#=GF ID   Polyoma_agno
#=GF AC   PF01736.20
#=GF DE   Polyomavirus agnoprotein
#=GF AU   Bashton M;0000-0002-6847-1525
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Pfam-B_1917 (release 4.1)
#=GF GA   27.00 27.00;
#=GF TC   32.30 82.90;
#=GF NC   20.00 18.90;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF WK   Agnoprotein
#=GF RN   [1]
#=GF RM   3027418
#=GF RT   Role of the agnoprotein in regulation of simian virus 40
#=GF RT   replication and maturation pathways. 
#=GF RA   Hou-Jong MH, Larsen SH, Roman A; 
#=GF RL   J Virol 1987;61:937-939.
#=GF RN   [2]
#=GF RM   6262654
#=GF RT   Identification of the SV40 agnogene product: a DNA binding
#=GF RT   protein. 
#=GF RA   Jay G, Nomura S, Anderson CW, Khoury G; 
#=GF RL   Nature 1981;291:346-349.
#=GF DR   INTERPRO; IPR002643;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family consist of the DNA binding protein or agnoprotein
#=GF CC   from various polyomaviruses. This protein is highly basic and
#=GF CC   can bind single stranded and double stranded DNA [2]. Mutations
#=GF CC   in the agnoprotein produce smaller viral plaques, hence its
#=GF CC   function is not essential for growth in tissue  culture cells
#=GF CC   but something has slowed in the normal replication  cycle [1].
#=GF CC   There is also evidence suggesting that the agnogene and
#=GF CC   agnoprotein act as regulators of structural protein synthesis
#=GF CC   [1].
#=GF SQ   5
#=GS AGNO_POVJC/1-63        AC P03086.1
#=GS AGNO_SV40/1-62         AC P03084.1
#=GS L0N1W4_9POLY/1-68      AC L0N1W4.1
#=GS A0A0S2VEK3_9POLY/1-62  AC A0A0S2VEK3.1
#=GS Q0PCM8_POVBK/1-62      AC Q0PCM8.1
AGNO_POVJC/1-63                   MVLRQLSRKASVKVSKTWSGTKKRAQRILIFLLEFLLDFCTGEDSVDGKkRQR......HS.GLTEQ---tys.....
AGNO_SV40/1-62                    MVLRRLSRQASVKVRRSWTESKKTAQRLFVFVLELLLQFCEGEDTVDGK.RKK......PE.RLTEKPES........
L0N1W4_9POLY/1-68                 MVLRQLSRQASVKVGKTWTGTKRRAQRILIFILEILLDFCRGEDSVDGK.KKKdsltdnTE.TLTEKKES........
A0A0S2VEK3_9POLY/1-62             MVLRQLSRQASVKVGKTWTGTKRRAQRIFIFILEILLEFCRGEDSVDGK.QKK......REsTLTDK---tg......
Q0PCM8_POVBK/1-62                 MVLRQLSRQASVKVSKTWTGTKKRAQRILIFILELLLEFCRGEDSVDGK.NKS......TT.--------alpavkds
#=GC seq_cons                     MVLRQLSRQASVKVuKTWTGTKKRAQRILIFILElLL-FCRGEDSVDGK.+KK......sE.sLTEK...sh......
//