#=GF ID   PilZN3
#=GF AC   PF20424.2
#=GF DE   PilZN3 domain
#=GF AU   Galperin MY;0000-0002-2265-5572
#=GF AU   Chuguransky S;0000-0002-0520-0736
#=GF SE   Galperin MY
#=GF GA   27.40 27.40;
#=GF TC   33.70 27.70;
#=GF NC   24.50 25.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Domain
#=GF RN   [1]
#=GF RM   31740493
#=GF RT   Structural Conservation and Diversity of PilZ-Related Domains.
#=GF RA   Galperin MY, Chou SH;
#=GF RL   J Bacteriol. 2020; [Epub ahead of print]
#=GF DR   INTERPRO; IPR046853;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   This is a noncanonical PilZ domain found in spirochaetes, such
#=GF CC   as B. burgdorferi BB0733 and Treponema denticola TDE0214
#=GF CC   proteins. They have a PilZN3-PilZ domain architecture and affect
#=GF CC   the motility and virulence of these organisms. Secondary
#=GF CC   structure predictions suggest that this domain retains the
#=GF CC   C-terminal alpha-helix of PilZ and three additional alpha
#=GF CC   helices [1].
#=GF SQ   42
#=GS A0A841R782_9SPIO/4-134   AC A0A841R782.1
#=GS F2NTT2_TRES6/7-141       AC F2NTT2.1
#=GS S3KE51_TREMA/7-140       AC S3KE51.1
#=GS U2KVX5_TRESO/7-142       AC U2KVX5.1
#=GS S6A1R1_9SPIR/7-142       AC S6A1R1.1
#=GS A0A1H9CI20_9SPIR/7-141   AC A0A1H9CI20.1
#=GS F4LNP5_TREBD/7-140       AC F4LNP5.1
#=GS F5Y791_LEAAZ/7-141       AC F5Y791.1
#=GS F8EX86_GRAC1/7-141       AC F8EX86.1
#=GS A0A0A0X0M6_9SPIR/7-144   AC A0A0A0X0M6.1
#=GS CDGB_TREDE/7-142         AC Q73R77.1
#=GS A0A840SCT2_9SPIR/8-142   AC A0A840SCT2.1
#=GS V5WHJ9_9SPIO/7-142       AC V5WHJ9.1
#=GS A0A098R0R3_9SPIO/7-142   AC A0A098R0R3.1
#=GS A0A7T8B7Y2_9SPIR/9-140   AC A0A7T8B7Y2.1
#=GS G0GFW1_SPITZ/7-142       AC G0GFW1.1
#=GS O83124_TREPA/19-153      AC O83124.1
#=GS A0A7T3V4Y8_9SPIR/7-141   AC A0A7T3V4Y8.1
#=GS E7NRG8_TREPH/7-141       AC E7NRG8.1
#=GS A0A841R9B6_9SPIO/8-139   AC A0A841R9B6.1
#=GS A0A1N6WF93_9SPIO/7-142   AC A0A1N6WF93.1
#=GS A0A5C1QAX3_9SPIO/3-138   AC A0A5C1QAX3.1
#=GS F5YCA2_LEAAZ/1-129       AC F5YCA2.1
#=GS A0A5C1QFD0_9SPIO/7-141   AC A0A5C1QFD0.1
#=GS A0A1T4L4L1_TREPO/9-143   AC A0A1T4L4L1.1
#=GS O51675_BORBU/5-139       AC O51675.2
#=GS E1R4G4_SEDSS/7-142       AC E1R4G4.1
#=GS A0A5C1QGJ7_9SPIO/7-144   AC A0A5C1QGJ7.1
#=GS I0XCN1_9SPIR/7-141       AC I0XCN1.1
#=GS A0A1T4MAP0_9SPIR/7-141   AC A0A1T4MAP0.1
#=GS A0A7W8G940_9SPIR/7-142   AC A0A7W8G940.1
#=GS A0A841R5P8_9SPIO/7-142   AC A0A841R5P8.1
#=GS A0A4R4BRP1_9SPIR/7-141   AC A0A4R4BRP1.1
#=GS A0A4R4BRB9_9SPIR/14-145  AC A0A4R4BRB9.1
#=GS H7EJT0_9SPIR/7-145       AC H7EJT0.1
#=GS H9UHA9_SPIAZ/7-142       AC H9UHA9.1
#=GS A0A370AZR7_9SPIO/7-144   AC A0A370AZR7.1
#=GS W6U0X2_9SPIR/5-140       AC W6U0X2.1
#=GS A0A841R5T8_9SPIO/9-143   AC A0A841R5T8.1
#=GS A0A1Y1RVW2_9SPIO/7-142   AC A0A1Y1RVW2.1
#=GS F8F2T8_GRAC1/8-139       AC F8F2T8.1
#=GS F5YPS4_TREPZ/7-141       AC F5YPS4.1
A0A841R782_9SPIO/4-134              ..yv--IDQNFEKFKARKIHLDNYTIKKLGIVGNQTVLKINDFH....LYCIPYDLGLRDCKVLMILDAKEIEFFK..R.SFdkIHSIHFVF.DNPIYKKPIS..L.FNRCKITNLNVMNP-ETRHCLVSLEYTVIPN--------------dykeilinf
F2NTT2_TRES6/7-141                  ....QVINRYYENYKNTEITFSKEIIHTLKMDPRQVYIKCSGLQ....WPCIINSTSFSQAKIILGTKSGAYAVLS..N.KS..APPVSLRFcFYQPDGQLMS..F.FVTAKVYLIEPYM-NSTDLSIITIQYTQRPPDDLILMIGNILDAN.........
S3KE51_TREMA/7-140                  ....QQISRFYDSYRNTEIMFSKETIKALNLDPRQVYIKCNSGQ....WPCIINSSSLSIARIIIGTKGGAYAAIQ..K.VN.tPVSLRFFF.SDPN-GQTMS..F.FVNAHVSAMDPYM-NSKELAIATLAFNSKPPDDLIEIVGRLLETK.........
U2KVX5_TRESO/7-142                  ....QQITNYYDSYCDKEVIFSREILHTLRVAPREIYIKCGGNQ....WPCIINSTSLLAAKIILGKTGGAFTAIT..Q.KNapPVSLRFCF.FIDKGTETMS..F.FIAGKVTNTAQYT-DSKDLAVVTLTYTQRPPDDFIVKIGTLIEAN.........
S6A1R1_9SPIR/7-142                  ....QQLNRYYDLYKDIDVTFSREVILALNLDPRQAFIRCSGGQ....WPCIINSASMTKAKIICGKKSGFIENLK..A.GT.tAISLRFTF.FEPEAKDTLS..F.FVSAKLIGISSYEAGNHELVLISLEYTQRAPDDLIEKLGILLEAN.........
A0A1H9CI20_9SPIR/7-141              ...h-HISRYYDYYRDKEIVFTKANLKSLRIDPRQIYLKSNGGQ....WPCIINSSSLQQAKVIIGTASGIYSTVQ..K.NR..TAPISIRYcFFDQNNEPIQ..F.SVNCNVIDIKPFQ-DSNELAMLTLNFTQRPPDDLILRIGEFIEVN.........
F4LNP5_TREBD/7-140                  ....QQLLRYYELYRDKEVTFSKEVIKTLNLDPRQVYIKCTDSQ....WPCIINSTSFQGAKIIIGSKGGAYARLS..Q.EK.gTVNLRFCF.LQAD-KQPIS..F.FIGSRVVEITPYM-NSPDLAVVSLAYIQRPPDALIECIGKLLEAN.........
F5Y791_LEAAZ/7-141                  ....QKITVYYDRFKTIDVTFTKEIIQVTSLITNQVFLKCGSDF....WPCVIYSSSFQGAKIVANIKSGILHKLE..Q.AN.qMASLRFSF.KNPDTGSPVT..F.FINTKSLGYSAYG-GSADVALFNLQFTQRPPDDLIEIMGRILDAN.........
F8EX86_GRAC1/7-141                  ....QQITKYYERYRTISVTFTKEIITATGLVTQQVYLKCLGEA....WPCVIYSTSFEEAKVIINTKSGLYGKLQ..Q.AN.nLVNLRYSF.KISDKTDPMF..F.FVSCRVVGSAPYQ-GSQDISMMTLQFTQRPPDDLIEIMGRLLDAN.........
A0A0A0X0M6_9SPIR/7-144              ....QQLNRYYDFFQKAEITFTKEVIQAMSLNAQQSSIRCVGSEg.gpWPCVINSSSMIGAKVIVPQHCGIYEKIC..A.GS.tAISLWFSF.SQTNGKSDLS..F.FVSGKVVSCTPYT-VTPDLLLLNIEYTQRAPDDLIEKLGLLVDAK.........
CDGB_TREDE/7-142                    ....QQLNRYYNLYKNIDVTFSKEVVSTLNFEPKQVFVRCSGGQ....WPCIINSASMTKAKIICGKKSGFLARLR..S.GI.tSVNIRFAF.FDTEGKDSLS..F.FVAAKLVGISSYEAGNQDLVLITFEYTQRAPDDLIEKLGILLEAN.........
A0A840SCT2_9SPIR/8-142              ..qi--TNRLYNDYKDTELTFTKDIIHTLAMDPRQIAIKSEGSQ....WPCILNSTSFNIARIIVGTKGGAFQQLV..K.KD..IPPVSVRFcFYKQDGQLMS..F.FISGKVQNIQPYM-NSNDLAIVTIRFTQRPPDDLILMVGRLLDAN.........
V5WHJ9_9SPIO/7-142                  ....QQISKLYDRYSEQDVLFNKDINRALLLNTKGIHLRCLGYQ....WPCILYSSSMTSAKLVVNVKTPIKKVIE..Q.AN.rMVSLNYSF.LQKDKANPIS..F.FMKAKVVSYAPYHPEKPDLNFLNLEFAHRPPDELIFRLGELLEAQ.........
A0A098R0R3_9SPIO/7-142              ....QQIAKYYSDFQNVDVTFTKDVIRATLLYAKNVQIRCLGYQ....WPVLLYSSSMSSAKVIANIKGPLKEVTS..K.AK.nMVQLRFSF.IQKEKTDPIT..F.FINSKIVSFVPYNKDQPDLNFINLVYTNRPPDELIYRLGTLLEAN.........
A0A7T8B7Y2_9SPIR/9-140              aqil-------ARFGDQSVACSQYALSKLGVDRSHCFLKIDEYI....ILCVPFQLGFKRSLFLASLSKQELTFFQ..RyVN.gIVGLSISF.FPPNRQEPIK..L.YVRCNLATIGQMK-GRENVGLFVVDFKN-TPDDYVTLLGNYLDS-q........
G0GFW1_SPITZ/7-142                  ....QQITRYYNQFKHIEVTFTKGINAAIGLVPTQTYVKCLDEQ....WPCIIYSSSMEGAKIILNNKLNFMDKLK..E.AK.nLVSLRFCF.QEREKHQPLS..F.FVSAKVAGITPYGKQDASVSFLTLSYTHRPPDDLIEILGTLLEAN.........
O83124_TREPA/19-153                 ...e-QLNRYYDLYKDVDVTFSKDVMQALCFNARQVCVRSAGGQ....CSCVMNSVSMVGAKVILSRKSSLLESIQ..V.EG.aSVSIRFSF.FESDARDAVS..F.FVTARVLGVEDYA-QSTELVVLSVAYTQRIPDMLIERLGLLVEAN.........
A0A7T3V4Y8_9SPIR/7-141              .qln---NRYYKDYLNTEVTFTKDIIRTLKMDPRQIYIKCAGSQ....WPCIINSTSFTTAKIILGTKGGAYEVLS..K.KD..PPPLSVRFsFYQQDGQLMS..F.FVSGKVYTIKEYA-GSSDLVIVTVQYTQRPPEDLIGMLGHLLDAN.........
E7NRG8_TREPH/7-141                  ....QQLNKFYDSYKNIDVTFTKDVIQALSLNTQQVYVRCAGSQ....WPCIINSASMVGAKIIAGKKSGLYAKIE..E.GH.tNLRIRFFF.FEPGAKDSLS..F.FVSAKLIDTTPYG-SSADLVIFSLEYTQRAPDDLIEKLGFLLEAN.........
A0A841R9B6_9SPIO/8-139              .qln---NQLYNKYKDQRILFSTSVAKSIGLQQSETILKIGMEK....TKGALISATMNDMVILAKMTEALRRRIY..S.EN.gMVTVHLKF.FDSLFKKEMI..F.NLYTKFVNMNNHGLPGQDMQYLSLKLRRRIPYELVSVFGK-----h........
A0A1N6WF93_9SPIO/7-142              ....QQITRYYQEFEHTEVTFTQEIIKALFLNTKQIFIKCLGYQ....WPCIVYSSSMTGARVITTLQPSLKAALS..K.SK.nMVSLRFSF.IQREKTDPLA..F.FVTARITGFSPYGDPSKGLSFITLHYTQRPPDDLIERLGNLLSA-t........
A0A5C1QAX3_9SPIO/3-138              ...r-RLNDIYNNHKDHDITFNQSVIRSLGLKVDQIYLKVGDRK....FPSILYSSSLTSSRIIIKLTPLQIEFLK..K.NR.nNLAIKYCF.KIPTEKSNIV..F.YINSKIISLVPYGNQEQELYFATFEFINRAPNDLISILGTYI---qdq......
F5YCA2_LEAAZ/1-129                  ..ma--------RFSESSIPCNQYALAKLGVDRAHCSLKIEEYV....ILCVPFQLGFKRSIFLASLSVQELTFFQ..RyVN.gIVGLSIAL.NPEARPEPVK..F.FIRCNLSTIGQMK-GRENVGLFVVDFKT-SPDEMINILGNFMDT-q........
A0A5C1QFD0_9SPIO/7-141              ....QDIDNFYKNYQNEEVIFTKSIASLLGLQPKHIYFKFKDIQ....RPCIIYSSSMTKAKIIASVPKSIIEIIK..T.ET..NINLRFALkNEEKKNDSLF..F.FIKCRTIDITPYKP-EQNLYIIHFEYISKPPEALITILGRLLEAK.........
A0A1T4L4L1_TREPO/9-143              ....QIINRYYDLYRENEIIFTKDIIRYLKIDLRQIYVKCAGAQ....WPCIINSTSFQMTKIIIGTAGGAFQQIT..K.KD..APPVNIRYcFIEDDGHPIY..F.FVSCHVTEVTPYM-NSKDLAVVTLTFTQRPPDDLILKLGTLLDAK.........
O51675_BORBU/5-139                  ....RKIRDYGAKYRGKEIKMSTEINSFLNLR-NTIEMRIGSYT....AFGVIYSISMDSLKLIFQEDTVLPALAK..N.KN..LGSIQLKK.NSDSKSSAAF..FpFLSVKLLSASAYSSLNKEYNLLTLEFLSPAPEEIAIKVGKLLDLK.........
E1R4G4_SEDSS/7-142                  ....QQINRFYQHYREIDVTFNKDVIRATGLLAKHIFLKFLGSQ....IPCIIFSASMTGAKVIANISSETFERLR..Q.AN.nLVSLRLSF.QESDKNDPLA..F.FVASKISGFNPYNKEHPTLNFVNLEFTQRPPDDLIGILGTLLEA-s........
A0A5C1QGJ7_9SPIO/7-144              ....QIIKDLYNKYRSIEVTFNKEVIKSTGLQPKKVFLKLKEGP....HACLLYATSLESARILVSLTDTMVSNII..E.EE.pNISLRLSF.LRDDQPKPVElnF.FIQGRLSNFTKYSANQPDLYFSTLTYSTRPPDDLIEILGFLLEAN.........
I0XCN1_9SPIR/7-141                  ...t-KISRYYDYFRDKEVVFTKANLNFLRMDPRQIYLKCNGGQ....WPCIINSTSLQMAKVIVGTSSGAYVEIN..K.KK..ETPVSLRFcFIDEDGAPIF..F.FVNCTVAEVKPYQ-GSNELAIVNLSFTQRPPDDLIARVGEFVEVN.........
A0A1T4MAP0_9SPIR/7-141              ....QQLQRYYDQYRDTEITFTKDIIRALGLDPRQIYIKCNRGQ....WPCIINSTSFLQAKIIVGAKGGAFQALS..D.QS..TSGINLRFcFLESENDLMS..F.FVAGHVTNIVPYM-NSSELAVITIAFNQRPPDDLIEAVGRLLEAN.........
A0A7W8G940_9SPIR/7-142              ....QQLTKYYDQYRDTEITFTKDIIRALGLDPRQVYVKCNGGQ....WPCIINSTSFQHAKIIVGTKGGAFQALA..A.KNnpTANLRFCF.NEQEGDGIIT..F.LVSSRVAEIRPYM-NSKDLVIVTLQFAARPPDDLIEICGRLLEAN.........
A0A841R5P8_9SPIO/7-142              ....QQLNKYYSSYKSVDVTFTKELINTTGLDGRQTFFKFKQGQ....KPCIIYSSSMVGAKIIASIDSELFNVLR..N.EN.nLMSLRFAF.QQKESSDPIL..F.FIQGKITGFAPINKDKPDLHFATIEYTNRPPDDLIQILGSIVDA-a........
A0A4R4BRP1_9SPIR/7-141              ....QQITKYYERYKSIHVTFTKEVIKATGLLTQFVFLKCLGEA....WPCVIYSSSFEQAKVIINTKTGLLGKIQ..Q.AN.nLVNLRYSF.KLSDKTDPLM..F.FVSAKVAGSSPYQ-GSSEMHLLTLQFTQRPPDDLIEIMGKLLDAN.........
A0A4R4BRB9_9SPIR/14-145             ..mh-----YLQRYGDLQIPCTPYTLKKLGFEQSLCLLKVDDYN....LMIAPFQLGFKRSVFMGSLSIQEITFFQkyT.NS..IAGLSLGF.SVPTRKEPLL..F.FIRCTILSLSPMK-GRDTVALFTLDYKN-SPDEYIGILGSYLE--gq.......
H7EJT0_9SPIR/7-145                  ....QKLTQYYDQYRDTEVTFTKDIIRTLKLDPRQIQIKYTDKDdmkfRPCILNSTSFQKAKIIVSTKDECFEVIA..G.KE..PPPVHLKFsFFGENGQPIS..F.FIATKVTEKKPYN-NSNELAQITLQFTQRPPDDLIEIVGKLLEAN.........
H9UHA9_SPIAZ/7-142                  ...t-QITRYYEDFKDIDITFTKEVIRASLLNTKQIYLKLLGYQ....WPCIIYSSSLSGAKIIANITPQLKKAMQ..Q.SK.sGISLRFSF.LQRDKRDPIS..F.FVPCKVAGFTPYQSAKGNLHFINMNFTQRPPDDLIEILGRILEAN.........
A0A370AZR7_9SPIO/7-144              ....QTIKELFNRFRSIEVTFNKEVSKATGLQPRKIFLKFKESA....RPCILYASSMEAARVIVSLPTAILQNLK..E.NE.sNVALKLSF.IKDEQPKPIElnF.FIQGRLSSFTRYSDDQPDVYFCSINFSTQPPDDLIETLGFLLEAN.........
W6U0X2_9SPIR/5-140                  ....KKIKDYEAKYRGKEIKMSTEINSFLNIK-NSVEIKVGTYV....VVGVIYSISMNFIKIILQQDEILPILAQ..N.GN..LGNLNIKN.YDNNVVDNAF.cIpSLIVKLVSTSSYSIQNKEYNLLTLEFVSSMPEEILVKIGKLLDLK.........
A0A841R5T8_9SPIO/9-143              ...r-EINDFYDRYKDSKIVYSQGVVRDIGLVQRDTSIKVGEQV....LKSVLISSTMEDFVFMASLNDSVRETFY..D.LG.gSLKVQLKF.LDPESSKSIL..F.TLDTKFLNFNNQGLTRDDLVFIAMKIRRKIPNDLIRLFG------lyhtv....
A0A1Y1RVW2_9SPIO/7-142              ....QQLSRFFERYNDVNLTFTKDVVRATRLLQRNTHIKCLGDH....WPCVLYSCSMKGAKVIASLSKSFYEKLK..S.AN.nLVTLHLAF.AQEDKSTPLS..F.FVTSKINGFTPYDKSKPNLNFLSLEYTQRPPDDLIVILGTLAEAN.........
F8F2T8_GRAC1/8-139                  ...a----QYLERFAEQQVNCSQYALQKMGVDKTSSFIKIDEYM....ILCAPFQLGFKRGIFLASLSKQEMTFFQ..RyLN.gIVGVSMVF.NQANRKEPLK..L.FIRGSLAAIGPMK-GKDNVGLLVVDYKN-SPDDYVTILGTHLE--ym.......
F5YPS4_TREPZ/7-141                  ....QKIASYYERYKEIDVTFTKEIIQVTGLITQQVLLKCVGDF....WPCVIYSSSFQGAKVVANIKSGLTEKLQ..Q.AN.nSVSLRLCF.KSADSASPVT..F.FVTARVAGYSPYG-GSSDTALFTLLFTQRPPDDLIEIMGRILDAN.........
#=GC seq_cons                       ....QplscYYcpY+ch-lTFoK-llpsLsLss+plalKssstp....aPCll.SoShptAKlIsuhpsuhhptlp..p.ts.shlsL+hsF.hpsppscslp..F.Flsu+lsshsPYt.sss-LslloLpaopRPPDDLIphlGpLL-Ap.........
//