGPLQRDELA..RW...P.DLS..SALAVAARELE..AHLF....S.RQ-P.LSW......TL.P..HSHAWPLVLPTTFHWLHpKALLR.TPE.GAALCA..LLD...qHIQPMVFDG.LPDLTQAQSDHYLALFGLT.PE..VADTLvPL...AGAADAVLFTGTGAWDKAWNLRLRDSQLRaIATLHQHHCFDG...L------...RAIGYKGHP.ANCDHDAAIQAALgD..D......VIALPQRVPLEVLLMAGLLPQRVAGVLSTFHLTMP....AAMIDAVL---.-------.----.------------------cqagp................
#=GC seq_cons                       ..........................................................................................................plalp.solP.h..hhphhpt.pD..p..+lhuh.Rhplspphlpth....ltah.....s....pth...h...h...pt..t.hplphHhNlhHsh.....hlt....h.phhp.......pLphYDDGStshsph.php..pt.....ph...ttl.tttppl...phhh....p.tphp.hs..........l..hRYhWpphasopYahlp.schLc.psc.hpsL+p..hls....php.hsast.atpLotcppphhhpllshs.pp..lpphh.ph.....ptssalFhGTshap.stphh.hhsp.p.lphlpphhpspu...phalGpp...hhlhaKGHP.pstphNchlhtth....s......hhhlPspIshEhLhhhuhhspclGGhhSohahshs....ttplt.llh.s................................s....................
//