#=GF ID   Peptidase_C41
#=GF AC   PF05417.15
#=GF DE   Hepatitis E cysteine protease
#=GF AU   Studholme DJ;0000-0002-3010-6637
#=GF SE   Manual
#=GF GA   27.00 27.00;
#=GF TC   380.00 377.50;
#=GF NC   21.90 21.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8219799
#=GF RT   Molecular organization and replication of hepatitis E virus
#=GF RT   (HEV). 
#=GF RA   Reyes GR, Huang CC, Tam AW, Purdy MA; 
#=GF RL   Arch Virol Suppl 1993;7:15-25.
#=GF RN   [2]
#=GF RM   1518855
#=GF RT   Computer-assisted assignment of functional domains in the
#=GF RT   nonstructural polyprotein of hepatitis E virus: delineation of
#=GF RT   an additional group of positive-strand RNA plant and animal
#=GF RT   viruses. 
#=GF RA   Koonin EV, Gorbalenya AE, Purdy MA, Rozanov MN, Reyes GR,
#=GF RA   Bradley DW; 
#=GF RL   Proc Natl Acad Sci U S A 1992;89:8259-8263.
#=GF RN   [3]
#=GF RM   10963340
#=GF RT   Expression of the hepatitis E virus ORF1. 
#=GF RA   Ropp SL, Tam AW, Beames B, Purdy M, Frey TK; 
#=GF RL   Arch Virol 2000;145:1321-1337.
#=GF DR   INTERPRO; IPR008748;
#=GF DR   MEROPS; C41;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   Corresponds to MEROPs family C41. This papain-like protease
#=GF CC   cleaves the viral polyprotein encoded by ORF1 of the hepatitis E
#=GF CC   virus (HEV).
#=GF SQ   1
#=GS POLN_HEVCH/432-592  AC Q81862.1
POLN_HEVCH/432-592             AQCRRWLSAGFHLDPRVLVFDESAPCHCRTAIRKAVSKFCCFMKWLGQECTCFLQPAEGAVGDQGHDNEAYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLETNGPERHNL
#=GC seq_cons                  AQCRRWLSAGFHLDPRVLVFDESAPCHCRTAIRKAVSKFCCFMKWLGQECTCFLQPAEGAVGDQGHDNEAYEGSDVDPAESAISDISGSYVVPGTALQPLYQALDLPAEIVARAGRLTATVKVSQVDGRIDCETLLGNKTFRTSFVDGAVLETNGPERHNL
//