#=GF ID PilJ_C
#=GF AC PF18223.5
#=GF DE Pili PilJ C-terminal domain
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF03122
#=GF GA 26.70 26.70;
#=GF TC 26.70 27.10;
#=GF NC 26.20 25.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0327
#=GF RN [1]
#=GF RM 24362261
#=GF RT Structure of Clostridium difficile PilJ exhibits unprecedented
#=GF RT divergence from known type IV pilins.
#=GF RA Piepenbrink KH, Maldarelli GA, de la Pena CF, Mulvey GL, Snyder
#=GF RA GA, De Masi L, von Rosenvinge EC, Gunther S, Armstrong GD,
#=GF RA Donnenberg MS, Sundberg EJ;
#=GF RL J Biol Chem. 2014;289:4334-4345.
#=GF DR INTERPRO; IPR040599;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the C-terminal domain of PilJ, a Type IV pilin found in
#=GF CC gram-positive Clostridium difficile. Incorporation of PilJ into
#=GF CC pili exposes the C-terminal domain of PilJ to create a novel
#=GF CC interaction surface. This C-terminal domain is not observed in
#=GF CC other Type IV pilin proteins [1].
#=GF SQ 34
#=GS N9WD77_CLOIN/214-310 AC N9WD77.1
#=GS G5I9V3_9CLOT/247-342 AC G5I9V3.1
#=GS A0A0M2NNH4_9FIRM/9-116 AC A0A0M2NNH4.1
#=GS A0A6B1UD70_9FIRM/180-268 AC A0A6B1UD70.1
#=GS R6I690_9FIRM/243-333 AC R6I690.1
#=GS A0A318KRN1_9FIRM/152-242 AC A0A318KRN1.1
#=GS A0A395YIL4_9CLOT/139-231 AC A0A395YIL4.1
#=GS A0A136Q0C6_9FIRM/137-240 AC A0A136Q0C6.1
#=GS R6I6W7_9FIRM/153-236 AC R6I6W7.1
#=GS Q189V3_CLOD6/147-239 AC Q189V3.1
#=GS A0A7G9G6K1_9FIRM/144-233 AC A0A7G9G6K1.1
#=GS A0A1T4P8H4_9FIRM/158-246 AC A0A1T4P8H4.1
#=GS A0A1T4NBU3_9FIRM/153-239 AC A0A1T4NBU3.1
#=GS A0A1M5QZK0_9CLOT/155-246 AC A0A1M5QZK0.1
#=GS A0A318LFY4_9FIRM/170-254 AC A0A318LFY4.1
#=GS A0A1M4T331_9CLOT/157-251 AC A0A1M4T331.1
#=GS F0YWT7_9CLOT/168-266 AC F0YWT7.1
#=GS A0A2K2TWY4_9CLOT/643-726 AC A0A2K2TWY4.1
#=GS A0A1C7IGF0_9FIRM/144-231 AC A0A1C7IGF0.1
#=GS A0A2Y9BGU1_9FIRM/151-256 AC A0A2Y9BGU1.1
#=GS A0A1B2I6M6_9BACT/151-248 AC A0A1B2I6M6.1
#=GS A0A6N8UDC1_9FIRM/154-251 AC A0A6N8UDC1.1
#=GS B9YAH4_9FIRM/148-250 AC B9YAH4.1
#=GS E7GJJ7_CLOSY/150-255 AC E7GJJ7.1
#=GS A0A7G9B4L3_9FIRM/137-225 AC A0A7G9B4L3.1
#=GS A0A396QD28_9FIRM/143-231 AC A0A396QD28.1
#=GS E7GBF3_9FIRM/166-258 AC E7GBF3.1
#=GS R6QSI1_9FIRM/151-254 AC R6QSI1.1
#=GS D6E7Z0_9ACTN/120-216 AC D6E7Z0.1
#=GS A0A4Q7PN05_9FIRM/155-251 AC A0A4Q7PN05.1
#=GS A0A1H4AHV5_9FIRM/255-364 AC A0A1H4AHV5.1
#=GS A0A4R6Q9B6_9FIRM/132-225 AC A0A4R6Q9B6.1
#=GS A0A8J6IQL9_9FIRM/237-349 AC A0A8J6IQL9.1
#=GS A0A0L6U3L5_9FIRM/140-230 AC A0A0L6U3L5.1
N9WD77_CLOIN/214-310 ..........yanng---.-YY.SNDRM....REY.LYTGV..YN..SSI.PKFDNSAASNFp.........eKFE.GK..TFYMKTYCS---.-DGK....................K....lSFVYANEKS........tMNNGDW.E.ASMIFNVEDGHWYDV---..----telngnki....
G5I9V3_9CLOT/247-342 ...............MTWnQIN.NNDKF....RSA.L--TK..VN..GDW.PTVAEEGLAEElh.......mlEEE.SQ..KWYVNIYVV--V.KDDC....................R.....VVPYISKAPr.......lGVGDQW.R.ARYL--QIDGVWYQPKEA..PSA-s...........
A0A0M2NNH4_9FIRM/9-116 .etnaerqeylginn---.NNF.SNDTF....RAK.LAELMgkYY..SFP.LTVDSNVQSQG..........aYCQ.DK..DLYYQVYFV-KD.GDSR....................A.....AVVYASEASg.......lDSGNRW.E.AWMVYQ--NGTWFESQKT..----hsyn........
A0A6B1UD70_9FIRM/180-268 .........nkdpsl---.--I.NNESF....RNA.V--YK..KN..GGW.GELK-------...........-AD.GQ..TFYVQPYYN-TV.KQDK....................Te..nsLVIFANTNP.........NNSGNW.T.ANYIYNRDDGSWYQCATG..SK--sin.........
R6I690_9FIRM/243-333 ..............s-LW.QLG.NNDKI....REY.LLSEK..YG..GAW.FSVN-------...........-IN.GK..TVYMNPYGYGDT.NVPI....................Tv..dnVFLIGYTDP.........DKTTGW.N.VNYVYNPENKKWYHLIKN..SGVSv...........
A0A318KRN1_9FIRM/152-242 .............nd--W.QLN.SNDQV....RAI.L-KKA..NG..GKW.PTLI-----LD...........GSD.TV..-YYVQPYMD-TY.KSET....................Tt..psGQKYVYAS-.........-TGENW.F.ASLIYDRDSGKWYQPSTK..----nqtilia.....
A0A395YIL4_9CLOT/139-231 ......tekgdyikk---.---.--STD....RKK.LIEEI..YNqrGSL.LEVSSGFKNGT..........iAEG.MN..NLYWRPYYL---.-KDG....................T.....IVMYAASGN........tASHAGW.G.AYLVYV--NGEIYESTK-..----vgan........
A0A136Q0C6_9FIRM/137-240 ........tgnavky---.--L.NNDTL....RSY.LIGSV..YD..GKW.PAFPSSMLEQN...........GIS.GN..-YYIQPYID-AN.GAGGrn...............pskN.....VTVYANTNDg.......sSTSDLW.R.ANLIFNPENGKWYHGNNG..SVI-rvm.........
R6I6W7_9FIRM/153-236 ..........sgvlv---.--K.TNDGF....REA.Y--YK..EK..GKW.PSG-------V...........DLN.GN..TIYFKFHLT---.-ADG....................S.....FLTYANGNGd.......fKNSGDW.G.TNYIYDSAAKKWYYSPQG..TN--lg..........
Q189V3_CLOD6/147-239 ..............i-PG.ASK.GNDDF....RKY.LLDNK..YK..NGW.PTIPDEFKAKY...........GLS.KD..TLYIQPYAYSPT.KSDA....................T.....VVVFANNK-.........-TGGNW.Y.TSLVYDYDEGRWYKGKNG..ISV-a...........
A0A7G9G6K1_9FIRM/144-233 ...........aeqs---.SQK.KNYAL....REA.FLKE-..YG..GQW.PTLT-------...........-VD.GE..TYYIQPFYSESA.DSSLpm................eqR.....TWLYATKDP.........GTASNW.S.VPYVFDPVTQEWYGAT--..----kwngs.......
A0A1T4P8H4_9FIRM/158-246 ...........vsdn---.-GV.RNDTM....RDA.LL-AL..YG..GTW.PKLDDNILKAAg.........iNTN.GK..TYYYQPFFTTGT.NVE-....................-.....-ILFASENS.........GADKNW.N.SQLFFF--EGTWYKSSK-..----vtg.........
A0A1T4NBU3_9FIRM/153-239 .thffsndvsskkyy---.---.-----....---.---EE..LG..GAW.KTLGEDIKALA...........GIT.GT..-YYVRPYYC---.-ESG....................E.....PIIFANQSN........aINGGGW.AdVPVLYY--EGSWYKCTKG..T---vqm.........
A0A1M5QZK0_9CLOT/155-246 ............inn---.NNF.SNDTY....RAY.ILKND..FN..GTW.PTLSVDLPKKYe.........iTIN.GS..ELKIMPFSN--S.KDLS....................D.....PVIYASTN-.........-TGNSW.N.SPVFYY-PGKGWYIHKNS..YNV-y...........
A0A318LFY4_9FIRM/170-254 ...........qsyv---.-LN.NNDEL....RNY.L-QYI..NG..GSW.PTLQ-------...........-VN.GQ..TLYVQPYIDSHRsNSSG....................D.....IIIYASPN-.........-GNGNW.N.TNYIYDSNTGKWWTGKKS..FSVS............
A0A1M4T331_9CLOT/157-251 ...fydgkladgsky---.---.-ND--....RKD.LIEDL..YNkrGSL.LKVSSQFTKGT...........AYEgGK..EMYWRPYYL---.-NDG....................T.....MVMYATNEN........sATHAQW.R.GALMYV--DGKVYELPEG..V---ke..........
F0YWT7_9CLOT/168-266 ...............ITD.LKK.DNPNLnsldRLK.LIENA.aKN..GGL.LSVTERQKKGT...........PYE.KN..DLYWHPYYIGSV.GQEN....................P....pMVLFANTAA.........ETHGGW.S.AKLIYV--DGKVYQAPDK..SNIN............
A0A2K2TWY4_9CLOT/643-726 lgdilemskasklet---.---.-----....---.-----..--..---.---------KD...........VLT.EE..NAYLNVYIK--P.GATP....................Q.....LIPYISKDSgaklfegnnNVADKW.R.AYLVYNYEDGNWYECENG..S---yad.........
A0A1C7IGF0_9FIRM/144-231 .......elssagft---.---.----N....REA.VIQKV.aDE..KGF.LKISDTIKNKT...........VFA.DK..DLYWKPYYL---.-ADG....................K.....MVLYGTTNT........gNAWSNW.E.GYLIYV--DGQIYQSTN-..----tdtn........
A0A2Y9BGU1_9FIRM/151-256 dwlsspnsnkyagre---.---.-----....--T.LTRLLieKY..GLL.PSVDSTLIPDR...........YTN.TS..-LYWQPYYIANN.KTGLqg................stS.....TLLLATPNDgsg...nlsNIQNSW.K.AYMIYF--EGVVYVLPEG..S---ena.........
A0A1B2I6M6_9BACT/151-248 ........ldgsakq---.---.--DAI....NKL.LGDGV.nIG..GSVnTNISDALLEKMgg......wpkWEK.DD..SLYVHPHFL---.NGKG....................E.....VIYFANSDK.........NAVTGW.N.AKAIYY--KGQWYQKVDA..----ngkvvs......
A0A6N8UDC1_9FIRM/154-251 ...........vtsl---.-YL.NNDEF....IMY.MFHYY..YG..RNW.PDFNKELQKQLp.........eSLQ.NK..AYVIRTFMSSPI.NDSS....................T.....IIVYATEYT........sAIKGSW.G.TSLIYDYGDG--------..----edpntaagwyym
B9YAH4_9FIRM/148-250 .............lt--G.NSKlNNDAI....RNF.MKNEI..YG..GSW.PALDNGIVNAA...........NLP.KG..DYKIQICYR-HV.TDPNvenpy.........nnpvpeN.....AIIYASTI-.........-QGGNW.N.TSLIYNQDDNKWYSGK--..----slvin.......
E7GJJ7_CLOSY/150-255 ..............l-PT.NSI.RNDTI....REY.LLKEV..YG..GQW.PKVDKSLFTGA...........NYG.GD..-LYIQPYINVKN.TSGGnisd............tnkdS.....VFAYIGPSKd.......dISGQKW.Q.AYFIYDPDSKQWYRDAKGnaC---lim.........
A0A7G9B4L3_9FIRM/137-225 ...........vpsn---.EIN.RNDSL....RTH.F-YEA..NG..NKW.PTLT-------...........-VD.GV..EYQIEPYYS-EA.GKNA....................EdrldyIWLFARQKTd.......gVVNGRW.S.VPLLYNPVDGIWYRS---..----ygy.........
A0A396QD28_9FIRM/143-231 ..............y-TG.GRN.DNNSI....RTA.F-YNN..NG..GKW.PTLT-------...........-VN.GE..SYSVQPFYRKDE.SA-Adl................tgQ.....VWLYATKDYd.......dCTNGSW.N.VQMVYNPMDSKWYQATN-..----yng.........
E7GBF3_9FIRM/166-258 .......tkelakgq---.--T.-TLDR....KEL.IGKLI..NE..NKL.QKVDNNILEKI...........NSQ.TD..-LYWRPYYI-GE.KDNP....................E.....MILYANSSC.........TSNPDW.R.ANIVYV--NGKIYQCNIG..IS--sy..........
R6QSI1_9FIRM/151-254 ...........lyke---.GKV.NNWAS....REL.LMKYMydHG..NGY.MPVDSSFLKSKy.........fDEL.ED..QLYWQPYYLSSK.GVSG....................Sf...gSLLIATKSDgs....npnNMHGQW.K.AYLVYY--DGKIYETGK-..----tttn........
D6E7Z0_9ACTN/120-216 ttsksylsdwnkfid---.---.-----....--S.ITDPK..IK..NNN.SKMRELFFAEYgs......pllTYQ.GK..DYNVQPFFK---.-STG....................E.....TWLFAREG-.........-TGDNW.S.ANFVYDPIDQSWYRCVKE..----ngtpt.......
A0A4Q7PN05_9FIRM/155-251 ..asdlhangnrypg---.---.-----....RESvIAEMV..KN..GGL.LAVDSYQKRGTv.........yQND.SD..QLYWRPYYI--D.ITNP....................Q.....SFLFANTGN.........TGHAKW.E.AKLVYY--NGSIYQSTKK..----dangn.......
A0A1H4AHV5_9FIRM/255-364 ...........yfkt---.-NP.NNDNI....LKY.LFQYK..YH..SEW.PKFPQPQDNKLekypeiknfyyPTV.TK..SLYMRPYCGVMS.TTDAal...............agkN.....TFVFVSPN-.........NAATGWaD.IYFIIDCQSGTMYASTKV..----ssg.........
A0A4R6Q9B6_9FIRM/132-225 ...ekwhsgddliak---.---.-----....--V.I--EA..NN..GKL.VSVSTSSLFGDs........alKTS.DT..TLYWRPKVV-ES.NGKK....................V.....VFLYANAGN.........SGTAGW.K.GYAVYY--NGSYYVSTKK..----tyggki......
A0A8J6IQL9_9FIRM/237-349 ...........snva---.-SF.SNDQM....RDY.VRSTY..YG..GTW.PDID-LGLERF...........SVE.NT..-NKLNPYVKGDL.KDIAplelqfhaanvpgtndpdkmS.....IVIYAVQKGpa.....nsNNHSMW.R.PLVVYDPYDSYWYA----..----pfpt........
A0A0L6U3L5_9FIRM/140-230 ..........iedsn---.--F.SNDTY....RAK.IF-RD..NG..NTW.NAFPVDLIKKS...........RYL.KDetDYMIQPYFT---.-LDG....................D.....VVMFANSVN.........AAQGSW.G.TKLVFNHEEGTWYEYIDN..----ngr.........
#=GC seq_cons ..............t........pN-ph....Rph.lhpth..hs..Gsa.sslspthhtth...........ths.sp..shYhpPYhh....tsss....................s.....sllaAssss.........sssssW.p.u.hlYs..sGpWYpsspt......t...........
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