#=GF ID Phage_holin_3_5
#=GF AC PF16085.9
#=GF DE Bacteriophage holin Hol, superfamily III
#=GF AU Coggill P;0000-0001-5731-1588
#=GF SE Jackhmmer:Q9S583
#=GF GA 27.00 27.00;
#=GF TC 30.10 47.40;
#=GF NC 25.20 25.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP Family
#=GF CL CL0564
#=GF RN [1]
#=GF RM 11069649
#=GF RT The R-type pyocin of Pseudomonas aeruginosa is related to P2
#=GF RT phage, and the F-type is related to lambda phage.
#=GF RA Nakayama K, Takashima K, Ishihara H, Shinomiya T, Kageyama M,
#=GF RA Kanaya S, Ohnishi M, Murata T, Mori H, Hayashi T;
#=GF RL Mol Microbiol. 2000;38:213-231.
#=GF DR INTERPRO; IPR032128;
#=GF DR TC; 1.E.20;
#=GF DR SO; 0100021; polypeptide_conserved_region;
#=GF CC Phage_holin_6_2 is a family of holins classified as 1.E.20 in
#=GF CC the TC database. The hol gene (PRF9) product (117 aas) of
#=GF CC Pseudomonas aeruginosa PAO1 exhibits a hydrophobicity profile
#=GF CC similar to holins of P2 and phiCTX phages with two peaks of
#=GF CC hydrophobicity that might correspond to either one or two TMSs.
#=GF CC Hol functions in conjunction with the lytic enzyme, Lys, a
#=GF CC glycosyl hydrolase that breaks-up the murein in the bacterial
#=GF CC cell-wall, causing lysis of the cell and hence entry of phage
#=GF CC particles [1]. Several members are annotated as pyocin R2_PP
#=GF CC when encoded on the chromosome.
#=GF SQ 28
#=GS Q4KF73_PSEF5/1-113 AC Q4KF73.1
#=GS A0A077LL49_9PSED/27-135 AC A0A077LL49.1
#=GS A0A0N0E0Y1_9PSED/1-113 AC A0A0N0E0Y1.1
#=GS A0A0X1T136_PSEAA/1-110 AC A0A0X1T136.1
#=GS A0A6B3NYU5_9PSED/1-112 AC A0A6B3NYU5.1
#=GS J8RSS0_PSEPU/1-82 AC J8RSS0.1
#=GS A0A2I0CTM2_9PSED/4-108 AC A0A2I0CTM2.1
#=GS A0A3N4AD92_9PSED/9-120 AC A0A3N4AD92.1
#=GS A0A2D2M3U1_9PSED/1-110 AC A0A2D2M3U1.1
#=GS A0A8H9YW24_9PSED/1-113 AC A0A8H9YW24.1
#=GS Q88IF9_PSEPK/1-113 AC Q88IF9.1
#=GS I4N8S8_9PSED/1-111 AC I4N8S8.1
#=GS G8Q3I6_PSEO1/1-113 AC G8Q3I6.1
#=GS A0A2D2M8F9_9PSED/1-104 AC A0A2D2M8F9.1
#=GS A0A139SN06_9GAMM/2-108 AC A0A139SN06.1
#=GS L1M6Q0_9PSED/1-111 AC L1M6Q0.1
#=GS A0A024HBJ0_PSEKB/1-113 AC A0A024HBJ0.1
#=GS A0A7W7P552_9PSED/1-114 AC A0A7W7P552.1
#=GS Q4KHE1_PSEF5/1-113 AC Q4KHE1.1
#=GS A0A1V0B9H9_9PSED/9-121 AC A0A1V0B9H9.1
#=GS A0A315WYZ3_9PSED/1-110 AC A0A315WYZ3.1
#=GS A0A0N0E5P8_9PSED/1-114 AC A0A0N0E5P8.1
#=GS A0A2D2M663_9PSED/1-112 AC A0A2D2M663.1
#=GS A0A7X6EEP6_9PSED/1-112 AC A0A7X6EEP6.1
#=GS A0A024HCS1_PSEKB/1-111 AC A0A024HCS1.1
#=GS Q9I5T0_PSEAE/33-145 AC Q9I5T0.1
#=GS A0A105T3R9_9PSED/1-113 AC A0A105T3R9.1
#=GS G8QC35_PSEO1/1-113 AC G8QC35.1
Q4KF73_PSEF5/1-113 ...MTNEQQALAEMPIWLVIVLALVGGVSGEMWRADKE.GARGW.ALVRRLALRSGACIVCGMAAMMLLIGAGVSVWTAGAFGCLTAMAGADVAIGLYERWAAKRIGVCEVP------pvpedr
A0A077LL49_9PSED/27-135 ...MTDGQQTLNELPLWLLITLALAGGVTGELWRADKD.GLCGS.KIVRRLVLRSGSSVMCGVSTMMLLYAAEVPMMAAAAVGSLTAMAGADLAISFYERWAARRLGLT---------rrdad.
A0A0N0E0Y1_9PSED/1-113 ...MTNEQQALIEMPIWMVIVLSLVGGVSGEAWRADKA.GMRGW.PLMRRLALRSGACVVCGLSTMMLLNAAGVSILAAGSIGCITAMAGADVAIGLYERWAAKRLGVCDVPPV----dsgq..
A0A0X1T136_PSEAA/1-110 ...MTSEQQALADMPIWLVIVLAVIGGVCGEMWRADKE.GARGW.PLLRRLALRSGACMVCGVSTIMLLYAAGLSIWTAGAFGCLTAMAGADVAIGLYERWAAKRLGVGE--------gpppe.
A0A6B3NYU5_9PSED/1-112 ...MTNEQHALIEMPIWMVIVLSLVGGVSGEMWRADKA.GVRGW.GLVRRIALRSGACIVCGLSTMMLLYSMGVSIWAAGAFGCLTAMAGADVAIGLYERWAAKRLGVCEMP------pptqp.
J8RSS0_PSEPU/1-82 .mk----------------------------LLRASGA.DLSLR.QILQRVALRFLASGLLGMATLLLAMALWSNLYLAAGLGIVIAVIGADVAGGLYTQFLAKRAGVS---------teer..
A0A2I0CTM2_9PSED/4-108 dsh---TQQALADLPTWLLILVAL-AGLVGEMRQADVS.GVAMS.EIIKRVVLRFGSNALFGMATLLLILALGHGPYIAGALGIVVGLLGADVAGALYTRYLSRQAGV----------dsd...
A0A3N4AD92_9PSED/9-120 pig-----KAIAEIPLWMAILLALASGLSGEMLRASTL.INLTWkQLAARIGMRFGAAGLVGIAVFMAAFALAVHPYLSAALCIFSAMLGGDVASSLFERWAAKRAGVCDLPSQR---ppd...
A0A2D2M3U1_9PSED/1-110 ...MTNEQQALIEMPLWLVIVLSLVGGVSGEMWRADKA.GARGW.GLARRIVLRSGACIVCGLSTNMLLYSMGVSVWASAAFGCLTAMAGADVAIGLYERWAAKRLGVCDVPDQQ---......
A0A8H9YW24_9PSED/1-113 ...MTNEQQVLAEMPVWLVIALALVGGVSGEMWRADKE.GARGW.SLIRRLALRSGACMVCGVSALMLCYAAGMSIWTAGAIGCLTAMAGADVAIGLYERWAAKRIGVNEPPNSR---pdq...
Q88IF9_PSEPK/1-113 ...MNSEQQALVEMPIWLVIFLSLVGGVSGEMWRADMA.GVSGW.FIFRQVLLRSGACVVCGLSTIMLLYSAGMSMWSASAIGCLTATAGADVAIGLYKRWVAKRLGVCDVTSRSGEP......
I4N8S8_9PSED/1-111 .mq--LNQAFLQEVPVWLVVMLALLGGVTGEMWRADKE.GAQGW.HLLRRVLMRSGACMACGLAGTMLLYGAGLSLWSASALGCMTAMAGADVALSLYERWVVKRLGLGT--------agrrkr
G8Q3I6_PSEO1/1-113 ...MTSEQQALAEMPIWLVILLALVGGVSGEMWRADKD.GARGW.VLLRRLALRSGGCVVCGVSAMMLMIAAGMSLWTAGALGSLTAMAGADVAIGLYERWAAKRLGVAEAPP-----saggq.
A0A2D2M8F9_9PSED/1-104 ...MNSEHQALADVPLWLLVLLSM-AGLSGEMLRASGT.DLGLR.QILQRVALRFLASGLLGMATLLLAMALWSNLYLAAGLGIVIAVIGADVAGGLYTRFLAKKAGI----------sp....
A0A139SN06_9GAMM/2-108 .pa--SQHQTLSDLPLWLF-PLAFLAGLFGETWRAEAA.GLAFG.DLIKRALLRCGASSTFGMCAGMLAMAYGAHPLMAGALTGMVAVGGADIASALYSRWLKRKLRMCD--------dep...
L1M6Q0_9PSED/1-111 ...MTSEQQTLLEMPIWLVIVLALLGGVSGEMWRADKA.GARGG.ALLRRLVLRSGACMVCGVSTVMLLYASGLSMWAASALGCLTAVGGADITMGLYERWAAKRLGLGT--------dskers
A0A024HBJ0_PSEKB/1-113 ...MGNEPQTLAEMPLWVLILLAALGGVSGEMWRADKA.GLGGW.VLLRRLALRSGASIVCGVAVMLLAMSCGASLLLSAAVGSLTAAAGAEIAVGLYERWAARRLGVCEVPEHND--qq....
A0A7W7P552_9PSED/1-114 ...MGNEPQTLADVPLWGLILLAVAGGISGEMWRADKA.GLGGW.RLLRRLALRSGASIVCGMAVMFLAMSCNASLTLAAAIGSLTAAAGAEIAVGLYERWAAKRLGVCELPPN----ergqe.
Q4KHE1_PSEF5/1-113 ...MTNEQQALLDMPIWLVIVLALVGGVSGEMWRADKE.GARGW.SLLRRLALRSGACVVCGVSAIMLLYAAGVSIWTACAFGCLTAMAGADVAIGLYERWAAKRIGVCEPPSRDSH-s.....
A0A1V0B9H9_9PSED/9-121 pig-----KAIAEIPLWMAILLALASGLSGEMLRASALiNLSWK.QIAARIGMRFGAAGLVGIAVFMAAFALAVHPYLSAALCIFSAMLGGDVASSLFERWAAKRAGVCEVPP-----hgrtgq
A0A315WYZ3_9PSED/1-110 ...MTNEQQALLDMPIWLVIVLALLGGLSGEMWRADKA.GIRGW.GLFRRLLLRSGACMVCGVSAVMLLYASGMSIWTASAFGCLTAMAGADVAIGLYERWAAKRLGITQ--------sqtdr.
A0A0N0E5P8_9PSED/1-114 ...MTNEQQALADMPIWLVIVLAVIGGVSGEMWRADKE.GARGW.PLLRRLVLRSGACMVCGVSTIMLLYAAGVSIWTAGAFGCLTAMAGADVAIGLYERWAARRIGIDEPVVR----nsqsd.
A0A2D2M663_9PSED/1-112 ...MTNEQQALIEMPIWMVVVLSLVGGVSGEMWRADKA.GARGW.GLVRRIALRSGACIVCGLSTIMLMYSMGVSIWAAASIGCLTAMAGADVAIGLYERWAAKRLGVCDVPP-----pshp..
A0A7X6EEP6_9PSED/1-112 ...MTNEQQALLDMPIWLVILLAVAGGVSGEMWRADKE.GARGW.PLLRRLALRSGACMICGVSAIMLLYAAGMSIWAAGAFGCLTAMAGADVAIGLYERWAAKRIGVCEVPPRD---pq....
A0A024HCS1_PSEKB/1-111 ...MPNEQQALAEMPVWVLILLAAAGGVSGEMWRADKA.GLTGW.VLLRRLALRSGASVVCGVAVMFLAMAMGAALLLAAAIGSLTAAAGAEVAVGLYERWAAKRIGVCDVQ------pgae..
Q9I5T0_PSEAE/33-145 ...MGNEPQTLTEMPLWVLILLAALGGVSGEMWRADKA.GLGGW.ALLRRLALRSGASIVCGVAVMLLALACGAALLFAAALGSLTAAAGAEIAVGLYERWAARRLGVCELPEEQSDD......
A0A105T3R9_9PSED/1-113 ...MTPEEHALLDMPIWLVIVLALLGGVSGEMWRADKE.GARGW.PLVRRIALRSGACMVCGVSATFLLYANGVSMLAASAFGCLTAMAGADMAIGLYERWTAKRLGVCDIPPRD---tpp...
G8QC35_PSEO1/1-113 ...MTNEQQALLDMPIWLVIVLALVGGVSGEMWRADKE.GARGW.PLLRRVVLRSGACVVCGVSATMLLYALGMSIWSACALGCLTAMAGADVAIGLYERWVAKRIGIYEVPPRD---vpp...
#=GC seq_cons ...MssEQQALh-MPlWLVIlLALlGGVSGEMWRADKs.GspGW.sLlRRluLRSGAChVCGlushMLhaAsGsSlasAuAlGsLTAMAGADVAlGLYERWAAKRlGVs-.s......ss....
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