#=GF ID Peptidase_M60_C
#=GF AC PF18630.5
#=GF DE Peptidase M60 C-terminal domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF07779
#=GF GA 26.20 26.20;
#=GF TC 26.70 26.50;
#=GF NC 26.00 25.60;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0159
#=GF RN [1]
#=GF RM 28096352
#=GF RT Recognition of protein-linked glycans as a determinant of
#=GF RT peptidase activity.
#=GF RA Noach I, Ficko-Blean E, Pluvinage B, Stuart C, Jenkins ML,
#=GF RA Brochu D, Buenbrazo N, Wakarchuk W, Burke JE, Gilbert M,
#=GF RA Boraston AB;
#=GF RL Proc Natl Acad Sci U S A. 2017;114:E679.
#=GF RN [2]
#=GF RM 27005013
#=GF RT The outer-membrane export signal of Porphyromonas gingivalis
#=GF RT type IX secretion system (T9SS) is a conserved C-terminal
#=GF RT beta-sandwich domain.
#=GF RA de Diego I, Ksiazek M, Mizgalska D, Koneru L, Golik P,
#=GF RA Szmigielski B, Nowak M, Nowakowska Z, Potempa B, Houston JA,
#=GF RA Enghild JJ, Thogersen IB, Gao J, Kwan AH, Trewhella J, Dubin G,
#=GF RA Gomis-Ruth FX, Nguyen KA, Potempa J;
#=GF RL Sci Rep. 2016;6:23123.
#=GF DR INTERPRO; IPR041333;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is C-terminal domain (CTD) of M60-peptidases Pfam:PF13402
#=GF CC [1]. It Can also be found at the C-terminal region of gingipain
#=GF CC B (RgpB) from P. gingivalis. It was found to possess a typical
#=GF CC Ig-like fold encompassing seven antiparallel beta-strands
#=GF CC organized in two beta-sheets, packed into a beta-sandwich
#=GF CC structure that can spontaneously dimerise through C-terminal
#=GF CC strand swapping. Translocation of gingipains from the periplasm
#=GF CC across the OM is dependent on the conserved CTD, which appears
#=GF CC to be important for secretion of the proteins and in particular,
#=GF CC truncation of the last few C-terminal residues of this domain
#=GF CC leads to accumulation of gingipains in the periplasm.
#=GF CC Subsequently, the T9SS targeting signal was demonstrated to
#=GF CC reside within the last 22 residues at the C-terminus of the CTD.
#=GF CC During gingipain translocation across the OM, the CTD is cleaved
#=GF CC off by PorU [2].
#=GF SQ 42
#=GS CPG2_PORGI/673-730 AC P95493.2
#=GS A0A1T5A433_9BACT/857-913 AC A0A1T5A433.1
#=GS A0A374V8F2_9BACE/873-935 AC A0A374V8F2.1
#=GS F8N5N5_9BACT/944-1004 AC F8N5N5.1
#=GS A0A3L7Z5I7_9BACE/791-856 AC A0A3L7Z5I7.1
#=GS R6ZST0_9BACE/702-767 AC R6ZST0.1
#=GS R5P7K5_9BACT/876-939 AC R5P7K5.1
#=GS R6DZU9_9BACE/798-864 AC R6DZU9.1
#=GS A6KYY0_PHOV8/900-965 AC A6KYY0.1
#=GS A0A060RCA2_9BACT/773-836 AC A0A060RCA2.1
#=GS A0A174QPU7_9BACE/882-951 AC A0A174QPU7.1
#=GS L1MF38_9BACT/932-997 AC L1MF38.1
#=GS A0A0B7IHA5_9FLAO/777-838 AC A0A0B7IHA5.1
#=GS E6SQ24_BACT6/871-933 AC E6SQ24.1
#=GS A0A1K1LIX4_9BACT/714-775 AC A0A1K1LIX4.1
#=GS F3PW04_9BACE/875-937 AC F3PW04.1
#=GS L1MSG8_9BACT/1078-1139 AC L1MSG8.1
#=GS D9RXH2_PREMB/927-993 AC D9RXH2.1
#=GS A0A1G4G3Q0_9BACT/862-922 AC A0A1G4G3Q0.1
#=GS A0A174H0T5_9BACE/791-853 AC A0A174H0T5.1
#=GS A0A374VBJ6_9BACE/887-949 AC A0A374VBJ6.1
#=GS A0A3N2MGU8_9BACT/796-861 AC A0A3N2MGU8.1
#=GS A0A174WZA3_9BACE/885-947 AC A0A174WZA3.1
#=GS R6DCX5_9BACE/823-897 AC R6DCX5.1
#=GS Q89ZX7_BACTN/791-856 AC Q89ZX7.1
#=GS A0A521BYB3_9BACT/676-735 AC A0A521BYB3.1
#=GS W4P724_9BACE/857-916 AC W4P724.1
#=GS A0A174N077_9BACE/887-950 AC A0A174N077.1
#=GS R6DN37_9BACE/882-951 AC R6DN37.1
#=GS A0A174NKF2_9BACE/814-882 AC A0A174NKF2.1
#=GS W4UMJ4_9BACE/545-607 AC W4UMJ4.1
#=GS F3PN55_9BACE/984-1043 AC F3PN55.1
#=GS A0A5P8E716_9BACT/871-926 AC A0A5P8E716.1
#=GS R5C872_9BACE/885-947 AC R5C872.1
#=GS R6A834_9BACT/942-1010 AC R6A834.1
#=GS A0A174STS8_9BACE/731-796 AC A0A174STS8.1
#=GS Q89ZU9_BACTN/931-993 AC Q89ZU9.1
#=GS A0A3P1Z972_9BACT/931-996 AC A0A3P1Z972.1
#=GS G5GDC2_9BACT/909-971 AC G5GDC2.1
#=GS R6DEY0_9BACE/726-791 AC R6DEY0.1
#=GS R6D9D4_9BACE/935-1003 AC R6D9D4.1
#=GS A0A3P1Z1V4_9BACT/895-956 AC A0A3P1Z1V4.1
CPG2_PORGI/673-730 ............PYTVAVSGK.TITVES..--PAAGLTIFDMN....GR..R....VATAK.......N.......RMVFEAQNG--.----.-......VYAVRiaTEGKTYT..........
A0A1T5A433_9BACT/857-913 ...........n---VARSGQ.QLSFTN..WKNVVAFEVYNDT....--..E....LVFIS.......P.......STSFTSKSS--.--FN.Q......VYAVA..ANGTKV-k.........
A0A374V8F2_9BACE/873-935 ..........ag--TAAYSGS.KLTMTG..WKNVVAFEVYDNS....S-..K....LIFVS.......P.......ETSFTVNAT-L.PQGF.K......VYAVA..ANGTK--tq........
F8N5N5_9BACT/944-1004 .krtytfvpmnn---------.------..--HVVGFKIYSSG....D-..T....LIYFA.......N.......TKTFTIPAAVM.KKAN.Nd...vkVKVCG..SDGSE--vd........
A0A3L7Z5I7_9BACE/791-856 ............AISATISGN.AVSIQN..GEEAVAFEVRERS....EN.gK....ILYFS.......N.......SFTFDVPASIS.MTNA.K......VFAVQ..ADGKRV-p.........
R6ZST0_9BACE/702-767 ............AVCHTVSGR.TYTVTN..GENAVAFELRKGG....AD.gE....LVYFF.......N.......RFSYTIPEGVD.LTGT.G......LFAVQ..ADGKRIE..........
R5P7K5_9BACT/876-939 ............NVTYKLSGT.AIRITN..GEEAVAFELRDAQ....D-..K....LIWFS.......N.......FLNFEVSSSVL.DKMD.K......IYAVQ..ANGTRIT..........
R6DZU9_9BACE/798-864 ..........tp--TYSLSGN.NITVNN..GTQAVAFEIRKDN....EN.gE....LLYFF.......N.......FLSYSIPSTVV.IDGTtK......FYAVQ..ADGKRIE..........
A6KYY0_PHOV8/900-965 ...........t-LSSSHQGA.TIRVSD..GEEAVAFEVRENE....AN.sR....LLYFS.......N.......SFTFTVPSKVY.QSSA.K......VYAVQ..ADGQRI-l.........
A0A060RCA2_9BACT/773-836 ............NISYTLNGE.AVSILN..GGNAVGFEVRAGS....PT.aK....VLAFS.......V.......RFGFTTNK---.LSGAnK......LYAVQ..ADGTRIE..........
A0A174QPU7_9BACE/882-951 .........gtn---ATRSGN.TITIKN..WQNVVAYEVKDQT....G-..K....LVFVSsgettssT.......TDMFTLSGN-W.DSSY.K......LYAVS..AAGKRT-e.........
L1MF38_9BACT/932-997 ...........v-YETKISGN.RITVDRksGKGAVGFKIYDLN....G-..K....LVRVS.......N.......TYTFTIPSEIV.KAGY.F......MTIAH..GNGKES-i.........
A0A0B7IHA5_9FLAO/777-838 ..........kg--TATRRGT.TVTTSG..YKNVVAYEVYSNN....D-..-....LIYAT.......N.......KNSFDFKNT-V.ATNV.I......VYAIA..YDGTRT-e.........
E6SQ24_BACT6/871-933 ..........tp--KYSRSGQ.HISISN..GEEAVAFEVMKGD....--..K....LLFFS.......N.......FLSFEVPSSIK.LEGC.D......IYAVQ..ADGKR--kq........
A0A1K1LIX4_9BACT/714-775 ........ldvq---------.-VNHTN..GTGAVGFKVYDGQ....N-..R....LVFLS.......N.......TYEFSVPSSIY.SQIR.Agd..frIVAAG..ADGND--qe........
F3PW04_9BACE/875-937 ..........tp--KYSRSGQ.RISISN..GDEAVAFEVKKGD....--..K....LLFFS.......N.......FLSFEVPSSIA.LEGC.S......IYAVQ..ADGHR--kq........
L1MSG8_9BACT/1078-1139 .........nav----RIDGR.TVRIQ-..GTGAVGYKVYNEA....G-..K....LVMVA.......N.......TNDFTLLDNLE.LSKL.T......VTVAG..GNGEEV-e.........
D9RXH2_PREMB/927-993 .....qsdangr--------R.TYTMEA.kNSHVVGFKIYDSK....G-..N....LIYFA.......N.......TKTFTIPKKVM.EDAQ.Nn...ivIKVCG..SDGSE--vd........
A0A1G4G3Q0_9BACT/862-922 ...........g--TATANGT.TIVMTG..WENVVAYEVYQGD....D-..-....LLFVS.......N.......KSKFTIDQK-Y.NDSI.V......VYALS..YDGNRT-k.........
A0A174H0T5_9BACE/791-853 ...........q-ITYTISGH.QVNVQN..GEQAVAFEIKEND....--..N....LKYFG.......T.......SFQFEIPNTIS.PDRV.K......LYAVQ..ADGVRIE..........
A0A374VBJ6_9BACE/887-949 ............TITCSRSGR.AFTVAN..GDEAVAFELRKNG....--..K....ILYFS.......N.......FFNFAVPDGID.LEGA.G......FYAVQ..ADGTRIE..........
A0A3N2MGU8_9BACT/796-861 ............NISATVSGR.TVTVSN..ASEAVAIEIRRSD....ES.gD....IVFFS.......N.......FTTFEIPSDVN.TNGC.R......IYAVR..ANGDR--rh........
A0A174WZA3_9BACE/885-947 ..........tp--TYSASGQ.QVTIIN..GNEAVAFEIWKDG....--..K....RKYFS.......N.......FLKFTLPDELP.VSQC.T......IRAVQ..ADGKLIT..........
R6DCX5_9BACE/823-897 .......tytek---ASTQGK.AISVSN..GEQAVAFEVRKQEtgsnGE..KimgdVVYFS.......N.......SFEFFVPRTVS.IAGC.G......IYAVQ..ADGARI-l.........
Q89ZX7_BACTN/791-856 ............AITAELAGR.KVSIQN..GDEAVAFELREND....EN.gK....LLYFS.......T.......FTTFEIPSSIL.MVNA.K......LYAVQ..ADGKRI-l.........
A0A521BYB3_9BACT/676-735 ...........g--TAAVTGN.DISVTG..HSNAVSFEQHRNG....--..K....LIFIA.......T.......RPTFTVPS--F.ATND.K......LYAVG..YDGNRVE..........
W4P724_9BACE/857-916 .........tai-----KSGK.NITMNG..WQNVVAYEVYDGE....--..T....LVFVS.......N.......KASFSLDTD-V.NSGI.K......VLAVA..YDGSK--te........
A0A174N077_9BACE/887-950 ............NVTYTRSGQ.HITISS..GDEAVAFEVKKGS....--..E....IMYFS.......N.......FFSFDIPASIPwNDSM.K......IYAVQ..ANGER--ke........
R6DN37_9BACE/882-951 ..........ga--SATRSGN.TITIKN..WQNVVVYEVRDEA....D-..N....LVFVS.......SgettpsaTDMFTLSGN-W.NDGY.K......LYAVS..ATGKR--tg........
A0A174NKF2_9BACE/814-882 .........tmv---ASVTGS.EITIKN..GEQAVAFEVRKQSt..dGTmgE....VVYFS.......N.......FLKFSVPRNIP.LIRT.G......IYAVQ..ADGERI-l.........
W4UMJ4_9BACE/545-607 ..........tp--TYSASGQ.QVTIIN..GNEAVAFEIWKDG....ER..-....-KYFS.......N.......FVKFTLPEKLP.IGQC.T......IKAVQ..ADGKLIT..........
F3PN55_9BACE/984-1043 .........aic------KGN.TFTMKN..WKNVVAYEVFRNG....--..K....LVFVA.......P.......LQHFTVENVVV.DAKT.K......VYAIA..SDGSR--ek........
A0A5P8E716_9BACT/871-926 ...........n-IGFKRSGA.NFTIT-..GTGAVGYKIYDDK....G-..E....LVFIS.......F.......KNTFKTSNAIA.----.-......-----..-------rginegrysl
R5C872_9BACE/885-947 ............TISYSRSGQ.QISITD..GDEAVAFEVRKDN....--..K....LLYFS.......N.......AFHFTVPSSIS.LEGA.G......IYAVQ..ADGKRIE..........
R6A834_9BACT/942-1010 ...........g-YTYTRRDS.TITMK-..GEGAVGYKVYDNE....G-..N....LLYFA.......N.......TNTFTLPQSVV.NALA.AdgksmvVKVAQ..PDGTDVT..........
A0A174STS8_9BACE/731-796 ........dikg----NINGR.EVSITN..GDEAVAFELREKD....AN.gK....LLYFS.......T.......FIKFEVPLTVS.LTYA.K......LYAVQ..ADGKRI-l.........
Q89ZU9_BACTN/931-993 ............TVSYTVSGR.TYTVTN..GEQAVAFELIKDG....--..K....KVWFA.......N.......RFVFTVPAEAD.IEGA.E......LYAVQ..ADGQRIK..........
A0A3P1Z972_9BACT/931-996 ...........p-YTCTVSATgKVTIQK.dGKGAVGFKVYDTN....R-..K....LVYVS.......N.......TWTFNLPESIR.KAGY.Y......ICVAY..GNGKQ--qs........
G5GDC2_9BACT/909-971 fttsvtnpravq---------.-----A.vGTGAVGFKVYDKD....G-..N....LVFMA.......N.......TNKFTLPESLV.GQPY.T......IKAAQ..GNGEDV-l.........
R6DEY0_9BACE/726-791 ........dikg----HINGR.EVTITN..GDEAVAFELREKD....AN.gK....LLYFS.......T.......FTKFEIPLAVS.LTYA.K......LYAVQ..ADGKRI-n.........
R6D9D4_9BACE/935-1003 ...........e-VTATISGK.EITVASnvGSKAVAFEARKGN....SSdgE....LVYFS.......N.......DFKFTLPDNIK.TSEV.R......LWAVQ..ADGAR--ks........
A0A3P1Z1V4_9BACT/895-956 ........advr-----LIGR.SVIVS-..GEGAVGYKVYDKS....N-..K....LIMIS.......N.......RNRFVLPENVA.LADL.I......VKVGG..GNGEDV-e.........
#=GC seq_cons ..............phshoGp.plolps..GppAVAFElhcss....t...c....LlahS.......N.......phsFslPssl..hsss.p......lYAVp..ADGpRh...........
//
