#=GF ID Polo_box_3
#=GF AC PF18544.5
#=GF DE Polo box domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF01982
#=GF GA 34.20 34.20;
#=GF TC 35.70 37.60;
#=GF NC 33.00 33.10;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF CL CL0708
#=GF RN [1]
#=GF RM 24980795
#=GF RT Structure of the C. elegans ZYG-1 cryptic polo box suggests a
#=GF RT conserved mechanism for centriolar docking of Plk4 kinases.
#=GF RA Shimanovskaya E, Viscardi V, Lesigang J, Lettman MM, Qiao R,
#=GF RA Svergun DI, Round A, Oegema K, Dong G;
#=GF RL Structure. 2014;22:1090-1104.
#=GF DR INTERPRO; IPR040734;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC In metazoans, Plk4 kinases control daughter centriole assembly.
#=GF CC Plk4 homologs have an N-terminal kinase domain, a C-terminal
#=GF CC polo box, and a central domain termed the 'cryptic polo box'
#=GF CC (CPB) that has been shown to dimerize, to be sufficient for
#=GF CC centriole localization and to be required for Plk4 to promote
#=GF CC centriole assembly. Probable serine/threonine-protein kinase
#=GF CC zyg-1 (EC:2.7.11.1) (ZYG-1) is a Plk4 homlog found in C.
#=GF CC elegans. Crystal structure for the CPB of C. elegans ZYG-1,
#=GF CC reveals that it forms a Z-shaped dimer containing an
#=GF CC intermolecular beta-sheet with an extended basic surface patch.
#=GF CC Electrostatic interactions between the basic patch on the ZYG-1
#=GF CC CPB dimer and the SPD-2 acidic region dock ZYG-1 onto centrioles
#=GF CC to promote new centriole assembly. ZYG-1 CPB contains two tandem
#=GF CC polo boxes (PB1 and PB2), each containing a six-stranded
#=GF CC beta-sheet with an alpha-helix packed against one side [1]. This
#=GF CC entry represents PB2.
#=GF SQ 39
#=GS A0A0D8XFY7_DICVI/479-574 AC A0A0D8XFY7.1
#=GS A0A2A2JBR1_9BILA/382-475 AC A0A2A2JBR1.1
#=GS A0A0N4TP27_BRUPA/539-634 AC A0A0N4TP27.1
#=GS A0A8L7T766_BRUMA/544-639 AC A0A8L7T766.1
#=GS A0A0K0F6X7_STRVS/513-602 AC A0A0K0F6X7.1
#=GS G0NAV2_CAEBE/13-108 AC G0NAV2.1
#=GS A0A8R1IV58_CAEJA/452-546 AC A0A8R1IV58.1
#=GS A0A2A2JC52_9BILA/386-479 AC A0A2A2JC52.1
#=GS A0A016TU87_9BILA/22-116 AC A0A016TU87.1
#=GS A0A2G5V4L5_9PELO/18-116 AC A0A2G5V4L5.1
#=GS A0A0N5CXE0_THECL/527-590 AC A0A0N5CXE0.1
#=GS A0A0J9Y956_BRUMA/544-639 AC A0A0J9Y956.1
#=GS ZYG1_CAEEL/463-561 AC Q9GT24.1
#=GS A0A8R1TRC2_ONCVO/521-615 AC A0A8R1TRC2.1
#=GS A0A182EG67_ONCOC/518-612 AC A0A182EG67.1
#=GS A0A368GL08_ANCCA/31-126 AC A0A368GL08.1
#=GS A0A090LE65_STRRB/514-605 AC A0A090LE65.1
#=GS A0A5S6PN34_BRUMA/544-639 AC A0A5S6PN34.1
#=GS A0A0K0EJQ0_STRER/513-603 AC A0A0K0EJQ0.1
#=GS A0A2G5V4J9_9PELO/9-107 AC A0A2G5V4J9.1
#=GS A0A3P7DJ50_WUCBA/116-211 AC A0A3P7DJ50.1
#=GS A0A016TUE2_9BILA/22-117 AC A0A016TUE2.1
#=GS ZYG1_CAEBR/464-562 AC Q621J7.1
#=GS W2SUZ2_NECAM/434-529 AC W2SUZ2.1
#=GS A0A0B2UW39_TOXCA/790-885 AC A0A0B2UW39.1
#=GS A0A0B2W3G9_TOXCA/682-777 AC A0A0B2W3G9.1
#=GS A0A8L7T720_BRUMA/544-639 AC A0A8L7T720.1
#=GS A0A3P6V974_LITSI/535-630 AC A0A3P6V974.1
#=GS A0A261CF72_9PELO/475-573 AC A0A261CF72.1
#=GS A0A8R1TPC4_ONCVO/526-621 AC A0A8R1TPC4.1
#=GS A0A182EMB2_ONCOC/248-343 AC A0A182EMB2.1
#=GS A0A0N4XE09_NIPBR/4-99 AC A0A0N4XE09.1
#=GS A0A1I7W2S3_LOALO/528-624 AC A0A1I7W2S3.1
#=GS E3M4S7_CAERE/28-126 AC E3M4S7.1
#=GS A0A8J2Q8V1_9BILA/544-639 AC A0A8J2Q8V1.1
#=GS A0A2G9TRV1_TELCI/39-75 AC A0A2G9TRV1.1
#=GS A0A498SEA0_ACAVI/510-605 AC A0A498SEA0.1
#=GS A0A3P6R1L0_ANISI/494-598 AC A0A3P6R1L0.1
#=GS A0A0K0CU68_ANGCA/22-117 AC A0A0K0CU68.1
A0A0D8XFY7_DICVI/479-574 ..........RVDKVVYQRPPQFPSAVAKIMENSSFRIVFRDQrRLVQKSGSRDVQIHFP..GGNKEDVL.......D..pDTLSKFDEVRKFLRKVENIWE---.EQIGRFPLLFAISRE............
A0A2A2JBR1_9BILA/382-475 .......stv---KIVYRRPPQFPLSEAKLMENGDVRVALRSE.VLVRKFLTKDVIRIV-..EQQKSRVN.......D..rETIQQMNEVFERLLQIESAWE---.ISVGEFPFYFG----fnva........
A0A0N4TP27_BRUPA/539-634 ..........RVVKIIFKPSC---DSTARLMENGDFRIKFQDGrLAILKKSAKSIVVTMN..NKTPSSLS.......N...EERCMFECAHTDALLLETFLESAPlKTVKSFPFHFSNNS-q...........
A0A8L7T766_BRUMA/544-639 ..........RVVKIIFKPSC---DSTARLMENGDFRIKFQDGrLAILKKNAKSIVVTTN..NKTPASLS.......N...EERCMFECAHTDALLLETFLESAPlKTVKSFPFHFSNN--si..........
A0A0K0F6X7_STRVS/513-602 ..........RAAKIILNSPDGLPRCTVKYMFNGDFRLLFPDGrIAVQKVDSLDISCTDI..NNRSASLT.......N...EEIDSFKRVRNFCLNYNNL-----.---------------pnstnlsdkenf
G0NAV2_CAEBE/13-108 ..........RVTKITYRRPPQFPDAHAQLMENGDLRIKCEKG.VIVRRKENGEIYNSI-..GNRKEEVH.......G...SVLMKVKEVYNYLVRFERCLLGMG.SGMICFPIVFSAGPD............
A0A8R1IV58_CAEJA/452-546 ..........RVAKITFRRPPQFPDAQAQLMENGDLRIKFPKS.LVVRKIATGEVFNCV-..ETRKEPVH.......G...STLGKVNEVFAYLTRFDECLSGM-.GQLTCFPIVFNIG--ip..........
A0A2A2JC52_9BILA/386-479 .......stv---KIVYRRPPQFPLSEAKLMENGDVRVALRSE.VLVRKFLTKDVIRIV-..EQQKSRVN.......D..rETIQQMNEVFERLLQIESAWE---.ISVGEFPFYFG----fnva........
A0A016TU87_9BILA/22-116 ..........RVDKVVYHRPAQFPSAVAKIMENGAFRIVFRDQrRLVQKPGSKDVQMHFP..DGRKEDVV.......D..sETLGRFAEVRGFLKQVEAIWE---.QQIGRFPLSFSLSK-............
A0A2G5V4L5_9PELO/18-116 ..........RVAKITHRRPSQFPDASAQLMENGDLRIRFPNS.LIVRRKSNGEVHNYIDgfANNKEEVR.......G...LQLSKVREVYACLTQLEQCLSRMN.PTMKILPMVFSAGPD............
A0A0N5CXE0_THECL/527-590 ..........RVVKIMFKPSS---NTTARLMENGDFRVKFQDGrLALLKKNANSISVTSS..DKAPEVL-.......-...------------------------.---------------ssgaifflid..
A0A0J9Y956_BRUMA/544-639 ..........RVVKIIFKPSC---DSTARLMENGDFRIKFQDGrLAILKKNAKSIVVTTN..NKTPASLS.......N...EERCMFECAHTDALLLETFLESAPlKTVKSFPFHFSNNS-q...........
ZYG1_CAEEL/463-561 ..........RVAKVTFRRPSQFPDAQAQLMENGDLRIKLPRS.VIVRKMDNGEIFNCIDgiATQKQAVS.......G...ITLTKVNEVYKYLIRFEQCLNGMD.RGMVCFPIVFSAGT-n...........
A0A8R1TRC2_ONCVO/521-615 ..........RVVKIIFKPSS---NSVARLMENGDFRVKFQDGrLAILKKSADSIVITN-..NKTPASLS.......N...DERCMFEYAHKDALLVETFLENAPlKSVKSFPFHFSNNS-q...........
A0A182EG67_ONCOC/518-612 ..........RVVKIIFKPSS---NSVARLMENGDFRVKFQDGrLAILKKSADSIVITN-..NKTPASLS.......N...DERCMFEYAHKDALLVETFLENAPlKSVKSFPFHFSNNS-q...........
A0A368GL08_ANCCA/31-126 ..........RIDKVVYHRPSQFPSAVAKIMENGAFRIVFRDQrRLVQKPGSKDVQMHFP..DGRKEDVL.......D..sETLARFAEVRGFLKQVEGIWE---.QQIGRFPLSFSVSKD............
A0A090LE65_STRRB/514-605 ..........RVAKITINSPMGLPRCIVKYMFNGDFRIVFPDGrVAVQKVDSLNIICTDI..NNRSTNLS.......N...DEIESYKHIKNFCLSYKNICSTTN.---------------ssekenfil...
A0A5S6PN34_BRUMA/544-639 ..........RVVKIIFKPSC---DSTARLMENGDFRIKFQDGrLAILKKNAKSIVVTTN..NKTPASLS.......N...EERCMFECAHTDALLLETFLESAPlKTVKSFPFHFSNNS-q...........
A0A0K0EJQ0_STRER/513-603 ..........RVAKIVINSPNGLPRCTIKYMFNGDFRIHFPDGrVAVQKVDSPDIVCTDA..NNRSTHLS.......N...EEIEAYKHVKNFCLSYKNLLSTS-.---------------sssdkenfi...
A0A2G5V4J9_9PELO/9-107 ..........RVAKITHRRPSQFPDASAQLMENGDLRIRFPNS.LIVRRKSNGEVHNYIDgfANNKEEVR.......G...LQLSKVREVYACLTQLEQCLSRMN.PTMKILPMVFSAGPD............
A0A3P7DJ50_WUCBA/116-211 ..........RVVKIIFKPSC---DSTARLMENGDFRIKFQDGrLAILKKSANSILVTKN..NKTPASLS.......N...EERCMFKCAHTDALLLETFLENAPlKTMKSFPFHFSNNS-q...........
A0A016TUE2_9BILA/22-117 ..........RVDKVVYHRPAQFPSAVAKIMENGAFRIVFRDQrRLVQKPGSKDVQMHFP..DGRKEDVV.......D..sETLGRFAEVRGFLKQVEAIWE---.QQIGRFPLSFSLSKD............
ZYG1_CAEBR/464-562 ..........RVAKITHRRPSQFPDASAQLMENGDLRIRFPNS.LIVRRKSNGEVHNYIDgfANNKEEVR.......G...LQLSKVREVYACLTQLEQCLSRMN.PTMKILPMVFSAGPD............
W2SUZ2_NECAM/434-529 ..........RVDKIVYQRPAQFPSAVAKIMENGTFRIVFRDQrRLIQKRGSKEVQMHYP..DGKKEDVL.......D..sDTLRLFEEVFRFLKKVEDVWE---.HQIGSFPLSFSISKD............
A0A0B2UW39_TOXCA/790-885 ..........RIEKIVFKPSA---ATTARLMENGDFRLKFSDGrLAVQKRGTDSISVSDD..GTSKATLS.......D...EEMRLFHHSRSDALEMERLLEKGAfLCVKPFPFHFSNASE............
A0A0B2W3G9_TOXCA/682-777 ..........RIEKIVFKPSA---ATTARLMENGDFRLKFSDGrLAVQKRGTDSISVSDD..GTSKATLS.......D...EEMRLFHHSRSDALEMEQLLEKGAfLCVKPFPFHFSNAS-l...........
A0A8L7T720_BRUMA/544-639 ..........RVVKIIFKPSC---DSTARLMENGDFRIKFQDGrLAILKKNAKSIVVTTN..NKTPASLS.......N...EERCMFECAHTDALLLETFLESAPlKTVKSFPFHFSNN--si..........
A0A3P6V974_LITSI/535-630 ..........RVVKIIFKPSC---DSTARLMENGDFRVKFQDGrLAVHRKNTNSIVVTIN..NKDPASLS.......S...EERYMFDCAHKDALLVETFLEGAPfKTVKSFPFHFSNSS-q...........
A0A261CF72_9PELO/475-573 ..........KVAKITFRRPSQFPEAHAQLMENGDLRIKFPRS.VIVRKKDNGEVYNCIDgqSKNREVVS.......G...SKLIKVNEVYSYLIQFEKCLNGMD.HRMICFPIVFSAGPE............
A0A8R1TPC4_ONCVO/526-621 ..........RVVKIIFKPSF---DSTARLMENGDFRVKFQDGrLAILKRSTDSIVVTTN..NKAPAFLS.......S...EERCMFKYAHEDALLMETFLENAPlKTVKSFPFHFSND--sq..........
A0A182EMB2_ONCOC/248-343 ..........RVVKIIFKPSF---DSTARLMENGDFRVKFQDGrLAILKRSTDSIVVTTN..NKAPAFLS.......S...EERCMFKYAHEDALLMETFLENAPlKTVKSFPFHFSND--sq..........
A0A0N4XE09_NIPBR/4-99 ..........RVDKVIYHRPNQFPNAVAKIMESGAFRIVFRDQrRLVQKSGSKDVQVHFP..DGRKEDVL.......D..lDTLGRFNEVRNFLCNVESIWE---.SQIGRFPLSFSLSKE............
A0A1I7W2S3_LOALO/528-624 krilneisap------------SSDSTARLMENGDFRVKFQDGrLAILKKNANSIVVTTN..NKAPASLS.......N...EERCMFECAHTDALLLETFLEGAPfKTMQSFPFHFSNSS-q...........
E3M4S7_CAERE/28-126 ..........KVAKITFRRPSQFPEAHAQLMENGDLRIKFPRS.VIVRKKDNGEVYNYIDgqSKNREVVS.......G...SKLIKVNEVYSYLTQFEKCLHGMD.NRMICFPIVFSAGPE............
A0A8J2Q8V1_9BILA/544-639 ..........RVVKIIFKPSC---DSTARLMENGDFRVKFQDGrLAVLKKSANSIAVTTS..NKDLASLS.......N...EERCMFECAHKDALLVETFLEGAPfKIVKSFPFHFSNSS-q...........
A0A2G9TRV1_TELCI/39-75 ..........RVDKVVYQRPSQFPNAVAKIMENGAFRIVFRDR.----------------..--------.......-...------------------------.---------------kcdn........
A0A498SEA0_ACAVI/510-605 ..........RVVKIIFKPSC---DSTARLMENGDFRVKFQDGrLAMLKKGADSIVVTTN..NKDLTSLS.......S...KERCMFECAHKDAVLVETFLESAPlKTVKSFPFHFSNSS-q...........
A0A3P6R1L0_ANISI/494-598 ..........RVEKIVFKPSA---NCTARLMENGDFRMKFSDGrLAVQKQGNGSVSVSSD..ASSKAILStgkxqckSkamDEMNRFNESRSDALEMERILEKGIfLNFKPFPFHFSNT--s...........
A0A0K0CU68_ANGCA/22-117 ..........RVDKVVYQRPPQFPSAVAKIMENGSFRIVFRDQrRMVQKPGSRDVQLHFP..NGRKEDVL.......E..pDTLSRFDEVRTFLQKVESVWE---.EQIGRFPLSFTISSE............
#=GC seq_cons ..........RVsKIla+.ss...susA+LMENGDFRI+FpDuRlhVpK+sspslhsshs..sps.tsls.......s...-phshFcps+s.hl.lEshLEths.ppltpFPhhFSss..............
//
