#=GF ID   Phi-29_GP3
#=GF AC   PF05435.15
#=GF DE   Phi-29 DNA terminal protein GP3
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_14111 (release 8.0)
#=GF GA   25.00 25.00;
#=GF TC   33.30 26.20;
#=GF NC   21.80 24.80;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   6779279
#=GF RT   Protein p3 is linked to the DNA of phage phi 29 through a
#=GF RT   phosphoester bond between serine and 5'-dAMP. 
#=GF RA   Hermoso JM, Salas M; 
#=GF RL   Proc Natl Acad Sci U S A 1980;77:6425-6428.
#=GF DR   INTERPRO; IPR008770;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of DNA terminal protein GP3 sequences from
#=GF CC   Phi-29 like bacteriophages. DNA terminal protein GP3 is linked
#=GF CC   to the 5' ends of both strands of the genome through a
#=GF CC   phosphodiester bond between the beta-hydroxyl group of a serine
#=GF CC   residue and the 5'-phosphate of the terminal deoxyadenylate.
#=GF CC   This protein is essential for DNA replication and is involved in
#=GF CC   the priming of DNA elongation [1].
#=GF SQ   26
#=GS A0A514AAM3_9CAUD/1-263    AC A0A514AAM3.1
#=GS A0A3G8F2I0_9CAUD/6-138    AC A0A3G8F2I0.1
#=GS A0A8F2EUW2_9CAUD/120-299  AC A0A8F2EUW2.1
#=GS A0A7T8C649_9CAUD/1-268    AC A0A7T8C649.1
#=GS A0A7M1RPD2_9CAUD/116-295  AC A0A7M1RPD2.1
#=GS A0A1B1PAD7_9CAUD/6-119    AC A0A1B1PAD7.1
#=GS A0A3T0IJ19_9CAUD/5-131    AC A0A3T0IJ19.1
#=GS A0A8D6UBA3_9CAUD/1-263    AC A0A8D6UBA3.1
#=GS Q9FZW9_BPGA1/1-264        AC Q9FZW9.1
#=GS A0A1B1PAM7_9CAUD/6-138    AC A0A1B1PAM7.1
#=GS A0A0L0BZD0_LUCCU/1-259    AC A0A0L0BZD0.1
#=GS A0A3T0IIZ2_9CAUD/5-131    AC A0A3T0IIZ2.1
#=GS A0A142IG83_9CAUD/1-265    AC A0A142IG83.1
#=GS B7SSM3_BPNF/1-265         AC B7SSM3.1
#=GS A0A1X9SHL5_9CAUD/6-142    AC A0A1X9SHL5.1
#=GS A0A8F2EUW2_9CAUD/6-136    AC A0A8F2EUW2.1
#=GS A0A3T0IIV8_9CAUD/3-89     AC A0A3T0IIV8.1
#=GS A0A1X9SGQ4_9CAUD/1-266    AC A0A1X9SGQ4.1
#=GS M4W5Y2_9CAUD/6-147        AC M4W5Y2.1
#=GS A0A0N7GFF6_9CAUD/1-224    AC A0A0N7GFF6.1
#=GS A0A7L7SSB2_9CAUD/6-298    AC A0A7L7SSB2.1
#=GS TERM_BPPH2/1-265          AC P03681.1
#=GS A0A1W6JSA3_9CAUD/1-247    AC A0A1W6JSA3.1
#=GS A0A5Q2WB31_9CAUD/1-205    AC A0A5Q2WB31.1
#=GS A0A1B1PAI1_9CAUD/6-298    AC A0A1B1PAI1.1
#=GS A0A7M1RPD2_9CAUD/6-131    AC A0A7M1RPD2.1
A0A514AAM3_9CAUD/1-263               .............................................MARDNEYQLTPDEKALYSKL...SRSVKNKIKRVEENYGVKLGGEIRV.P.A........PDM.FPSRAEFTRWRKQAESFTDRNNRKYQYVKNKFG...IVASKAYLD....ELQENT....KR.A.QKLSKE.....FT...-SRFDERPII......AKGKPIG.VTV.........GEQKMFFAKPDKG.IGKV...RD.FNF..DDITSRDTLTRRFETARLRSEEAYYENSLITMQDNFIR.SVEGSFNS-.-EADYLVDLLRLVPPDAFYELY.S..IYN.EIDFE.IFDSEGQFINA..NEDILSRIEMYVEDYLAGKTDMSLKG..........................................
A0A3G8F2I0_9CAUD/6-138               ...........................................tk--KQPKFTIREIDVNEFNRL...QNNAKAMIRSRKKKYGVDISGEIDL.KtS........IND.FKTRKGFNAWKEAMSKLRYRADL--QIKKV-GD...TIASQKQIN....QSQREV....NV.M.KRKL-Q.....KV...----------......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------dgeyqnkykvkfnekqlfeltlqtnva...............
A0A8F2EUW2_9CAUD/120-299             .....................tnkygarftieqikvmnlqtniar--------------------...-------------------------.-.-........---.---------------------------------...---------....------....--.-.------.....--...DLEMKRKEYI......ESIPRYD.RKG.........NLIKPTKKDKTEGsVIVR...EK.FDP..TKIQSNVTVKMREENLKLVSDPQRYEKRSSQLKENSIK.ALREMLGD-.-DVEDIIEYFNDMSNSEFNNFF.F..MYS.KSS--.-----------..--------------------------mgfdyiyqsgeyslsegdlddrlegvaeairtdisrydk...
A0A7T8C649_9CAUD/1-268               .............................................MPRDRNNDLTQSDKDEYKRL...VKNVKSKLGRIKKNHGIDLTERVNI.P.N........FSE.FPDKESFNFWKKDMKEVTRRDNKNFQFRTNQYG...LTISEVDVQ....NIENMI....EK.Y.NKKVSE.....VM...SKL-NAKETV......ERGIKTG.QTA.........QEQARI-QARVKD.IYRP...IEpFDFnsSKFMNPEDVYKYVENLMRLSDEYNFDQRQETFKDNLIR.SIEGTFSDP.EITRDLVERLRRIRADHFLEMY.Y..TFN.EFSFN.NWDSEGQLMTA..EEDNVAILESYVDLYEQGKLDF----fstqd.....................................
A0A7M1RPD2_9CAUD/116-295             vnkykvefsekqlfkitlqtnvardmeisrqqylesiprfdrkgr--------------------...-------------------------.-.-........---.---------------------------------...---------....------....--.-.------.....--...----------......-------.---.........-EIRETKKDKTGGsVIVR...EK.FDP..NKIQTPAKVKIREEGLKEVSDPERYSKRENQLKENNIK.ALREMLGD-.-DAEVVIEYFEEMSNAEFANFF.T..MYN.-----.-----------..--------------------------rssmgfdyiyqrgeysfkegsladrlegvlesietdigryqk
A0A1B1PAD7_9CAUD/6-119               ...........................................sk--KQPKFTIREVDVNEFNRL...QNNAKAMIRSRKKKYGVDISGEIDL.KtS........ISD.FKTRKGFNAWKEAMSKLRYRAD--LQIKKTKEG...TVATQKQINqsnlEAKRNI....RK.L.------.....--...----------......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------tpiegkkgly................................
A0A3T0IJ19_9CAUD/5-131               ..........................................rak--KQPKFTIREVDIKDFQRL...QRNAKRMIKNRQDKYGIDITKDIDLrS.D........IKT.FKSRKDFNVWKEKMEKLKYRADL--QIKKV-GD...TVASVAQIN....KSKQEV....NV.M.LRKL-N.....KV...DKNKYENKY-......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------kvsftkeklme...............................
A0A8D6UBA3_9CAUD/1-263               ...........................................ma------VRISKNDRAKLEKIygkSNKARKKYNRLRQK-GVEERQLPTV.P.TskkslidyVKStNMSRSDFNKLLDELVDFAQPYNENYIFEINKRN...VAISRAQIK....EAQIKT....EQ.A.QKAKEE.....HY...-KELN--KVQ......VKKPTEN.TIV.........TPTILTELGADLP.FQSI...PD.FNI..DSFTSPEGVQSYLENIG-KQDEQYFDERDQLYYDNFRQ.AMFTIFNS-.-DADDIVRLLDSMGLDLFMKTY.V..S-N.FLDMNlDYIYDEAEVQQ..KKDQVY--------------------skiakvietetggevp..........................
Q9FZW9_BPGA1/1-264                   .............................................MARESDFRLTKAQREEVSKL...SRSVKAKTTRLLKNYGQDFTGYISP.K.S........PDD.IKSIEQFNAFKKRAESFTDRSNRDFQFVKNEYG...VVVSKTELD....EILSDT....KK.A.QEVA-E.....KI...LDRFNDVEVI......SGGQSTGfTVG.........ENKELLAKPD-KG.FGRI...ED.FDF..NKVKTQEGLDRFANRAKKRSQEAYYEESLRRLQDNFIRnSVEGTFNS-.-EADDVVSKLRSLPADDFYECF.S..IYN.EISFE.NFDSENALGMA..SESILERVRMYVNDYFEGKSDLSLKG..........................................
A0A1B1PAM7_9CAUD/6-138               ...........................................tk--KQPKFTIREIDVNEFNRL...QNNAKAMIRSRKKKYGVDISGEIDL.KtS........IND.FKTRKGFNAWKEAMSKLRYRADL--QIKKV-GD...TIASQKQIN....QSQREV....NV.M.KRKL-Q.....KV...----------......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------dgeyqnkykvkfnekqlfeltlqtnva...............
A0A0L0BZD0_LUCCU/1-259               .............................................MARKRPIRITKNDRAEYKRL...SKNAKSKLNRTVKNYGIDLSNDVDI.P.K........LSD.FKTRKEFNDWKQKITSFTSRSNQEYQFRKNEYG...VVASVKELN....EIKRNT....KK.A.QKIAKE.....KI...DKAMK-LDFY......VEGERQG.KVK.........DRIKLMKKEEVAG.VSVP...VD.FDF..DKIQTRKRLEDKAGFMEERATGDYYRKKDIQMKENFIS.MIEQGFNS-.-DADEVIKKLKKIPPDDFVELT.I..VTD.EIDFR.NYGSKNEGGIN..DEDKLEELNNTLNDY----FNETTTD..........................................
A0A3T0IIZ2_9CAUD/5-131               ..........................................rak--KQPKFTIREVDIKDFQRL...QRNAKRMIKNRQDKYGIDITKDIDLrS.D........IKT.FKSRKDFNVWKEKMEKLKYRADL--QIKKV-GD...TVASVAQIN....KSKQEV....NV.M.LRKL-N.....KV...DKNKYENKY-......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------kvsftkeklme...............................
A0A142IG83_9CAUD/1-265               .............................................MARNSRIRITNNDKALYAKL...VKNTKAKISRTKKKYGIDLSNEIEL.P.P........LES.FQTREEFNKWKQKQESFTNRANQNYQFVKNKYG...IVASKAKIN....EIAKNT....KE.A.QRIVDE.....QR...-EEIEDKPFI......SGGKQQG.TVG.........QRMQILSPSQVTG.ISRP...SD.FNF..DDVRSYARLRTLEEGMAEKASPDYYDRRMAQMHQNFIE.IVEKSFNSD.WLSDELVERLKKIPPDDFFELY.L..IFD.EISFE.YFDSEGEDVTA..TEAMLNKIHSYLDRYERGDVNLDLK-g.........................................
B7SSM3_BPNF/1-265                    .............................................MARNSRIRITNNDKALYAKL...VKNTKAKISRTKKKYGIDLSNEIEL.P.P........LES.FQTREEFNKWKQKQESFTNRANQNYQFVKNKYG...IVASKAKIN....EIAKNT....KE.A.QRIVDE.....QR...-EEIEDKPFI......SGGKQQG.TVG.........QRMQILSPSQVTG.ISRP...SD.FNF..DDVRSYARLRTLEEGMAEKASPDYYDRRMTQMHQNFIE.IVEKSFNSD.WLSDELVERLKKIPPDDFFELY.L..MFD.EISFE.YFDSEGEDVEA..SEAMLNKIHSYLDRYERGDVNLDLK-g.........................................
A0A1X9SHL5_9CAUD/6-142               ...........................................sk--KQPKFTIRDVDVNEFNRL...QNNAKAMIRSRKKKYGVDISGEIDL.KtS........ISD.FKTRKGFNAWKEAMSKLRYRADL--QIKKV-GD...TVASQKQIN....QSQREV....NV.M.KRKL-Q.....KV...----------......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------dgeyqnkykvrfnekqlleltlqtnvardme...........
A0A8F2EUW2_9CAUD/6-136               ...........................................sk--KQPKFTIREVDVNEFNRL...QKNAKAMIRSRKKKYNVDISGEIDL.KgS........ISE.FKTRKEFNAWKEAMNKLRYRAD--LQITKTKEG...TVASKKQIN....ISNLES....KRlI.KKLTPV.....KG...EK--------......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------gvytnkygarftieqikvmn......................
A0A3T0IIV8_9CAUD/3-89                ........................................kkrak--KQPKFTIREVDIKDFQRL...QRNAKRMIKNRQDKYGIDITKDIDLrS.D........IKT.FKSRKDFNVWKEKMEKLKYRADLQ---------...---------....------....--.-.------.....--...----------......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------ikksrrhcc.................................
A0A1X9SGQ4_9CAUD/1-266               .............................................MAKYVPIRLSQNDRKEYARL...VRNAKAKIRRTKKNYGVDISSQIDL.P.S........IET.FKTRKQFNEWKEKQGKL--RFDTSLQFVKNEYG...VVASKKEIR....KAEKDT....KT.A.IVNAKK.....MI...-KSLEKLPVY......IDKKKQM.TMK.........QRMGIMDTASVTG.INVP...KP.FNF..KEIKDKYQLGAKVRGMAKQASDDYYDKKMEVFKRNFID.KLNFTFGFMgDELDEFLNKLEQMDTLEFYQMFqM..YPD.SFDFS.LYGSEGDEGYEglTEDFFYRIQSDYEHYMQTEY------grndl.....................................
M4W5Y2_9CAUD/6-147                   ...........................................kk--KQPKFTISEKDLNEFNRL...QRNAKAMIRSRKKNYGVDISGEIDL.KgS........ISE.FKTRKGFNAWKETMGKLKNRADL--QIRKVG-D...TVASVKQIN....ETNKEV....RG.MmNKL--E.....KV...-KGEKD-KFK......NKYKVEF.TKK.........QLIQLTLQTNV--.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------ardmemn...................................
A0A0N7GFF6_9CAUD/1-224               .............................................--------------------...------------------MTNDLTP.P.S........LDS.FKTRDEFNTWKEFASKL--RYNPNFQFMKHEEGnkpVVVTKKRWN....QLLKDT....KD.V.QRKALA.....MI...-KSIEDIPVM......KDKKQVM.TKE.........AQMYMTSPESVSG.INIP...KT.PVF..KEIKSQRILEDRIESMRDRSRGDFYNERMEIFKENFIQ.KLKGSFNS-.-DADLLVEAINQLSAREFYEMY.Q..QYSySYDFD.LYDSDGQSDVA..DESHLGRMMEDYKEF-----------mntkdmnd..................................
A0A7L7SSB2_9CAUD/6-298               ...........................................sk--KQPKFTIRDVDVNEFNRL...QNNAKAMIRSRKKKYGVDISGEIDL.KtS........ISD.FKTRKGFNAWKEAMSKLRYRADL--QIKKV-GD...TVASQKQIN....QSQREVnvmkRK.L.QKVDGEyqnkyKVrfnEKQLLELTLQtnvardMEIARQK.QLEsiprfnkkgQQIKDVRKDKTGGtVIVR...DK.FDP..TILDNNQRVKIREYNLKQVSDPERYSRREQQLKENQLT.RLKQAFGS-.-DAEDVIRYIEDMSSQEFNNFY.FmfMDS.SLGFN.EFDSEQYIGQS..AETD----------------------dqllgaieairtdiqrydknrek...................
TERM_BPPH2/1-265                     .............................................MARSPRIRIKDNDKAEYARL...VKNTKAKIARTKKKYGVDLTAEIDI.P.D........LDS.FETRAQFNKWKEQASSFTNRANMRYQFEKNAYG...VVASKAKIA....EIERNT....KE.V.QRLVDE.....KI...-KAMKDKEYY......AGGKPQG.TIE.........QRIAMTSPAHVTG.INRP...HD.FDF..SKVRSYSRLRTLEESMEMRTDPQYYEKKMIQLQLNFIK.SVEGSFNSF.DAADELIEELKKIPPDDFYELF.L..RIS.EISFE.EFDSEGNTVEN..VEGNVYKILSYLEQYRRGDFDLSLKG..........................................
A0A1W6JSA3_9CAUD/1-247               .............................................-------------------M...VRNAKAKIRRTKKNYGVDISSQIDL.P.S........IET.FKTRKQFNEWKEKQGKL--RFDTSLQFVKNEYG...VVASKKEIR....KAEKDT....KT.A.IVNAKK.....MI...-KSLEKLPVY......IDKKKQM.TMK.........QRMGIMDTASVTG.INVP...KP.FNF..KEIKDKYQLGAKVRGMAKQASDDYYDKKMEVFKRNFID.KLNFTFGFMgDELDEFLNKLEQMDTLEFYQMFqM..YPD.SFDFS.LYGSEGDEGYEglTEDFFYRIQSDYEHYMQTEY------grndl.....................................
A0A5Q2WB31_9CAUD/1-205               ..........................................mkd--------------------...-------------------------.-.-........---.----------------ITRRDNKKFKFRTNQYG...LTISEIDVQ....NIENMI....NK.Y.NKKVEE.....VM...SKLNK-KETI......ERGIKTG.QTA.........EEQARI-QARVKD.IYRPiepFD.FNS..SKFMNSDDVYKYVENLMKLSDEYNFDQRQETFKDNLIR.SIEGTFSDP.EITRSLVERLRRIRADHFLEMY.Y..TFN.EFSFN.NWDSEGQLMTA..EEDNVAILESYVDLYEQGKLDF----fstqd.....................................
A0A1B1PAI1_9CAUD/6-298               ...........................................sk--KQPKFTIRDVDVNEFNRL...QNNAKAMIRSRKKKYGVDISGEIDL.KtS........ISD.FKTRKGFNAWKEAMSKLRYRADL--QIKKV-GD...TVASQKQIN....QSQREVnvmkRK.L.QKVDGEyqnkyKVrfnEKQLLELTLQtnvardMEIARQK.QLEsiprfnkkgQQIKDVRKDKTGGtVIVR...DK.FDP..TILDNNQRVKIREYNLKQVSDPERYSRREQQLKENQLT.RLKQAFGS-.-DAEDVIRYIEDMSSQEFNNFY.FmfMDS.SLGFN.EFDSEQYIGQS..AETD----------------------dqllgaieairtdiqrydknrek...................
A0A7M1RPD2_9CAUD/6-131               ...........................................sk--KQPKFTIRQVDIDEFNRL...QRNAKRMIKNRKEKFGIDISPEIDL.KtN........ISE.FKTRKGFNAWKEAMSKLRYRADL--QIKK-VDG...TVASVKQIN....QSQREV....NV.M.KRKLNK.....KD...GKFV------......-------.---.........-------------.----...--.---..--------------------------------------.---------.----------------------.-..---.-----.-----------..--------------------------nkykvefsekqlfki...........................
#=GC seq_cons                        ............................................t..+pschpIppsDhs-apRL...ppNAKuhIppp+KpYGlDlos-IDL...s........lps.FKTRctFNtWKEthpclp.Rush..QhpKs.hs...sVASptpIs....p.pcps....cp.h.p+hh.p.....ph....cth....h........th......h..........t....h..tts.s.h..........s...p.h.s...l..h...h...tp...appp...h..N.hp..h...hs......c.hlp.hp.h....F.phh......s..............................................tt..t.....................................
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