#=GF ID   Pilin_PilX
#=GF AC   PF11530.12
#=GF DE   Minor type IV pilin, PilX
#=GF AU   Pollington J;0000-0002-8158-8998
#=GF SE   pdb_2opd
#=GF GA   25.00 25.00;
#=GF TC   25.10 33.50;
#=GF NC   23.40 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0327
#=GF RN   [1]
#=GF RM   17893339
#=GF RT   3D structure/function analysis of PilX reveals how minor pilins
#=GF RT   can modulate the virulence properties of type IV pili. 
#=GF RA   Helaine S, Dyer DH, Nassif X, Pelicic V, Forest KT; 
#=GF RL   Proc Natl Acad Sci U S A. 2007;104:15888-15893.
#=GF DR   INTERPRO; IPR025922;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   PilX is a protein from Neisseria meningitidis which is crucial
#=GF CC   for the formation of bacterial aggregates and adhesion to human
#=GF CC   cells [1]. The structure of PilX is similar to all pilins as it
#=GF CC   has the common alpha/beta roll fold. PilX subunits have
#=GF CC   surface-exposed motifs which are thought to stabilise bacterial
#=GF CC   aggregates against pilus retraction. It also illustrates how a
#=GF CC   minor pilus component can modulate the virulence properties of
#=GF CC   pili which have a simple composition and structure [1].
#=GF SQ   8
#=GS A0A220S3Q4_9NEIS/34-150  AC A0A220S3Q4.1
#=GS A0A5Q3S676_9NEIS/35-156  AC A0A5Q3S676.1
#=GS A0A1X3DFZ3_9NEIS/35-153  AC A0A1X3DFZ3.1
#=GS A0A0J0YTC9_9NEIS/35-144  AC A0A0J0YTC9.1
#=GS G4CQB6_9NEIS/35-149      AC G4CQB6.1
#=GS A0A3S5F9W8_9NEIS/38-160  AC A0A3S5F9W8.1
#=GS Q9JZV0_NEIMB/36-162      AC Q9JZV0.1
#=GS Q5F9E2_NEIG1/36-162      AC Q5F9E2.1
A0A220S3Q4_9NEIS/34-150             r-YIERGYRAQAHSELVDINNQIKTWLLKNPS.SL.PADVQTKLGAFKDF--NDPQLKTKYTLTAA...MEDVAKGRRYRLSATPKAGSGYKLSVWMDSNGNAYFCDTAAGATDYKKTKT--DGC--------ep........
A0A5Q3S676_9NEIS/35-156             r-YIERGYLAQAHTELVNVNNQIKTELVKNPS.LDiADKLAKFEDNYVKG--MDKAVTDRYTFKAQ...LANKDSGRRYRISAVPKSETGYTLAMWIDSLGNAYRCSDAASATAF----STDGKCEPISNKKK..........
A0A1X3DFZ3_9NEIS/35-153             h-YIERGHLTDAHAELVDINNNIKTKRVSEPG.SL.--SSQTDLESHISGLFKEPDLVARYDITVA...MPDATKSSRYSLVVTPKANSGYTLALWMNSVGEAYRCQDAASAQAYLTTG--------------kceqiggk..
A0A0J0YTC9_9NEIS/35-144             r-YVERGDLVSAQADMMKINALLKTEQVKNPK.VD.LQ---NAVTI---SNELDKRVNEKYTVALK...LKEAGCPTTYCLVSVPKD-SNYTLAAWMDSLGNNYSCTTAAAANGFN-----------------tsgacek...
G4CQB6_9NEIS/35-149                 r-YVERGHVTNAKAALIQIYSVVKQRMIVNPTlIK.YDEFNQNLANIVDEVKGNVD----ASVSER...Y-DISVPDSQHLAATPKASTGYSLSVRVDRHGNALFCKDAAAAREK------------------qpdtakckps
A0A3S5F9W8_9NEIS/38-160             g-YLEKGRLTMAQAELMDLNNVIRLDRVRNPG.KS.NIHAEYSGSELAKKFRVHPKVAEYYDISVAppgNTAAKSTPAYYLLAVPNAKSGYSKAVWMKSTGEVYRCDSADSARNFE-----------------tsgkcervgg
Q9JZV0_NEIMB/36-162                 .SYIEKGYQSQLYTEMVGINNISKQFILKNPL.DD.NQTIENKLEIFVSGYKMNPKIAKKYSVSVK...FVDKEKSRAYRLVGVPKAGTGYTLSVWMNSVGDGYKCRDAASAQAHLETLSSDVGCEAFSNRKK..........
Q5F9E2_NEIG1/36-162                 .SYIEKGYQSQLYTEMVGINNVLKQFILKNPQ.DD.NDTLKSKLKIFVSGYKMNPKIAKKYSVSVR...FVDAEKPRAYRLVGVPNAGTGYTLSVWMNSVGDGYKCRDATSAQAYSDTLSADSGCEAFSNRKK..........
#=GC seq_cons                       +.YIERGalopAauELVsINNllKpchlKNPs.sc.spphpspLstalsuhchcPclsc+Yololp...hsDsspscsY+LluVPKAsoGYTLuVWMcSlGsuY+CcDAASApua..................ps........
//