#=GF ID Pullulanase_Ins
#=GF AC PF18494.5
#=GF DE Pullulanase Ins domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF01537
#=GF GA 27.40 27.40;
#=GF TC 27.40 27.40;
#=GF NC 27.30 27.30;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -E 1000 -Z 75585367 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 24375572
#=GF RT Functional and structural studies of pullulanase from
#=GF RT Anoxybacillus sp. LM18-11.
#=GF RA Xu J, Ren F, Huang CH, Zheng Y, Zhen J, Sun H, Ko TP, He M, Chen
#=GF RA CC, Chan HC, Guo RT, Song H, Ma Y;
#=GF RL Proteins. 2014;82:1685-1693.
#=GF RN [2]
#=GF RM 26688215
#=GF RT Structural Basis of Pullulanase Membrane Binding and Secretion
#=GF RT Revealed by X-Ray Crystallography, Molecular Dynamics and
#=GF RT Biochemical Analysis.
#=GF RA East A, Mechaly AE, Huysmans GHM, Bernarde C, Tello-Manigne D,
#=GF RA Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ,
#=GF RA Francetic O;
#=GF RL Structure. 2016;24:92-104.
#=GF DR INTERPRO; IPR041111;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Pullulanases (pullulan 6-glucanohydrolase, EC 3.2.1.41) are
#=GF CC debranching enzymes that are able to hydrolyze the
#=GF CC alpha-1,6-glycosidic linkage in pullulan, starch, amylopectin,
#=GF CC and related oligosaccharides. Type I pullulanases specifically
#=GF CC cleave the alpha-1,6-glycosidic linkages in pullulan and
#=GF CC branched oligosaccharides to produce maltotriose and linear
#=GF CC oligosaccharides, respectively [1]. Structural analysis of
#=GF CC Klebsiella lipoprotein pullulanase (PulA) illustrates that the
#=GF CC catalytic core is composed of two major regions: the TIM-barrel
#=GF CC domain A and beta-sandwich fold domain C. PulA contains an extra
#=GF CC domain, a highly mobile Ins subdomain of unknown function which
#=GF CC is inserted into the catalytic TIM-barrel domain A of Klebsiella
#=GF CC pullulanases. The Ins subdomain is rich in helical and loop
#=GF CC secondary structure. A disulfide bond between Cys491 and Cys506
#=GF CC and two Ca2+ ions presumably stabilizes this domain.This
#=GF CC insertion is also found in pullulanases from other Gram-negative
#=GF CC genera that have a functional T2SS, such as Vibrio, Aeromonas,
#=GF CC and Photorhabdus. Functional analysis indicate that this domain
#=GF CC is required for PulA secretion via the T2SS [2].
#=GF SQ 94
#=GS D0LWI8_HALO1/381-461 AC D0LWI8.1
#=GS A0A0Q0P172_9GAMM/536-603 AC A0A0Q0P172.1
#=GS Q7MGB0_VIBVY/600-674 AC Q7MGB0.1
#=GS A0A1B7UQB4_9GAMM/530-595 AC A0A1B7UQB4.1
#=GS A0A7X8YHM5_9VIBR/492-558 AC A0A7X8YHM5.1
#=GS K6YE11_9ALTE/576-642 AC K6YE11.1
#=GS A0A1Y6BJH9_9PROT/548-613 AC A0A1Y6BJH9.1
#=GS A0A0H3GJK2_KLEPH/436-509 AC A0A0H3GJK2.1
#=GS A0A090II19_9GAMM/659-732 AC A0A090II19.1
#=GS A0A0U2ZI01_9ALTE/1364-1438 AC A0A0U2ZI01.1
#=GS A0A0J1JJY1_9GAMM/497-570 AC A0A0J1JJY1.1
#=GS A0A2S7UUE0_9GAMM/342-409 AC A0A2S7UUE0.1
#=GS I8U5E5_9ALTE/530-596 AC I8U5E5.1
#=GS A0A2N8Z9V1_9VIBR/646-719 AC A0A2N8Z9V1.1
#=GS D0Z2Y1_PHODD/504-577 AC D0Z2Y1.1
#=GS A0A178K9H3_9GAMM/501-574 AC A0A178K9H3.1
#=GS A0A411PEU9_9GAMM/536-603 AC A0A411PEU9.1
#=GS A0A0Q2R312_VIBFU/595-668 AC A0A0Q2R312.1
#=GS A0A1H4DHN4_ALKAM/526-592 AC A0A1H4DHN4.1
#=GS Q487M0_COLP3/392-459 AC Q487M0.1
#=GS A0A6G8D3I8_9VIBR/595-669 AC A0A6G8D3I8.1
#=GS Q7NA40_PHOLL/489-562 AC Q7NA40.1
#=GS A0A0C5WL42_9GAMM/500-573 AC A0A0C5WL42.1
#=GS Q6LIJ2_PHOPR/508-581 AC Q6LIJ2.1
#=GS A0A0S2JD52_9GAMM/385-452 AC A0A0S2JD52.1
#=GS A0A553L6G1_9ALTE/535-605 AC A0A553L6G1.1
#=GS A0KFY5_AERHH/505-578 AC A0KFY5.1
#=GS A0A378EBW5_KLEPR/501-574 AC A0A378EBW5.1
#=GS A0A7Y0LAW8_9GAMM/1547-1618 AC A0A7Y0LAW8.1
#=GS D3VAM0_XENNA/334-407 AC D3VAM0.1
#=GS A0A4P7JLL3_9GAMM/345-413 AC A0A4P7JLL3.1
#=GS A0A859RHX0_9ENTR/489-562 AC A0A859RHX0.1
#=GS A0A368NNE3_9GAMM/1548-1623 AC A0A368NNE3.1
#=GS A0A1A6L300_9VIBR/501-565 AC A0A1A6L300.1
#=GS A0A0F7HH58_SERFO/486-559 AC A0A0F7HH58.1
#=GS W7QJJ4_9ALTE/351-418 AC W7QJJ4.1
#=GS A0A1G9HZ93_9PSED/447-514 AC A0A1G9HZ93.1
#=GS K6YWF7_9ALTE/566-632 AC K6YWF7.1
#=GS C9P1U4_VIBME/589-663 AC C9P1U4.1
#=GS A0A5R9QGZ5_9GAMM/451-518 AC A0A5R9QGZ5.1
#=GS A0A4P7JQJ1_9GAMM/537-603 AC A0A4P7JQJ1.1
#=GS W1IQI1_9GAMM/336-409 AC W1IQI1.1
#=GS J2XCV9_KLEPN/501-574 AC J2XCV9.1
#=GS A0A068QQE1_9GAMM/344-417 AC A0A068QQE1.1
#=GS A0A090T6K0_9VIBR/146-219 AC A0A090T6K0.1
#=GS A0A261GL12_9GAMM/1363-1439 AC A0A261GL12.1
#=GS A0A316TZ65_9BACT/345-409 AC A0A316TZ65.1
#=GS W1IW97_9GAMM/381-454 AC W1IW97.1
#=GS A0A3N2R3D5_9GAMM/462-529 AC A0A3N2R3D5.1
#=GS A0A1M5VLE0_9VIBR/616-690 AC A0A1M5VLE0.1
#=GS Q484T3_COLP3/527-593 AC Q484T3.1
#=GS A0A090TR67_9VIBR/644-717 AC A0A090TR67.1
#=GS R9PMK5_AGAAL/493-556 AC R9PMK5.1
#=GS A0A316G0K8_9GAMM/536-602 AC A0A316G0K8.1
#=GS A0A1M5IVC2_9ALTE/548-616 AC A0A1M5IVC2.1
#=GS A0A1D8RTA2_9GAMM/351-417 AC A0A1D8RTA2.1
#=GS A6T4V2_KLEP7/485-558 AC A6T4V2.1
#=GS A0A371QL81_9BACT/397-464 AC A0A371QL81.1
#=GS A0A099L586_9GAMM/576-642 AC A0A099L586.1
#=GS A0A2K8KYF2_9GAMM/473-542 AC A0A2K8KYF2.1
#=GS A0A1D8RT97_9GAMM/571-637 AC A0A1D8RT97.1
#=GS A0A3A6U5T0_9GAMM/530-597 AC A0A3A6U5T0.1
#=GS A7N5R6_VIBC1/492-558 AC A7N5R6.1
#=GS A0A1H7Q530_9GAMM/451-518 AC A0A1H7Q530.1
#=GS A0A2N7DIK8_9VIBR/495-561 AC A0A2N7DIK8.1
#=GS A4B910_9GAMM/481-551 AC A4B910.1
#=GS A0A6N8F7B9_9GAMM/335-401 AC A0A6N8F7B9.1
#=GS A0A2N0VDX7_9BACT/343-421 AC A0A2N0VDX7.1
#=GS R9PFB1_AGAAL/478-546 AC R9PFB1.1
#=GS A0A2V1H064_9GAMM/500-573 AC A0A2V1H064.1
#=GS A0A1G7Y4M8_9VIBR/598-672 AC A0A1G7Y4M8.1
#=GS A0A545UJN7_9GAMM/534-600 AC A0A545UJN7.1
#=GS D3UXA1_XENBS/363-436 AC D3UXA1.1
#=GS T0PBC8_PHOTE/487-560 AC T0PBC8.1
#=GS A0A545TVC3_9GAMM/1168-1244 AC A0A545TVC3.1
#=GS Q87FP0_VIBPA/492-558 AC Q87FP0.1
#=GS A4VNQ8_PSEU5/520-587 AC A4VNQ8.1
#=GS A0A1E7Z8W0_9ALTE/532-600 AC A0A1E7Z8W0.1
#=GS A0A1S8CEC2_9GAMM/522-595 AC A0A1S8CEC2.1
#=GS A0A2K8KU94_9GAMM/471-541 AC A0A2K8KU94.1
#=GS A0A345UK94_9BACT/333-410 AC A0A345UK94.1
#=GS A0A2T3N2N9_9GAMM/653-726 AC A0A2T3N2N9.1
#=GS A0A545TEH6_9GAMM/534-602 AC A0A545TEH6.1
#=GS A0A1E5D2Q8_9VIBR/604-678 AC A0A1E5D2Q8.1
#=GS A0A0A5JQD8_PHOS4/633-707 AC A0A0A5JQD8.1
#=GS A0A1I6GFZ7_9GAMM/469-537 AC A0A1I6GFZ7.1
#=GS N6WQ01_9GAMM/465-532 AC N6WQ01.1
#=GS A0A396U419_9GAMM/577-643 AC A0A396U419.1
#=GS L8JBK5_9GAMM/598-671 AC L8JBK5.1
#=GS B7VQD8_VIBA3/517-583 AC B7VQD8.1
#=GS A0A0J1HG68_9GAMM/590-663 AC A0A0J1HG68.1
#=GS A0A084A0M6_9GAMM/494-567 AC A0A084A0M6.1
#=GS A0A346NSF5_9ALTE/535-603 AC A0A346NSF5.1
#=GS A0A7D5IWM6_9PSED/450-517 AC A0A7D5IWM6.1
D0LWI8_HALO1/381-461 .IATINEDESARVDIDEdgSFGLLC---DQLGASA.vPAGSCTe.dAGKSVRTVLDELlaaSESDgvR.GDTEAIQALVD...AVRGIDAY.................
A0A0Q0P172_9GAMM/536-603 .IATVNEDPAERVDISD..TLGTLC---DKIDDN-..-ADACLtqdKSATIQSILEGT...----..L.PGSKDAQALVN...AMRGYDSF.................
Q7MGB0_VIBVY/600-674 .IATINEDPTKVANINQ..PFAKLCELDASVKNDA.dFGNYCD...SNETLSTVFETL...AKKD..S.KESAVVQRLNS...HVRNLDSF.................
A0A1B7UQB4_9GAMM/530-595 .MATVNEDATKRVDLNN..TVADLCKINATAPV--..----CLm.nATTKLEDVMKGY...----..Q.NSGENAQALAQ...AMRGTDSF.................
A0A7X8YHM5_9VIBR/492-558 .IATVDEDEAKRVDITD..TIGKLCEVNKNAS---..VCGKVD...NASIIEDVLDGY...----..K.PETGDAQALMN...DLRMLDSF.................
K6YE11_9ALTE/576-642 .IATIGEDLTNRVNISD..TVADLCALNSTAPVC-..--GVAD...SSSTLLSVFESY...----..D.PSTSDAQALAN...AMRGLDSF.................
A0A1Y6BJH9_9PROT/548-613 f-ATVNEKRSEQVNLDD..PIDKVCG--PE----N..PPKLCVd.nAGKTFREVFAAA...----..S.KSNGDIQELNA...LLRNRDGF.................
A0A0H3GJK2_KLEPH/436-509 .LATVNEFSDKVADIQQ..PFSRLCEVNSAVKSSE..FAGYCD...SGSTVEEVLTQL...KQND..S.KDNPQVQALNT...LVAQTDSY.................
A0A090II19_9GAMM/659-732 .IATINEDPKKVANIDQ..AFSKLCELNPTIKQSE..FSNYCT...SDGSIADAFAEL...AEVD..S.KNNAKVQELNE...YVRSVDSY.................
A0A0U2ZI01_9ALTE/1364-1438 .ISSVNENPAERIDLDS..PFSALCAVSD----AD.vVQSRCQq.yGDMAIYEVLTEL...KDAD..-.PTTAEIQAITSaenSVQSKDGF.................
A0A0J1JJY1_9GAMM/497-570 .IASINENPDEVANIDE..PFSKLCQVNKDVAGSE..FGQYCD...SELLISEVFDRV...AQDD..T.KENPAVQALNR...YVSSSDSF.................
A0A2S7UUE0_9GAMM/342-409 .ISTVDEDTNSAIDLND..SMTKVCQLYPQLSHC-..-NDQDI...ANKTLKQLLASF...----..D.TRGSQAQDVME...RIRAKDNY.................
I8U5E5_9ALTE/530-596 q-ANINEDANRRINLTD..TIGRLCQLNAQAPVC-..--GVEN...ANATIESVLQSY...----..L.PYESKAQELVQ...SMRAIDGF.................
A0A2N8Z9V1_9VIBR/646-719 .IATINEDPSKVADINE..PFSKLCTVNPATKSSD..FAKYCD...SGSTIAEVFEEI...KASD..S.KETPKVQDLNE...LVRGVDSY.................
D0Z2Y1_PHODD/504-577 .IATIDEDTQQVANIEQ..PFSTLCAINPEVSQST..FSADCQ...SNLTIAEVLERE...QSSD..S.AENPKVQELNR...LISATDSF.................
A0A178K9H3_9GAMM/501-574 .IATINEDPTKVANIND..PFSELCAVNKAVTTSR..FSNYCV...SGLTIAEVLDIE...RDND..T.PTNPVVQELNR...YVSATDSF.................
A0A411PEU9_9GAMM/536-603 .IASVNEDAAERVDISD..TLSKLC---DKIDDN-..-ADACKtedKNATIEEVLAGF...----..I.AGSDDAQNLVN...AMRGYDSF.................
A0A0Q2R312_VIBFU/595-668 .IATINEDPDQVADIDQ..PFSKLCELQPTVSADS.dFGAYCS...SSQTIADVFSAL...-QSD..D.KQTQAVQRLNA...FVRDVDSF.................
A0A1H4DHN4_ALKAM/526-592 q-ANINEDVSQRVEITD..TVGRLCQLNPQAPVC-..-GVESN...SA-TIISVLESY...----..L.PYETKAQALVQ...SMRHLDGF.................
Q487M0_COLP3/392-459 .IATVNEDDSKHLDIDD..SLGKVCAITKNISLC-..-QQPYD...EKQSIKSLLQSY...----..E.VAGEQTQQLVS...ELREVDNY.................
A0A6G8D3I8_9VIBR/595-669 .IATINENPDQVVNLEA..SFSRLCDLNSTIKNDD.dLASYCA...TSNTLQSVFEDL...QQQD..R.QDNAIVQRLNS...YVRDVDGF.................
Q7NA40_PHOLL/489-562 .VASINEFSNEVADLNH..PFSRLCQVNPRVKNSR..FANYCS...GSQTVGEVLQAL...QRGD..N.ANNPQVQELNA...MIAETDSY.................
A0A0C5WL42_9GAMM/500-573 .IATINENPDEAANIEE..SFSKLCEVNTAVKSSK..FAKYCS...SGLTIAEALEEV...KQDD..T.KENPAVQELNR...FVSDVDGF.................
Q6LIJ2_PHOPR/508-581 .IATINEDPDQVANINE..PFSKLCDVNSDVKTSS..FKNDCS...SGLTIAEILERE...QGND..T.AANPSVQELNR...LVSATDSF.................
A0A0S2JD52_9GAMM/385-452 .MATVNEDASKHLDIDD..NLAKVCAITANISIC-..-QQAYN...AEQSIKSLLQSY...----..A.VAGEQAQQLVS...ELRQVDNY.................
A0A553L6G1_9ALTE/535-605 .IATIEEDESRSVGMDS..TVAKLCDLNRRAAIC-..QDASVD...RTQTLQQVFDNI...--SA..V.SNAGEAQELVN...DIRGVDRF.................
A0KFY5_AERHH/505-578 .IATVNEDPAKVANISD..DFGKLCQVNPEVQNSK..FAGYCS...SGQTIEAVLGDL...QGSD..S.KENPQVQELYG...YLRGVDSF.................
A0A378EBW5_KLEPR/501-574 .LATVNEFSDKVADIQQ..PFSRLCEVNSAVKSSE..FAGYCD...SGSTVEEVLTQL...KQND..S.KDNPQVQALNT...LVAQTDSY.................
A0A7Y0LAW8_9GAMM/1547-1618 .IASVNEDRAARVELDD..SVERLCQYS----DDE.vVQSHCAt.aAGLSIAELLTNL...AEQD..-.SATTDVQAIVS...AMDDLDGF.................
D3VAM0_XENNA/334-407 .IASVNEFSHQVADLEQ..SFSHLCQINPAVKNSR..FADYCR...SSLTVREVLQQL...RHDD..N.IKNPQVQELNT...MVANTDSY.................
A0A4P7JLL3_9GAMM/345-413 .IGTVNEVTEQRVSLSD..TVAKLCEIQENHLLC-..SDKSVE...KSQTIASVLQSY...----..D.SQTQHAQAVVS...QLRSVDDY.................
A0A859RHX0_9ENTR/489-562 .LATVNEFSDKVADIQQ..PFSRLCEVNSAVKSSE..FAGYCD...SGSTVEEVLNQL...KQGD..S.QDNPQVQALNT...LVAQTDSY.................
A0A368NNE3_9GAMM/1548-1623 l-GSIREDGTMRADLDD..PYSKLCAL---VTTPA..VQARCGd.fDGLTLGEALTQL...KDAD..-.PLNAEIQAI--...--------lyeprsdaavsvdg...
A0A1A6L300_9VIBR/501-565 .IATVNEE--ETVDIND..TVGDLCDIRPSAVVCD..VE---D...SNATLDSVLQSY...----..D.PTTDQVQLLMN...DLRDLDSF.................
A0A0F7HH58_SERFO/486-559 .LATVNEFSDKVADLTH..PFSRLCELNSAVKQSR..FAGYCG...SSITIGDVLEEL...KQND..S.QDNPQVQELNG...YVAQTDSY.................
W7QJJ4_9ALTE/351-418 l-GTINETPQQVIELDE..SVAELCRMFAEIHLC-..-SRDEI...QQQTIRQVFASM...----..D.PLSSDVQAVVE...KIRGSDPY.................
A0A1G9HZ93_9PSED/447-514 .IATVDEDPARRVDLDD..PFSKLCALSAGVREK-..WSGYCG...GE-RIRNVLERF...----..D.PAGPDAQALYA...DLRALDAF.................
K6YWF7_9ALTE/566-632 .IASIQEDTSQRVDVTD..TVAKLCQLNNTAPVCG..V---EN...NQLTLLQVLESY...----..D.PSTTDAQALVE...SMRAFDGF.................
C9P1U4_VIBME/589-663 .IATINEDPTKVADIDQ..PFSKLCQLQPAVKNDD.dFGHYCS...DSMTISAVFHQL...KGND..T.KQNPVVQRLNS...FVRDVDSF.................
A0A5R9QGZ5_9GAMM/451-518 .IATVDEDPAQRVDIND..PFARLCERSASARET-..WAGYCG...GQ-SIRSVLEGF...----..D.PASGQAQALHD...ALRGLDSF.................
A0A4P7JQJ1_9GAMM/537-603 .IASINEDSDSMVNIND..TVGKLCEM----KSD-..-APVCGvedDNATLLSVLQGY...----..S.PYTNDAAKLID...VLREFDSF.................
W1IQI1_9GAMM/336-409 .IASVNEFSHQVADLDQ..PFSRLCQINPIVRNSR..FAAFCH...SSLTVREVLQQL...RRDD..N.INNPQVQELNT...MVAKTDSY.................
J2XCV9_KLEPN/501-574 .LATVNEFSDKVADIQQ..PFSRLCEVNSAVKSSE..FAGYCD...SGSTVEEVLTQL...KQND..S.KDNPQVQALNT...LVAQTDSY.................
A0A068QQE1_9GAMM/344-417 .IASVNEFSHQVADLEH..PFSRLCQINPEVKNSR..FADYCR...STLTVREVLQQL...LRDD..N.INNPQVQELNT...LVAKTDSY.................
A0A090T6K0_9VIBR/146-219 .IATINEDPNKVADIDQ..PFSRLCDLNPSVKQSK..FASYCN...SGGTIADAFSEL...AQQD..T.KESPVVEELNE...YVRGVDSY.................
A0A261GL12_9GAMM/1363-1439 .LASVKENPDDQVNLDD..PYSRLC---DKVSVPA..VQEGCEe.fGDTSIRDVFTQL...KDAD..-.PVNTRIQAINY...DMR-----tegfpsvdgf.......
A0A316TZ65_9BACT/345-409 .IASVIEDRSERVDLDD..PYRLLC---DRLGIEE..LAEECEr.yGDQPIRDVFEEM...AEND..-.PVTLEIQ----...--------ntlga............
W1IW97_9GAMM/381-454 .IASVNEFSHQVANLEN..PFSRLCQINPTVRNSR..FAEYCH...SSLTLRQVLQQL...KRED..S.IHDPQVQELNA...MVAGTDSY.................
A0A3N2R3D5_9GAMM/462-529 f-ATVNEDPSQVVDIDD..DFSRLCDLSDAAATE-..WADQCS...AG-SIRSVLESF...----..D.PTTGNAQALYD...TLRGLDSF.................
A0A1M5VLE0_9VIBR/616-690 .IATINEDPSQIATIDT..RFSFLCQLDGTIQNDP.dFGHYCT...SDETLASVFQAL...AETD..H.KDNAVVQRLNS...HVRNIDAF.................
Q484T3_COLP3/527-593 .IATIDEDADKIIDLDS..TVLALCKVNFKAPPC-..YQN--L...DDQTLRAVFESY...----..S.PYSNEAVKLTE...AMRDTDSF.................
A0A090TR67_9VIBR/644-717 .IATINEDPNKVADIDQ..PFSRLCELNPSVQQSQ..FAPYCA...SGGTIAEAFEEL...SQND..S.KEDAKVEALNE...YVRGVDSY.................
R9PMK5_AGAAL/493-556 .IATVDEEG--AIDIDA..PLSDLC---DKIQKT-..-DDYCA..dASGTIEAKLESF...----..D.PTTGDAQSLMN...DLRGLDSF.................
A0A316G0K8_9GAMM/536-602 .IATINEFENLIVDVDD..TIGDLCRVNTDASVC-..-GSESE...SS-IIQDVLESY...----..G.PLSEQAQALVN...DMRQYDSF.................
A0A1M5IVC2_9ALTE/548-616 .IATIDEDPANTVDIYD..TVARLC-----VKRP-..NAQVCS...EADPSSTLLDVY...NSYD..PlSEAGSAQALTQ...ELRSLDSF.................
A0A1D8RTA2_9GAMM/351-417 .IGTANENDTQVIDLNN..PISKLCQLVPEHKLCR..LE---D...RAMTIQEYLETL...----..P.AATHERQAIVS...SIREIDNY.................
A6T4V2_KLEP7/485-558 .LATVNEFSDKVADIQQ..PFSRLCEVNSAVKSSE..FAGYCD...SGSTVEEVLTQL...KQND..S.KDNPQVQALNT...LVAQTDSY.................
A0A371QL81_9BACT/397-464 .IASIYENWELRVDLDD..PYSRICEI---VEVEG..LQENCDk.yGDTPIWEVFEQM...ADED..-.PITKEIQRTY-...--------aerge............
A0A099L586_9GAMM/576-642 .IASINEDSATRVNLTD..SVADLCA------QND..SAPVCG...VEDDAATLLSVF...ESYD..-.ASTTDAQALLQ...SMRGLDSF.................
A0A2K8KYF2_9GAMM/473-542 .IATINESAEQQVKLDD..PVSRLCQLSPSMQTSS..FAEHCQ...SDQSIASLLRSL...----..P.GDSEQQQALMA...YIRPLDSF.................
A0A1D8RT97_9GAMM/571-637 .IASINEDTVNRINLDN..TVSELCAK----KSD-..-APVCGvenASDTLAEVFASY...----..D.PTSTAAQALAE...SLRGLDSF.................
A0A3A6U5T0_9GAMM/530-597 .IASINEDVSERIDIND..TLGELCDI---IDNN-..-ANACK...TESHTSTIIDLL...-EGS..L.SGSGDAQALVE...AMRSMDSF.................
A7N5R6_VIBC1/492-558 .IATVDENAANRVDITD..TVGKLCDIKPAASIC-..--ETED...DAKIIEDVLNSY...----..D.PATGAAQALMN...DLRMLDSF.................
A0A1H7Q530_9GAMM/451-518 .IATVDENPAQQVNLDD..SFSKLCELSPQAAED-..WASYCN...SG-TIRQALERF...----..D.PAGPEAQALHS...VLRNVDGF.................
A0A2N7DIK8_9VIBR/495-561 .IATVDENPQTRVEITD..SVEKLCSIKPDATVC-..--DEVG...SEVIIEDLLTSY...----..D.PTTTDAQALMN...DLRALDGF.................
A4B910_9GAMM/481-551 .IATIDEDDTMRVDITD..TLANYCALSTAAEAKAlaLSLNCD...TT-IIQDALATF...----..D.TSTGEAQDFYS...HLRGVDSF.................
A0A6N8F7B9_9GAMM/335-401 l-STINEDPAQAIDLSD..SMTKVCDL---VDDLS..ICDEDV...KDKSLNELLSSY...----..D.PRSDKAQDLME...KIRGYDNY.................
A0A2N0VDX7_9BACT/343-421 .IASIKEDTNNRVDLDD..PFNRICEI---IGTND.qLAEDCEk.yGTTPIREVFESL...-SED..D.PTTLEIQRIYR...--------spehenkladydgf...
R9PFB1_AGAAL/478-546 .IATVDEV--NRVDIDG..TIGELCELNANAGVC-..-EDGTD...KSAVIEDVLQAY...-VDE..N.PATEKVQALVN...DLRQYDSF.................
A0A2V1H064_9GAMM/500-573 .LATVNEFTDKVADLPQ..PFSRLCELNSAVRQSR..FADYCS...SASTIGEVLNKL...KQDD..S.KDNPQVQELNG...YVSQTDSY.................
A0A1G7Y4M8_9VIBR/598-672 .IATINEDPDQVANIDA..SFSKLCELNSDVSSDS.dLGNYCS...SADTLAEVFASL...KAQD..S.SSNAIIQRLNG...YVRDVDGY.................
A0A545UJN7_9GAMM/534-600 .IASIGEDPANIVDIDD..TVGDLCAANADAPVC-..-GVES-...DSATILSVLQSY...----..A.PYSEDAQALVN...SMRGLDSF.................
D3UXA1_XENBS/363-436 .IASIDEFSRNVADLNQ..SFNRLCQVNTTVKNSR..FADYCN...RSMTVREVLQAL...QRGD..S.ASNPQVQELNK...MLAETDSY.................
T0PBC8_PHOTE/487-560 .LASVNEFSDQVADLNH..PFSRLCQVNTMVRNSR..FADYCN...SSQTVGEVLQEL...RSGD..S.ASNPQVQELNA...MIAETDSY.................
A0A545TVC3_9GAMM/1168-1244 l-GSIRENPADRVELDD..PYSRLCEKTNVIAIE-..--EGCAq.yGDTPIRQVYEQL...RAAD..-.PLNTDIQAINY...--------ddrtlgfpavdsf....
Q87FP0_VIBPA/492-558 .IATVDEEAANRVDITD..TVGKLCGIKPEAS---..VCDEVD...GAKVIEDVLNSY...----..D.PATGSAQALMN...DLRMLDSF.................
A4VNQ8_PSEU5/520-587 .IATIDEDPARRINLDD..PFAKLCDLSDQARQR-..WAQYCS...AA-SIRQVLQGF...----..D.PASGQAQSLYD...DLRGLDDF.................
A0A1E7Z8W0_9ALTE/532-600 .IASVDENPANVVNIND..TIGDLCRLNRNAAIC-..-EEEP-...EGTVIKDLLESY...--DP..A.SEGGKAQALID...QMRGYDSF.................
A0A1S8CEC2_9GAMM/522-595 .LATVNEFSDKVADLPQ..PFSRLCELNSAVKQSR..FADYCN...SASTIGEVLNAL...KQDD..S.KDNPQVQELNG...YVSQTDSY.................
A0A2K8KU94_9GAMM/471-541 .IATIDEDASARVDIDD..TLADYCAISSAAQAKAleLGLTCD...ST-LISAALASL...----..N.PTTGAAQDFYV...YLRPQDSF.................
A0A345UK94_9BACT/333-410 .ITTVIENRDLRIDLDQ..PYSRLCEQMPD--ADS..LKPYCEr.fGDTPIYEAFQTL...AAED..-.PANTSIQ----...--------lpysirgryhslarmdg
A0A2T3N2N9_9GAMM/653-726 .IATINEDPEKVANIDQ..PFSKLCEVNPAVKTSE..FSSYCT...SGNTIADVFAEL...AEAD..T.KDNAKVEALNE...YVRSVDSY.................
A0A545TEH6_9GAMM/534-602 .IASINEDASRIVDIND..TVADLCAVNEN-----..-AQVCS..dLGATNTTVLQDL...FESY..L.PSSADAQTLAN...DMRGYDSF.................
A0A1E5D2Q8_9VIBR/604-678 .IATINEDPSQVANIDQ..PFSKLCSLKPEIKNDD.kFKEYCD...SGNTIAEAFEEL...QTED..N.KDNAVVEALNE...YVRAVDSY.................
A0A0A5JQD8_PHOS4/633-707 .IATINEDPDKVANIDQ..PFSKLCDLNTAVKSDA.eFSQYCS...GDQTIAEVFETI...LPDD..R.LQNPVVQRLND...YVRSVDSY.................
A0A1I6GFZ7_9GAMM/469-537 .IATINEDPAEVVDIDD..PFSRLCDLSDEAAVS-..YASFCS...SGQSIRQVLAGF...----..D.PLTGNAQALYN...TFRGLDSF.................
N6WQ01_9GAMM/465-532 .IATVNEDPSKVVDIED..DFNQLCSLSEEAATR-..WADKCS...AG-TIRSVLASF...----..D.PATGDAQALYS...TLRGIDSF.................
A0A396U419_9GAMM/577-643 .IASINEDNAKTVNLTD..TVADLCAVNSAAPVCG..VED---...NSATLFAVMESY...----..S.SNSESAQALVE...AMRGIDSF.................
L8JBK5_9GAMM/598-671 .IATINEDPAKVAEIDQ..PFSKLCDVNSGVKESR..FKQYCS...SEKTIADVLETI...KADD..S.PSNPVVQELNR...FVSQTDGF.................
B7VQD8_VIBA3/517-583 .IATINEDDASRVDITD..TVSKLCNVKPTATLC-..--GTED...ENKTIEAVLNSY...----..N.SSTGDAQALMN...DLRMLDSF.................
A0A0J1HG68_9GAMM/590-663 .IATINEDPAATANIDA..PFSKLCTVNPAVTSSS..FGSYCT...SGKLISEVLSDL...RQED..T.PDNPVVQQLNR...FISETDGF.................
A0A084A0M6_9GAMM/494-567 .LATVNEFTDKVADLPQ..PFSRLCELNSAVRQSR..FADYCN...SASTISEVLNQL...KADD..S.QDNPQVQELNG...YVSQTDSY.................
A0A346NSF5_9ALTE/535-603 .IATIEEDPTKTVNLYS..SVAQLCQLNASA----..--AVCA...EEDAERQLIDVY...QSYD..PiSEQGKAQALTQ...QLQDIDTF.................
A0A7D5IWM6_9PSED/450-517 .LATVDEDPAQRVDLDD..PFARLCERSPRARQQ-..YAAYCA...AG-SVREVLQRF...----..D.PAGSEAQALYG...LLRDLDSF.................
#=GC seq_cons .IATlNE-ssphlDlsc..shu+LCplsstspss...hushCs...ustTIppVLpsh.........s.sssspsQtLss...hlRshDSa.................
//
