#=GF ID   Potyvirid-P3
#=GF AC   PF13608.10
#=GF DE   Protein P3 of Potyviral polyprotein
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Jackhmmer:P04517
#=GF GA   25.30 25.30;
#=GF TC   65.30 64.00;
#=GF NC   24.70 24.70;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -E 1000 --cpu 4 -Z 75585367 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   18408156
#=GF RT   An overlapping essential gene in the Potyviridae.
#=GF RA   Chung BY, Miller WA, Atkins JF, Firth AE;
#=GF RL   Proc Natl Acad Sci U S A. 2008;105:5897-5902.
#=GF DR   INTERPRO; IPR039560;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This is the P3 protein section of the Potyviridae polyproteins.
#=GF CC   The function is not known except that the protein is essential
#=GF CC   to viral survival.
#=GF SQ   8
#=GS MVP_SBMVN/777-930    AC P0CK08.2
#=GS MVP_PVYN/771-959     AC P0CJ93.2
#=GS MVP_TUMVJ/842-1030   AC P0CK11.3
#=GS POLG_SBMVN/777-1215  AC P21231.2
#=GS POLG_PVYN/771-1208   AC P18247.2
#=GS POLG_TUMVJ/842-1279  AC P89509.2
#=GS POLG_RGMVD/722-1167  AC O11436.1
#=GS POLG_BVY3/1081-1520  AC A0AUJ5.1
MVP_SBMVN/777-930               a-LITSIFKPKRMIQILENDPYILLMGLVSPSILIHMYRMKHFEKGVELWISKEHSVAKIFIILEQLTKRVAANDVLLEQLEMISETSERFMSILEDC........PQAPHS..........YKTAKDLLTMYIERKASNNQLVENGFVDMNDKLYMAYEKNLLRSLE-----...........--------------..-------......---.....----------------.----------------------...----------------.-----------------------------...---------------------.------------------------------.------------------------------..--.--------------------------------------------------.---------------------...----------------.---------------------agmar...............................
MVP_PVYN/771-959                .LLLKGIFRPKVMRQLLLDEPYLLILSILSPGILMAMYNNGIFELAVRLWINEKQSIAMIASLLSALALRVSAAETLVAQRIIIDAAATDLLDATCDG........FNLHLT..........YPTALMVLQVVKNRNECDDTLFKAGFPSYNTSVVQIMEKKLSKSLERCLE-...........--------------..-------......---.....----------------.----------------------...----------------.-----------------------------...---------------------.------------------------------.------------------------------..--.--------------------------------------------------.---------------------...----------------.---------------------rfnlarklsatwysyrakrsihsvhkthrkgrferv
MVP_TUMVJ/842-1030              r-LIKGVYKPKQLKEDMLANPFLPLYALLSPGVILAFYNSGSLEYLMNHYIRVDSNVAVLLVVLKSLAKKVSTSQSVLAQLQIIERSLPELIEAKANVn......gPDDAAT..........-RACNRFMGMLLHMAEPNWELADGGYTILRDHSISILEKKLSTNLGRSM--...........--------------..-------......---.....----------------.----------------------...----------------.-----------------------------...---------------------.------------------------------.------------------------------..--.--------------------------------------------------.---------------------...----------------.---------------------ervklvgalcykillvkasnlyterfanekrsrfrr
POLG_SBMVN/777-1215             a-LITSIFKPKRMIQILENDPYILLMGLVSPSILIHMYRMKHFEKGVELWISKEHSVAKIFIILEQLTKRVAANDVLLEQLEMISETSERFMSILEDC........PQAPHS..........YKTAKDLLTMYIERKASNNQLVENGFVDMNDKLYMAYEKIYSDRLKQEW--...........-----RALSWLEKF..SITWQLKr....fAPH.....TEKCLTKKVVEESSAS.SGNFASVCFMNAQSHLRNVRNT...LFQKCDQVWTASVRAFvKLIISTLHRCYSDIVYLVNICIIFSLLVQ...MTSVLQGIVNTVRRDKAL---.LSGWKRKEDEEAVIHLY-----EMCEKMEG.---GHPSIEKFLDHVKGVRPDLLPVAVSMTgqSE.DVSAQAKTATQLQLEKIVAFMALLTMCIDNERSDAVFKVLSKLKAFFSTM.GEDVKVQSLDEIQSIDEDKKL...TIDFDLETNKESSSVS.FDVKFEAWWNRQLEQNRVIPH....................................
POLG_PVYN/771-1208              .LLLKGIFRPKVMRQLLLDEPYLLILSILSPGILMAMYNNGIFELAVRLWINEKQSIAMIASLLSALALRVSAAETLVAQRIIIDAAATDLLDATCDG........FNLHLT..........YPTALMVLQVVKNRNECDDTLFKAGFPSYNTSVVQIMEKNYLNLLNDAWKDltwrenypqhgTHTEQNALSTR---..-----YI......KPT.....----EKADLKGLYNIS.PQAF---LGRSAQVVK-GTASG...LSERFNNYFNTKCVNIsSFFIRRIFRRLPTFVTFVNSLLVISMLTS...VVAVCQAIILDQRKYRRE---.IELMQIEKNEIVCMELY--------ASLQR.KLERDFTWDEYIEYLKSVNPQIVQFAQAQM..EEyDVRHQRSTPVVKNLEQVVAFMALVIMVFDAERSDCVFKTLNKFKGVLSSL.DYEVRHQSLDDVIKNFDERNE...IIDFELSEDTIRTSSV.LDTKFSDWWDRQIQMGHTLPH....................................
POLG_TUMVJ/842-1279             r-LIKGVYKPKQLKEDMLANPFLPLYALLSPGVILAFYNSGSLEYLMNHYIRVDSNVAVLLVVLKSLAKKVSTSQSVLAQLQIIERSLPELIEAKANVn......gPDDAAT..........-RACNRFMGMLLHMAEPNWELADGGYTILRDHSISILEKSYLQILDEAWNE...........L-----SWSERCAIryYSSKQAIf...tqKDL.....PM-KSEADLGGRYSVSvMSSY----ERSKQCMK-SVHSS...IGNRLRSSMSWTSSKVsNSVCRTINYLVPDVFKFMNVLVCISLLIK...MTAEANHIVTTQRRLKLDVEE.TERRKIEW----ELAF-------HHAILTQ.SAGQHPTIDEFRAYIADKAPHLSEHIEP--..EEkAVVHQAKRQSEQELERIIAFVALVLMMFDAERSDCVTKILNKLKGLVATV.EPTVYHQTLNDIEDDLSERNL...FVDFELSSDGDMLQQLpAEKTFASWWSHQLSRGFTIPH....................................
POLG_RGMVD/722-1167             .LLIRSTFDHVLLERALETDPYYILYSALSPTVLKQMYTSKSYANALRVFVRSNQSLFQVVCTLENLARRMTRAQSIEQQIMQLQSLYPQLLDMLADNipdsplswLSHHVT..........----TDSMQRAIELNNCDIELARGGYASINTSWRKKKEQYYADLIKEYY--...........-----NALSPQAKI..FVSRAYIgylhatTPL.....FANARKISSEIASNIC.TQAYSRTIGRGISIVSSGGRKGktwLTARGDSFYKTMIS--.----RAIKLYTPEVSAVIGVATVVGILLS...TMTTLHTYLVKNKQTAQKTNEkFEELMYDK-----VALYIPKYDAEHSHLQG.---KDLDFEHFARWLMARDKKLSSFVQSHL..VD.TVTHQAKDDTNVWIEKCIATIVLMMMAIDSNKSDKLYQILCKLRTVFSTMgQTVVTHQSIDEILDIDESKRT...TIDFERVEVMQPTQPI.LKTTFEGFWDMQIQMGRTVAH....................................
POLG_BVY3/1081-1520             .SLMQD--KRKLLHELMLT-PTWAFYALSSPTLLKILYRSGALKRTYEHAVMANHNAVDLVHELNFLPERVSRAQTLQDEITAWEANVGRVLQQV-DG........---YLTrnhdpplqrwYADASARLQHLK----IDVDLLKNGFRSSQREHVEKKEQLLCDSFERLYNE...........QNSSLESLKTRCGM..GSARALI......KPSgkcesPEPAKQLSCKDLICST.KDKYALMLYTQADALKRKIVAG...----SQSAFTTVCAGV.AYRATKVMLRTP--FNLLNALNTYSLLIAavnVMVLVQNYRRDQRKRAQYVNN.LETQSMIRHYFAHLEQYIVNYVPRDEQFEViKAKFDEEFPEYNVMFKEVYKERIQFQSA--..--.--------DEGKNMCKIFASAILVMMVFDAHRADLMYKSFSQVRALFNTL.-----YDSGNPFNIIFQAERTiapTMDVIIQEPKPAIPST.SSCTFETWFRNCVNANNVIPV....................................
#=GC seq_cons                   ..LI+ulFKPKhh+plLLs-PYllLhuLLSPulLhtMYssGpaEhulclaIppcpSlAhlhslLcsLA+RVSsupoLlsQlphI-pssscLl-thsDs.........stthT..........YtsApchLphllchspssspLscuGFsshNcchlphhEKphscpLccta...................uhp............hh......ts...........php.....s.s..tta.....hthp.h..thhts........pp.hph..........ptl.hhhs....hhs.h.hhuhLht...hhs.hpthh.p.+p.t......hp...h.......ht..........t.hp......c.ph.ca..hhhth..ph..h..s....................hpphhA.hhLhhMhhDsp+uDhhhp.hsph+shhsoh......hpohs.h....ptcp....hhDh.h.psh........phpFtsaap.plp.s.slsh....................................
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