#=GF ID   Peptidase_C21
#=GF AC   PF05381.16
#=GF DE   Tymovirus endopeptidase
#=GF AU   Studholme DJ;0000-0002-3010-6637
#=GF SE   Merops A17
#=GF GA   25.00 25.00;
#=GF TC   25.70 30.60;
#=GF NC   24.90 23.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0125
#=GF RN   [1]
#=GF RM   8599230
#=GF RT   Identification of the cleavage site recognized by the turnip
#=GF RT   yellow mosaic virus protease. 
#=GF RA   Bransom KL, Wallace SE, Dreher TW; 
#=GF RL   Virology 1996;217:404-406.
#=GF RN   [2]
#=GF RM   7710355
#=GF RT   Papain-like proteinase of turnip yellow mosaic virus: a
#=GF RT   prototype of a new viral proteinase group. 
#=GF RA   Rozanov MN, Drugeon G, Haenni AL; 
#=GF RL   Arch Virol 1995;140:273-288.
#=GF RN   [3]
#=GF RM   1831310
#=GF RT   Proteolytic maturation of the 206-kDa nonstructural protein
#=GF RT   encoded by turnip yellow mosaic virus RNA. 
#=GF RA   Bransom KL, Weiland JJ, Dreher TW; 
#=GF RL   Virology 1991;184:351-358.
#=GF DR   INTERPRO; IPR008043;
#=GF DR   MEROPS; C21;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Corresponds to Merops family C21. The best-studied plant
#=GF CC   alpha-like virus proteolytic enzyme is the proteinase of turnip
#=GF CC   yellow mosaic virus (TYMV). The TYMV replicase protein undergoes
#=GF CC   auto-cleavage to yield two products.  The auto-peptidase
#=GF CC   activity has been mapped to the central part of this
#=GF CC   polyprotein.
#=GF SQ   7
#=GS POLG_MRFVC/717-826          AC Q91TW9.1
#=GS A0A1L3KJX4_9VIRU/537-642    AC A0A1L3KJX4.1
#=GS A0A385L3F5_9VIRU/749-851    AC A0A385L3F5.1
#=GS A0A1B2RVP2_9VIRU/614-721    AC A0A1B2RVP2.1
#=GS RDRP_GFKVM/810-916          AC Q8UZB6.1
#=GS A0A140H645_9VIRU/1055-1126  AC A0A140H645.1
#=GS POLR_TYMV/779-885           AC P10358.2
POLG_MRFVC/717-826                     ptra---ACLLVAVSQATGLPTRTLWAALCANLPDSVLDDGSLATLGLTTDHFAVLARIFSLRCRFVSEHGD.VELGLHDATSRFTIRHTPGHFELVADNFSLPALV---------gassvpg............
#=GR POLG_MRFVC/717-826          sAS   ........*...................................................................................*..........................................
A0A1L3KJX4_9VIRU/537-642               psqn---TCLFQALADLTCHTPAQLFDRLAEYVHAEQLVGPEQLQFGWATEHLQALAWIMKWRVTVVTDRGHrQTHGPTDGLL-LTIYHLS-------------------------npahwqahppsqivrlsgk
A0A385L3F5_9VIRU/749-851               ..pl----CLLDALENSTGVSRNIMIEAL-RILPKKSVVNEETKREGLSDWHAAALAYYFCWELNIYNAWVK.RVMGVRNGA-KVDIWHVMVGS---MGHFTHVRPRTAT------lakga..............
#=GR A0A385L3F5_9VIRU/749-851    pAS   ........*..........................................................................................*...................................
A0A1B2RVP2_9VIRU/614-721               .ksn---TCLFQSISELTEIPQSQLWTSLSSSMPNSLLVNATTTQFGFELFHAAALCYLLRFRLHVHSTQSAsFIVGPVDAPSLHNLYHAPGHW-SSVPQLSPAA-----------stprtrpy...........
RDRP_GFKVM/810-916                     ....PALDCLLVSCSAASGIPKEDLWATLCHIFPPSDL----VSDLGLSTNHLTALAFTYQWLVTLRSGELV.QRHGLLSAPFAFEITHTPPVPPATVGHFALSAPLTPTSACLTG...................
#=GR RDRP_GFKVM/810-916          pAS   ........*..........................................................................................*...................................
A0A140H645_9VIRU/1055-1126             ...p-LNDCLLRAIENTTGVDRQEVWRVCCRVLPRAELEGPEVDEGGLTT--LCALAFAYEYRC--------.-------------------------------------------qfhilgdlqghhpe.....
POLR_TYMV/779-885                      ....PTLNCLLSAVSDQTKVSEEHLWESLQTILPDSQLSNEETNTLGLSTEHLTALAHLYNFQATVYSDRGP.ILFGPSDTIKRIDITHTTGPP----SHFSPGKRLLGSQPSAKG...................
#=GR POLR_TYMV/779-885           AS    ........*..........................................................................................*...................................
#=GC seq_cons                          .......sCLLpAlustTslspppLWpsLsphlPsupLss.pssphGLoT.HhsALAahapacsplhosps...hhG.hsu..hhsIhHsss......sphs.st...............h..............
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