#=GF ID PMT_C2
#=GF AC PF20899.1
#=GF DE Pasteurella multocida toxin, C2 domain
#=GF AU Lazaro Pinto Beatriz;0000-0001-6837-2941
#=GF AU Chuguransky S;0000-0002-0520-0736
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE ECOD:4311.1.1
#=GF GA 27.00 27.00;
#=GF TC 31.60 30.50;
#=GF NC 24.20 23.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RC Paper describing PDB structure 2ebf
#=GF RN [1]
#=GF RM 17360394
#=GF RT Crystal structures reveal a thiol protease-like catalytic triad
#=GF RT in the C-terminal region of Pasteurella multocida toxin.
#=GF RA Kitadokoro K, Kamitani S, Miyazawa M, Hanajima-Ozawa M, Fukui A,
#=GF RA Miyake M, Horiguchi Y;
#=GF RL Proc Natl Acad Sci U S A. 2007;104:5139-5144.
#=GF RC Paper describing PDB structure 5w6l
#=GF RN [2]
#=GF RM 30279169
#=GF RT The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves
#=GF RT Ras through an atypical mechanism to disrupt Ras-ERK signaling.
#=GF RA Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer
#=GF RA MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, Stephen
#=GF RA AG, Holderfield M, Satchell KJF;
#=GF RL Sci Signal. 2018; [Epub ahead of print]
#=GF RC Paper describing PDB structure 6a7h
#=GF RN [3]
#=GF RM 30282804
#=GF RT Structural basis of inactivation of Ras and Rap1 small GTPases
#=GF RT by Ras/Rap1-specific endopeptidase from the sepsis-causing
#=GF RT pathogen Vibrio vulnificus.
#=GF RA Jang SY, Hwang J, Kim BS, Lee EY, Oh BH, Kim MH;
#=GF RL J Biol Chem. 2018;293:18110-18122.
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Pasteurella multocida toxin (PMT) inhibits osteoblastic
#=GF CC differentiation in mammals and birds. Its N-terminal region
#=GF CC binds to target cells, while its C-terminal region, with a
#=GF CC Trojan horse-like shape, carries the intracellularly active
#=GF CC moiety. The latter consists of three distinct domains: C1
#=GF CC (Pfam:PF11647), C2 and C3. This entry represents the larger of
#=GF CC these domains, the central region C2, which has 18 helices and
#=GF CC nine beta-strands and is organised into two subdomains with
#=GF CC typical alpha-beta structures characteristic of
#=GF CC nucleotide-binding proteins [1]. This domain is also found in
#=GF CC the Ras/Rap1-specific endopeptidase (RRSP), an effector domain
#=GF CC from the multifunctional-autoprocessing repeats-in- toxin
#=GF CC (MARTX) toxin from Vibrio vulnificus responsible for the
#=GF CC disruption of host innate immune defenses during infection
#=GF CC [2,3].
#=GF SQ 9
#=GS D3VAK8_XENNA/3082-3466 AC D3VAK8.1
#=GS A0A2U8I5M8_9GAMM/719-1022 AC A0A2U8I5M8.1
#=GS T0P9P3_PHOTE/173-556 AC T0P9P3.1
#=GS A0KHZ7_AERHH/3238-3574 AC A0KHZ7.1
#=GS G2GXI0_9ENTR/748-1075 AC G2GXI0.1
#=GS A0A383TWB5_9FLAO/703-1086 AC A0A383TWB5.1
#=GS Q7MDK6_VIBVY/3740-4080 AC Q7MDK6.1
#=GS G2H0T5_9ENTR/22-359 AC G2H0T5.1
#=GS Q7N4E0_PHOLL/184-567 AC Q7N4E0.1
D3VAK8_XENNA/3082-3466 ...............rneargdtpgltdlmvrwvkedpylaaklgyqgeipadlafnpkfhvdlgdqfdd---------------------------------------------------------FKQCLSKAQDKGLLINARIDE..Q..NkrVHLGYSYNELLDMTG..SEDVK.-MAVYFLKEVAK.Q.A..DPNFA....gSH..EAILLNRFANPAYLVQLEQGRLAQIEAIYHSSHQTDIAAWDKQY...SSdalTQ...L...N.RQL....SdGT.D.LNS...QLSLLLKDRQGLLIGES....HGSdlngLR...FVNEQMDALKVHGVTVIGLEHLRSDLAQPLIDKFLAGGDMPA.ELTAM.IET-.-----..KHLPV....D....LFEQAKSKGIKIIALDDNSTTRPAIEGSQHGLMYRaG...AANNVAVKRLGllA..EGEKFVAIYGDAHLQSHEGIDHFVPGMTHRLGLPALKVDANNRFTAQADDISLR------------------khyddvpqleknl...........
A0A2U8I5M8_9GAMM/719-1022 ......................lslgysyqdlsdlatgdapaamvftylkeiaerlnahysdapfdqlml------------------------------------------------------------------------------..-..-..---------------..-----.------------.-.-..-----.....--..-----NQFADREYLHRLQDTRLAQATRMYYHSRNMDFDTWDRQYskqGT...AA...L...N.QGL....R.NL.A.FSE...QLALLLQDRPGLLMGEE....GDT....ITgqrVVIAQIDSLKQRGITTLGLGYLRHDRYQPLIDEYLGSTAPMSgELKAI.LAGK.S-VDIttNGIKK....KslilLFEIARAKGMKILALGDNNMVRPETENGHIWQAVA.A...NSRVVDILKAL..P..EGEKFVVIHDSRYLTSQQGIDRFIPGLAQRLGLPALAFNAN-------------------------------qlqviadedanrplft........
T0P9P3_PHOTE/173-556 .................rgntpgltdlmvrwvkedpylatktgyqgeipndlpfepkfhvelgaqfdnfk-----------------------------------------------------------KWLNIAQSQGLLTHARLDE..P..SkrVHLGYSYNELLDMTG..VESVQ.MAVYF-LKEAAKqA.D.pGFAGS.....QE..-AILLNRFANPAYLAQLEQGRLSQIEAIYHSSHNTDVAAWDKQF...DAdalVQ...L...N.HQL....NgST.D.LDS...QLSLLLKNRQGLLIGES....HGSdlngLR...FVNEQMDALKAHGVSVIGLEHLRSDLAQPLIDNFLASGDMSA.ELAAM.IKT-.--KHL..DPA--....-....LFEQARIKSMKIIALDDNSTTRPVVAGTQHGLMYRaG...AANNVAVERLQ..QlpVGEKFVAIYGNAHLQSHEGIDHFIPGMTHRLGLPALKVDANNHFVAQADDTSQRK-----------------ryddvanvpriqlip.........
A0KHZ7_AERHH/3238-3574 ............................................................hialgehhgd---------------------------------------------------------LKKWLTEAQGKGLLSRAVLDDtrK..L..LHLGYSYQELQDMTG..EQSAQ.MAVYFIKEAAKQ.A.A..PGSDL.....SA..EHIMLDKFGDRRYLGELESRRIEQIENIYHSSKQTDVAAWDARY...GS...DA...LrtlN.AQL....D.GD.StLAG...QLARLLDNRNGLLIGEThgsdVNG....LR...FVNEQMDALKAQGVTVIGLEHLRGELAQPLIDRYLAGGEMSP.ELATM.LKSK.---HL..E---P....S....LFERARERGLRIVALDDGSTARPVIGGTEHGLMYRaG...AANNVAVDVLG..KlpAGEKFVAIYGSAHLASHKGIEGFVPGITHRLGLPALKVDADNRFHLQGDDVSQRVE----------------yadvgrkw................
G2GXI0_9ENTR/748-1075 lgnkftvfkanllaaqaqnvlnnvyldekkiahigysyneltalkgnehvgiiiytiilaiqekrdsnfi------------------------------------------------------------------------------..-..-..---------------..-----.------------.-.-..----G.....QT..DLLMLKNFANQRYLQDMQRERLADINQIGKSDPNTEIAEWDKHY...SG...QT...G...EqLQQrlldK.NL.N.INS...WLDVLLENRKGLLISEN....NYG....LD...FVTRHLIGLKSKGITTIGLGVLNAKFAQPLIDDYLRTGNLSG.ELAVM.V---.---ET..NG-LG....K....LFESAFAKKMKIIALGVDSRRKGIEEDDYENIYRI.D...KTNQGVVEAFN..Q..PGGKFVAILSSEFLQSQPGIEGPLSGITHRLGLPALTANESG-FTWLA------------------------dniyqrkayqplslnsie......
A0A383TWB5_9FLAO/703-1086 ..................................................................nytt-----YPFAGFAEELPTQLSFTPYYVIPETSEFSILEHAYYNDSLFEGLGFDNNIDVLKYTIERIKSENLLSEIEEID..N..K..LYIGYNFEELNQIIS..TFSCA.EETQYSEYPLTF.I.Q..MLQELgsikgQGipEKGLMHVYSSAKYYQDTVEKRMNTVETAFQISDNYDFSIWDNNF..pGN...QN...Y...I.EFL....K.NQeT.TNS...AISTAVSTSMGVAFDDS....AES....LR...FITENLETFYEEGIRNIFVRRLNHRLLKRDIALYLRGENMTD.RLNAAlLTTL.EHGH-..-DLYR....A....LIREAKKIKINVIPTGGHDGIISGALDIYESYYAN.V...EQTIREFNLIN..D..SSGKFLIITPPTALRPIAGIHAPFPNIAELTNIPVLKVTE--------------------------------nklldlsvaigrekldvrvpawte
Q7MDK6_VIBVY/3740-4080 .........................................................fdakyhvdlgehy-------------------------------------------------------ADFKQWLETSQSNGLLSKATLDE..StkT..VHLGYSYQELQDLTG..AESVQ.MAFYFLKEAAKK.A.D..PISGD.....SA..EMILLKKYADQSYLSQLDSDRMDQIEGIYRSSHETDIDAWDRRY...SG...TG...Y...D.ELTnklaS.AT.G.VDE...QLAVLLDDRKGLLIGEVhgsdVNG....LR...FVNEQMDALKKQGVTVIGLEHLRSDLAQPLIDRYLATGVMSS.ELSAM.LKT-.KHLDV..-----....T....LFENARANGMRIVALDANSSARPNVQGTEHGLMYRaGaanNIAVEVLQNL-..P..DGEKFVAIYGKAHLQSHKGIEGFVPGITHRLDLPALKVSDSNEFTVEQDDVSLRV-----------------vyddvank................
G2H0T5_9ENTR/22-359 ..............................................evkaalllaqakgvmtlaqlddst------------------------------------------------------------------------------..K..S..LHLGYRYQELNQLAAghPQASLvVAQLKEVVNAAR.GgD..LVQSV.....EE..-V-MLDKFADKQFLRQWQGARLTQVERIYHSSRAVDFDTWDRQY...SA...QAgdtL...N.QQL....S.AL.P.SNDvsgQLTLLLENRQGLLISET....HGSdlngQR...LVIEQMKVLKDQGVMTIGLEHLRRELAQPLIDDYLRTGIMSG.DLRAM.LNSRpEKLTI..EGAERpalmY....LFEQARENGMKIVALDDSSTVRPASAH--GLIYRV.GtanNVAVDALRAL-..P..AGEKFVAICGQAHLQSHQGTDRFLPGITQRLGLPALQVNAANQLTVMADDLSQR------------------tlfmlldr................
Q7N4E0_PHOLL/184-567 .................gntpgltdlmvrwvkedpylaaktgyqgkipndlpfepkfhvelgaqfddfkk------------------------------------------------------------WLDTAQSKELLTHTRLDE..QnkQ..VHLGYSYNELLDMTG..VESVQ.MAV-YFLKEAAK.Q.AepGSTKS.....QE..DILL-HRFANPTYLAQLEHSRLAQIEAIYHSSHDTDVTAWDQQF...ASdalTQ...F...N.HQL....NnTV.D.LNS...QLSLLLKDRQGLLIGES....HGSdlngLR...FVEEQMEVLKAHGVTVIGLEHLRSDLAQPLIDKFLASGNEP-.-MPAE.LAAL.LKTKH..LSA--....N....LFEQARSKQMKIIALDNNSTTRPTVEGTQHGLMYRaG...AANNVAVERLR..QlpAGEKFVAIYGNAHLQSHEGIDHFLPGITHRLGLPALKVDENNRFTAQVDNINQR------------------kryddvvelpriqlt.........
#=GC seq_cons .........................................................hhhhhtht.s.tp............................................................hlp..psptLL.ph...-..p..p..lHLGYsYpEL.phsu..spust..th.a.h.tstp.t.s....pts.....pt..-hlhLc+FAstpYLtpLppsRLsQIEsIY+SS+sTDlssWD+pY...uu...ss...h...N.pQL....s.sh.s.lsu...QLulLLcsRpGLLIGEo....tso....LR...FVsEQM-uLKscGVTsIGLEHLRu-LAQPLIDcYLuoGsMou.ELsAM.Lpo....hch..psh......p....LFEpARt+uMKIlALDssSosRPsstsspculhhp.G...sssssslctLt..t..sGEKFVAIaGsAHLQSHpGI-tFlPGITHRLGLPALKVsssNpFsh.sDshs.R..................ph.sshst................
//
