#=GF ID Peptidase_S7
#=GF AC PF00949.25
#=GF DE Peptidase S7, Flavivirus NS3 serine protease
#=GF PI Flavi_helicase;
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE Pfam-B_199 (release 3.0)
#=GF GA 20.00 20.00;
#=GF TC 20.00 20.00;
#=GF NC 19.90 19.90;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF CL CL0124
#=GF RN [1]
#=GF RM 7642575
#=GF RT Association between NS3 and NS5 proteins of dengue virus type 2
#=GF RT in the putative RNA replicase is linked to differential
#=GF RT phosphorylation of NS5.
#=GF RA Kapoor M, Zhang L, Ramachandra M, Kusukawa J, Ebner KE,
#=GF RA Padmanabhan R;
#=GF RL J Biol Chem 1995;270:19100-19106.
#=GF RN [2]
#=GF RM 2174669
#=GF RT Flavivirus genome organization, expression, and replication.
#=GF RA Chambers TJ, Hahn CS, Galler R, Rice CM;
#=GF RL Annu Rev Microbiol 1990;44:649-688.
#=GF RN [3]
#=GF RM 8269709
#=GF RT Evolution and taxonomy of positive-strand RNA viruses:
#=GF RT implications of comparative analysis of amino acid sequences.
#=GF RA Koonin EV, Dolja VV;
#=GF RL Crit Rev Biochem Mol Biol 1993;28:375-430.
#=GF RN [4]
#=GF RM 10026173
#=GF RT Dengue virus NS3 serine protease. Crystal structure and insights
#=GF RT into interaction of the active site with substrates by molecular
#=GF RT modeling and structural analysis of mutational effects.
#=GF RA Murthy HM, Clum S, Padmanabhan R;
#=GF RL J Biol Chem 1999;274:5573-5580.
#=GF DR INTERPRO; IPR001850;
#=GF DR MEROPS; S7;
#=GF DR MEROPS; S7;
#=GF DR SCOP; 1bef; fa;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC The viral genome is a positive strand RNA that encodes a single
#=GF CC polyprotein precursor. Processing of the polyprotein precursor
#=GF CC into mature proteins is carried out by the host signal peptidase
#=GF CC and by NS3 serine protease, which requires NS2B (Pfam:PF01002)
#=GF CC as a cofactor [4].
#=GF SQ 30
#=GS A0A0U5C451_ASPCI/129-185 AC A0A0U5C451.1
#=GS A0A2U0I7L8_9FLAO/366-427 AC A0A2U0I7L8.1
#=GS POLG_DEN1W/1492-1643 AC P17763.2
#=GS A0A2L2TBK6_9HYPO/27-70 AC A0A2L2TBK6.1
#=GS A0A1Y2BIF4_9FUNG/83-127 AC A0A1Y2BIF4.1
#=GS C5J5N2_MESCH/18-75 AC C5J5N2.1
#=GS A0A2V1MW33_9LACO/309-430 AC A0A2V1MW33.1
#=GS K8DZM9_9FIRM/260-324 AC K8DZM9.1
#=GS A0A0A8EBZ9_MESFC/37-228 AC A0A0A8EBZ9.1
#=GS Y591_MYCPN/171-291 AC Q50336.1
#=GS A0A164NVM4_9CRUS/286-437 AC A0A164NVM4.1
#=GS A0A6I1MIK9_9CLOT/257-353 AC A0A6I1MIK9.1
#=GS A0A1Z5HQ28_9THEO/243-316 AC A0A1Z5HQ28.1
#=GS Y298_MYCGA/335-468 AC P33276.3
#=GS Y584_MYCPN/1-69 AC P75196.1
#=GS C8W2Y8_DESAS/112-164 AC C8W2Y8.1
#=GS A0A0A2TJV7_9FIRM/47-90 AC A0A0A2TJV7.1
#=GS Y589_MYCPN/14-134 AC Q50338.1
#=GS POLG_ZIKV/1515-1666 AC Q32ZE1.1
#=GS A0A1B8AKE3_FUSPO/572-614 AC A0A1B8AKE3.1
#=GS Y577_MYCPN/197-333 AC P75203.1
#=GS A0A1H7IQ85_9PROT/268-301 AC A0A1H7IQ85.1
#=GS A0A182G8Y9_AEDAL/294-439 AC A0A182G8Y9.1
#=GS POLG_YEFV1/1503-1655 AC P03314.1
#=GS A0A4R0QQG0_9STRE/2-58 AC A0A4R0QQG0.1
#=GS W5UUK1_9MOLU/832-912 AC W5UUK1.1
#=GS Y586_MYCPN/154-286 AC P75194.1
#=GS Y580_MYCPN/2-70 AC P75200.1
#=GS A0A5N7MKT1_9HYPH/6-45 AC A0A5N7MKT1.1
#=GS A0A0K9QPV2_SPIOL/111-151 AC A0A0K9QPV2.1
A0A0U5C451_ASPCI/129-185 ...............................................................................................................................................................qtvyletwehtfthgrgsgkfvc----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.-..-..---..R..PGDSGSLVF....N..KD...K......KVVG.L.FFGGSDTQ....----DVGY---fts.........................
#=GR A0A0U5C451_ASPCI/129-185 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A2U0I7L8_9FLAO/366-427 ...............................................................................................................................................................gtevwlvggvsvgegngweigtt----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.-..-..---..E..SGSSGSPLF....N..QN...G......KIIGqL.YAGNASCDg..lE----------nnneydiy....................
#=GR A0A2U0I7L8_9FLAO/366-427 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
POLG_DEN1W/1492-1643 .....................................................................................................................................................................................v--LDDGIYRILQRGLL..GRSQ.......VGVGVFQ.EG.VFHTMWHVTRGAVLMY....QGKRLEP.SWAS........V.KKDLI..S.YG..GG.W..R.F.Q.GSWNA....gEE.....VQVIavepgknpknv................................................................qtapgtfktpeG...-E.....VG.....A.I..A..LDF..K..PGTSGSPIV....N..RE...G......KIVG.L.YGNGVVTT....SGTYVSAIAQ-a...........................
#=GR POLG_DEN1W/1492-1643 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
#=GR POLG_DEN1W/1492-1643 sAS ....................................................................................................................................................................................................................................*.....................................*.........................................................................................................................................................................................................................................................
A0A2L2TBK6_9HYPO/27-70 ................................................................................................................................................................................rwtyca----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.-..-..---..-..KGDSGSIVF....D..ED...G......KVIG.L.YSIGVKTRk..sDINEEFGIV--t...........................
#=GR A0A2L2TBK6_9HYPO/27-70 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A1Y2BIF4_9FUNG/83-127 ....................................................................................................................................................................................yy----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.H..N..VNT..N..NGSSGSPLL....N..KN...Y......KVLG.I.HKAKEEYN....DNSFKQ-----niaik.......................
#=GR A0A1Y2BIF4_9FUNG/83-127 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
C5J5N2_MESCH/18-75 ...............................................................................................................................................................................lflytkd----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....KK.....INSI......................................................................................N...DK.....LY.....V.E..N..IDF..N..DGSSGSPLF....Y..-K...N......KIVG.V.YKGKEVVQ....-----------gkltsffn....................
#=GR C5J5N2_MESCH/18-75 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A2V1MW33_9LACO/309-430 .....................................................................................................................................................................................a-ELEDGAYRIKQKGIL..GYSQ.......IGAGVYK.EG.TFHTMWHVTRGAVLMH....KGKRIEP.SWAD........V.KKDLI..S.YG..GG.W..K.L.E.GEWKE....gEE.....VQVLalepgknprav................................................................qtkpglfktntG...-T.....IG.....A.V..S..LDF..S..PGTSGS---....-..--...-......----.-.--------....-----------............................
#=GR A0A2V1MW33_9LACO/309-430 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
K8DZM9_9FIRM/260-324 .............................................................................................................................................................gtvtavgatmevklddentayfadq----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....-V.....V.T..D..MKS..Q..GGDSGSLVL....N..QE...N......RAVG.L.LFAGS---....-----------dkvtvcnhi...................
#=GR K8DZM9_9FIRM/260-324 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A0A8EBZ9_MESFC/37-228 ..............................................................................................................................................................lkiesnvfnfsvskgkqnlsrfta----------------..----.......TLLKKTK.EKlIFVTTHHSLNFVKLKI....NEQNFNI.HLEQ........F.SKINF..E.IQ..IK.S..K.F.K.IEYEN.....KE.....KDILlfslntskllpflttnfidfgvledftsskns.....................lfslgfvtllksnffpyasrllfytddkipeleE...DN.....VL.....I.Q..N..IDY..S..QGSSGSPLF....F..RN...-......KLVG.L.YRGKK---....-----------ikskkl......................
#=GR A0A0A8EBZ9_MESFC/37-228 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
Y591_MYCPN/171-291 ......................................................................................................................................................................................WECKQGAERFSYGYFY..SNMA.......RLTKNLR.QG.------DPNAGSKTHI....EYSNELL.DKDS........M.DQGIV..R.FS..TF.L..G.A.N.INYHD.....YD.....YRQQ......................................................................................G...YG.....LT.....L.T..D..TNL..P..GGSSGSLVF....N..QD...K......KISS.I.YSAATESD....----SVGYAQL............................
#=GR Y591_MYCPN/171-291 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A164NVM4_9CRUS/286-437 ....................................................................................................................................................................................kl---PDGVYAINAKGLL..GSRR.......VGASVVV.RG.VFHTCWRVTDSNPIVY....QERLLLP.HSTH........K.EQDIV..T.YG..GP.W..Q.G.V.VGEQD.....DL.....V--Tllalepndeivvnt..........................................................adpgnieledvdgnV...KK.....CR.....V.L..W..ADH..P..PGTSGSLIL....N..PR...G......ELVG.L.YGFG----....-----------fflstdrfgny.................
#=GR A0A164NVM4_9CRUS/286-437 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A6I1MIK9_9CLOT/257-353 .................................................................................................................................iefknmflrignplgitepkvdmivkkigagsgysegiiisthckelidfkgi----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....YNCY......................................................................................F...HN.....QI.....N.A..D..LNT..T..DGDSGSLVL....N..AD...N......KVVG.L.FY------....-----------sssdnias....................
#=GR A0A6I1MIK9_9CLOT/257-353 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A1Z5HQ28_9THEO/243-316 ...............................................................................................................................................................vvrksgrttgvtegivkalhvnl----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.K.VNMGN.....DV.....YAMF......................................................................................D...-D.....QV.....I.T..S..MDS..A..GGDSGSLVL....D..KN...N......QAVG.L.LFAG----....-----------sdrftv......................
#=GR A0A1Z5HQ28_9THEO/243-316 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
Y298_MYCGA/335-468 ......................................................................................................................................................................................WPTTPQYTKFSVPSLS..-RRQ.......IPITSDS.RG.SPGWTINALNPTELDG....QKIASST.SLSSt.....ggI.RAGIY..N.AD..IA.R..N.F.Q.LVYRN.....VK.....YKQY......................................................................................G...YG.....YI.....I.Q..N..SNL..S..AGSSGSLAL....T..SN...N......QALG.I.YFGTVSVD...aKKEATFGLVA-s...........................
#=GR Y298_MYCGA/335-468 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
Y584_MYCPN/1-69 ....................................................................................................................................................................................mn----------------..----.......-------.--.----------------....-------.----........-.----Y..D.LS..QK.F..K.V.Y.LEFSG.....KK.....YRIY......................................................................................G...QS.....IG.....I.S..H..LDL..G..GGSSGSLLL....N..DK...K......QIAG.I.YFGVDGAN....---NELGLAQL............................
#=GR Y584_MYCPN/1-69 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
C8W2Y8_DESAS/112-164 ....................................................................................................................................................................vtlqvqiseteigwfseq----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....-V.....V.C..D..MNS..Q..PGDSGSLIV....N..NN...K......KAVG.L.LFAG----....-----------sdkft.......................
#=GR C8W2Y8_DESAS/112-164 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A0A2TJV7_9FIRM/47-90 ...................................................................................................................................................................................ifi----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.-..-..-QL..N..AGNSGSPVI....N..NQ...A......QVVG.V.IFGVTTFEn..eG----------vsesrglai...................
#=GR A0A0A2TJV7_9FIRM/47-90 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
Y589_MYCPN/14-134 ......................................................................................................................................................................................FEWTKTEQRFNHDDFY..GSMP.......TLTKNLR.QG.------QPVAGSKVHT....DYSNGFL.NEYS........L.NQGIV..D.FG..TF.K..S.A.I.TDYHG.....YE.....YKNH......................................................................................G...YG.....LA.....L.T..D..TDL..L..GGSSGSLVF....N..QD...K......KISS.I.YSAATESD....----SVGYAQL............................
#=GR Y589_MYCPN/14-134 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
POLG_ZIKV/1515-1666 ......................................................................................................................................................................................-ETTDGVYRVMTRRLL..GSTQ.......VGVGVMQ.EG.VFHTMWHVTKGAALRS....GEGRLDP.YWGD........V.KQDLV..S.YC..GP.W..K.L.D.AAWDG....lSE.....VQLLavppgerarni................................................................qtlpgifktkdG...-D.....IG.....A.V..A..LDY..P..AGTSGSPIL....D..KC...G......RVIG.L.YGNGVVIK....NGSYVSAITQ-g...........................
#=GR POLG_ZIKV/1515-1666 AS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
#=GR POLG_ZIKV/1515-1666 sAS ....................................................................................................................................................................................................................................*.....................................*.........................................................................................................................................................................................................................................................
A0A1B8AKE3_FUSPO/572-614 .................................................................................................................................................................................ltyca----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.-..-..---..-..KGDSGSIVF....N..KH...G......KVIG.L.YSTGIKIRm..sLDNEEFGIV--t...........................
#=GR A0A1B8AKE3_FUSPO/572-614 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
Y577_MYCPN/197-333 .....................................................................................................................................................................................v-ESNIAALNLNQTEVK.pTRPE.......-DVAQVT.FK.EPWSVDHHREIPTLTTn.qlTTIKTKH.FSGS........K.LSWPF..D.HT..KS.F..K.I.K.NKWLG.....QN.....YQMY......................................................................................G...HG.....LG.....I.D..Q..VNL..R..KGTSSSLVI....N..QK...R......QIVG.I.YFATVITNp.kkAVRNDVGLVQM............................
#=GR Y577_MYCPN/197-333 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A1H7IQ85_9PROT/268-301 ....................................................................................................................................................................................gd----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.-..-..---..-..NGDSGSLIV....N..AA...G......EAVG.L.YFAGDPRD....-----------pyglan......................
#=GR A0A1H7IQ85_9PROT/268-301 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A182G8Y9_AEDAL/294-439 ...................................................................................................................................................................................dlp----NGVYRIIVRSFM..ENRQ.......RGIGVAK.NG.VFHTLMHVTRGEPLNW....RGRLVSL.HSGS........A.LRDVV..S.YG..GP.W..Q.L.D.SPTVA.....DE.....VLLMackpdktvey.................................................................hkykpgvvkidD...ET.....VM.....F.I..S..VDF..G..KGSSGSPFF....-..IN...G......EVVG.F.YGYGF---....-----------yidgiyrsiv..................
#=GR A0A182G8Y9_AEDAL/294-439 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
POLG_YEFV1/1503-1655 ......................................................................................................................................................................................-HLEDGIYGIFQSTFL..GASQ.......RGVGVAQ.GG.VFHTMWHVTRGAFLVR....NGKKLIP.SWAS........V.KEDLV..A.YG..GS.W..K.L.E.GRWDG....eEE.....VQLIaavpgknvvnv................................................................qtkpslfkvrnG...GE.....IG.....A.V..A..LDY..P..SGTSGSPIV....N..RN...G......EVIG.L.YGNGILVG....DNSFVSAISQT............................
#=GR POLG_YEFV1/1503-1655 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
#=GR POLG_YEFV1/1503-1655 sAS ....................................................................................................................................................................................................................................*.....................................*.........................................................................................................................................................................................................................................................
A0A4R0QQG0_9STRE/2-58 .............................................................................................................................................................................ytmfgqied----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....---I......................................................................................G...SE.....YL.....V.Y..K..IDT..E..AGQSGSPVL....N..SQ...N......QIVG.T.--------....-----------hilgdtdqnyarrvkdd...........
#=GR A0A4R0QQG0_9STRE/2-58 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
W5UUK1_9MOLU/832-912 .......................................................................................................................................................................witdtrnafignlsy----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..K.R.D.RNFDN.....YG.....TKQYq....................................................................................sA...RS.....IS.....L.P..G..LKG..G..HGMSGSLVV....N..EY...N......QVLG.I.FWGGVFPE....TSAS-------ssklvsgi....................
#=GR W5UUK1_9MOLU/832-912 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
Y586_MYCPN/154-286 ......................................................................................................................................................................................YLLGYPFLRNKAASLF.lNQTEqrkehmdKTTQILH.EK.PFVVLTDPAKPTLIRN...kGANFTGN.TWTS........-.NYDLS..K.KS..GL.Y..H.-.-.-KFLG.....KK.....YQIY......................................................................................G...KS.....IV.....I.S..D..LNL..S..SGSSGSLLL....N..DR...K......QIVG.I.YFGVDGPK....---DELGFSQL............................
#=GR Y586_MYCPN/154-286 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
Y580_MYCPN/2-70 ...................................................................................................................................................................................taq----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..-Y.Y..Q.L.D.EKFNQ.....QT.....YEQY......................................................................................G...KG.....LA.....L.N..D..LYI..R..RGASGSLVF....N..QD...Q......QISG.I.FFAVASHS....-----------dpkpgektlvql................
#=GR Y580_MYCPN/2-70 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A5N7MKT1_9HYPH/6-45 ..................................................................................................................................................................................pqsg----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.-..-..---..P..HGSSGGPVL....N..SR...D......EVVG.L.YSRS----....-----------spngnavsvtldg...............
#=GR A0A5N7MKT1_9HYPH/6-45 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
A0A0K9QPV2_SPIOL/111-151 ..................................................................................................................................................................................iiqc----------------..----.......-------.--.----------------....-------.----........-.-----..-.--..--.-..-.-.-.-----.....--.....----......................................................................................-...--.....--.....-.N..R..LNF..R..EGCSGSPVF....N..TK...G......EIVG.M.L-------....-----------icevnscdialh................
#=GR A0A0K9QPV2_SPIOL/111-151 pAS .................................................................................................................................................................................................................................................................................................................................................................................................................................................*..................................................................................
#=GC seq_cons ..................................................................................................................................................................................................................................................................................................................h..h...........................................................................................t......h.....h....s..hsh..t..sGsSGS.ll....N..pp...s......cllG.l.Yhus...p...........................................
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