#=GF ID   Peptidase_C3G
#=GF AC   PF12381.12
#=GF DE   Tungro spherical virus-type peptidase
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   MEROPS_C03.024
#=GF GA   22.00 22.00;
#=GF TC   22.00 22.30;
#=GF NC   21.90 21.40;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0124
#=GF RN   [1]
#=GF RM   9683576
#=GF RT   Rice tungro spherical virus polyprotein processing:
#=GF RT   identification of a virus-encoded protease and mutational
#=GF RT   analysis of putative cleavage sites.
#=GF RA   Thole V, Hull R;
#=GF RL   Virology. 1998;247:106-114.
#=GF RN   [2]
#=GF RM   15503215
#=GF RT   3C-like protease encoded by Rice tungro spherical virus is
#=GF RT   autocatalytically processed.
#=GF RA   Sekiguchi H, Isogai M, Masuta C, Uyeda I;
#=GF RL   Arch Virol. 2005;150:595-601.
#=GF DR   INTERPRO; IPR024387;
#=GF DR   MEROPS; C3;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is the protease for self-cleavage of the positive
#=GF CC   single-stranded polyproteins of a number of plant viral genomes.
#=GF CC   The protease activity of the polyprotein is at the C-terminal
#=GF CC   end, adjacent to the putative RNA polymerase.
#=GF SQ   26
#=GS A0A3G2LQG0_9VIRU/1048-1212  AC A0A3G2LQG0.1
#=GS A0A1L3KJ38_9VIRU/1081-1209  AC A0A1L3KJ38.1
#=GS A0A1L3KNA9_9VIRU/1286-1512  AC A0A1L3KNA9.1
#=GS A0A1L3KMF1_9VIRU/1112-1221  AC A0A1L3KMF1.1
#=GS A0A1L3KKY2_9VIRU/1173-1258  AC A0A1L3KKY2.1
#=GS A0A1L3KJ45_9VIRU/1012-1180  AC A0A1L3KJ45.1
#=GS POLN_CRPVC/1032-1211        AC Q9IJX4.1
#=GS A0A1L3KMA5_9VIRU/1338-1429  AC A0A1L3KMA5.1
#=GS A0A1L3KJ54_9VIRU/2570-2658  AC A0A1L3KJ54.1
#=GS A0A1L3KM88_9VIRU/901-1129   AC A0A1L3KM88.1
#=GS A0A1L3KGY9_9VIRU/938-1033   AC A0A1L3KGY9.1
#=GS A0A1L3KME6_9VIRU/998-1159   AC A0A1L3KME6.1
#=GS A0A1L3KNB1_9VIRU/1297-1378  AC A0A1L3KNB1.1
#=GS A0A1L3KHH2_9VIRU/909-992    AC A0A1L3KHH2.1
#=GS A0A1L3KKS7_9VIRU/1994-2212  AC A0A1L3KKS7.1
#=GS A0A1L3KL07_9VIRU/1228-1321  AC A0A1L3KL07.1
#=GS A0A1L3KNI0_9VIRU/1398-1494  AC A0A1L3KNI0.1
#=GS A0A1L3KKV6_9VIRU/966-1186   AC A0A1L3KKV6.1
#=GS A0A1L3KNP7_9VIRU/1060-1292  AC A0A1L3KNP7.1
#=GS A0A1L3KMN9_9VIRU/1088-1323  AC A0A1L3KMN9.1
#=GS POLG_RTSVA/2630-2860        AC Q83034.1
#=GS A0A1L3KL02_9VIRU/990-1140   AC A0A1L3KL02.1
#=GS A0A1L3KJC7_9VIRU/2114-2309  AC A0A1L3KJC7.1
#=GS A0A1L3KKV9_9VIRU/1016-1216  AC A0A1L3KKV9.1
#=GS A0A1L3KJF9_9VIRU/2024-2244  AC A0A1L3KJF9.1
#=GS POLN_ABPVR/1120-1353        AC Q9DSN9.1
A0A3G2LQG0_9VIRU/1048-1212             .........................................................................................................iyisreeivirpfltkngeai-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...-D.......LVSVI.LP.K....QVPAHATLTK....QFMKLSDLPSFRNA.RGNLF-.SVYSSvlkgiER.PT.ERLNTVVSLNA..I..--DS...KVYTADH.NG.TSTEYTL..RR.GYMYEAE..TQA.GD..CTS.PLVISNP.QM..P...RKIVGLHVAG.ATT..-.G...R..A..L..ALSVTQDMLL---------dhisqidd.............
A0A1L3KJ38_9VIRU/1081-1209             .....................................................................sfqvgadrvgnfafrsdypqhisnipftmrapktesdvvfgefatavdnivvhnssp-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-------.--.-HCEYQI..RT.GYRYRGF..TNG.GD..CGA.MMVVLDNkQP..K...RKIFGMHVAG.VSD..K.L...VsnGysY..SASVCQEDIVA--------dlalf................
A0A1L3KNA9_9VIRU/1286-1512             .........................................................................................................cdnnaqdvsskimsknfvrly-----------------.---.-..---.----KPNSNYYTHGLFVCGRMLLMPKHLF....D.CLN...GSVDIVSI.G.D......SGKV..RVPVaiKsS.KH....VT..RG....DI....E...VD.......IVICE.LG.A....SISARKDIIS....YFPRKNELSSLS--.-GLMAN.GEMRVf...tTV.NF.NKDNFLIPKDSsaT..FTKV...VDHVESR.SP.DGSSYYI..RQ.GFEAKGN..SVH.GD..CCA.PYIIFNP.SS..R...AKIVGLHCAG.FAQ..T.S...R..V..F..AQMITQEDIASAMP-----ttha.................
A0A1L3KMF1_9VIRU/1112-1221             ............................................................................................vnytvrllvpnlgnspdtvtqihcgsakaldrvv-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-----SY.DD.GDGAEVI..MRqYYMYKFD..TQK.GF..CGS.LLYKEDS.KN..S...AKIIGMHVCG.VEK..K.S...V..G..L..ASAICCEAIRECVSQFS--ve...................
A0A1L3KKY2_9VIRU/1173-1258             ........................................................................................................kslndvhnyeqelkisvenesy-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-------.--.-----IH..RA.GYLYNGD..TMK.GD..CGG.PLIIKSN.SL..L...RKIVGMHISG.ATG..-.-...E..G..Y..SAKLYQELLQDHIDLLSK-k....................
A0A1L3KJ45_9VIRU/1012-1180             ..............................................................................................................naflpkgieietddfl-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.KR....IV..EV....EE....K...QD.......LILVD.LT.T....LIPAAKDITR....HFITRDDLHKL--T.SFRTVL.SGYRN.....-L.GS.NTVVLHASTGE..G..EAST...AIKYSME.EP.NGSIVQVhcVR.NIAYDID..TAP.GD..CGM.IASTSHS.SI..R...NKILGLHVAG.GNK..QrF...S..N..H..ASLVTTETLNEIITK----hfs..................
POLN_CRPVC/1032-1211                   ................................................................................................vpvshfiapnaervelttactrihykdetp-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...RD.......CVLVN.LHrR....MCHPHRDILK....HFVKKSDQGNLRGVfQGTLAT.FHQSA.....NE.LC.RAYQWLQAIRP..L..DQEItiyHEDTDMF.DY.ESESYTQ..RD.CYEYNAP..TQT.GN..CGS.IVGLYNK.RM..E...RKLIGMHIPG.NVS..E.C...H..G..Y..ACPLTQEAIMDGLNRLEK-l....................
A0A1L3KMA5_9VIRU/1338-1429             .................................................................................................................flsgltmstakyd-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...---SQSY.TH.RDIEYSL..ND.GLRYLAD..TTM.GD..CGT.PIMMAEG.KH..A...NKCVGLHVAG.SIR..K.QgvpT..G..L..AVRLTREMIEEAIG-----eflp.................
A0A1L3KJ54_9VIRU/2570-2658             ............................................................................................................tlkmtsgkatgdaffqyt-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-------.-D.LKGDTYK..QR.GWRIEMT..TVQ.GD..CGG.LLMGLGA.HLppP...GKILGIHVAG.YHN..K.A...I..G..Y..DVLITREQLES--------laska................
A0A1L3KM88_9VIRU/901-1129              ..............................................................................................................vgdlgfieqhqatmlr-----------------.---.-..-NA.VLLKSSDQKSVINAVFVTGRTVLVPYHFY....DvAIR...NNETFTLT.N.PfqqnlsTPIM..KDQC..F.F.HR...cVD..KF....GE....H...TD.......AMLIS.LP.L....SIPSRPNIIE....KFCKAQDFNKLDE-.-GEVVL.CGLNT.....IN.GM.TVVKTNTATEH..H..VESS...QV--EYP.DS.VGNIHKI..NQ.IIAYNMT..TRA.GD..CGS.LLFARNS.LL..V...GKILGIHVAG.DTK..A.G...Y..G..V..SLAISRENLSRNI------lcfaek...............
A0A1L3KGY9_9VIRU/938-1033              .............................................................................................ltnvklstreytqgeieipylskfipakkivlp-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-------.--.-------..-E.GYEFRVN..GVAvGD..CGL.ILMNTDE.KM.nA...RKIMGIHVAG.SVK..G.N...I..G..L..ANTVYQEDIQQAYE-----lag..................
A0A1L3KME6_9VIRU/998-1159              ................................................................................................................qidgtkikpsecaf-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.ER....VS..KS....GH....D...QD.......LVIVN.LP.R....HIPSRPNILN....KIVEQSNQAVIADC.SASLVG.--FN-.....--.QV.NYLET--MFER..TfeSMEV...KNITT-T.DC.VDERRVI..RC.GYAYHVA..SKP.GD..CGS.LLFTHST.QA..N...GKLIGFHTAG.NAK..L.G...Q..G..Y..AEALDRTTLTEILKRLN--vg...................
A0A1L3KNB1_9VIRU/1297-1378             ..................................................................................................................gqvravddcrpy-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...------A.DN.LGNSYKL..RS.GYQYNLE..TKD.GD..CGA.ILMGVHS.GL..A...RKIIGIHVAG.TLG..I.-...-..G..M..-------------------ssplniddirrglaeve....
A0A1L3KHH2_9VIRU/909-992               .......................................................................................................................igerfdr-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...------Y.MV.DGGKRTV..KR.GYKYNIP..TAK.GD..CGG.LLMLGPK.TV..LtggRKITGMHSAG.SPK..L.G...L..G..F..STIVTRQQVCEALNRF---hei..................
A0A1L3KKS7_9VIRU/1994-2212             ...................................................................................................dtltrivdrntftlrvqymnpngnltn-----------------.---.-..---.---------RDFRCVGLRQHYALLIDHYVfwidQ.HFD...ENTEIFYI.K.N......QIIY..KVNW..S.D.IR....KS..LK....QL....E..nSA.......LCVVE.LP.I....QIPSFRNIIK....FMISAKETSNMSA-.-GGYLL.QKNEE.....-N.NT.LLLKSFDRIVR..E.sGIDV...SND----.--.-DDSVTV..VD.HVYKYPY..GGR.GV..CGS.V-LCTDN.NN..Y...NGIIGIHIAG.LRD..C.S...V..G..Y..AEALVRESFDW--------ivdngep..............
A0A1L3KL07_9VIRU/1228-1321             ...............................................................................................................vrtrtglfltdavrd-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...---VNSY.SY.DGMSFYL..TD.GFMYQGL..THS.GD..CGI.PILLAET.KA..V...RKCIGLHVAG.TVN..K.D...Y..P..YglAVRISREMIEEAI------gedlek...............
A0A1L3KNI0_9VIRU/1398-1494             ........................................................................................................ltvkmlredgwsmvraqvmgnv-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-----HY.DH.PGKKIYL..ER.GLIYNMK..TLI.GD..CGApLVVESPP.SL..N...GKIIGIHVAG.NEN..C.T...K..G..L..ATIVTKEDLDEAMQ-----enfe.................
A0A1L3KKV6_9VIRU/966-1186              .................................................anallrnripqstgvvavydsnerkigsmhltmlkgrigvtashlllgkpsflkvyfvnkqpyeysiselvfhedts-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...RD.......LLFIE.FP.N....RHEQFKDITK....QFVIKSDFKHMTNT.KGALYT.YPNLA.....DC.DLsRSCYKSGNVYA..V..TTDY...VIHTSLK.DE.TAGIVRR..LD.GLTYDIN..TDF.GE..CGS.CLVMANP.ML..P...RKIAGIHIAG.QDA..S.P...S..G..L..ASVITQEYLEEV-------fvrcn................
A0A1L3KNP7_9VIRU/1060-1292             ..........................................................................................................................mqmw-----KDQVAQNIINNRiLSN.L..YKI.SVKRGDREMPLLNGLFVRATNMLVPGHLI....G.FLC...DDDI---I.S.L......TNLF..EVRF..EiP.WK....DV..IV....NT....I...TDrfgdskeAALLT.FP.R....YVHQHSDLVK....HFSDGESMSMYRTA.DTCIPT.IRFSD.....KL.RK.-FVLTILGNQT..A..RCLD...RVVTLC-.DD.EKGDFYL..RQ.GLEYKCP..TKN.GD..CGS.PVVINET.RV..L...RKIAGIHVAG.ADD..-.G...T..A..Y..AESVTQNDLERVFKK----ipvn.................
A0A1L3KMN9_9VIRU/1088-1323             ..........................................................................................................................emqv----WKDQAAQTLITNR.IFSnLykICR.VINDTDS-MPLLHGLFVKGNIMLVPSHLT....D.FVD...DSESIEIInC.F......ETSF..QVPW..K.EiKK....IR..LT....NAi.geE...KE.......ATLLV.FP.N....YIPQHSDIVK....HFSDADAMGLYKRA.EVCLPL.LRYSQ.....KV.KK.FLINILGNTEA..I..ASDV...--PITIM.DAdIGKDYII..RE.GLYYKSN..TTN.GD..CGA.PLVVNET.QV..L...RKIAGIHVAG.D-Y..T.G...M..A..Y..SESVTQKDLERAFVR----ipan.................
POLG_RTSVA/2630-2860                   ..............................................................................................................................RAGVDRDLSMTNLIDTH.MAG.M..SCI.IISELGNVFRTFGVLRLCGTYVCMPAHYL....D.EIT...SEHTLYFV.C.P......SKIT..QIQL..E.R.HR....VC..LV....NG....F...QE.......TVVWD.LG.P....SVPPSRNYID....FIANADDWKNYKAT.SGALVM.SKYSV.....DS.ML.QCVHFLDSIEL..T..EANV...SVPTSYY.EA.NGGIHTI..IS.GLRYRVH..CMP.GF..CGR.AIMRADA.TC..F...RKIIGMHVSG.LRN..K.C...M..G..Y..AETLTQEHLMQAIETLKE-t....................
A0A1L3KL02_9VIRU/990-1140              ................................................vraeditvvansdhdlallqfpnhirdhadisphicdhqelskfpdmgvqgamimagekaqmikyahvymdtdvhyed-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-------.SA.NNAKYHL..VS.NFRYKME..MKK.GD..CGS.LLVAVNA.NF..R...KKILGIHVAG.RTG..H.P...Y..G..H..AAPVCA-------------rimnemlthqsld........
A0A1L3KJC7_9VIRU/2114-2309             .................................................................................................................dfdgciarlqgvc-----------------.---.-..---.----------------IGGKVCLLPRHFF....M.KAR...DGDFFYFV.R.N......NDKI..QVEY..N.S.IN....KI..DI....-L....E...KD.......ACLYY.MG.A....RFDSKPKILN....CFAKEEEILKLNLT.TPAMLI.GLTA-.....--.--.DGIYTQKSC-V..A..KAN-...--QKCSY.PV.YGGIQYL..MT.GWQYDID..TQK.GD..CGS.LLLACTN.RL..Sa.pQKIVGMHTAG.YHD..Q.R...G..G..F..SVIFTQEQISNSLDEL---vrr..................
A0A1L3KKV9_9VIRU/1016-1216             adgmrvgvlfltgrtmlcnhhawaaaerrgqfqlrnpgaiesttikikecryervnrggeydqdlmmvelpvhvpmrpdimskivkgahqggleersatlvgfnrisgletlsekpindlsvtdik-----------------.---.-..---.-----------------------------....-.---...--------.-.-......----..----..-.-.--....--..--....--....-...--.......-----.--.-....----------....--------------.------.-----.....--.--.-----------..-..----...-----TK.SQ.DGQVHTI..RK.GYAYTAV..TRA.GD..CGS.LLFTNST.LA..E...GKLIGFHSAG.IPK..D.G...V..G..F..SEALERGTLEATMSKLQ--vk...................
A0A1L3KJF9_9VIRU/2024-2244             ...................................................................................................sddpeavqvarnkihpllysfgwqkgn-----------------.---.-..---.-------NPVQLQGLAIGGKVIMTPYHFF....R.RAK...DGDQFYFV.R.G......TDKI..VVEF..V.K.SR....LQ..RL....DD....-...KD.......CAIYY.VG.A....QFDSRKSILN....CFVKEQDLGRLGKK.IPAILV.GVTQG.....GV.CL.EKS--------..C..KAES...NQIIKYKgQD.EGAEEFV..QI.GWKYDID..TLK.GE..CGS.-ILIACS.KM..LpppSKIVGMHTAG.YTS..T.R...G..G..F..SIVLTREQVETALQQI---var..................
POLN_ABPVR/1120-1353                   ..........................................................................................................................mqmw-----KDQVAQKLITNRvLTN.L..YKIcLVKENGDMVPLLNGLFVRSNIMLAPGHLV....G.FLS...DSDTIEIRnL.F......DVVF..RVPW.kD.V.KK....VD..VV....NA....FgesKE.......AVLLC.FP.K....FVCQHTDLVK....HFQDSESMSKFKRC.EVTLPV.LRYS-.....DK.MN.RFLATLIECDK..V..EAY-...DRPYTLN.DS.SKGQYIL..RQ.GLEYTMP..TTN.GD..CGA.PLVINET.QV..I...RKIAGIHVAG.DA-..R.G...K..A..Y..AESISQKDLIRAFSKI---dvs..................
#=GC seq_cons                          ....................................................................................................................hh.hthpphh..........................................................................................................................................................................................................................................h.ss..ssphhl..pp.GatYphs..Tpt.GD..CGu.hlhhsss.ph..h...pKIlGlHVAG.ssp..p.s...h..G..a..AtslopEplppsh......hh...................
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