#=GF ID   Pox_VP8_L4R
#=GF AC   PF04498.16
#=GF DE   Poxvirus nucleic acid binding protein VP8/L4R
#=GF AU   Kerrison ND;0000-0002-1471-953X
#=GF SE   DOMO:DM04340;
#=GF GA   25.00 25.00;
#=GF TC   25.80 27.40;
#=GF NC   24.30 23.20;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   9321647
#=GF RT   Vaccinia virion protein VP8, the 25 kDa product of the L4R gene,
#=GF RT   binds single-stranded DNA and RNA with similar affinity. 
#=GF RA   Bayliss CD, Smith GL; 
#=GF RL   Nucleic Acids Res 1997;25:3984-3990.
#=GF DR   INTERPRO; IPR007586;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   The 25 kDa product of Vaccinia virus gene L4R is also known as
#=GF CC   VP8.  VP8 is found in the cores of Vaccinia virions and is
#=GF CC   essential for the formation of transcriptionally competent viral
#=GF CC   particles.  It binds both single stranded and double stranded
#=GF CC   DNA and RNA with similar affinities.  Binding is thought to
#=GF CC   involve cooperative interactions between protein subunits. The
#=GF CC   protein is proteolytically cleaved during viral assembly at an
#=GF CC   Ala-Gly-Ala site. Possible roles for VP8 include packaging and
#=GF CC   maintaining the DNA genome in a transcribable configuration;
#=GF CC   binding ssDNA during transcription initiation; and cooperation
#=GF CC   with I8R protein to unwind early promoter regions.  VP8 may also
#=GF CC   function in either transcription elongation or release of mRNA
#=GF CC   molecules from viral particles [1].
#=GF SQ   41
#=GS A0A1C9HHS7_LSDV/33-250   AC A0A1C9HHS7.1
#=GS A0A2U9QHN1_9POXV/36-252  AC A0A2U9QHN1.1
#=GS Q9DHQ0_YLDV/33-248       AC Q9DHQ0.1
#=GS A0A220T6C5_9POXV/33-249  AC A0A220T6C5.1
#=GS A0A2C9DT39_9POXV/31-247  AC A0A2C9DT39.1
#=GS Q08FB0_DPV84/33-249      AC Q08FB0.1
#=GS Q98241_MCV1/31-250       AC Q98241.1
#=GS VP8_VACCW/33-248         AC P03295.1
#=GS Q775V4_CAMPS/33-248      AC Q775V4.1
#=GS Q070F8_CPRVZ/31-240      AC Q070F8.1
#=GS Q77TK7_VACCT/33-248      AC Q77TK7.1
#=GS H6TA55_9POXV/35-250      AC H6TA55.1
#=GS A0A0H4YFH6_9POXV/32-242  AC A0A0H4YFH6.1
#=GS A0A1V0QGW9_CNPV/32-252   AC A0A1V0QGW9.1
#=GS M1L511_MONPV/33-248      AC M1L511.1
#=GS Q9Q913_RFVKA/33-248      AC Q9Q913.1
#=GS F1AX34_ORFV/32-249       AC F1AX34.1
#=GS Q6VZH1_CNPV/31-251       AC Q6VZH1.1
#=GS A0A3F2YKL7_SHEVT/33-250  AC A0A3F2YKL7.1
#=GS D3IZJ7_9POXV/32-249      AC D3IZJ7.1
#=GS VP8_FOWPN/32-252         AC P15913.1
#=GS Q8V3N4_SWPV1/34-250      AC Q8V3N4.1
#=GS Q0NPB7_9POXV/33-248      AC Q0NPB7.1
#=GS U3UBJ3_9POXV/33-249      AC U3UBJ3.1
#=GS Q08FT0_DPV83/33-249      AC Q08FT0.1
#=GS A0A1L3IZI2_9POXV/35-250  AC A0A1L3IZI2.1
#=GS Q6TVS0_ORFSA/32-249      AC Q6TVS0.1
#=GS A0A097IVT9_9POXV/35-250  AC A0A097IVT9.1
#=GS Q9Q8N8_MYXVL/33-248      AC Q9Q8N8.1
#=GS Q6TUV0_YMTV5/33-249      AC Q6TUV0.1
#=GS A0A6B9R326_9POXV/37-254  AC A0A6B9R326.1
#=GS A0A1B1MRG1_9POXV/34-250  AC A0A1B1MRG1.1
#=GS Q0GNZ3_HSPV/33-248       AC Q0GNZ3.1
#=GS A0A223FMU1_9POXV/33-247  AC A0A223FMU1.1
#=GS VP8_VAR67/33-248         AC P0DSW9.1
#=GS K4JL49_9POXV/33-248      AC K4JL49.1
#=GS A0A385HAJ9_FOWPV/32-252  AC A0A385HAJ9.1
#=GS A0A0M3ZEM5_9POXV/32-253  AC A0A0M3ZEM5.1
#=GS VP8_VACCC/33-248         AC P20981.1
#=GS G3EIE9_9POXV/33-248      AC G3EIE9.1
#=GS A0A223FNC2_9POXV/33-247  AC A0A223FNC2.1
A0A1C9HHS7_LSDV/33-250              ....AKIKYPRSFLSIFNIIPRNMTKYEMDLVQTENITGAVFTTAFNIKKNLGIVD..EKLTIESIENYYLDPNNDVLTLMINNTSLDNV....TTRK.KRSKR.NKNPVLFRQGSIPLFFIFESR.KKVEIYKENVdKASSDNSYMKIDDNIAVASKYAN..MSLLDVHSPSASMKLNGVYGF.TYKNELRKLSSDKEIDEYSNKP.LQEPVRLNDFIGLFDCVKKNIPLTNI-p..............................
A0A2U9QHN1_9POXV/36-252             ....ARARFPKSLLSLFHIIPRTMTRYNIELINSEPIVGSVFTTVYNIKRNIGMGS..EVLTIKHIEKYFLDPANEVLTLMIRNTSFNDL....KQFK.RKGRK.VSSPVVFRQGSAPLLLILESKdKQLGIYREDT.-SKQNDAYTSVGTNLALIGKYAG..LYLLDIHNPASSMNLTAIYGI.QNNNSLKKLTNDKELKEYQESP.LTEPVRLKDFINLFDSIKQNIPMTSV-p..............................
Q9DHQ0_YLDV/33-248                  ....AKVKYPRSFLSIFNIIPRNMTKYELDLVQTENITGAVFTTAFNIKKNLGMGD..EKLTIEAIEGYYLDPNNDILTLMINNTSLSEV....-VPK.RKSKR.NKNPVLFRQGSVPLFFIFESR.KKVEIYKENM.ESQKDSSYSQINENIALISKYSN..MHLLDIHSPSAFMKLNGVYGF.THKNELRKLSSNKEIEEYSNKP.LQEPVRLNDFINLFDCVKKNIPLTNVI...............................
A0A220T6C5_9POXV/33-249             ....AKVKYPRSFLSIFNIIPRTMTKYQLELIQTENITGAVFSTAYNIKKNLSMGD..DKLTIEAITNYYLDPNNEVLTLMVNNTSLANV....-TPR.KKSKR.NKNPVVFRQGSVPLLFIFESK.KKMSVYKEDPnKLTSDGTYTKISDSIALINKYAT..MTLADIHTPSVSMKLNAIYGF.THKHELRKLSTNKELDEYSKMP.LQEPVRLNDFVTLYDSIKKNISLTNI-p..............................
A0A2C9DT39_9POXV/31-247             ....AKSRFPKSLLSMYRIIPRTMTRFQMRLLTTDVVTGIVVTTVYNIKRNAGLAA.dTVLTMQEIERYYLSKENDVLSLMVGNTSVQDL....-ANR.KKARR.AASQTVFREISSPLILLFNSK.KRINVYSEDL.SAETDNTYTKIGANVALLGRYGD..AFLLDVHGPGTALILSAVYGL.NASLDLTKLASASDLESYQSGS.LGRSVDLESFAAVFDSAKKHLQLTNL-d..............................
Q08FB0_DPV84/33-249                 ....AKVKYPRSFLSIFNITPRNMTKYELELVQTENITGAVFSTAFNIKKNLGITD..EKLTIEAIESYYLDPNNDVLTLMINNTSLDGV....-TPR.KRSRR.NKNPVLFRQGSVPLFCIFDSR.KKIGVYRENMnSPSKDNSYMQIEDNVALINKYAN..MSLLDVHSPSASMKLNAVYGF.THKNELRKLVSNKEIEEYSRKP.LQEPVRLNDFIGLFDSVKKNIPLTNI-p..............................
Q98241_MCV1/31-250                  ....AKVKFPRSLLSMYRVVPRTMSRYELALVQSETVTGVVFTTVYNVRRNLGLEE.rEALSLPALEKYYLDKANDVLTLMVNNTNLEHI....AAYR.MRSRR.LLNPVVFRAGAVPLALVFTSR.KKLSIYREDTsQAAEDSTYTKIAANVALAGKYAG..LLLLDVHTPGTALMLTAVYGL.DDRRELRKLADSTALENHQQSGaLSEAMKLSDFRAVFEGLKKSVPLTNL-e..............................
VP8_VACCW/33-248                    ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESASTEYTPIGDNKALISKYAG..INILNVYSPSTSIRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p..............................
Q775V4_CAMPS/33-248                 ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESASTEYTPIGDNKALISKYAG..INVMNVYSPSTSMRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLFECVKKNIPLTDI-p..............................
Q070F8_CPRVZ/31-240                 ....AKLRYPKSFLSIYRVVPRNTSKYRLRKLATETLVGFAMTTMESVRKSLNV--..TTATAQQVEEYFLD--NDVVTLAVGNTDVSKL....GSYK.KRSRA.-KNPVVYRKSSAPVLLVFRSK.NKMDVMIEDR.-EETTGTYARHEAG-AVVNTYLQ..TNFIDVYDPADQLTLDAVYGVpGSDLSLVKM-EGKALEKYQVTG.IQESITLSEFKELFSSAKKNIGVSNFI...............................
Q77TK7_VACCT/33-248                 ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESASTEYTPIGDNKALISKYAG..INILNVYSPSTSIRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p..............................
H6TA55_9POXV/35-250                 ....AKIKYPRSFLSIFNIIPRNVTKYELELVQNDNITGAVFTTAFNIKKNLGITD..DKLTIEAIENYYLDPNNDVLTLMTNNTTLDGI....-TPR.KKSRR.NKNPVLFRQGSVPLFFIFESR.KRVDIYRENM.NKQNDNSYVQIDDNIALISKYSN..MTLLDVHSPSASMKLNAVYGF.THKNELKKLSTNKEIDEYSKKT.LQEPVRLNDFTGLFDCIKKNIPLTSI-p..............................
A0A0H4YFH6_9POXV/32-242             smtg------KSVLSTLRIRPRTKTRKGLTSQKMTSIVAYTILSWDSIWKFINNGAplEDSSMGDLLNYVNS--RQSYSFLTNVSDLSDV....SVRA.HKDDT.AEKPLV-KPENMTFVVILDIK.TDGLHWIDPTpVTETEVDFTELTDKKTVMSKYLGnkLWLLDTYNMTN-AKLIDVYHL.VKNNKLVKIVPDT---------.---------------------------wktlmtkksesvelnmknlqaihkelapklt
A0A1V0QGW9_CNPV/32-252              ....ARYKSPKSVLSIYKIVPKLMTRYPMKLLTNESISGAVITTVYNLKKSMSIPE.kTKLTKQDIERYYLDKSIEVLNLMVSNTSFEDLs..cGRQRrKRSAK.KKDPVIFLGISAPIIILMTSK.KAVNTYVQDK.ESEPGADYVNITPGIAVLESYGN..THLLDVHNPSAVLTVSAVYGL.DSNMELKKLTTVSEMENYQNTS.IGKPIDLKKFTEIFSTIKKHLSLSNF-t..............................
M1L511_MONPV/33-248                 ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTTV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESVSTEYTPIGDNKALISKYAG..INILNVYSPSTSMRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p..............................
Q9Q913_RFVKA/33-248                 ....AKLKYPRSFLSIFNIVPRNMTRYELDLVQTENITGAVFTTVFNIKKNLGILE..EKLTIEAIENYYLDPNNDVLTLMIDNTSLNEI....-SPR.KKSKR.TKNPVLFRQGSIPLFFIFESR.KKVDIYKENV.NKAVDGSYIKIDDNVALMGKYAN..MSLLDVHSPSAFMKLNAVYGF.THKNELRKLVSDKEIEEYSNHP.LQEPVRLNDFIGLFDGVKKSIPLTSI-p..............................
F1AX34_ORFV/32-249                  ....ARVRFPRSLLSLFNVVPRTMTRYETELVGTEMVVGAVFTTAYNVRRNLGLGE..EPVTMRDIEKYFLDSENEVLTLIVHNTDFSAM...sGVRR.RGGRR.IANPVIFRSGSTPLLIVMESR.KKTNIYRERT.AEQANASYREVGSSLALVTRYAG..LQLVDVHTPSSVLTVSAVYGF.TEDKGLKKLGSDKELADYQSTP.LTDPIRLSDFSKLFDGVKKSIQLTNV-p..............................
Q6VZH1_CNPV/31-251                  ....AKYKFPKSLLSIYKIVPKIMTRYPMKLLTNESISGVVITTVYNLKKNLSIPE.kTKLTKQDIEKYYLDKNIEVLNLMISNTSVEDLa..cGRQR.RKRTAkRKEPVIFLGVSAPIIVLMTSK.KAVNTYVQDK.ESDPSTDYVNITPGIAVLENYGN..TRLLDVHNPSAVLTVSAVYGL.DSNMELKKLSTVAEMENYQNTN.IGKPIDLKKFTEIFSTIKKHLSLSNF-t..............................
A0A3F2YKL7_SHEVT/33-250             ....AKIKYPRSFLSIFNIIPRNMTKYEMDLVQTENITGAVFTTAFNIKKNLGIVD..EKLTIESIENYYLDPNNDVLTLMINNTSLDNV....TTRK.KRSKR.NKNPVLFRQGSIPLFFIFESR.KKVEIYKENVdKASSDNSYMKIDDNIAVANKYAN..MSLLDVHSPSASMKLNGVYGF.TYKNELRKLSSDKEIDEYSNKP.LQEPVRLNDFIGLFDCVKKNIPLTNI-p..............................
D3IZJ7_9POXV/32-249                 ....ARVRFPRSLLSLFNVVPRTMTRYETELVGTEMVVGAIFTTAYNIRRNLGLGE..EPVTMRDIEKYFLDSENEVLTLVVHNTDFSTM...tGIRR.RGGRR.IANPVIFRSGSTPLLIVMESR.KKTNIYRERT.ADPANASYKEVGSSLALVTRYAG..LQLVDVHTPSAVLTVSAIYGF.TEDKGLKKLGSDKELAEYQSAP.LTDPIRLGDFSKLFDGVKKSIQLTNV-p..............................
VP8_FOWPN/32-252                    ....ARSKFPKSLLSMYRVTPRVMTRYPLKLITNESITGVVITTVYNLKKNLNIPQ.nNKLTTQDIERYYLDKSVEVINLMVGNTSLGDLa..cGRPR.RTKSSkKKDPVIFLGISAPLILVMNSK.KSINTYIQDK.KSDPSSDYVNINPGIGVLENYGN..TYLLDIHNPSSVLTISTIYGL.DNNMELKKLSTASEIDAYQDVN.IGKSVDLKKFNEIFNTMKKHLSLSNF-s..............................
Q8V3N4_SWPV1/34-250                 ....AKIKYPRSFLSIFNIIPRNMTRYSLDLIQTENITGAVFTTVFNIKKNLGMTD..ENLTIEAIENYYLDPNNDVITLMINNTSLDFI....-NPR.KKSRR.NKNPVLFRQGSVPLFFIFDSR.KKVEIYKENIdKMNENNTYTKINDNIALAGKYAN..LSLLDVHSPSASMKLNAVYGF.THKNELRKLSSDKEIEEYSKKP.LQEPVRLNDFIGLFDCVKKNIPLTNI-p..............................
Q0NPB7_9POXV/33-248                 ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESASTEYTPIGDNKALISKYAG..INVLNVYSPSTSMRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p..............................
U3UBJ3_9POXV/33-249                 ...s-RTKYPRSFLSLFNIVPRTMTRYALELVNTEAITGAAFTTAYNVRRNLGLGE..EPLRIDCLTSYYLDPSNEVLTLMTNNTSLDAV....TTVK.RRGRR.VRNPVVFRQGSVPLLLIFESR.KKMGVYREDVsKPAADNAYTAIGDNVVLASKYAG..LNLLDVHSPSNSMTLSAVYGV.KE-GELHKLSNDKELTEYQKSA.LKDPIRMDEFNNLFESVKKSIPLTNI-s..............................
Q08FT0_DPV83/33-249                 ....AKVKYPRSFLSIFNIIPRNMTKYELELVQTENITGAVFSTAFNIKKNLGITD..EKLTIEAIESYYLDPNNDVLTLMINNTSLDGV....-TPR.KRSRR.NKNPVLFRQGSVPLFCIFDSR.KKIGVYRENMnSPSKDNSYMQIEDNVALINKYAN..MSLLDVHSPSASMKLNAVYGF.THKNELRKLVSNKEIEEYSRKP.LQEPVRLNDFIGLFDSVKKNIPLTNI-p..............................
A0A1L3IZI2_9POXV/35-250             ....AKIKYPRSFLSIFNIIPRNVTKYELELVQNDNITGAVFTTAFNIKKNLGITD..DKLTIEAIENYYLDPNNDVLTLMTNNTTLDGI....-TPR.KKSRI.NKNPVLFRQGSVPLFFIFESR.KRVDIYRENM.NKQNDNSYVQIDDNIALISKYSN..MYLLDVHSPSASMKLNAVYGF.THKNELKKLSTNKEIDDYSKRT.LQEPVRLNDFTGLFDCIKKNIPLTSI-p..............................
Q6TVS0_ORFSA/32-249                 ....ARVRFPRSLLSLFNVVPRTMTRYETELVGTEMVVGAVFTTAYNIRRNLGLGE..DPVTMRDIEKYFLDSDNEVLTLIVHNTDFSAM...sGVRR.RGGRR.ITNPVIFRSGSTPLLIVMESR.KKTNIYRERT.AEQANASYREVGSSLALVTRYAG..LQLVDVHTPSSVLTVSAVYGF.TEDKGLKKLGSDKELADYQSTP.LTDPIRLSDFSKLFDGVKKSIQLTNV-p..............................
A0A097IVT9_9POXV/35-250             ....AKIKYPRSFLSIFNIIPRNVTKYELELVQNDNITGAVFTTAFNIKKNLGITD..DKLTIEAIENYYLDPNNDVLTLMTNNTTLDGI....-TPR.KKSRR.NKNPVLFRQGSVPLFFIFESR.KRVDIYRENM.NKQNDNSYVQIDDNIALISKYSN..MTLLDVHSPSASMKLNAVYGF.THKNELKKLSTNKEIDEYSKKT.LQEPVRLNDFTGLFDCIKKNIPLTSI-p..............................
Q9Q8N8_MYXVL/33-248                 ....AKLKYPRSFLSIFNIVPRNMTRYELDLVQTENITGAVFTTVFNIKKNLGILE..EKLTIEAIENYYLDPNNDVLTLMIDNTSLKEI....-SPR.KKSRR.TKNPVLFRQGSIPLFFIFESR.KKVDIYKENV.NKAVDGSYIKIDDNVALMGKYAN..MSLLDVHSPSAFMKLNAVYGF.THKNELRKLVSDKEIEEYSGQP.LQEPVRLNDFIGLFDGVKKSIPLTSI-p..............................
Q6TUV0_YMTV5/33-249                 ....AKVRYPRSFLSIFNIIPRNMTKYELELVQTENITGAVFTTAFNIKKNLGMND..ENLTIEAIEGYYLDPNNDILTLMINNTSLMEV....-VPK.RKSKR.NKNPVLFRQGSVPLFFIFESR.KKVDIYKENIeNKKDSTSYSQIDENIALISKYSN..MQLLDVHSPSAFMKLNGVYGF.THKNELRKLSSNKEIEEYSNKP.LQEPVRLNDFINLFDCVKKNIPLTNVI...............................
A0A6B9R326_9POXV/37-254             ....ARAKYPKSFLSIFNIVPRVMTKYDLKLMHNEIITGAVITTAYNVKRNLGICD..ESLKIDSIDNYFLDVNNEVMTLMINNTNLSCV....INKK.KGGRR.VKNPVIFRIGSVPMMLIFESR.KKVNIYIEDTtKCTPDNAYVNIGDNIALVNKYAG..IYLLDVHTPSANMKLTGLYGF.INGQELKKISSDCELDEYMKKS.LTEPIRMDDFIELFESVKKNIPLTNL-s..............................
A0A1B1MRG1_9POXV/34-250             ....ARVKFPKSMLSLFHIIPRTMSRYNLELVNTENIVGGTFTTAYNIRRNMGITS..DPLTIKLIEKYFLDSANEVLTLMIRNTSFSNL....KQFK.KKGKR.NNNPVIFRSGSSPLLLIIESKtKQISIYKEDT.-SKQNDSYTPVGENVALVSKYAG..ITLLDVHTPSKFMELTAIYGI.KGNNTLKKLSTDKDLKEYQESP.LSEPVRLNDFINLFESIKQNIPMTSV-p..............................
Q0GNZ3_HSPV/33-248                  ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESASTEYTPIGDNKALISKYAG..INILNVYSPSTSIRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLLECIKKNIPLTDI-p..............................
A0A223FMU1_9POXV/33-247             ....AKAKYPRSMLSIFNIVPRTMTKYNMDMIQNENITGAVFTTMYNVRNNLGLGN..DKLTIEAIENYFLDPNNEVMSLIINNTDISAV....-IPK.KRSRRqNKNMVIFRQGSSPILCIFETR.KKINIYKENT.--TTTTDYTPIGDNKAVIAKYAG..INILNVYSPSSSLRLNAIYGF.TNKNKVEKLSTNKELEAYSENP.LQEPIRLNDFINVVECVKKNIPLIDI-p..............................
VP8_VAR67/33-248                    ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESASTEYTPIGDNKALISKYAG..INVLNVYSPSTSMRLNAIYGF.TNKNKLEKLSTNKELELYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p..............................
K4JL49_9POXV/33-248                 ....AKLKYPRSFLSIFNIVPRNMTRYELDLVQTENITGAVFTTVFNIKKNLGILE..EKLTIEAIENYYLDPNNDVLTLMIDNTSLKEI....-SPR.KKSRR.TKNPVLFRQGSIPLFFIFESR.KKVDIYKENV.NKAVDGSYIKIDDNVALMGKYAN..MSLLDVHSPSAFMKLNAVYGF.THKNELRKLVSDKEIEEYSGQP.LQEPVRLNDFIGLFDGVKKSIPLTSI-p..............................
A0A385HAJ9_FOWPV/32-252             ....ARSKFPKSLLSMYRVTPRVMTRYPLKLITNESITGVVITTVYNLKKNLNIPQ.nNKLTTQDIERYYLDKSVEVINLMVGNTSLGDLa..cGRPR.RTKSSkKKDPVIFLGISAPLILVMNSK.KSINTYIQDK.KSDPSSDYVNINPGIGVLENYGN..TYLLDIHNPSSVLTISTIYGL.DNNMELKKLSTASEIDAYQDVN.IGKSVDLKKFNEIFNTMKKHLSLSNF-s..............................
A0A0M3ZEM5_9POXV/32-253             ....AKLKFPKSLLSMYKIIPRMMTKYPMKLVSNESITGVVITTTYNLKKNLSIPA.eNKLTKQDIETYYLNKNIEVLNLMIGNTSVKDLscekPKPR.ASKNK.RKEPTIFLGIASPLILVMTSK.KPVNVYVIDK.KSEPTADYVNITPGTAILETYGN..TQLLDIHSPGSVLNISAIYGL.DANMELKKLNTVNEIENYQTTT.IGKAVDLKKFIELFANIKKYLSLSNF-t..............................
VP8_VACCC/33-248                    ....AKSKFPRSMLSIFNIVPRTMSKYELELIHNENITGAMFTTMYNIRNNLGLGD..DKLTIEAIENYFLDPNNEVMPLIINNTDMTAV....-IPK.KSGRRkNKNMVIFRQGSSPILCIFETR.KKINIYKENM.-ESASTEYTPIGDNKALISKYAG..INVLNVYSPSTSMRLNAIYGF.TNKNKLEKLSTNKELESYSSSP.LQEPIRLNDFLGLLECVKKNIPLTDI-p..............................
G3EIE9_9POXV/33-248                 ....AKAKYPRSMLSIFNIVPRTMSKYNMEMIQNENITGAVFTTMYNVRNNIGLGN..DKLTIETIENYFLDPNNEVMSLIINNTDMSAV....-IPK.KRSRKqNKNMVIFRQGSSPILCIFETR.KKINIYKEDV.-SSSNNDYMPIGDNKAVISKYAG..ISILNVYSPSVSLRLNAIYGF.TNKNKVEKLSTNKELESYSDNP.LQEPIRLNDFIKLVESVKKSIPLIDI-p..............................
A0A223FNC2_9POXV/33-247             ....AKAKYPRSMLSIFNIVPRTMTKYNMDMIQNENITGAVFTTMYNVRNNLGLGN..DKLTIETIENYFLDPNNEVMSLIINNTDMSTV....-IPK.KRSRRqNKNMVIFRQGSSPILCIFETR.KKINIYKENT.--STTTDYTPIGDNKAVIAKYAG..INILNVYSPSSSLRLNAIYGF.TNKNKVEKLSTNKELEAYSENP.LQEPIRLNDFINVVECVKKNIPLIDI-p..............................
#=GC seq_cons                       ....AKsKaPRShLSIFNIlPRsMT+Y-L-LlpsENITGAVFTTsYNI++NLGls-..-KLTIEuIEsYaLDPNN-VloLMINNTslssl.....hP+.K+uRR.sKNPVlFRQGSsPLlhIFESR.KKlsIY+Esh.tpsssssYspIsDNlALluKYAs..hsLLDVHSPSush+LNAlYGF.TpKNcL+KLSosKElEpYSssP.LQEPlRLNDFlsLF-sVKKNIPLTsl.P..............................
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