#=GF ID Peptidase_M99_m
#=GF AC PF17130.8
#=GF DE beta-barrel domain of carboxypeptidase M99
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE pdb:4q6p
#=GF GA 27.50 27.50;
#=GF TC 27.50 27.70;
#=GF NC 27.00 27.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 25372672
#=GF RT Structural basis for the recognition of muramyltripeptide by
#=GF RT Helicobacter pylori Csd4, a D,L-carboxypeptidase controlling
#=GF RT the helical cell shape.
#=GF RA Kim HS, Kim J, Im HN, An DR, Lee M, Hesek D, Mobashery S, Kim
#=GF RA JY, Cho K, Yoon HJ, Han BW, Lee BI, Suh SW;
#=GF RL Acta Crystallogr D Biol Crystallogr. 2014;70:2800-2812.
#=GF DR INTERPRO; IPR033398;
#=GF DR MEROPS; M99;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the central, beta-barrel, domain of the
#=GF CC metallo-carboxypeptidase that maintains helical cell-shape in
#=GF CC Helicobacter. It shows a novel fold. It has a highly positively
#=GF CC charged surface which contributes to a high overall isoelectric
#=GF CC point. A calcium-binding channel is formed from residues in the
#=GF CC C-terminal Ig-like domain in conjunction with some of the long
#=GF CC side-chains of residues from strands beta-14 and beta-18 of this
#=GF CC domain [1].
#=GF SQ 31
#=GS A0A2D3W5J2_9PROT/268-338 AC A0A2D3W5J2.1
#=GS A0A5P8P0L1_9PROT/264-334 AC A0A5P8P0L1.1
#=GS A0A1G7NW87_9DELT/248-320 AC A0A1G7NW87.1
#=GS A0A329ZSS2_9HELI/267-334 AC A0A329ZSS2.1
#=GS O25708_HELPY/268-340 AC O25708.1
#=GS A0A3D8HZI9_9HELI/246-314 AC A0A3D8HZI9.1
#=GS A0A268TSF6_9HELI/268-341 AC A0A268TSF6.1
#=GS A0A076F9C0_9PROT/274-344 AC A0A076F9C0.1
#=GS T1D0H9_9HELI/267-355 AC T1D0H9.1
#=GS E7G5D6_9HELI/263-335 AC E7G5D6.1
#=GS T2GFH4_MEGG1/275-343 AC T2GFH4.1
#=GS A0A1B1U6M4_9HELI/261-333 AC A0A1B1U6M4.1
#=GS A0A3D8IIZ8_9HELI/263-331 AC A0A3D8IIZ8.1
#=GS A0A329ZIK1_9HELI/261-340 AC A0A329ZIK1.1
#=GS V8CKD0_9HELI/266-338 AC V8CKD0.1
#=GS A0A268TGH6_9HELI/267-339 AC A0A268TGH6.1
#=GS A0A5C2HIV6_9GAMM/272-339 AC A0A5C2HIV6.1
#=GS A0A3D8J3V8_9HELI/248-320 AC A0A3D8J3V8.1
#=GS F8KRB2_HELBC/275-347 AC F8KRB2.1
#=GS A0A3G9MGG1_RHOOP/1-35 AC A0A3G9MGG1.1
#=GS H5VEN1_HELBI/92-164 AC H5VEN1.1
#=GS A0A1B8J8K4_9HELI/305-377 AC A0A1B8J8K4.1
#=GS D3UGK0_HELM1/229-300 AC D3UGK0.1
#=GS A0A4Q0XNR4_9PROT/273-341 AC A0A4Q0XNR4.1
#=GS A0A2A2GUN2_9HELI/273-348 AC A0A2A2GUN2.1
#=GS V8C5S9_9HELI/280-352 AC V8C5S9.1
#=GS A0A3D8HTQ3_9HELI/240-316 AC A0A3D8HTQ3.1
#=GS A0A3D8IU32_9HELI/259-330 AC A0A3D8IU32.1
#=GS I7HEC1_9HELI/271-344 AC I7HEC1.1
#=GS Q7VIS2_HELHP/268-340 AC Q7VIS2.1
#=GS A0A345J8U9_9PROT/268-338 AC A0A345J8U9.1
A0A2D3W5J2_9PROT/268-338 ...dndifisfnd---------KKIFIPLSRIRPWISYFPVKKGD-..--QITFKPSSPVMTV.....L.............EE.E.N.Q.YV...V..YYGNKKLTTLVPEYLD..
A0A5P8P0L1_9PROT/264-334 ...nndiyismyd---------NKIKLPLSKIRNYLRYFPIKKDQ-..--EVKFRASNPLLTI.....V.............QK.D.N.E.YT...I..QYGNRRLSRLKADYME..
A0A1G7NW87_9DELT/248-320 ...enlgvsfadn----------RIFLPLEDARPTINYLPLPKEAQ..ATAVPSKPIMAVLPC.....E.............RD.D.G.Q.YC...V..HYGNRMITLIRPEW--re
A0A329ZSS2_9HELI/267-334 .............DENILIHFDNRITLPINRLKSIINYFPMTKNL-..----GYHSDNPIVHY.....Y.............VK.G.K.N.HL...I..KYGNRVSTKLSPDF--fs
O25708_HELPY/268-340 .............DKNLWAKISSLPKMPLFNLRPKLNHFPLPHNTK..IPQIPIESNAYIVGL.....V.............KN.K.Q.E.VF...L..KYGNKLMTRLSPFYIE..
A0A3D8HZI9_9HELI/246-314 ........hedtn-----IVINDIIELPLYNIKPVINHFPIQKEN-..---IDFYSNTPIVWL.....F.............KD.E.K.N.YR...I..KHGNKNLVYLKPFYTE..
A0A268TSF6_9HELI/268-341 .............DKSLTVDIEGKITLPMFGLRPYLNYFPLPEGVP..LADITLESRAHILGL.....L.............PNsD.G.S.VS...L..KYGNRVLTRFKPFYTD..
A0A076F9C0_9PROT/274-344 ekeieivlfnnkf------------YLSLNNPRAKIGYVPIPKDT-..--ALEYNCTSPLAAL.....I.............KD.K.N.G.YT...V..HYGNKILTKLVPEFID..
T1D0H9_9HELI/267-355 .............DQNLSVSIQDLPALPFFGLREMQNNFPLPKGKA..FDEIELGSSARILGL.....VpqnsannakkngvSK.N.N.K.SLilaL..KYGNRVLTKLVPYYVD..
E7G5D6_9HELI/263-335 .............DKTLTLTLNQNILLPLYGLRPRLKFFPFPKHVA..IDKNSLDSQSYILGL.....L.............PH.K.N.K.IW...L..KYGNKLMTRLTPLYLN..
T2GFH4_MEGG1/275-343 ...nlslalydnr-----------IFLDLENIRSQLNYFPLKKDA-..--DMPFAASSPLVTV.....L.............GA.G.E.E.YT...V..YHGNKVLTRLRPEYFE..
A0A1B1U6M4_9HELI/261-333 .............DRKSWVKITPLIELPLFDLQKNLTFFPFPSGVK..PDGLKLDSNQYITGL.....V.............SK.E.K.N.IV...L..KYGNRVMTTLTPLYL-k.
A0A3D8IIZ8_9HELI/263-331 .............DKNMNIVINDIIELPLYNIKNSLNYFPIQKDN-..---LRFYSNTPIIWL.....F.............ED.G.N.N.FR...I..KNGNKNIVYLKPFFID..
A0A329ZIK1_9HELI/261-340 .............DKNLTLTIDSSITIPLFHLKSPINFFPIPLSAKgdVQNLALESKSYILGLspegdF.............KA.D.S.M.VF...L..KYGNRTMARIKPLYLE..
V8CKD0_9HELI/266-338 .........drsq----TFKLENLPEMPLFGLRTPLASFPIPKGKK..ASEITITSNNKILGL.....L.............PR.D.G.S.LT...L..KYGNNVMTKILPKRID..
A0A268TGH6_9HELI/267-339 .............DKSLDVVIDENILLPLYGLRPTINYFPLPKDIQ..ITQIPLTSKAYILGL.....L.............PK.N.N.Q.VW...L..KYGNKLMSRINPEYME..
A0A5C2HIV6_9GAMM/272-339 ......plqltlp---------DRLQLPLENIRSQLNYFPLPTHT-..LPT--WQSNNPLLAV.....V.............NR.G.D.S.WQ...I..NYGNRRLTQLKPQFFD..
A0A3D8J3V8_9HELI/248-320 .............DAKLNIEIEDNIRLPIYGLKSELNFFPLPKKS-..IQSIKVTGDSYLMGL.....S.............PR.DnQ.Q.IF...V..KYGNKLATKLNPQYFD..
F8KRB2_HELBC/275-347 .............DPNLTLTMNQNILLPLYGLRSQLKFFPFPKDTP..INQISLQSQSYILGL.....L.............PR.K.N.Q.IW...L..KYGNKLMTRLHPLYLD..
A0A3G9MGG1_RHOOP/1-35 .............---------------------------------..-----MESNAYIVGL.....V.............KN.K.Q.E.VF...L..KYGNKLMTRLSPFYIE..
H5VEN1_HELBI/92-164 .............DPNLTLTMNENILLPLYGLRSQLKFFPFPKDTP..INQISLQSQSYILGL.....L.............PR.K.N.Q.IW...L..KYGNKLMTRLHPLYLD..
A0A1B8J8K4_9HELI/305-377 ......dpkqrfs-------IEGMPSFPLFGLRALQASFPLPKGKD..YGTIRIESDNKILGL.....L.............PR.E.N.L.LV...L..KYGNRVMSKFAPNFIE..
D3UGK0_HELM1/229-300 .............DTHLDVRIAKSITLPLYGLREELNYFPLPKQS-..ISSIPLESRAHILGL.....L.............QK.D.N.Q.VL...L..KYGNKVMTKFSPEYLD..
A0A4Q0XNR4_9PROT/273-341 .....diyisfyn---------DKIKLPLSEVRPHLNYFPVKKDGT..LKFTP---SNPLMTV.....L.............KT.G.N.D.YS...I..HYGNVRLAKLSPDYLD..
A0A2A2GUN2_9HELI/273-348 .............DPNITFSIDSLITLPLLDLKSPLNYFPMPQSAKtqLQDLPIDSQSYIVGL.....M.............HR.E.DsT.IG...I..KYGMRTMGVIKPLYLE..
V8C5S9_9HELI/280-352 .............DRNLRVGIEGMPPFPLFDLRDEIRGLPLPVGKR..FETIVLDSRAKILGL.....L.............PK.G.N.S.FT...L..KYGNNAMTKIVPKYVE..
A0A3D8HTQ3_9HELI/240-316 ..........dps---ITLTIDEILTLPLFSLKSPLNFFPMPLSAKndLQSVKIESKSKILGL.....S.............QA.P.Q.G.TA...LdiKYGNRTMARLNPLYLE..
A0A3D8IU32_9HELI/259-330 .............DKNARIQITDLITLPMMGLKKKISYFPLPSKD-..IASIAIKSNHYIVGM.....L.............KK.N.N.V.IL...L..KYGNRVVTQFSPLYLE..
I7HEC1_9HELI/271-344 ............t-TDLYAKIEDSIFLPLDSLRTNLAYFPLPKQNS..PKQLKIESPSYLLGI.....V.............PG.K.NgK.LN...L..HYGSRKLSTLSPQWY-e.
Q7VIS2_HELHP/268-340 ............t-AHLQAHIEGLITLPLDSLRPLITYFPLPQGVE..PKHIKIQSPSHILGL.....V.............KN.Q.Q.GgIE...I..KYGSRTLSTLSPQW--s.
A0A345J8U9_9PROT/268-338 ...dndisisfyd---------DKIKLPLREIRNSLNYFPIKKDG-..--SIEFVGSNPLMTV.....I.............KD.G.N.L.YN...I..HYGNRRVSRLSPDYFE..
#=GC seq_cons ..................h.lpshIpLPLhsLRs.lsaFPlPKss...htpltlpSsuhIlGL.....l.............pc.c.s.p.hh...l..KYGN+hhT+LsP.Yl-..
//
