#=GF ID Pallilysin
#=GF AC PF18663.5
#=GF DE Pallilysin beta barrel domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF07598
#=GF GA 25.00 25.00;
#=GF TC 29.20 32.60;
#=GF NC 23.20 21.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0116
#=GF RN [1]
#=GF RM 27683203
#=GF RT The Structure of Treponema pallidum Tp0751 (Pallilysin) Reveals
#=GF RT a Non-canonical Lipocalin Fold That Mediates Adhesion to
#=GF RT Extracellular Matrix Components and Interactions with Host
#=GF RT Cells.
#=GF RA Parker ML, Houston S, Petrosova H, Lithgow KV, Hof R, Wetherell
#=GF RA C, Kao WC, Lin YP, Moriarty TJ, Ebady R, Cameron CE, Boulanger
#=GF RA MJ;
#=GF RL PLoS Pathog. 2016;12:e1005919.
#=GF DR INTERPRO; IPR041037;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The Treponema pallidum protein, Tp0751 (also known as
#=GF CC pallilysin), possesses adhesive properties and has been
#=GF CC previously reported to mediate attachment to the host
#=GF CC extracellular matrix components laminin, fibronectin, and
#=GF CC fibrinogen. Tp0751 adopts an eight-stranded beta-barrel with a
#=GF CC profile of short conserved regions consistent with a
#=GF CC non-canonical lipocalin fold. Lipocalins, along with fatty
#=GF CC acid-binding proteins and avidins, are members of the calycin
#=GF CC superfamily, which is defined by the distinct features of a
#=GF CC central beta-barrel and a key structural signature consisting of
#=GF CC three short conserved regions (SCR1, SCR2, and SCR3). However,
#=GF CC Tp0751 does not contain all three conserved regions, hence it is
#=GF CC considered an outlier to canonical lipocalins. In SCR1, there is
#=GF CC a GxW motif [1].
#=GF SQ 33
#=GS A0A7T7XJJ8_9SPIR/270-389 AC A0A7T7XJJ8.1
#=GS A0A1T4QKI5_9SPIR/254-371 AC A0A1T4QKI5.1
#=GS A0A1N6P4M1_9SPIO/267-382 AC A0A1N6P4M1.1
#=GS A0A840SB57_9SPIR/256-371 AC A0A840SB57.1
#=GS S5ZX21_9SPIR/254-372 AC S5ZX21.1
#=GS F8F0E1_GRAC1/261-378 AC F8F0E1.1
#=GS A0A841R594_9SPIO/255-372 AC A0A841R594.1
#=GS U1FBV3_TRESO/277-394 AC U1FBV3.1
#=GS H9UJH7_SPIAZ/276-389 AC H9UJH7.1
#=GS A0A098R1P7_9SPIO/252-375 AC A0A098R1P7.1
#=GS Y751_TREPA/106-226 AC O83732.1
#=GS A0A4R4BSF1_9SPIR/264-381 AC A0A4R4BSF1.1
#=GS G0GD04_SPITZ/260-373 AC G0GD04.1
#=GS A0A5C1QDL9_9SPIO/251-362 AC A0A5C1QDL9.1
#=GS A0A7W8LKW8_9SPIR/256-373 AC A0A7W8LKW8.1
#=GS H7EHP1_9SPIR/257-373 AC H7EHP1.1
#=GS F4LPY2_TREBD/255-372 AC F4LPY2.1
#=GS E1R3A6_SEDSS/256-371 AC E1R3A6.1
#=GS E7NQ12_TREPH/250-367 AC E7NQ12.1
#=GS V5WHB0_9SPIO/267-377 AC V5WHB0.1
#=GS F5Y8I5_LEAAZ/263-381 AC F5Y8I5.1
#=GS S3K422_TREMA/255-372 AC S3K422.1
#=GS A0A1Y1S1D7_9SPIO/258-372 AC A0A1Y1S1D7.1
#=GS F2NSA1_TRES6/255-371 AC F2NSA1.1
#=GS A0A1T4JQX8_TREPO/260-377 AC A0A1T4JQX8.1
#=GS A0A7T3V5S3_9SPIR/255-372 AC A0A7T3V5S3.1
#=GS A0A0A0X412_9SPIR/246-364 AC A0A0A0X412.1
#=GS Q73PF9_TREDE/254-372 AC Q73PF9.1
#=GS A0A370AYB7_9SPIO/242-355 AC A0A370AYB7.1
#=GS A0A1H9HRE3_9SPIR/266-383 AC A0A1H9HRE3.1
#=GS F5YL89_TREPZ/266-385 AC F5YL89.1
#=GS I0X6G6_9SPIR/285-402 AC I0X6G6.1
#=GS A0A5C1QHR5_9SPIO/267-378 AC A0A5C1QHR5.1
A0A7T7XJJ8_9SPIR/270-389 .....QRQVRELLSGSADKFEHFIDGLWYYVS...PEGt..lDQ.....RQ.....YIY.FDPDNREIIFFADETQQVFSWHNSS....PT.RY....G..LYISSQNISVTTLRRFLEIELATLESIRVKVSE.DV.RLKIGVSAPWNGTYRK............
A0A1T4QKI5_9SPIR/254-371 .....AKELARIQDGTVATFSKFLEGLWYKTE...NSG....GN.....VR.....YIF.FDPQTHEIIFHYQDSEEVYSWLDAK....LR.RN....G..MYFTSINQSIENLQRRFDISLVNVDEIRIRIQD.DV.RMIISESTLWDGNYKK............
A0A1N6P4M1_9SPIO/267-382 ....q-AQLRELYDADTAGMEQFLSGPWFRST...ESAa..gSP.....AE.....LAF.FDTANQRVSLFHSDAQEQYEWVNSY....KA.IYqsgpG..LLMNLRNAVLRTVRRQIAVTVLGTDTIRINVD-.--.-----GAEYWNGQY--qr..........
A0A840SB57_9SPIR/256-371 ....r-KELAKIQDGTVETFAGFLEGLWYKSD...SSS....--.....LY.....YLY.FDYLQKEIIFVRSDIEEVYNWIRSD....LR.RN....G..IYLSSVNQEIQNLQRRIDISLRSVDEINIRIQD.DV.RMLISENNVWDGVYKK............
S5ZX21_9SPIR/254-372 ...st--LLRKLQTGNMESFIDFLSQLWYQSE...NGK....NS.....GR.....SIY.LDKNDNNIIFNFDNIEEIYEIKTTL....PR.RY....G..LFFTANNKSIPNIIRRVDIEIKGVDEIQIRVIE.DVaRIKFGTSSLWNGTYKK............
F8F0E1_GRAC1/261-378 .....QRQIRELLDGTAGKFEQFLSGLWFYTG...SQE....DA.....KR.....YVY.FDPVKREIIFHEDTTQEIYRWQNSS....PT.RY....G..VYISSQNLSVTTLRRLIDISLESRDSIAIRIFE.DV.QLKIGISGHWDGVYQK............
A0A841R594_9SPIO/255-372 ..nen---LLNFYRGTSEDYLDFLKGPWFKTK...DLNgnatHN.....MN.....EIFqIIPEEKTITFYSGDIQESFTWNENTepvkYR.QI....L..SFFSVRNNFLTSMSFSISISIDSFETIQVKIRG.--.----------------nqrwggtys...
U1FBV3_TRESO/277-394 .....ARELARIQDGTVETFADFLDGLWYKMS...SSQ....DG.....IR.....YLF.FDHAQKEVIFLYENTEEVYAWEDSN....LR.RS....G..IYITTTNKSITNMQRRCDISLAGIDEVRIHIID.DV.RMIIKENNLWDGSYRK............
H9UJH7_SPIAZ/276-389 ...et--QLQQLYSSGATTFENFLEGPWYRTR...GGSp.gdPD.....MV.....LVS.FFPRRREIVFLENDMQQVFNWDVSS....RT.IY...rN..IRMDVRNQILPSIS--------TFGSVAVTGLE.TI.RLQLQGHNDWDGEYRR............
A0A098R1P7_9SPIO/252-375 ...ea--QLAELYNSDVTTFTNYIRGPWYKIT...ANQ....NEispslIR.....IIH.FDPEQRNISFYRDTRTISFDWTGST....KS.TY....GgrLRVDIQNEVIPTISSVGWVTLRDLDTLEVSLSG.TD.K-WTSLPQEWTGRYR-r...........
Y751_TREPA/106-226 alwnr------ATHGEQGALQHLLAGLWIQTEispNSG....DI.....HP.....LLF.FDREHAEITFSRASVQEIFLVDSAH....TH.RK....T..VSFLTRNTAISSIRRRLEVTFESHEVIHVRAVE.DVaRLKIGSTSMWDGQYT-r...........
A0A4R4BSF1_9SPIR/264-381 .....QRQLRNLVDGTPGKVEAFLQGLWYSVQ...SAT....SG.....RR.....SIY.FDPERREIIFYSEGTQEVYSWTNSS....PT.RY....G..LYITCQNISITTLKRFIDVNLENGDTITLRIYE.DV.KIKIGVADSWDGVYQK............
G0GD04_SPITZ/260-373 ....s-EELRRLFEGTAEAIATFVAGPWFKEE...THE....--.....ET.....FLV.LDYENREISFYREDIQEIYLWQNSI....KNfYR....G..ISIIAQNKTLPGLSISIYLSLQDANTIQISITT.--.-PEIRDPSPWNGTYS-r...........
A0A5C1QDL9_9SPIO/251-362 ...ke--KLRNVYYGNKNNFLKFINGEWLSKG...LDP....QE.....NR.....III.IDSKNDKVLFKYKDGVEEYYIYSFY....QS.FK....K..LIINLRNSDVSTIPYKLYFTLDSTDSFTITPPS.--.----NTSTLWDGSYN-r...........
A0A7W8LKW8_9SPIR/256-373 .....AKELARIQDGTVATFGKFLEGLWYKTE...NTG....SK.....IR.....YIS.FDYANSEIIFEYEDSEEVYSWLKST....LR.RN....G..IYFSAVNKSIENLQRRFDISLVSTDEIKIKLQD.DV.RMLINESTQWDGNYKK............
H7EHP1_9SPIR/257-373 .....AKELAKIQDGTVSSFAKFLNGLWYKAD...GAE....-K.....RR.....FIF.FDQQNEEIVFQFEDNEEVYSWTNSN....LR.RN....G..IYFSSVNKSIENLQRRFDISLVDLDEIRVKIQD.DV.RMLIGEENLWDGNYKK............
F4LPY2_TREBD/255-372 .....AKELARIQDGTVETFAHFLDGLWYKTS...NTA....DG.....IR.....YVF.FNFREKEIIFQFGDSQEVYTWVNST....LR.RN....G..IYLSTVNGSVTNLTRRIDISLTGIDEIKIKNQD.DV.RMLIGENTLWDGQYKK............
E1R3A6_SEDSS/256-371 ....d-RKLRELFNSGVDAFEEFLSRNWN---...--G....DH.....NS.....TIL.FDKSSQEITLYSGDIQEIYHWNSSY...rFL.SN....S..ISIKGENELVPYIRVEISIRILDSGSIRVSLYDiDNqTWRKSLNDSWSGTY--ya..........
E7NQ12_TREPH/250-367 .....AQLLQKLSTGNVNLFEDFLSGLWYQPS...SGK....-N.....GR.....TLF.FSTEENEVIFSIDNIEEIYMIDAAA....SR.RY....G..IYFSTKNASISSIHRRLDVKLNGVDEIQVRVIE.DVaRLKIGTASTWDGVYKK............
V5WHB0_9SPIO/267-377 ...ed--QLAELYSGNLDDYHRFIDGPWEH--...--Q....DG.....NR.....IVF.FSRITDSIQLATDDRQLNFSWTDSS....RW.GF....GssIRIQMENEIIRSVIRRMQVSVLDLNTMVIQLSG.E-.----------------ennkfwsgtytr
F5Y8I5_LEAAZ/263-381 ..qrr---VRELL-GNPGAFEDFITGLWYYIS...PQGt..iDL.....KQ.....YIY.FDPSSREIIFYGDETQQVFTWQNSS....AT.RY....G..LYVASQNISVTTLRRSIDIELETLDSIRVKVFE.DV.RLKIVVNPPWDGSYRK............
S3K422_TREMA/255-372 .....AQELAKIQDGTEKTFAAFLNGLWTKAG...TTA....EK.....NR.....YLF.CDYDKKEVIFFQNDRQEIYAWERST....LR.RN....G..ILVYTTNRSMPNISRRFDIALVSADEIRIKVVD.DL.GMLIGSETLWDGNYKK............
A0A1Y1S1D7_9SPIO/258-372 ...de--RLNRLFRSNENDFEAFLQGPWLKTS...QDAs.grVS.....HS.....VLY.FQPESRFFANYSGDVQEEYIWQASN....RT.NY...nQ..LYIIGANDLIRYIRKQLSITVRDIHNIHIWTSD.--.-----INDTWSGEYQ-r...........
F2NSA1_TRES6/255-371 .....AKELAKIQDGTVATFAGFLNGLWYMPE...SNG....-N.....LR.....YVF.FDYDSREIIFFKDDTEEVYKWAHSN....IR.RN....G..IYLSTINQEIENLQRRIDISLKSTEEIHIRIQD.DV.RMLISENAVWDGNYKK............
A0A1T4JQX8_TREPO/260-377 .....ARELSRIQNGNVDTFGQFLTGLWYKTN...NSS....ST.....PS.....YIY.FNYNDREVIFLSDDTEGVYSWEDSS....LR.RS....G..IYLTTVNSIISSMKRRFDIMLTGINEVSVHVHD.NV.GMIIKESNQWDGTYKK............
A0A7T3V5S3_9SPIR/255-372 .....AKELARIQDGTVATFAGFLNGLWVKSG...ARE....GE.....MS.....SLF.FDYNLKEIIFFRDDVEEVYNWAHST....IR.RN....G..IYLTAINQEIQNLQRRVDVSLRSVDSIHIRIQD.DV.RMPIIESNVWDGDYKK............
A0A0A0X412_9SPIR/246-364 ....s-QFLQKFQTGDSNSFQEFLDGLWYQPS...AKR....DQ.....NR.....SIF.FNRSENEIIFSVDNIQELFTIDSIT....PR.RF....G..IYFSTKNASISSIHRRISIELIGVDEVHVRVID.DIaRLKIGVASNWDGTYRK............
Q73PF9_TREDE/254-372 ....i-QLLRKLQSGNMESFIDFLSGLWFQEE...GNK....ET.....GR.....SVY.FDKNDSHIIFNLDNVEEIYEIKTTL....PR.RY....G..LFFTTNNKSIPNIIRRVEIEIKGLDEIQVRVIE.DVlRIKFGTASLWNGKYKK............
A0A370AYB7_9SPIO/242-355 ...ee--NLKKLYRGDLDDFKAFLSGPWHRVS...DSV....GE.....KQpflqdILY.FQPDEDQVIFTIDDIQEIYDWDDTY....RTiFK....G..IYIQSQNILIQSLRRDILITVEDMDSIKVKIQ-.--.----------------gttewggyy...
A0A1H9HRE3_9SPIR/266-383 ....a-TELSRIQDGTVETFAAFLDGLWYKTS...NTD....GN.....IR.....YMY.FNYPDTEIIQLYKDIQEVYEWEDSK....LR.HN....G..IYLTAVNADIMNLHRRFDIALINTDEIKITLRD.DI.NLIISENTQWDGNYKK............
F5YL89_TREPZ/266-385 .....QRRVRELLNGGKEEFEKFVTGLWYYVS...PQGt..lDN.....RQ.....YIY.FDPPSREIIFYGEEIQQVFTWQNSS....AT.RH....G..LYVSSQNISVTTLRRFLDIELESLDSIRVKVFE.DV.RLKIYVTAPWDGSYRK............
I0X6G6_9SPIR/285-402 .....AKELSKIQDGTVESFAAFLNGLWYKTS...NAD....GN.....IR.....YLF.FDYNNREIIHLFNDTQEVYQWDDSK....LR.HN....G..IYLTTVNSDILTLHRRFDIALINTDEIRITIRD.DI.NLLIKESTTWDGNYKK............
A0A5C1QHR5_9SPIO/267-378 ...ee--KLKDLYRGDLDDFKEFLSGPWHRIS...DLN....EE.....KQpfleeIMY.FHPDENQVIFTAGDVQEIYDWNETY....RTiFK....G..IYIQSVNQLIDSLRRDLYITVEDMDSIRVKIQ-.--.----------------gttewgg.....
#=GC seq_cons ......ppLpcl.cGssssFtpFLsGLWa+ss...sss....sp.....tp.....hla.FD.ppcEIIFhtcDhQElYsWpsSs....hp.Rh....G..lYlospNpsIsslpRcl-IsLpshDpI+l+l.-.Dl.phhIstss.WDGsY+K............
//
