#=GF ID   Phlebovirus_NSM
#=GF AC   PF07246.15
#=GF DE   Phlebovirus nonstructural protein NS-M
#=GF AU   Moxon SJ;0000-0003-4644-1816
#=GF SE   Pfam-B_17508 (release 10.0)
#=GF GA   27.20 27.20;
#=GF TC   27.20 27.20;
#=GF NC   26.40 26.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF DR   INTERPRO; IPR009879;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consists of several Phlebovirus nonstructural NS-M
#=GF CC   proteins which represent the N-terminal region of the M
#=GF CC   polyprotein precursor. The function of this family is unknown.
#=GF SQ   22
#=GS A0A6M4ALR6_9VIRU/6-313    AC A0A6M4ALR6.1
#=GS I1T324_9VIRU/1-265        AC I1T324.1
#=GS A2T069_RVFV/1-95          AC A2T069.1
#=GS A0A482KFT4_9VIRU/1-284    AC A0A482KFT4.1
#=GS A0A5C0E4I4_9VIRU/2-318    AC A0A5C0E4I4.1
#=GS A0A7G8PYJ9_9VIRU/1-276    AC A0A7G8PYJ9.1
#=GS A0A1S5SHT8_9VIRU/9-278    AC A0A1S5SHT8.1
#=GS A0A286XN02_CAVPO/457-614  AC A0A286XN02.1
#=GS D9YRN1_9VIRU/4-294        AC D9YRN1.2
#=GS F2W3Q1_9VIRU/1-278        AC F2W3Q1.1
#=GS A0A0F6ZQV4_PTPV/2-270     AC A0A0F6ZQV4.1
#=GS A0A286XB91_CAVPO/457-614  AC A0A286XB91.1
#=GS A0A343X9V7_9VIRU/1-303    AC A0A343X9V7.1
#=GS A0A7G8PYJ5_9VIRU/1-277    AC A0A7G8PYJ5.1
#=GS GP_RVFVZ/1-95             AC P21401.1
#=GS A2T069_RVFV/89-144        AC A2T069.1
#=GS GP_RVFVZ/89-144           AC P21401.1
#=GS A0A288KH56_9VIRU/4-294    AC A0A288KH56.1
#=GS A0A482KC00_9VIRU/4-304    AC A0A482KC00.1
#=GS L0GAZ6_9VIRU/2-287        AC L0GAZ6.1
#=GS I1ST83_9VIRU/4-281        AC I1ST83.1
#=GS A0A4P8D7U2_9VIRU/4-255    AC A0A4P8D7U2.1
A0A6M4ALR6_9VIRU/6-313               lvlltslaglseplikvgsihpg--------.--------..----------GSSKVCLSNRTPAETVLYYWEDQFSK---LPQGQYLCQVG.SERKEEMDFKRIRKLVREV...GESITAV..FFQCQ.yK.ENEGYGIN.VMFDGFDNtEEGT.YIADCEDGrKKISDVrllS.S..GSRGRT..V........EH.D.I...VMSpDAannrvrgdlktlqDKVDRMHLEhEKLNLENdklkdkm.....kneglltSSKIQIL..QEKLDEAVDDLEDRKLE....--R.DRAISDHKR.TLDE-AAELRVEINHLHKLIeaegdlkke...lqrelnesrDQIYNLKNA.PKSSV.....S...NKSISSYVTMA.........IPVITTLSLLGSA---aam.......................................................
I1T324_9VIRU/1-265                   ...................myie---IVSVM.LLASTVYC..AYILTASRPKGTTKICLSNLTPYNSLTSYW--NNLNS-DLENGDRQCSVG.TSGMSYTTNSTIMSLIREV...QISQAHI..TLTCK..PlEAEDEKIS.MRFDGLADdFHYP.SVLNCE--.--NSSL...S.L..GPIPNI..V.......pDM.G.D..lIRE.DA.............NDKIGFLRD.RLASMEEr.................lVSETKLLeaEREIRNQELNDHSERYHf..nDVR.LKAHE---D.DIKDKDDKISEQKHIIAMLS.....................KNITILHDK.LNKMS.....I...NPRAEMKVIPT.........VVSVALLSSSLTS---aal.......................................................
A2T069_RVFV/1-95                     .......................MYVLLTIL.-ISVLVCE..AV-IRVSLSSTREETCFGDSTNPEMIEGAW--DSLREEEMPE-ELSCS--.------------ISGIREV...KTSSQEL..Y----..-.--RALKAI.IAADGLNN.IT--.--------.------...-.-..------..-........--.-.-...---.--.............---------.-------...................-------..-----------------....---.---------.--------------------.....................---------.-----.....-...-----------.........----------------chgkd.....................................................
A0A482KFT4_9VIRU/1-284               ......................m-KILLYVK.-QMVLTLA..VYTLSSWSIEGTTRLCMSNESPLEGLVYYWEDKMKKNKLTIDKLSGCRIG.EGDLQEMVNKTIIKMIEEV...QLSMSPL..RFSCH..Q.SLNESGIS.IDFNGLDDtDSGY.HIVDCNNH.KIYEDL...G.V..LVGDGT..Aw.....esRY.N.K...SFN.EEiavktn.qlrlalSDLDRLTDL.RVDDQNEin...............slIRENQML..QHKISNITGVAYNYNNS....LQA.LLDDLHKRD.VEYELM-KIR--EQELKNLL.....................DEQNRTMDK.LKAVR.....TpadKYVMTTT-PKT........iLMTTLAVSLLSSS---sait......................................................
A0A5C0E4I4_9VIRU/2-318               .....flrtvtliallsgadsii--------.--------..--KIFSIHPEGSSKVCLSNQSPAEVISYYWSLQMDK--LAKE-NYMCSIG.DSIKENMDVNKIRRLVKQV...GESPTEI..SFQCQvaDvEKSGMGVS.YTFNGIDDtVPGT.HLVDCDNG.TKSIGVa.rA.T..GPQINR..LvgpppvlvEV.P.R...LEP.KVrgdla..elsrrvS--------.EAKEKEElmtker......ealksqaDLMQVKS..SAKFKELEEQIAELKED...iIDR.EFENNAIKK.EMRASEAESVALREEINGLHeilkleh.......eakkemnRSLEEAKSR.IQS--.....-...-----------.........----------------gynmrnqplraslgntkygvrmttvlpvltafsllsagaia.................
A0A7G8PYJ9_9VIRU/1-276               .....................mm--ILVLVF.LLTPCVLG..FTRIYSDSSSGVSETCFSSSTTFTWAVRQWMSEMTR---LPHTEKFCLLNsEEKAKYMTDEEAVGMIETL...VGLKKPA..NFSCT..D.IKNSFILG.LEVKPQVE.SHRS.SSIDCKDF.TMIRPL...S.EmkPEDLKP..Iat...skdDA.K.N...LEK.LE.............EELKKLKAF.NDKTLAEnlkla........tsldheLTKSRMS..MDDVRKTVSELEKIKDE....--M.AIKREEISE.VQRQL--------------Kaekeas........qryqqeiDNLKAIHQRrTNELR.....T...NSSVLSTTIKA.........ITVLSVMSSAS-----aef.......................................................
A0A1S5SHT8_9VIRU/9-278               ..................lkafa-----VLL.TQSVIAEG..LFMLKSFKPLSSAQVCFSSRTPLDGIGVYWISEMDK---LVNPTKLCSLG.GSPPSLMTKTSAFMATRAV...ILSEEPS..ELVCE..S.EDRSEGIS.LSNNGEEE.DLGP.AIINCRTR.EKQEDI...R.V..RVSA--..L........EE.N.D...I--.--.............---KRIIEM.TTEYPAT...................ESPRKIL..RTEIRKMETSKEELNDE....IAKlTARHEALVN.ALRETMTDRD--RENNRLLSe...................kVEMENEKRE.IEH--.....-...-----------.........----------------kikslnnllesekltvkylreelkrlqhqsnlekdklkeemetfnrr...........
A0A286XN02_CAVPO/457-614             .....nevlqsflqsqttieksi--------.--------..--------------------------------------------------.-------------------...-------..-----..-.--------.--------.----.--------.-LQSDK...A.L..TDGEKA..I........AA.E.R...AKK.EA.............AEKEQEVLRqKTEEQQQm.................mEAQERSF..QENMAQLKEKMEKERQD....ILR.EQERMLEHK.LKAQEELLRDGFRKKSEALN.....................REIHHLKEE.IEKTQ.....D...KKSFFSKIVDT.........VGTVLV----------avlpgagklv................................................
D9YRN1_9VIRU/4-294                   .......................ITILLIVLaTLFILVVG..NLKLESKMGNSLTSTCFSQNTGPGIIERYWGFEMAK---MPGFDLHCRFNeEGDSRYMTHENAMKQIKIV...TTAPDTM..KFSCR..D.ETESLGLS.ITNDGTKN.MMGP.AIIYCDTK.EFIRNI...T.T..GEQPPR..V........DY.E.K...LKK.NA.............EEKDATIQR.KTKEMEEvr..............avlDSRIQIA..HHEIQQKENEIQKLRNDlrdaIKK.GQEHESMKL.RVEESDARVRGLKEELKQLTykifd...........hqatkDELQRAKSE.MQSLR.....K...KIKDFESVPQAkkpsnssvaLVTTAVLSLLGSSMAA..........................................................
F2W3Q1_9VIRU/1-278                   .....................mk---ILHLL.TNIMYALG..AYIITGWSMEGTTRVCLSNESPLEGIVYYWETERKRRGMESSSNLDCRVG.EGELKRISNKTLIRLIEEV...QLSTYEL..KVSCE..K.SSNDTGLS.IDFNGLDDtEPGH.HIVDCEKM.RYVSDL...G.V..TVGDGL..Aw.....dsRYnE.S...YKQ.ELl..........rkDEK------.-LREFENelshlkltgiddkneimslIRENQML..QHRISNLTGSNENKNNSl..rILK.-NELMQAES.HRDNLEREILNHKDRHAKLE.....................GDFIKLKSS.MFSV-.....-...--QVVTTVLP-.........-----LLSLVGT----slaatpim..................................................
A0A0F6ZQV4_PTPV/2-270                .......................IFTILNVL.TRAMLVMS..MYSLTTWDSSSRNDICFSNDSPLEGLVYYWETHSKKHDYKKQGSQKCRVG.DSDKKMISNVTIISLISEI...QKSISEL..SLSCG..N.NDNSTGQV.LTFNGLEDtIRGD.YIVDCVTG.LYQSDI...G.V..GVGLGR..In......hDH.Q.Q...VKN.KAv..........viDEKEKMISLlETQQSEN...................DIKTQVL..MSEIEQLKNQLSKRRNE....--R.GQEKRDAEK.LMSDLMARNSDLRNHNVILT.....................DEISQIKNN.ITIHR.....N...RNMMSTTVVPA.........ILSVALLSSSVGPITA..........................................................
A0A286XB91_CAVPO/457-614             .....nevlqsflqsqttieksi--------.--------..--------------------------------------------------.-------------------...-------..-----..-.--------.--------.----.--------.-LQSDK...A.L..TDGEKA..I........AA.E.R...AKK.EA.............AEKEQEVLRqKTEEQQQm.................mEAQERSF..QENMAQLKEKMEKERQD....ILR.EQERMLEHK.LKAQEELLRDGFRKKSEALN.....................REIHHLKEE.IEKTQ.....D...KKSFFSKIVDT.........VGTVLV----------avlpgagklv................................................
A0A343X9V7_9VIRU/1-303               ......................m-FKKLVVL.TLALGQGD.cLYKITSLNQGARHELCMSNPTSFESVIDYWG-SMDR--ALGEGDRECDIG.GGVKSYTTASTTKKLVRTV...VDSMTAL..NMSCS..I.KDSPDKLIhLMFDAEYDgHLAP.MIVSCIDG.SAQGPL...R.IagSHSTNK..I.......iHF.P.KgasVEE.GTsppe....vsekpDDLSDEISY.RI----KsltsgnndpgslvhvisskDHELSTL..KEEINSLKSRLEHERED....---.------RDR.LRAEHKAQIGHGDAERKLLEdrlrare.......qdihndrAELQQLKAK.LRSLE.....N...ARVPVTTIAPKai....ttaLTVVSLLSAVG-----adln......................................................
A0A7G8PYJ5_9VIRU/1-277               ...................mlfy----LILL.-LTPLVQG..YTRVYSDSASGLSETCFSKNTSSTWAVRQWMFEMTR---LPHSEKFCLLNtEEKAKYTTDEDAVAIIESM...IEVGKPV..HFTCT..D.LSNTYVLG.VEVKAKVE.SFSA.SSIDCKDY.TKIRPL...S.E..NKPGDA..Vk.....itDV.NpP...IDS.VAe..........lrEELSKLKAH.NDKALEEnlrla........trldheLTKARIN..DQN-------VNKTLEE....LER.TKDEIQIKReRIKEVNRVLTEERRRSAILQ.....................EEIDNMKNI.ERQRTnevraA...KPSMLNMTMGA.........VTMMALLSTSSS----fvl.......................................................
GP_RVFVZ/1-95                        .......................MYVLLTIL.-TSVLVCE..AI-IRVSLSSTREETCFGDSTNPEMIEGAW--DSLREEEMPE-ELSCS--.------------ISGIREV...KTSSQEL..Y----..-.--RALKAI.IAADGLNN.IT--.--------.------...-.-..------..-........--.-.-...---.--.............---------.-------...................-------..-----------------....---.---------.--------------------.....................---------.-----.....-...-----------.........----------------chgkd.....................................................
A2T069_RVFV/89-144                   .....................it--------.--------..--------------------------------------------------.-------------------...-------..-----..-.--------.--------.----.--------.------...-.-..------..-........--.-.-...---.--.............--------C.HGKDPED...................-------..--KISLIKGPPHKKRVG....IVR.CERRRDAKQ.IGRETMAGIA----------.....................---------.-----.....-...-----------.........----------------mtvlpalav.................................................
GP_RVFVZ/89-144                      .....................it--------.--------..--------------------------------------------------.-------------------...-------..-----..-.--------.--------.----.--------.------...-.-..------..-........--.-.-...---.--.............--------C.HGKDPED...................-------..--KISLIKGPPHKKRVG....IVR.CERRRDAKQ.IGRKTMAGIA----------.....................---------.-----.....-...-----------.........----------------mtvlpalav.................................................
A0A288KH56_9VIRU/4-294               .......................ITILLIILaTIAVLVVG..NLRLDSKMGNSLASTCFSQNTGSSIIEKYWGFEMAK---MPGFDLHCRFNdEGAPKYMTHENAAKQLKVV...STAPDTM..KFSCE..N.DVGTLGLS.ITNDGTNN.MMEP.AVIYCDTK.EFIRSV...A.A..PEQPQR..E........NP.E.S...LRK.AA.............EEKDNMIQR.KTKELEEvr..............aalDAKIQVA..HHEIQQKENEVQRLRVElreaSKR.GHDQESLKF.RLEESDGRIKGLKEELKQLTfkifd...........hqatkDELQRAKSE.MQSLR.....R...KIKDMETASQArkptnssipLVTTAMLSLLSTSVA-v.........................................................
A0A482KC00_9VIRU/4-304               .....................kn------II.YLALLSCSdaALRIRGRKELGRSEVCFSDQSPDDAVMVYWLSELEK---VYSEDFVCSYS.GSDYISMNKQGINNRVEELfveNKRNVSV..SLACL..G.KDRAIEIE.VINLITEG.--KP.MIVNCNTG.EFIAEI...R.T..IHGKKR..V........AI.D.K...TPE.MV.............SAVMSEIES.RGEDFKSl................ydNILEQYN..KVTEELLNAQKDKLNSD....AQK.ISEIEKLKD.TTDMLEGVIERLRADMLKEKsls..............trleNELAILIDS.QNEKK.....K...-----------.........----------------eahhsesvslsqpggdikdnkihkvsqqlatsrhpltttmlpimmvtllttssaaaai
L0GAZ6_9VIRU/2-287                   ....................iel--ILLFV-.QCVVLVEP..RISLTITSPDYSSLSCFNSAAGPKFLQRKWKTEVSK---MGEFDQLCYYN.NDIPKRSTPENAEGLVTFA...MLSESPS..TFSCI..N.EDRSKTAV.VHSNGIRE.-DGDaAYVDCEKG.TMIHLI...SsA..GDIAPS..T........DP.L.K...MEH.QA............lRERFDELQR.KFSDDKAa.................lNDENRRL..RSELE----ELHKARESl..kLVR.ANQDQNITA.LNAVIHGLTKKVQDGEVALIgalnqarrdkealvyleedtdRKLEESQSV.IESLQ.....K...A----------.........----------------lrnatlsiprpalvttmatitllsstii..............................
I1ST83_9VIRU/4-281                   ....................yqi--IYLIVL.TS--GVSS..LVRLSSRKSSYLGKICFSAETPAEGVMVYWLSEVSK---MSPGAMDCSKA.GGDYRKMDRKEMSSYMTDV..vESAASGLddSFSCL..G.NNEGIEIV.SDQIRTED.--RP.MVVNCDTG.NFQEEV...R.V..IGIAGRppVr.....mpEK.T.P...VME.DP............vEENGAASRLsE-IQKEVell............rldqANKQKQL..NEAIEKMKKLKESHGLE....VD-.-KREDELDR.LIGEKKRLEGDLNKERSLSTr..................leNELSILKNE.IFRRE.....N...N----------.........----------------arkieeeaerkreadlagrttkpktttvr.............................
A0A4P8D7U2_9VIRU/4-255               .........ynllipqllsgclc--------.-------S..YL-LLVSTINRDAKICLSNTTPLRSLIEYW---SRISEGLSMEDSTCSLG.DSSYVRMSNKTIMNSIKLV...QDSVTEI..KLQCN..M.ANNS-NAL.LHFDGLSDsFDRP.QILNCESK.ESLGDI...N.Y..NPEY-E..I........HN.K.D...IKT.EL.............KSSDSILRD.RVAELEE...................RLRDETK..LLNAERIIRDME--MND....--H.SERYYSNDV.RMREHEEQVKNLDKMLVEKE.....................SYIARLQNN.ITSMI.....S...AIKPTKKAATL.........ITAISLLSSA------ypsp......................................................
#=GC seq_cons                        ......................h......lh.....hs.s..hh.l.s...ps.schChSspos.phl.hhW..p.t+...h.p.ph.Cphs.tt..p.hs.pphhphlctl.....u.p.h..phpC.....ttps.th..lt.suhps...ts..hlsCpph.ph.psl...s.h..s.t.tt..l........ch.p.p...h.p.th.............pch.t.h.h.cspp.cp....................tptphh..ppclpphptphcchpp-......+.tpcp.phcp.hhpphtt.htt.cpp...Lp.....................pplpph+sp.hpph......t...t...................................thh.......................................................
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