#=GF ID   PfUIS3
#=GF AC   PF11567.12
#=GF DE   Plasmodium falciparum UIS3 membrane protein
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2vwa
#=GF GA   25.00 25.00;
#=GF TC   31.10 25.70;
#=GF NC   24.90 21.10;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18577521
#=GF RT   Crystal Structure of Soluble Domain of Malaria Sporozoite
#=GF RT   Protein UIS3 in Complex with Lipid. 
#=GF RA   Sharma A, Yogavel M, Akhouri RR, Gill J, Sharma A; 
#=GF RL   J Biol Chem. 2008;283:24077-24088.
#=GF DR   INTERPRO; IPR021626;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   UIS3 is a membrane protein essential for sporozoite development
#=GF CC   in infected hepatocytes. This family is 130-229 of the
#=GF CC   Plasmodium falciparum UIS3 protein which is compact and has an
#=GF CC   all alpha-helical structure.PfUIS3(130-229) interacts with
#=GF CC   lipids, phospholipid lysosomes, the human liver fatty
#=GF CC   acid-binding protein and with the lipid
#=GF CC   phosphatidylethanolamine. The interaction with liver fatty
#=GF CC   acid-binding protein provides the parasite with a method to
#=GF CC   import essential fatty acids/lipids during rapid growth phases
#=GF CC   of sporozoites [1].
#=GF SQ   22
#=GS A0A1D3TE38_PLAMA/120-213  AC A0A1D3TE38.1
#=GS K6UY00_PLACD/102-195      AC K6UY00.1
#=GS A0A1A8ZSE2_9APIC/119-217  AC A0A1A8ZSE2.1
#=GS A5JZ15_PLAVS/120-213      AC A5JZ15.1
#=GS A0A024WLK4_PLAFA/129-229  AC A0A024WLK4.1
#=GS Q8IEU1_PLAF7/129-229      AC Q8IEU1.1
#=GS A0A024VMS9_PLAFA/129-229  AC A0A024VMS9.1
#=GS A0A024W3F2_PLAFA/129-229  AC A0A024W3F2.1
#=GS W7J7K4_PLAFA/129-229      AC W7J7K4.1
#=GS W7K0S6_PLAFO/129-229      AC W7K0S6.1
#=GS A0A1D3U986_9APIC/119-217  AC A0A1D3U986.1
#=GS A0A1Y1JLY5_PLAGO/119-212  AC A0A1Y1JLY5.1
#=GS A0A0L7KKX3_PLAFX/129-229  AC A0A0L7KKX3.1
#=GS A0A024X017_PLAFC/129-229  AC A0A024X017.1
#=GS A0A1A8W9P0_9APIC/119-217  AC A0A1A8W9P0.1
#=GS A0A384KLI1_PLAKH/120-213  AC A0A384KLI1.1
#=GS A0A1J1GJZ3_PLARL/112-209  AC A0A1J1GJZ3.1
#=GS W4IYI5_PLAFP/129-229      AC W4IYI5.1
#=GS Q7RK90_PLAYO/147-241      AC Q7RK90.1
#=GS A0A653HRM4_9APIC/41-140   AC A0A653HRM4.1
#=GS A0A1J1GKC7_PLARL/72-181   AC A0A1J1GKC7.1
#=GS A0A509ARS3_PLABA/121-217  AC A0A509ARS3.1
A0A1D3TE38_PLAMA/120-213             ..........................................INKVNIKGPIKVNTNEKDIPIKTFNVFLDNAKIALKHHYNNLSVIQQQYFKNDSSYIRKIVQSLQEKRSVSLSRAQEDKAVSQMGRFLDNMN---------ny....
K6UY00_PLACD/102-195                 ..........................................INKVNIKGPLVENTNENDVPLKKFNIFLDNARIAMRHHFSNLSTPQQEYYVKDRDYIRKIVQSVEERRNIQLSRMQEDLAVLNMEEFLQKI----------ske...
A0A1A8ZSE2_9APIC/119-217             ..........................................INKVNIKGPLVENTNETDVSIKRFNAFVDNARIAIRHNFNNLSEAQRSSCVNDRDYMRKVVQRLQERRNISLSRAQEDIAVLNMESFLHKIYNNKLD----dd....
A5JZ15_PLAVS/120-213                 ..........................................INKVNIKGPLVENTNENDVPIKKFNIFLDNARIAMRHHFSNLSQPQQEYYLNDRDYIRKVVQSLEERRNVHLSRMQEDMAVLNMEDFLQKI----------ske...
A0A024WLK4_PLAFA/129-229             ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
Q8IEU1_PLAF7/129-229                 ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
A0A024VMS9_PLAFA/129-229             ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
A0A024W3F2_PLAFA/129-229             ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
W7J7K4_PLAFA/129-229                 ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
W7K0S6_PLAFO/129-229                 ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
A0A1D3U986_9APIC/119-217             ..........................................INKVNIKGPLVENTNETDVSIKRFNAFVDNARIAIRHNFNNLSEAQRSSCVNDRDYMRKVVQRLQEKRNISLSRAQEDTAVLNMESFLHKIYNNKLD----nd....
A0A1Y1JLY5_PLAGO/119-212             ..........................................INKVDIKGPLVENTNENDVPLKKFNIFLDNARIALKYHFNNLSLTQQEYYMNDPDYIRKVLQSLGDKRNVHLSRNQEDMAVLNMRDFLNKHH---------nd....
A0A0L7KKX3_PLAFX/129-229             ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
A0A024X017_PLAFC/129-229             ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
A0A1A8W9P0_9APIC/119-217             ..........................................INKVNIKGPLVENTNETDVSIKRFNAFVDNARIAIRHNFNNLSEAQRSSCVNDRDYMRKVVQRLQEKRNISLSRAQEDTAVLNMESFLHKIYNNKLD----nd....
A0A384KLI1_PLAKH/120-213             ..........................................INKVNIKGALIENTNENDVPIKKFNIFLDNARIAMQHHFSNLSGPQQAYYVNDRDYIRMVVQSLEERRNVQLSRVQEDLAVLNMEHFLQNI----------ske...
A0A1J1GJZ3_PLARL/112-209             .........................................i-GTISLRGLFTENMNKGGISLKRFNSFVDSSKVAIAKHFRNLNSSKKNSFIKNKKIIRNVVKNLALKKNLKLSREQENVATEKLQGHLRVLHHN-------lkkk..
W4IYI5_PLAFP/129-229                 ..........................................INKINLNKPIIENKNNVDVSIKRYNNFVDIARLSIQKHFEHLSNDQKDSHVNNMEYMQKFVQGLQENRNISLSKYQENKAVMDLKYHLQKVYANYLSQEEN......
Q7RK90_PLAYO/147-241                 ..........................................VNKVNIKGKLKENNNDIDVPLKRFNTFMDNVKLAAKHHFSNLSNEQQKYLIKDYDYLRKIVQTLDENKDVNISRAQEDIAVLGVEHFLKEQY---------qpk...
A0A653HRM4_9APIC/41-140              .........................................l-NNLKLTDVAKVNTKVDDVPIKTFNILVDDARQLTQRYFKTLAQTEKAYFMQDNDFIQRFVQGVEKLNNVDLSKKQEDLAASKVKLHMYKLYED-------dyhnsg
A0A1J1GKC7_PLARL/72-181              iiykknskkrnsrtdvplnrkkygeegnkhsskesfkkmvfn---------------------------------LATKQFSDMSYDEKLNMIKDKNYFREMIKELAEKENISISKYEVDNIINHINSGLKDKFDLFLNNN--rn....
A0A509ARS3_PLABA/121-217             ..........................................INKVNIKGKLKENNNDIDIPLKRFNIFMDNVKLAAQHHFNDLSNEQHKYLINDYDYLRKIVQTLDESRDVNISKAQEDIAVLGVEHFLKEQYQQ-------kli...
#=GC seq_cons                        ..........................................INKlNlptPllENpNpsDVsIKRaNsFVD.ARlulp+HFppLSssQ+csaVNsh-YhpKhVQuLpEpRNISLS+hQEshAVhslchaLpKlYts.............
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