#=GF ID   Polo_box_2
#=GF AC   PF18531.5
#=GF DE   Polo box domain
#=GF AU   El-Gebali S;0000-0003-1378-5495
#=GF SE   ECOD:EUF01983
#=GF GA   31.90 31.90;
#=GF TC   51.30 50.30;
#=GF NC   30.70 25.00;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Domain
#=GF CL   CL0708
#=GF RN   [1]
#=GF RM   24980795
#=GF RT   Structure of the C. elegans ZYG-1 cryptic polo box suggests a
#=GF RT   conserved mechanism for centriolar docking of Plk4 kinases.
#=GF RA   Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R,
#=GF RA   Svergun DI, Round A, Oegema K, Dong G;
#=GF RL   Structure. 2014;22:1090-1104.
#=GF DR   INTERPRO; IPR040733;
#=GF DR   SO; 0000417; polypeptide_domain;
#=GF CC   In metazoans, Plk4 kinases control daughter centriole assembly.
#=GF CC   Plk4 homologs have an N-terminal kinase domain, a C-terminal
#=GF CC   polo box, and a central domain termed the 'cryptic polo box'
#=GF CC   (CPB) that has been shown to dimerize, to be sufficient for
#=GF CC   centriole localization and to be required for Plk4 to promote
#=GF CC   centriole assembly. Probable serine/threonine-protein kinase
#=GF CC   zyg-1 (EC:2.7.11.1) (ZYG-1) is a Plk4 homlog found in C.
#=GF CC   elegans. Crystal structure for the CPB of C. elegans ZYG-1,
#=GF CC   reveals that it forms a Z-shaped dimer containing an
#=GF CC   intermolecular beta-sheet with an extended basic surface patch.
#=GF CC   Electrostatic interactions between the basic patch on the ZYG-1
#=GF CC   CPB dimer and the SPD-2 acidic region dock ZYG-1 onto centrioles
#=GF CC   to promote new centriole assembly.  ZYG-1 CPB contains two
#=GF CC   tandem polo boxes (PB1 and PB2), each containing a six-stranded
#=GF CC   beta-sheet with an alpha-helix packed against one side [1].
#=GF SQ   16
#=GS ZYG1_CAEEL/351-460        AC Q9GT24.1
#=GS A0A261CF72_9PELO/362-472  AC A0A261CF72.1
#=GS A0A0D8XFY7_DICVI/365-477  AC A0A0D8XFY7.1
#=GS A0A0N4XIG4_NIPBR/274-351  AC A0A0N4XIG4.1
#=GS E3M4S5_CAERE/362-450      AC E3M4S5.1
#=GS G0PJX6_CAEBE/85-173       AC G0PJX6.1
#=GS A0A2A2JBR1_9BILA/270-380  AC A0A2A2JBR1.1
#=GS A0A2A2JC52_9BILA/274-384  AC A0A2A2JC52.1
#=GS A0A8R1E817_CAEJA/98-207   AC A0A8R1E817.1
#=GS ZYG1_CAEBR/350-461        AC Q621J7.1
#=GS A0A368F4W8_ANCCA/84-173   AC A0A368F4W8.1
#=GS A0A2G5V5D0_9PELO/357-445  AC A0A2G5V5D0.1
#=GS A0A016TU94_9BILA/363-451  AC A0A016TU94.1
#=GS W2SUZ2_NECAM/337-432      AC W2SUZ2.1
#=GS A0A0N4WBL6_HAEPC/361-450  AC A0A0N4WBL6.1
#=GS A0A8R1HZV1_CAEJA/282-370  AC A0A8R1HZV1.1
ZYG1_CAEEL/351-460                   ....QLWPIRMDRLEGQRVCTAGGRYIVELDTRCRFEVAAQGNFVKRILIVEVDE--MV.QTVYVHRIPDRTVRGRNGEEELITLTN..NPFVYTS.YSQMPKEVQNDYMRLQKMVAVTI.............
A0A261CF72_9PELO/362-472             ....QIWPIRMERLAGQRLRTAGGRYIIESDSRCRFEVAATGDVVKRILIVEYNRYQQK.QTVYVHKITDRVK-SRNERDELIDVPG..MPVVYTT.LSQLTKEVLNDYLRLQKMIVSN-i............
A0A0D8XFY7_DICVI/365-477             ....PVWPLPIYRCGGTRMVTAAGRYIILDDNLLIFEVANKSGLITKIVTVTIDIRGKQ.QVIFDKPLHMDVKQPK-EHDSLVVPAEgyDSKPFTS.YSAMNRYERDLYAQMANAVEAMR.............
A0A0N4XIG4_NIPBR/274-351             lgsr-----------------SGGEYIIVDDNLLVFEVANKNGLITKIITVSIDSHSRQ.EIVFGRPLQANISRPL-ERDPLLQTD-..-------.-----------------------ksydapplsry..
E3M4S5_CAERE/362-450                 ....QIWPIRMERLAGQRLHTAGGRYIIESDSRCRFEVAGQHEVVLRILIVEYNRYQQK.QTVYVHKIKNRGEKCRNERDELIDVSE..PLAVYT-.-----------------------t............
G0PJX6_CAEBE/85-173                  ....QLWPLRMERLNGQRIRTTAGRYIVEMDTRCRFEIASTGDIVRRIMIVELDDHNQQsQTVYVHRISDRIVQGRNEKDELIELSK..KPSVY--.-----------------------r............
A0A2A2JBR1_9BILA/270-380             ..en--WPLKLTRLGNNTAVLKTSRVFVENDSRAIMEIASSKGVVTDIMIVTIRY-GVQ.TVTLYKPVQNNVQKANDSTTPRVEIGQ..SGMRYKN.FSDLERRLQQHYDNLYKCVEN--fr...........
A0A2A2JC52_9BILA/274-384             ..en--WPLKLTRLGNNTAVLKTSRVFVENDSRAIMEIASSKGVVTDIMIVTIRY-GVQ.TVTLYKPVQNNVQKANDSTTPRVEIGQ..SGMRYKN.FSDLERRLQQHYDNLYKCVEN--fr...........
A0A8R1E817_CAEJA/98-207              ...d-MWPIRMERLAGQRIRTQGGRYVAELNTRCRFEVATRGDITTRILITEYDPYRRI.QTVFVHRIADRRERGREEGDDLIELTR..NPMVYTAeFSAFHTE----------------ynktnnrkaavdq
ZYG1_CAEBR/350-461                   ....QIWPIRMERLVGQRVRTPGGRYIVEMNTRCRFEVVSKGNIVLRILVVEYDPHLLI.QTVYVHKMSNRVEHARNETDDLIELTR..SPISYTS.LSQLPKEVMNDYMRLEKMMVSTI.............
A0A368F4W8_ANCCA/84-173              ..pp--WPLPIHRCGGTRLVTAAGRYVIVDDNTMMFEVANKSGFITKIVEVSIGTRGRQ.QVIFDKPLHLNVKRPL-EHDPLIPVTRerD------.-----------------------tapltr.......
A0A2G5V5D0_9PELO/357-445             ....QIWPIRMERLVGQRVRTPGGRYIVEMNTRCRFEVVSKGNIVLRILVVEYDPHLLI.QTVYVHKMSNRVEHARNETDDLIELTR..SPISYTS.-----------------------.............
A0A016TU94_9BILA/363-451             ..pp--WPLPIHRCGGTKLVTAAGRYVIVDDHTMVFEVANKSGFITKIVEISVGTRGRQ.QVIFGKPLHLDVKRPL-EHDPLISMTR..E------.-----------------------rdtaalt......
W2SUZ2_NECAM/337-432                 idva---------------------YVIVDDHKLVFEVANKNGFITKIVEVLIGTRGRQ.QVAFGKPAHSNVGLPL-EHDGLIPLARerNTVALTS.FSSMNRHERDVYAQIANAVEAMR.............
A0A0N4WBL6_HAEPC/361-450             ....PIWPLPIRRCGGTKLLSAAGRYVIVDDNLVVFEVANKSGFIAKIVTVSIDDHGKQ.QVTFGRPMHPEIRRPL-ENDNLIAKDRrhE------.-----------------------slpltr.......
A0A8R1HZV1_CAEJA/282-370             ...n-MWPIRMERLAGQRIRTQGGRYVAELNTRCRFEVATRGDIITRILITEYDPYRRI.QTVFVHRIAERKERGREEGDDLIELTR..NPMVYT-.-----------------------a............
#=GC seq_cons                        .....hWPl+hcRLuGpRlhTsuGRYllEsDoRshFEVAs+uslls+IllVplcshtpp.Qslas+.lpsclc+sppEpDsLIplsc..sshsYp.........................h............
//