#=GF ID   PMT2_N
#=GF AC   PF17987.5
#=GF DE   Phosphoethanolamine N-methyltransferase 2 N-terminal
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF04710
#=GF GA   27.80 27.80;
#=GF TC   30.30 35.00;
#=GF NC   27.70 25.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0123
#=GF RN   [1]
#=GF RM   24012478
#=GF RT   Evolution of structure and mechanistic divergence in di-domain
#=GF RT   methyltransferases from nematode phosphocholine biosynthesis.
#=GF RA   Lee SG, Jez JM;
#=GF RL   Structure. 2013;21:1778-1787.
#=GF DR   INTERPRO; IPR040516;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is the N-terminal vestigial domain found in Haemonchus
#=GF CC   contortus phosphoethanolamine N-methyltransferases 2 (PMT2).
#=GF CC   Structural analysis reveal changes leading to loss of function
#=GF CC   in the vestigial domains of the nematode PMT [1].
#=GF SQ   35
#=GS A0A0N4Y1K7_NIPBR/38-162   AC A0A0N4Y1K7.1
#=GS A0A7I8XF53_BURXY/120-235  AC A0A7I8XF53.1
#=GS E3LJV5_CAERE/42-168       AC E3LJV5.1
#=GS A0A3P7LB27_STRVU/40-163   AC A0A3P7LB27.1
#=GS A0A090MSA5_STRRB/54-175   AC A0A090MSA5.1
#=GS A0A016UKM5_9BILA/350-474  AC A0A016UKM5.1
#=GS A0A6V7U890_9BILA/59-192   AC A0A6V7U890.1
#=GS A0A0M3J7Q1_ANISI/16-140   AC A0A0M3J7Q1.1
#=GS A0A8R1HK44_CAEJA/80-205   AC A0A8R1HK44.1
#=GS A0A3P8ASA9_HAEPC/2-100    AC A0A3P8ASA9.1
#=GS A0A6G0UPB0_9BILA/34-154   AC A0A6G0UPB0.1
#=GS W2TML1_NECAM/41-165       AC W2TML1.1
#=GS G0MTV2_CAEBE/43-169       AC G0MTV2.1
#=GS A0A0C2CGJ5_9BILA/41-152   AC A0A0C2CGJ5.1
#=GS A0A4U5LNN9_STECR/43-173   AC A0A4U5LNN9.1
#=GS A0A0N4Y1K8_NIPBR/38-162   AC A0A0N4Y1K8.1
#=GS A0A8R1UAV5_PRIPA/34-165   AC A0A8R1UAV5.1
#=GS A0A6V7X6N3_9BILA/55-192   AC A0A6V7X6N3.1
#=GS A0A0K0EPS3_STRER/54-183   AC A0A0K0EPS3.1
#=GS A0A0K0FFV2_STRVS/54-183   AC A0A0K0FFV2.1
#=GS A0A090L2P8_STRRB/54-183   AC A0A090L2P8.1
#=GS A0A2G5T7M5_9PELO/44-169   AC A0A2G5T7M5.1
#=GS A0A7E4VHQ1_PANRE/96-220   AC A0A7E4VHQ1.1
#=GS A0A2G9U3C8_TELCI/41-120   AC A0A2G9U3C8.1
#=GS A0A2G9U1L7_TELCI/41-142   AC A0A2G9U1L7.1
#=GS A0A2A2KMM4_9BILA/41-167   AC A0A2A2KMM4.1
#=GS A0A368H9X1_ANCCA/41-165   AC A0A368H9X1.1
#=GS A0A016UML8_9BILA/41-165   AC A0A016UML8.1
#=GS A0A0K0FV17_STRVS/54-175   AC A0A0K0FV17.1
#=GS A0A261CDI6_9PELO/42-168   AC A0A261CDI6.1
#=GS PMT2_CAEEL/44-169         AC Q22993.1
#=GS A0A811L638_9BILA/38-153   AC A0A811L638.1
#=GS A0A6V7UGQ3_9BILA/55-192   AC A0A6V7UGQ3.1
#=GS A0A0N4U4I0_DRAME/41-159   AC A0A0N4U4I0.1
#=GS A8X7D2_CAEBR/44-169       AC A8X7D2.1
A0A0N4Y1K7_NIPBR/38-162              ..........................................FGSSASITFVSSVEWL..EEF.....KELDVLIVNEALEKE..MHDSRA....LDKFVASALHTLRMGGVLIVRQDLSKLNDPK.KVAMMTDYLDVF..RV...EEN....GEN.VGFSFYAVNEVEDSVYAHQNWQDFIWTLSKKSFP...............
A0A7I8XF53_BURXY/120-235             ..................................eeanaqgt-----------TIEAL..DKVe...sGSKDIVIINR-LSAG..EKNQPN....LDKIMKNTLRILKNEGVAVAYEDFDEITHS-.EVASLSTLFDTF..EN...KEG....ENT.SSFKLLAMNQTSEE--------------------ttegvywimikhta.
E3LJV5_CAERE/42-168                  .......................................fep--LSSNVTVHNSLEQL..STI.....RNADVLIFNNALSKI..VNNADL....LTDFLKNATNASAIGGIVIIREDLKNVADKR.QVARLTDYFDVF..RT..nDSD....GNN.TGLDLYTVDQIENSTYVEQNFLDFIFVFRKKVFA...............
A0A3P7LB27_STRVU/40-163              .....................................fglna-----TIS-IRGTDKI..DEF.....FGLDALVVNQALDKE..LHDSNV....LDKFITDALRALRPGGVCVIRQDLQGLGDAK.KVAKLTDYLDVF..RS...EQN....GEN.FGFSFYAVNGVEESIYAHQNWQDFIWTLVKKQFP...............
A0A090MSA5_STRRB/54-175              .........................................v-AKNSEIEYTRDINSLfnKKY.....SDKDLIILCDIITNN..YSNEKNf..nCEELFDATISCLKENGYIIIKENLRRHEGP-.LLTRINKFL---..--...---....QES.YLIKFYEMNQIKYSIYMEGNFLDIYWILRRE---dktft..........
A0A016UKM5_9BILA/350-474             .........................................f-GLGASVTLETGTKSI..EEL.....TELDVLVVNQALDKE..LHDSSA....LDRFVSNALKSLRPGGACIIRQDLTSLNDPK.KVAKLTDYLDVF..RT...EEH....GEN.FGFAFYAVNGVEDSIYAKQNWQDYIWTLVKKSFP...............
A0A6V7U890_9BILA/59-192              ....gelmniserldkedndneeenletrfdaaicsnlfigq----------------..---.....-------------GI..VNDRHR....IAQVLGLLLRLIRTDGVVIIRENLKQWG-SR.SIADLTKFLDVFafRK...QQNnqkqQQT.LGFNFYGMSQVQYSIYAHSNFLDVFWSLT-----tai............
A0A0M3J7Q1_ANISI/16-140              .........................nglkglcesasrgmnvf----------------..---.....---DAVIISKLIIEDhlIDKPSE....LDSLAKSILKVLKNDGVAIIREDLDGYRATE.KVCQFTSFFDLF..SDrldDST....CDV.AGFDFYSLKQLNATIHTTRNFFDFLWVLKKKQH-s..............
A0A8R1HK44_CAEJA/80-205              .......................................evl---PVKTQVHNSLEQL..PQI.....RNADVLIFNNALSHI..LNNADL....LTDFLTRATAATSVGGIVIIREDLKNATDKR.QVARLTDYFDVF..RT..tDSN....GNN.AGLDLYTVDQVQNSAFVEQNFLDFIFVFTKKAFA...............
A0A3P8ASA9_HAEPC/2-100               ....................................crntti----------------..---.....-------------QE..INDSEK....LDKFITGALRSLKTDGVLIIRQDLSKVKEMK.KMAMLTDYFDVF..RL...EEG....NGN.VGFQFYAVNEVLDSVYVHQNWLDFIWTLIKKPFP...............
A0A6G0UPB0_9BILA/34-154              .............................fthggplslnaqa----------------..---.....ETYDAIVLSNVLDDWnlIKRKHH....LGDLLKNVLTALKKNGTLVIRENMANHPIS-.TIPELTKFFDVF..IA..qDAS....GNA.LTFDFYTMLQVEDSLYSKNNHLDVYWILTR----asnv...........
W2TML1_NECAM/41-165                  ..........................................FGESTTVNSIKGTNSI..ETF.....VDLDVLVVNQALDKE..LQDSSA....LDKFVSNALQSLRLGGACVIRQDLTALNDPK.KVAKLTDYLDVF..RI...DEG....GEK.FGFSFYAVNEVEDSIYAHQNWQDYIWTLTKKQFP...............
G0MTV2_CAEBE/43-169                  ......................................feel---SANVKLNSSLEQL..SNT.....RNTDVLIFNNALSQI..LNNADL....LTDFLKNATNAASIGGLVIIREDLKNATDKR.QVARLTDYFDVF..RT..tDSD....GNN.TGLDLYTVDQVNNSAYVEQNFLDFIFVFRKKVFA...............
A0A0C2CGJ5_9BILA/41-152              ..........................................FGQAATVTLTTGTSSI..ERL.....AELDVLVVNQALDKE..LHDSNA....LDRFVSHALKSLRLGGACIIRQDLTSLNDPK.KVAKLTDYLDVF..RA...EEH....GEN.FGFSFYAVNGVEDSIYI-----------------frrl...........
A0A4U5LNN9_STECR/43-173              .....................................fngga-----DVDVVRHLSGI..SELaykqhSFYDALVVNKLLVTDqiVNEPQK....LDVLVSAALKVLKINGVFVIREDLSSFDAQ-.KIAQLTAYFDVY..RA...NED....GKS.IGFDFYAMNQVKAAIFAHQNFLDTYWVFTKKVFP...............
A0A0N4Y1K8_NIPBR/38-162              .........................................f-GPSASVTYVDNLESL..EKF.....SELDVLVVNEALEKE..LSDSDA....LDKFIASALHTLRMGGVLIIRQDLSKLNDPK.KVAMLTDYLDVF..RV...DEN....GEN.VGLSFYAVNEVEDSLYAHQNWQDFIWTLSKKSFP...............
A0A8R1UAV5_PRIPA/34-165              ........................................fs--GLLSSSTHSEVTSL..DSV.....SNADLIVVDKVLVSDglVTKDGLqggpLDSFLLSALTALNTGGVLVVREDLSQHANPRvTLPSLTDYVDVF..RR...DIS....GKY.VGFDFYCAEQLDSSIHLTGNYLDFVWILRKKEFT...............
A0A6V7X6N3_9BILA/55-192              emdigelmniserldkedndneeenletrfdaaicsnlfigq----------------..---.....-------------GI..VNDRHR....IAQVLGLLLRLIRTDGVVIIRENLKQWG-SR.SIADLTKFLDVFafRK...QQNnlkqQQT.LGFNFYGMSQVQDSIYAHSNFLDVFWSLT-----tai............
A0A0K0EPS3_STRER/54-183              .........................................v-ADKSTIEVCKDVDSL..TKFtd.nhKNLDFLLFNNILDVTdaIKEEKK....LNTIIDSALISLKEGGCLIIREDMEKYTGD-.KLALLTNHFDIY..RK...TVD....EKN.YGLDFYSMNQLKTSIHTKSNFLDVYWIFTKKHFP...............
A0A0K0FFV2_STRVS/54-183              .........................................v-VAKSTIEVCKNIEEL..STFpd.thKNLDFLFFNNILDCFgaIKEEKK....LDVIINSALASLKEGGCFIVRENMEKHTGS-.DLALLTNYFDIY..RK...TID....GKN.LGLNFYSMNQIEASVYTSNNFMDIYWIFTKQVFP...............
A0A090L2P8_STRRB/54-183              .........................................a-ATNSTIEVCKDIDSI..TKFtn.nhHNLDFLFFNNILDCFgaIKNEKK....LDIIVDSALVSLKEGGCFIIRENMEKHTGN-.ELALLTNYFDIY..RK...QIE....GKN.YGLDFYSMNQLKTSVYTSNNFMDVYWIFTKKYFP...............
A0A2G5T7M5_9PELO/44-169              ......................................eplg----ANVKVHNSLEQL..PTI.....RNADVLVFNNALSQI..VTNADL....LTDFLKNATNAASVGGIVVIREDLKNVADKR.QVARLTDYFDVF..RT..nDAD....GNN.TGLDLYTVDEVHNSTYVEQNFLDFIFVFRKKIFA...............
A0A7E4VHQ1_PANRE/96-220              .........................tdvtvahggplsltahs----------------..---.....KRYDAIILSNVLDEWnlIERKHH....LSDFLRSILVTLPPNGTLAIRENMAQHPVS-.VISELTKFFDVF..IA..qESD....GKTaITFDFYAMRQVEDSLYGGQNHLDVYWILTR----aas............
A0A2G9U3C8_TELCI/41-120              .......................................fgp---GATATTCKDITSL..EKL.....SDLNVLVVNQALEKE..LHDSQA....LDKFISGALRSLRVDGVLIVRQDLC------.------------..--...---....---.----------------------------------spklaglyldshkea
A0A2G9U1L7_TELCI/41-142              .........................................f-GSGATATTCKDITSL..EKL.....SDLNVLVVNQALEKE..LHDSQA....LDKFISGALRSLRVDGVLIVRQDLSKLNDPK.KVAMLTDYFDVF..RD...FLD....---.----------------------------------rtqytdtgifayew.
A0A2A2KMM4_9BILA/41-167              .......................................ypt---QVSIEAHSTLVTA..ESAa...hADADGLIIDQAINEI..LENVDE....LEKFVKLALKLLKYNGVAIIRQDLSQSKDSK.KVAKLTDLFDVY..RT...EIE....GKT.TGFAFYSTTEVEDSIHAHQNWLDFIWSLKKSEF-e..............
A0A368H9X1_ANCCA/41-165              ........................................fg--PAATVTLTTGSASI..GKF.....TELDVLVVNQALDKE..LHDSNA....LDKFVSHALKSLRTGGACIIRQDLTSLNDPK.KVAKLTDYFDVF..RT...AEH....GEN.FGFSFYAVNGVEDSIYAKQNWQDFIWTLVKKSFP...............
A0A016UML8_9BILA/41-165              .........................................f-GLGASVTLETGTKSI..EEL.....TELDVLVVNQALDKE..LHDSSA....LDRFVSNALKSLRPGGACIIRQDLTSLNDPK.KVAKLTDYLDVF..RT...EEH....GEN.FGFAFYAVNGVEDSIYAKQNWQDYIWTLVKKSFP...............
A0A0K0FV17_STRVS/54-175              .........................................i-AKNSEIEYTRDVNSL..FNKr...hSDKDLIILCDIITTNysIERNFN....CELLLEATVNCLKENGFIIIKENLRQHEGP-.---LLTKINK--..--...-LL....QES.YLVKFHEMNQLRYSIYMEGNFLDIYWILSRE---dkaft..........
A0A261CDI6_9PELO/42-168              .......................................fep--LSSNVTVHNSLEQL..STI.....RNSDVLIFNNALSKI..VNNADL....LTDFLKNATNASAIGGIVIIREDLKNVADKR.QVARLTDYFDVF..RT..nDSD....GNN.TGLDLYTVDQIENSTYVEQNFLDFIFVFRKKVFA...............
PMT2_CAEEL/44-169                    .......................................tpl---TSNVQVHTSLEQL..STI.....RNADVLIFNNALSQI..ITNADL....LTDFLKNATNATAIGGTVIIREDLKDCSDKR.QVARLTDYFDVF..RT..tDSD....GNN.TGLDLYTVDQVEHSNYVEQNFLDFIFVFRKKVFA...............
A0A811L638_9BILA/38-153              .................................eaakvrgvt------------VEEL..KNV....eADSHELVIINRLSAG..ETHKQN....LDKILQNSLRILKTDGVVVAYEDFENVTYQ-.EVGSLSTLFDSF..ES...KEN....GNS.ASFKLLAMNQTSE-----QTSEGVYWIMTK----yta............
A0A6V7UGQ3_9BILA/55-192              emdigelmniserldkedndneeenletrfdaaicsnlfigq----------------..---.....-------------GI..VNDRHR....IAQVLGLLLRLIRTDGVVIIRENLKQWG-SR.SIADLTKFLDVFafRK...QQNnqkqQQT.LGFNFYGMSQVQDSIYAHSNFLDVFWSLT-----tai............
A0A0N4U4I0_DRAME/41-159              .......................................lgn---DTAITKRKGCDDL..NDId...dDTFNVVVLNQVINTSkiLDDPPR....VDLLMKSILRVVLPQGTIVIRENLSNCPKIN.AMVQLTNFLDTY..KT...NLS....NSS.WSIKFVSMNQISDSIHAKN---------------skill..........
A8X7D2_CAEBR/44-169                  ......................................dplg----AKVKVHNSLEQL..PSI.....RNADVLVFNNALSQI..VTNADL....LTDFLKNATNAASVGGIVVIREDLKNVADKR.QVARLTDYFDVF..RT..nDAD....GNN.TGLDLYTVDEVHNSTYVEQNFLDFIFVFRKKVFA...............
#=GC seq_cons                        .........................................h....sslphppslppl..pph.....pshDlLllNpsLsp...lpcspt....L-cFlpsALpuL+hsGllIIREDLpphsss+.plApLTcYhDVF..Rs...cps....Gps.hGhsFYuhsQVcsSlYscpNahDhhWshpKc.F................
//