#=GF ID Peptidase_C53
#=GF AC PF05550.15
#=GF DE Pestivirus Npro endopeptidase C53
#=GF AU Studholme DJ;0000-0002-3010-6637
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE Merops
#=GF GA 27.00 27.00;
#=GF TC 33.20 395.80;
#=GF NC 24.30 20.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 11711606
#=GF RT Functional specialization and evolution of leader proteinases in
#=GF RT the family Closteroviridae.
#=GF RA Peng CW, Peremyslov VV, Mushegian AR, Dawson WO, Dolja VV;
#=GF RL J Virol 2001;75:12153-12160.
#=GF RN [2]
#=GF RM 10864644
#=GF RT Generation and characterization of a hepatitis C virus NS3
#=GF RT protease-dependent bovine viral diarrhea virus.
#=GF RA Lai VC, Zhong W, Skelton A, Ingravallo P, Vassilev V, Donis RO,
#=GF RA Hong Z, Lau JY;
#=GF RL J Virol 2000;74:6339-6347.
#=GF RN [3]
#=GF RM 9499122
#=GF RT N-terminal protease of pestiviruses: identification of putative
#=GF RT catalytic residues by site-directed mutagenesis.
#=GF RA Rumenapf T, Stark R, Heimann M, Thiel HJ;
#=GF RL J Virol 1998;72:2544-2547.
#=GF RN [4]
#=GF RM 8972567
#=GF RT Expression in E. coli and purification of the active
#=GF RT autoprotease P20 of classical swine fever virus.
#=GF RA Muyldermans G, San Gabriel MC, Hamers R, Wyns L;
#=GF RL Virus Genes 1996;13:135-142.
#=GF DR INTERPRO; IPR008751;
#=GF DR MEROPS; C53;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Unique to pestiviruses, the N-terminal protein encoded by the
#=GF CC bovine viral diarrhoea virus genome is a cysteine protease
#=GF CC (Npro) responsible for a self-cleavage that releases the N
#=GF CC terminus of the core protein. This unique protease is
#=GF CC dispensable for viral replication, and its coding region can be
#=GF CC replaced by a ubiquitin gene directly fused in frame to the
#=GF CC core.
#=GF SQ 1
#=GS POLG_BVDVN/1-168 AC P19711.2
POLG_BVDVN/1-168 MELITNELLYKTYKQKPVGVEEPVYDQAGDPLFGERGAVHPQSTLKLPHKRGERDVPTNLASLPKRGDCRSGNSRGPVSGIYLKPGPLFYQDYKGPVYHRAPLELFEEGSMCETTKRIGRVTGSDGKLYHIYVCIDGCIIIKSATRSYQRVFRWVHNRLDCPLWVTTC
#=GC seq_cons MELITNELLYKTYKQKPVGVEEPVYDQAGDPLFGERGAVHPQSTLKLPHKRGERDVPTNLASLPKRGDCRSGNSRGPVSGIYLKPGPLFYQDYKGPVYHRAPLELFEEGSMCETTKRIGRVTGSDGKLYHIYVCIDGCIIIKSATRSYQRVFRWVHNRLDCPLWVTTC
//
