#=GF ID Pro_3_hydrox_C
#=GF AC PF05373.15
#=GF DE L-proline 3-hydroxylase, C-terminal
#=GF AU Finn RD;0000-0001-8626-2148
#=GF SE Pfam-B_32425 (release 7.8)
#=GF GA 25.00 25.00;
#=GF TC 25.20 25.60;
#=GF NC 23.60 22.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 11737217
#=GF RT Structure of proline 3-hydroxylase. Evolution of the family of
#=GF RT 2-oxoglutarate dependent oxygenases.
#=GF RA Clifton IJ, Hsueh LC, Baldwin JE, Harlos K, Schofield CJ;
#=GF RL Eur J Biochem 2001;268:6625-6636.
#=GF DR INTERPRO; IPR008035;
#=GF DR SCOP; 1e5r; fa;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Iron (II)/2-oxoglutarate (2-OG)-dependent oxygenases catalyse
#=GF CC oxidative reactions in a range of metabolic processes. Proline
#=GF CC 3-hydroxylase hydroxylates proline at position 3, the first of
#=GF CC a 2-OG oxygenase catalysing oxidation of a free alpha-amino
#=GF CC acid. The structure contains conserved motifs present in other
#=GF CC 2-OG oxygenases including a jelly roll strand core and residues
#=GF CC binding iron and 2-oxoglutarate, consistent with divergent
#=GF CC evolution within the extended family. The structure differs
#=GF CC significantly from many other 2-OG oxygenases in possessing a
#=GF CC discrete C-terminal helical domain.
#=GF SQ 37
#=GS A0A1C4YS52_MICEC/194-287 AC A0A1C4YS52.1
#=GS A0A3R9KVP2_9VIBR/1-94 AC A0A3R9KVP2.1
#=GS A0A7W9IBI9_9ACTN/197-286 AC A0A7W9IBI9.1
#=GS A0A318KCD4_9NOCA/189-284 AC A0A318KCD4.1
#=GS A0A1E5PYU5_9ACTN/182-274 AC A0A1E5PYU5.1
#=GS A0A344L0B8_9PSEU/196-286 AC A0A344L0B8.1
#=GS A0A081XY40_STRTO/183-283 AC A0A081XY40.1
#=GS A0A510TL51_9ACTN/183-283 AC A0A510TL51.1
#=GS A0A4P9VJZ2_9GAMM/180-281 AC A0A4P9VJZ2.1
#=GS A0A5C2HS35_9GAMM/185-276 AC A0A5C2HS35.1
#=GS A0A109QDE6_9BACL/182-283 AC A0A109QDE6.1
#=GS A0A7X0M5L7_9ACTN/200-287 AC A0A7X0M5L7.1
#=GS A0A0Q5P6I2_9BURK/158-258 AC A0A0Q5P6I2.1
#=GS P4H_RHIME/177-276 AC Q92LF6.1
#=GS A0A068QPC1_9GAMM/185-278 AC A0A068QPC1.1
#=GS A0A7Z0KUJ6_9ACTN/188-274 AC A0A7Z0KUJ6.1
#=GS E5XT07_SEGRC/179-277 AC E5XT07.2
#=GS A0A6J5DDW6_9BURK/187-288 AC A0A6J5DDW6.1
#=GS A0A090IHU8_9GAMM/207-308 AC A0A090IHU8.1
#=GS A0A160FB59_9BACI/91-192 AC A0A160FB59.1
#=GS A0A1C4PY86_9ACTN/199-287 AC A0A1C4PY86.1
#=GS A0A2S6GPH4_9PSEU/182-282 AC A0A2S6GPH4.1
#=GS A0A149PKD8_9BURK/188-289 AC A0A149PKD8.1
#=GS Q0RMP5_FRAAA/179-274 AC Q0RMP5.1
#=GS A0A0D6Z7L6_9BACI/182-283 AC A0A0D6Z7L6.1
#=GS C7Q927_CATAD/199-287 AC C7Q927.1
#=GS A0A0M8VM83_9ACTN/192-274 AC A0A0M8VM83.1
#=GS D2AQP1_STRRD/183-282 AC D2AQP1.1
#=GS A0A3G2J6U6_9ACTN/182-276 AC A0A3G2J6U6.1
#=GS A0A6G4WV84_9ACTN/187-276 AC A0A6G4WV84.1
#=GS A0A3N6HKF9_9ACTN/196-286 AC A0A3N6HKF9.1
#=GS A0A510TNV2_9ACTN/183-283 AC A0A510TNV2.1
#=GS A0A6H9YTN1_9ACTN/196-287 AC A0A6H9YTN1.1
#=GS A0A4R1HUG8_PSEEN/178-278 AC A0A4R1HUG8.1
#=GS A0A1V6MHI3_9ACTN/170-266 AC A0A1V6MHI3.1
#=GS K0PU58_9HYPH/177-276 AC K0PU58.1
#=GS M1NR20_9CORY/182-282 AC M1NR20.1
A0A1C4YS52_MICEC/194-287 .......................gtpdtgipad-----------------.RMVS.RPAL.T.G.PER.ASLL.GLADVL.T.MD.TFNEVFSIVIKKHYRSDGGDDFVWSTLIDLARGSADPAVLPHALKLRRYYTLERSAQ-e........
A0A3R9KVP2_9VIBR/1-94 ..............................siw-----------NNDVQP.LIFD.RASL.K.DqDIE.DFIL.SVSQSIhS.IE.DIKQAVLNISSAHVHHDIPINKTYDLLIDSVKNKNDD-IYNLCCNMKKYYTVDRNLGE.........
A0A7W9IBI9_9ACTN/197-286 ...........................gtidag-----------------.RIVH.RPPL.P.D.AER.SSLA.LLSQVL.T.MD.TFNEVFSIVVKTHFRRDGGAGFVWDTMIDLARGSADPAVLTHATELRQYFTLDR----psgs.....
A0A318KCD4_9NOCA/189-284 .....................tfdadlsgnfpq----------------A.NICD.RPTL.S.D.AER.EGIL.SMSSVI.D.EE.NFMQVMGLVVRKHYRNDGGPDFVWRSMNEIAERSGNSTIVKMVSDLYR----------htnivrieg
A0A1E5PYU5_9ACTN/182-274 .........nsvpselpvriisrppvseadlae-----------------.----.----.-.-.---.--LM.DSAADM.N.AD.NLRASFRKFAAVHFTRQADATAAFDWFVEAAARTGDDALVAKAEAFRTYCIEERGY--re.......
A0A344L0B8_9PSEU/196-286 .........................adagiped-----------------.RMVK.RPPV.T.D.ADR.ASLL.RLADVM.T.ME.TVDEIFSIVIKKHYRYDGGDDFVWSTMIDIARACEDTEALRHIEELRRYFTIER----spc......
A0A081XY40_STRTO/183-283 .............................ekea----FADASVYTSDVSP.AIHE.RKPF.T.K.ERE.AGIL.ALSGVI.G.RE.NFRDILFLLSKVHYTYDVHPSETYEWLVAVSKEAGDDKMVEKAERIRDFAIGARAFGE.........
A0A510TL51_9ACTN/183-283 ...............................ek--EVFADASVYAPGATP.ELPD.RKPF.T.A.ERA.ERIR.SLADVI.E.RE.NFRDILFLLAKVHFTYDVHPSETYEWLIDISKKAGDGKMVEKAERIRDFAIGARDLGE.........
A0A4P9VJZ2_9GAMM/180-281 ..............................dvd---IFKNASSVVFNVKP.TYKQ.RQAL.P.E.SVR.ETIVeSMSLIL.S.KE.TFKDILFAISKYHFIYDIEVAECYEWFIDACVKGGHQDLELKARDLQRYLIEKRELNE.........
A0A5C2HS35_9GAMM/185-276 .......................dklaaaepir-----------------.-FIE.REPL.P.A.ELK.EHYL.ALAALM.T.RH.NYRDILAMVAKLPFLWQMELTDVFEITQQICHRSGDRLLIDNIAKTKHAFLHERA---td.......
A0A109QDE6_9BACL/182-283 ..............................pse---IFTNKALYNEQIKP.TIAK.REQLkP.E.AVE.HMIQ.SLSQII.D.KY.NFKDVLFMLSKIHFYKDVPVSAAYDWLEEITRRSGKEELLDKTQKLRKYMIEKRDLGE.........
A0A7X0M5L7_9ACTN/200-287 ...........................ipagrr-----------------.--VD.RPAL.P.D.DRR.AALL.RLADVL.T.MD.SFREVFSIVIKTHFRWDGGENFAWDTMTELARACDDPAVLPHTMELLRYYTLDR----sgsk.....
A0A0Q5P6I2_9BURK/158-258 ................................e-AAFRKSLPSADYKIEP.QFVQ.RPPL.G.D.SFD.QELS.SLAASL.T.ES.NLYQAVGLLSKVHFFRNAKVADFFDWLAVIAERSGKRSLQTKTEWYIGFLRDERRMG-d........
P4H_RHIME/177-276 ................................p-ESFLRNVE--QPVTTR.DMVDpRKEL.T.D.EVI.EGIL.GFSIII.S.EA.NYREIVSILAKLHFFYKADCRSMYDWLKEICKRRGDPALIEKTASLERFFLGHRERGE.........
A0A068QPC1_9GAMM/185-278 .........................shtlcvdn--------------LEP.DIIHdRQPL.P.T.SLR.DSLA.HIAEHA.D.EF.NIQSILFLATRFHFSYAVSIREYFQLLDECFSRNPYKSVRERYEALKDILVR------sgyt.....
A0A7Z0KUJ6_9ACTN/188-274 ..........................esaipag-----------------.NVAD.RPPL.D.E.RGR.SALL.GLAGVL.D.AR.NYQEIQTLLIKQHFLSDISGDDVFTLLKEIAAASGSSELLTRATAHEEYCMVR-----r........
E5XT07_SEGRC/179-277 ................................p-AAVLKNADRLRPIARD.PRIS.RSKL.D.H.EAL.ESLI.RGGRVV.T.LA.MWPALVQMLARIHLTSDAHPAELYDWLDDLADRSGNDELVAEARRMRRYFLT------dgis.....
A0A6J5DDW6_9BURK/187-288 ..............................ysm---IFKDHSIRDEAIEP.ALVA.RTRLeP.E.DLQ.DYLA.LLSTSF.N.DKdDAEHILVKLSKVHLRFESPVSDIYKNLTTVARMTRRQELVEHCERMQRFYIGS-----pqgf.....
A0A090IHU8_9GAMM/207-308 ............................ervif-----NQNADIDFEAQP.TYIS.REPV.N.E.ITK.EKIIaNVSELM.N.KH.TFRDLVFTLSKFHFTHKLPVREAYDWLIEAAKRTDDDHLVTKSQQMKRYLIEHREMNE.........
A0A160FB59_9BACI/91-192 ..............................pkd---VFINDSVYNPNLDP.TIIK.REEV.S.S.DFK.ESLVtSLSKVI.S.KY.NFRDIVFLLSKIHFYKNISVSDCYDWLVEITEKSGDSSVYNKAINLRRFLVEERKLGE.........
A0A1C4PY86_9ACTN/199-287 ...........................gipedr-----------------.-ISK.RPSL.T.E.TEL.EALY.RLADVV.D.LE.NYRDVLGLVIKKHYRRDGGEDFVWRTLTEIGRRCPDPAVRTKIQEELRFFLMERS---aqt......
A0A2S6GPH4_9PSEU/182-282 ...............................ek--EIFADPTVYSPGGEP.EFVP.RKPF.T.S.ETR.DRIL.SLANVL.E.RD.NFRDVLFMLSKVHFLYEVHPAQTYTWLVDIAKATGDEKMVTKAEQIRAFAIDARAL--td.......
A0A149PKD8_9BURK/188-289 ...............................sl---IFKDRSIHDETVEP.AVVS.RTPI.EsE.DLQ.DYLE.QLSERF.HdKD.DAEQILVKLSQIQLRFDSPVSDIYKNLSEVAKLTQREDLVEHCEKMRTFYIGSRAMNE.........
Q0RMP5_FRAAA/179-274 ...........................kirgdv------------PATEPiHIVD.RPAP.T.E.TEL.EELL.TCGNAL.A.TG.SMRHDFRRFAALHFARRAHAAAAFDWFEQAAARTGDPAAVAKARAFRTYCIEKRSYGE.........
A0A0D6Z7L6_9BACI/182-283 ................................p-EDIFVKKDTYNPNVSP.YIVP.RQDV.P.E.NFEaDLIR.SLSNVI.S.RY.NFKDIVFLLSKIHFYKNVPITSCYDVLVKIAEASGDDAIYEKAISLRKYLIEKRDLKE.........
C7Q927_CATAD/199-287 ...........................gvpaas-----------------.-AVD.RPQL.S.D.AER.AALA.RLADVL.T.MD.TFSEIFSVLVKKHFRRDGGEHFVWDTLTALARACPDPAVLPHTQELRRYFTLERP---sgs......
A0A0M8VM83_9ACTN/192-274 lidlpavtdadveeligsgpeltpdtlrtafrr-----------------.----.----.-.-.---.----.------.-.--.--------FAALHFERRAPVVAAFDWYLEAARRTGDDAMADKVRAFRTYCIGKRGY--re.......
D2AQP1_STRRD/183-282 ............................gdvfa------RAGDYDPAIRP.ALVE.RAPA.P.A.DLP.DRLR.ALSAVV.S.RH.NIKDIAFLLGKVHFTEEVPIGASWDWLVEITRASGDPALLDLAERARRFFVHSREVYE.........
A0A3G2J6U6_9ACTN/182-276 ................irgdvpaaqpvrildlp-----------------.----.--EV.T.D.ADI.EELI.GSGPRL.T.RE.TMRASFRRFAALHFERRAHATAAFDWYAEAARRTGDDVMVAKAEAFRTYCVDKRGY--re.......
A0A6G4WV84_9ACTN/187-276 ........................aeteqaipe----------------S.HIVR.RREP.R.R.GER.EAFL.ALSGVV.D.EV.NYRDVMAMIIKRFYVARIPVRETFAWLRDIIAASGHEKLLATVTAAEEEFLV------rr.......
A0A3N6HKF9_9ACTN/196-286 ........................ptgripedr-----------------.-VSK.RASL.T.D.GEL.QALY.RLSDVV.D.LE.NYRDVFGLVIKKHYRRDGGDDFVWRTLTEIGRRCPDPAVRSKIQEEQRFFLMERA---tp.......
A0A510TNV2_9ACTN/183-283 ...............................ek--EIFSDATVYAPGSTP.DLPE.RRPF.T.A.EQR.QRIL.SLGQVI.E.RE.NFRDILFLLSKLHYKYDVHPSHTYDWLIEIAQQTRDEKMVRKAEQIRDFAMAARTLSE.........
A0A6H9YTN1_9ACTN/196-287 .........................adagiped-----------------.RMVK.RPPV.T.D.ADR.ASLL.RLADVM.T.ME.TVDEIFSIVIKKHYRYDGGDDFVWSTMIDIARACEDTEVLRHIEELRRYFTIERS---pyt......
A0A4R1HUG8_PSEEN/178-278 ...............................es--EVFRDTAFHRPFLEP.CTPE.RAAF.T.D.EAL.SVVH.RIAGTL.N.RG.NFKELVFLVSKLHFVYDIPAGRTYDLLDELAQRCGDPALIEKSARLREFMIGTRTLGE.........
A0A1V6MHI3_9ACTN/170-266 ..........................iairddi------------PATEPvRIME.RPEI.T.E.AEL.EELL.ASGRDL.T.PA.TMRSRFRRFASLHFERRAHAAAAFDWFEEAARRTGDAGMVAKAQAFRAYCIEKRRDGE.........
K0PU58_9HYPH/177-276 ...............................pe--EVVRKTE--QPLGSN.SMVDtREEW.S.N.EAL.ECVL.GLSEII.S.EA.NYREIVSILAKLHFFYKVDCQAMYGWLKELCRRRGDPALIEKTDRLERFYLIDRAAGE.........
M1NR20_9CORY/182-282 .................................EASIFRDLSSYQPDLSP.EIRE.RAAF.T.S.DLE.QRLL.RLSEVV.N.RR.NFKDVLFLLSKIHFDYNVPGERTYDWLLDICRTAGDDQLIAKAEMVRDYMINVRALGE.........
#=GC seq_cons ...............................tt................s.thsc.R.sl.s.c.s.p.ptlh.sLupll.s.pc.sa+-lhhhluKhHFphcsssstsa-hLh-lu+psGDstlls+spph+cahltcRt............
//
