#=GF ID   Pico_P2A
#=GF AC   PF00947.23
#=GF DE   Picornavirus core protein 2A
#=GF AU   Finn RD;0000-0001-8626-2148
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_138 (release 3.0)
#=GF GA   26.00 26.00;
#=GF TC   28.40 26.40;
#=GF NC   24.00 21.30;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0124
#=GF RN   [1]
#=GF RM   10523291
#=GF RT   The structure of the 2A proteinase from a common cold virus: a
#=GF RT   proteinase responsible for the shut-off of host-cell protein
#=GF RT   synthesis. 
#=GF RA   Petersen JF, Cherney MM, Liebig HD, Skern T, Kuechler E, James
#=GF RA   MN; 
#=GF RL   EMBO J 1999;18:5463-5475.
#=GF DR   INTERPRO; IPR000081;
#=GF DR   MEROPS; C3;
#=GF DR   SCOP; 2hrv; fa;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This protein is a protease, involved in cleavage of the
#=GF CC   polyprotein.
#=GF SQ   8
#=GS POLG_POL1M/899-1025        AC P03300.3
#=GS A0A0V0T2H0_9BILA/37-163    AC A0A0V0T2H0.1
#=GS A0A0V0T4S7_9BILA/881-996   AC A0A0V0T4S7.1
#=GS A0A0V1KI70_9BILA/1-69      AC A0A0V1KI70.1
#=GS A0A0V1KJU5_9BILA/1-92      AC A0A0V1KJU5.1
#=GS A0A0V1GMQ2_9BILA/254-296   AC A0A0V1GMQ2.1
#=GS A0A0B5GG60_9PICO/937-1064  AC A0A0B5GG60.1
#=GS POLG_HRV8A/882-1007        AC P07210.3
POLG_POL1M/899-1025                   ........NYHLATQDDLQNAVNVMWSRDLLVTESRAQGTDSIARCNCNAGVYYCESRRKYYPVSFVGPTFQYME....ANNYYPARYQSHMLIGHGFASPGDCGGILRCHHGVIGIITAGGEGLVAFSDIRDLYAYEE.......................
#=GR POLG_POL1M/899-1025        AS    ..........*.................*..........................................................................*..........................................................
A0A0V0T2H0_9BILA/37-163               ........NRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARCDCQTGVYYCNSKRKHYPVSFSKPSLIYVE....ASEYYPARYQSHLMLAAGHSEPGDCGGILRCQHGVVGIVSTGGNGLVGFADVRDLLWLDE.......................
#=GR A0A0V0T2H0_9BILA/37-163    pAS   ..........*.................*..........................................................................*..........................................................
A0A0V0T4S7_9BILA/881-996              ........NRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARCNCQTGVYYCNSMRKHYPVSFSKPSLIFVE....ASEYYPARYQSHLMLAVGHSEPGDCA----------------------------------meqgvsdyikglgdafgmgftda
#=GR A0A0V0T4S7_9BILA/881-996   pAS   ..........*.................*..........................................................................*..........................................................
A0A0V1KI70_9BILA/1-69                 .......m--------------------------------------------------RKHYPVSFSKPSLIFVE....ASEYYPARYQSHLMLAVGHSEPGDCGGILRCQHGVVGIVSTGGNGLVGFAD---------.......................
A0A0V1KJU5_9BILA/1-92                 ........-------NDWANLVWEDSSRDLLVSSTTAQGCDTIARCDCQTGVYYCNSKRKHYPVSFSKPSLIYVE....ASEYYPARYQSHLMLAAGHSEPGDCGGIF-------------------------------llw....................
A0A0V1GMQ2_9BILA/254-296              ........NRHLATHNDWANLVWEDSSRDLLVSSTTAQGCDTIARCNCQTG------------------------....------------------------------------------------------------.......................
A0A0B5GG60_9PICO/937-1064             yhwvladw------HNNQRELVWADSDRDVVCFKHKTTHQPK--LCTCKRGY-WT-ANMCMFNTTKRARFSTWVEgfevESETRGDHIQLDAIQISKPIPEGWCGSPLFCEHGIVGMATASTDSSSFFTHIASM-----pfvk...................
POLG_HRV8A/882-1007                   ........NLHLFN-SDLDDSILVSYSSDLIIYRTNTEGNDVIPNCDCTECTYYCHHKDRYFPIRVTAHDWYEIQ....ESEYYPKHIQYNLLIGEGPCEPGDCGGKLLCKHGVIGMITAGGEGHVAFIDLRKFQCAEE.......................
#=GR POLG_HRV8A/882-1007        pAS   ..........*.................*..........................................................................*..........................................................
#=GC seq_cons                         ........NhHLhspNDhsNLVWtDSSRDLLVopTsAQGsDoIARCsCpsGsYYCpupRKaYPVSFotPohhaVE....ASEYYPARYQSHLhlusGauEPGDCGGhLhCpHGllGhhosuspu.shF.c................................
//