#=GF ID REC1
#=GF AC PF18501.5
#=GF DE Alpha helical recognition lobe domain
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE ECOD:EUF06452
#=GF GA 37.40 37.40;
#=GF TC 37.50 50.50;
#=GF NC 35.40 24.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 28431230
#=GF RT Structural Basis for Guide RNA Processing and Seed-Dependent DNA
#=GF RT Targeting by CRISPR-Cas12a.
#=GF RA Swarts DC, van der Oost J, Jinek M;
#=GF RL Mol Cell. 2017;66:221-233.
#=GF DR INTERPRO; IPR040787;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC Cpf1 is an RNA-guided endonuclease of a type V CRISPR-Cas
#=GF CC system. Cpf1 adopts a bilobed architecture consisting of an
#=GF CC alpha-helical recognition (REC) lobe and a nuclease (NUC) lobe,
#=GF CC with the small CRISPR RNAs (crRNAs)-target DNA heteroduplex
#=GF CC bound to the positively charged, central channel between the two
#=GF CC lobes. The REC lobe consists of the REC1 and REC2 domains where
#=GF CC REC1 comprises 13 alpha helices, and REC2 comprises ten alpha
#=GF CC helices and two beta strands that form a small antiparallel
#=GF CC sheet [1]. This entry represents REC1 domain.
#=GF SQ 38
#=GS A0A133Y4S8_9BACT/43-294 AC A0A133Y4S8.1
#=GS A0A373ACR6_9FIRM/57-292 AC A0A373ACR6.1
#=GS A0A2S0VW63_9ALTE/129-405 AC A0A2S0VW63.1
#=GS A0A0E3UUN7_9FUSO/50-253 AC A0A0E3UUN7.1
#=GS A0A5B7UHU0_9FLAO/1-98 AC A0A5B7UHU0.1
#=GS A0A0D6TKF1_9FLAO/45-290 AC A0A0D6TKF1.1
#=GS C4Z1Q1_LACE2/53-288 AC C4Z1Q1.1
#=GS R7NIP4_9FIRM/6-231 AC R7NIP4.1
#=GS A0A328EF35_9BACT/48-301 AC A0A328EF35.1
#=GS A0A5B7UI06_9FLAO/45-132 AC A0A5B7UI06.1
#=GS A0A2X4PJM6_9PORP/48-314 AC A0A2X4PJM6.1
#=GS G2Z495_FLABF/46-292 AC G2Z495.1
#=GS A0A2P2E441_9LEPT/48-303 AC A0A2P2E441.1
#=GS A0A066UMX8_9GAMM/47-299 AC A0A066UMX8.1
#=GS R9KJ83_9FIRM/53-287 AC R9KJ83.1
#=GS A0A1T4KTI7_TREPO/51-302 AC A0A1T4KTI7.1
#=GS H3NP38_9FIRM/46-311 AC H3NP38.1
#=GS M9SJC9_METAX/47-279 AC M9SJC9.1
#=GS A0A1D9P5I8_9FIRM/66-296 AC A0A1D9P5I8.1
#=GS R7NAK7_9FIRM/57-290 AC R7NAK7.1
#=GS A0A1T4JZ89_9FIRM/82-325 AC A0A1T4JZ89.1
#=GS A0A4R9C145_9FIRM/57-322 AC A0A4R9C145.1
#=GS A0A7T3RDH8_9SPIR/51-307 AC A0A7T3RDH8.1
#=GS A0A7J0AY55_9BACT/47-265 AC A0A7J0AY55.1
#=GS E0S4L0_BUTPB/48-276 AC E0S4L0.1
#=GS A0A2W4J069_9BACT/66-354 AC A0A2W4J069.1
#=GS A0A4Y9J6K2_9LACT/44-212 AC A0A4Y9J6K2.1
#=GS A0A328EL15_9BACT/48-304 AC A0A328EL15.1
#=GS A0A1Q2MH85_9BACT/51-308 AC A0A1Q2MH85.1
#=GS A0A388TJE5_9BACT/50-277 AC A0A388TJE5.1
#=GS A0A091FHB8_9DELT/49-289 AC A0A091FHB8.1
#=GS A0A840SFS7_9SPIR/49-300 AC A0A840SFS7.1
#=GS A0A328EET9_9BACT/165-394 AC A0A328EET9.1
#=GS D7JGI7_9BACT/48-295 AC D7JGI7.1
#=GS A0A0A7LCY1_9ARCH/48-285 AC A0A0A7LCY1.1
#=GS A0A2W4IMZ0_9BACT/56-296 AC A0A2W4IMZ0.1
#=GS D8E0G1_PREBR/57-300 AC D8E0G1.1
#=GS A0A073IR12_9BACT/49-291 AC A0A073IR12.1
A0A133Y4S8_9BACT/43-294 ................QEVKKLLDRYHKEFIAIALSS..FPT.........SPLAKEIIPKLKEfaq......iraTGDAKQISTIQDELRELVVK.GFKG..................eGEQERRYKILIG...AKGNPnad...................elfnTELINFLK---.--.DPAEQAL.......VKKFQKHTGYFLGFNENRKNMYS.AK......AQSTAIAYRLIHENLPRFLDNITTYEKVKTYLKEEIPQLE..........KELVRA..GA...-SLVSHV......DSVFTIDFFLEVF......TQSGIDQYNALIG-KIVNQEQGEVKGLNERINLYNQ.QHKQ.EAK--...LPLFKPLYKQI.............................
A0A373ACR6_9FIRM/57-292 ...............e-ELKGIMDDYYRNYIEMHLRD..VHDi......dwNELFEALTEVKKNq..........tDDAKKRLEKIQEKKRKEIYQ.YLSD...................---DAVFSEMFK...EKMIS..........................GILPDFIRCNE.EY.SEEEKEKkl...ktVALFHRFTSSFNDFFLNRKNVFT.KE......AIATAIGYRVVHENAEIFLENMVAFQNIQKSAESQISIIE..........RKN---..EH...YFMEWKL......SHIFTADYYMMLM......TQKAIEHYNEMCG----------V--VNQQMKEYCQ.KEKK.--NWN...LYRMKRLHKQI.............................
A0A2S0VW63_9ALTE/129-405 tdlfdkkfedwayqyk----------------EDMPN..FWR.........QDIAELEQKLQVSa..........nAKDQKFYKGIIKKLKNKIQKsELKA...................ETHKGLYSPTES...LQLLEwlv...................rrgdIKLTYLEIGKE.NE.KLNELVPlvelkdiHRNFNNFATYLSGFSKNRENVYS.TKfdrrsgYKATSVIARTFEQNLMFCLGNIAKWHKVTEFINQ-ANNYEllqehgidwnKQIAAL..EH...-KLDVCL......AEFFALNNFSQTL......AQQGIEKYNQVLAGIAEIAGQPKTQGLNELINLARQ.KLSA.-KRSQ...LPTLQLLYKQI.............................
A0A0E3UUN7_9FUSO/50-253 ..............fe--AKKIMTKYYLKVLDEILSE..ISV.........-DWKKLYNDLL--............---NKEKKEIDELLQKEIEK.KFKD...................---YPGIKNIFS...GKCIE..........................----DIKESPD.FN.EDEKRK-.......VEKFDKKTTYFTAYFKNIKNIFT.VN......GKSASAIYRIA-DNFKKYSKNVELYEKLKKDEK-----IM..........KYLNEN..K-...-FDEKTM......DNLFDVSKYNSYL......RQVDIEKYNTLLSGYSKENGE-KVKGLNELINEI--.----.-----...-----------hv...........................
A0A5B7UHU0_9FLAO/1-98 ................---------------------..---.........-------------............--------------------.----...................------------...-----..........................-----------.--.-------.......--------------------MYS.DK......EQSTAIAYRLIHENLPKFLDNIKIFERLKDIP-ELYEKCA..........DIYRDI..EE...YLNIREI......DEAFELDYFNEVL......TQKEIDVYNLIIGGRSPKEGEEKYKG----------.----.-----...-----------.............................
A0A0D6TKF1_9FLAO/45-290 ................QKMKKTIDEFHKYFIDLALNN..KKL.........SYLNEYIALYTQSaea......kkeDKFKADFKKVQDNLRKEIVS.SFTE...................GEAKAIFSVLDK...KELIT..........................IELEKW---KN.EN.NLAVYL-.......DESFKSFTTYFTGFHQNRKNMYS.AE......ANSTAIAYRLIHENLPKFIENSKAFEKSSQIAE-LQPKIE..........KLYKEF..EA...YLNVNSI......SELFEIDYFNEVL......TQKGITVYNNIIGGRTATEGKQKIQGLNEIINL-YN.QTKP.-KNER...LPKLKQLYKQI.............................
C4Z1Q1_LACE2/53-288 ...............t-ELKNIMDDYYREYIDKSLSG.vTDLd.......fTLLFELMNLVQSSp..........sKDNKKALEKEQSKMREQICT.HLQS...................---DSNYKNIFN...AKLLK..........................EILPDFIKNYN.QY.DVKDKAGkl...etLALFNGFSTYFTDFFEKRKNVFT.KE......AVSTSIAYRIVHENSLIFLANMTSYKKISEKALDE---IE..........VIEKNN..QD...KMGDWEL......NQIFNPDFYNMVL......IQSGIDFYNEICG----------V--VNAHMNLYCQ.QTKN.NY--N...LFKMRKLHKQI.............................
R7NIP4_9FIRM/6-231 ................KRIKEYISKYLADESDKCLSQ.pIKL.........KHLDEYYELYITK............DRDEQKFKSAEEKLRKELAD.FLKE...................-----ILKRLNK...KILND..........................-YLPEYLEDDE.KA.LED----.......IAKLSSFSTYFNSYYDNCKNMYT.DK......EQSTAIPYRCINDNLPKFIDNMKAYEKALEELK--PSDLE..........ELRNNF..KG...V-YDTTV......DDVFTLDYFNCVL......SQSGIDTYNAIIG-------NDKVKGINEYINL-HN.QTAQ.-QGHK...VPNLKRLYKQI.............................
A0A328EF35_9BACT/48-301 ................QELKPLFDALHNKFIAESLEN..SQIn......weSYFDHLKAKKSDFsd.......sekKKWEKDFEKIEKNLREEIGK.LYEKtaerw........kleineNPKKPILKDKSY...KILTE..........................SGILKVL---K.KI.FPDKQEF.......IDEFEGFFTYFSGFNQNRENYYTtKE......EKSTAIATRIVHENLPKFVANREAFKKHEEKYLEMYDKLN..........SKSRQI..RD...KKTGEMInisaitEDIFEIPFFNRAL......SQAGIDDYNRLIG------------HYNELINLYN-.QEFG.---EK...LPLFKILYKQI.............................
A0A5B7UI06_9FLAO/45-132 ................QKMKKTIDEFHKYFIDMALSN..VSL.........SLLDEFHNLYFASier......kkeDSYKKKLEKVQASLRKEIAE.GFKT...................GEAKEIFSKISK...KNS--..........................-----------.--.-------.......-----------------------.--......----------------------------------------..........------..--...-------......-------------......------------------------------------.----.-----...-----------sqsysn.......................
A0A2X4PJM6_9PORP/48-314 ...............r-RVKKIIDTYHKVFIDSSLEN.mAKMgie..neikAMLQSFCELYKKDh.........rtEGEDKALDKIRAVLRGLIVG.AFTGvcg............rrenTVQNEKYESLFK...EKLIK..........................EILPDFVLSTE.AE.SLPFSVEea..trsLKEFDSFTSYFAGFYENRKNIYS.TK......PQSTAIAYRLIHENLPKFIDNILVFQKIKEPIAKE---LE..........HIRADF..SAggyIKKDERL......EDIFSLNYYIHVL......SQAGIEKYNALIG-KIVTEGDGEMKGLNEHINLYNQ.QRGR.--EDR...LPLFRPLYKQI.............................
G2Z495_FLABF/46-292 ................QEMKKTIDKFHKYFIDLALSN..AKL.........THLETYLELYNKSaet......kkeQKFKDDLKKVQDNLRKEIVK.SFSD...................GDAKSIFAILDK...KELIT..........................VELEKWFENNE.QK.--DIYF-.......DEKFKTFTTYFTGFHQNRKNMYS.VE......PNSTAIAYRLIHENLPKFLENAKAFEKIKQVES-LQVNFR..........ELMGEFgdEG...LIFVNEL......EEMFQINYYNDVL......SQNGITIYNSIISGFTKNDI--KYKGLNEYINN-YN.QTKD.-KKDR...LPKLKQLYKQI.............................
A0A2P2E441_9LEPT/48-303 ................KIVKKIIDRYHKDFIDLAFES..AYLqk....kssDSFTAIMEASIQSysely.fikeksDRDKKAMEEISGIMRKEIVE.CFTGk................ysEVVKKKFGNLFK...KELIK..........................EDLLNFCE---.--.-PDELPI.......IQKFADFTTYFTGFHENRENMYS.NE......EKATAIANRLIRENLPRYLDNLRIIRSIQGRYKDF--GWK..........DLESNL..KR...IDKNLQY......SDFLTENGFVYTF......SQKGIDRYNLILGGQSVESGE-KIQGLNELINLYRQ.KNQL.-DRRQ...LPNLKELYKQI.............................
A0A066UMX8_9GAMM/47-299 ................QKVKVILDDYHRDFIADMMGE..VKL.........TKLAEFYDVYLKFrkn......pkdDELQKQLKDLQAVLRKEIVK.PIGN..................gGKYKAGYDRLFG...AKLFKdg.....................kelGDLAKFVIAQE.GE.SSPKLAH.......LAHFEKFSTYFTGFHDNRKNMYS.DE......DKHTAIAYRLIHENLPRFIDNLQILTTIKQKHSAL---YD..........QIINEL..TA...--SGLDV......SLASHLDGYHKLL......TQEGITAYNTLLGGISGEAGSPKIQGINELINSHHN.QHCH.-KSER...IAKLRPLHKQI.............................
R9KJ83_9FIRM/53-287 ................KSVKKIIDAYHKYFIDEALNG..IQL.........DGLKNYYELYEKKr..........dNNEEKEFQKIQMSLRKQIVK.RFSE...................---HPQYKYLFK...KELIK..........................NVLPEFTK---.-D.NAEEQTL.......VKSFQEFTTYFEGFHQNRKNMYS.DE......EKSTAIAYRVVHQNLPKYIDNMRIFSMILNTDI--RSDLT..........ELFNNL..KT...KMDITIV......EEYFAIDGFNKVV......NQKGIDVYNTILGAFST-DDNTKIKGLNEYINLYNQ.KNKA.----K...LPKLKPLFKQI.............................
A0A1T4KTI7_TREPO/51-302 ................KDVKIILDNYHKYFIDDVLQK..VNLd.......wTKLAASITDYNKN............KEDDSSVIKEQDFLRKEIVK.IISK...................DKRFACLTASTP...KDLFN..........................SILLEWFEKST.EF.SLNKKA-.......VETFKRFSSYFKGFQENRKNMYK.DE......PIPTAVPYRIVNENFPKFLQNAESFKEIQKKCPEV---IE..........LVEKEL..SA...YLGNDKL......SDIFCVKNFNRYLcqtgaeNQRGIDYYNQIIGGIVQKENDVKLRGINEFLNLFWQ.QHVD.FAKDN..rRIKFVPLYKQI.............................
H3NP38_9FIRM/46-311 ...............p-ILKNISDDYYRQYIKEKLSD..LNLd.......wQKLYDAHELLDSS...........kKESQKNLEMIQAQYRKVLFN.ILSGeldksge.....knskdliKNNKALYGKLFK...KQFIL..........................EVLPDFVNNND.SY.SEEDLEG.......LNLYSKFTTRLKNFWETRKNVFT.DK......DIVTAIPFRAVNENFGFYYDNIKIFNKNIEYLENKIPNLE..........NELKEA..DI...LDDNRSV......KDYFTPNGFNYVI......TQDGIDVYQAIRGGFTKENGE-KVQGINEILNLTQQ.QLRR.KPETKnvkLGVLTKLRKQI.............................
M9SJC9_METAX/47-279 ...............p-RAKELLDDNHRAFLNRVLPQ..IDMd.......wHPIAEAFCKVHKNp.........gnKELAQDYNLQLSKRRKEISA.YLQD...................---ADGYKGLFA...KPALD..........................-EAMKIAK-EN.GN.ESDIEV-.......LEAFNGFSVYFTGYHESRENIYS.DE......D-MVSVAYRITEDNFPRFVSNALIFDKLNESHP-------..........DIISEV..SG...NLGVDDI......GKYFDVSNYNNFL......SQAGIDDYNHIIGGHTTEDG--LIQAFNVVLNLRHQ.KDPG.FEKIQ...---FKQLYKQI.............................
A0A1D9P5I8_9FIRM/66-296 ................ERLKPVIDSFIRSTASRALSD..VDY.........-DFNAMHDAYI--............NKDKKSWAKEEKALKKVLMK.AVDE..................aLPKGLKCSQINS...AAFLQ..........................EVLREYVLHAT.DT.ELRKDVAl....kdIEETKGCLALFSKFLTTRITAL-.--......--TVWMPERVI-ENFKIYCSNIPRIEAIFNEAKDI-----..........--A---..--...NNYSDEL......ELMKTAQYYTKIL......SQDAIDGYNLVIAGKITENGI-ETKGLNVLINEYNI.DVKN.QKLDKp.yLRKINQLYKQ-t............................
R7NAK7_9FIRM/57-290 ...............l-ELKKIADEYYRNYITHKLND..INNld.....fyNLFDAIEEKYKKN...........dKDNRDKLDLVEKSKRGEIAK.MLSA...................---DDNFKSMFE...AKLIT..........................KLLPDYVERNY.TG.EDKEKALe.....tLALFKGFTTYFKGYFKTRKNMFS.GE......GGASSICHRIVNVNASIFYDNLKTFMRIQEKAGDEIALIE..........EEL---..TE...KLDGWRL......EHIFSRDYYNEVL......AQKGIDYYNQICG------------DINKHMNLYCQ.QNKF.KAN--...IFKMMKIQKQI.............................
A0A1T4JZ89_9FIRM/82-325 ...............i-KVKGYMDEYHKNFIESALNS..VVL.........NGVDEYCELYFKQn.........ksDSEVKKIESLEASMRKQISK.AMKEy.................tVDGVKIYPLLSK...KEFIR..........................ELLPEFLT---.-Q.DEEIET-.......LEQFNDFSTYFQGFWENRKNIYT.DE......EKSTGVPYRCINDNLPKFLDNVKSFEKVILALP--QKAVD..........ELNANF..NG...V-YNVDV......QDVFSVDYFNFVL......SQSGIEKYNNIIGGYSNSDAS-KVQGLNEKINLYNQ.QIAKsDKSKK...LPLLKPLYKQI.............................
A0A4R9C145_9FIRM/57-322 ...............p-ILKNIADDYYRQYIRNRLTD..LNLd.......wIKLYYAHELLNST...........dKESKKNLTTIQSEYRKILLN.ILSGeldknge.....kfskdivKKNKELYGKLFK...KEFIL..........................EILPKFVETTN.IY.NKEYFNG.......INLYNKFTTRLSNFWEARKNIFT.DK......DIATGIPFRVVNENFVYFYKNIQVFNKNIKYLEDKLDNLE..........KNLKSE..GI...MSIDKSI......KDFFNPNGFNYVI......TQKGIDTYQAIRGGFTKENGE-KVQGINEILNLTQQ.KLRR.NPYTKnikLGVLTKLRKQI.............................
A0A7T3RDH8_9SPIR/51-307 ...............v-EVKNLIDDFHRSFIAERLDK..VSLd.......wTNLFNALNEYQKNqkd.....kllkAKCKKVLEAQQKEMRKKIVQ.LFTGd.................kDNKDPVYEKLFK...KELIE..........................DLLPEAIKKDT.SGiITQKEEA.......LAKFHQFCTYFTNFHENRKTIYS.AE......DKSTAISNRIVNENFPKYVANIKVFEYLSKNFPKI---ID..........DTENQL..KN...DLSGKKL......KDIFTINGFNNVL......SQKGIDFYNIIIGGIPEKEGIPRKQGINEAINLLRQ.GLPP.ERKNE..lKQRMTFLYKQI.............................
A0A7J0AY55_9BACT/47-265 ..............vh--IKKLIDEYHKAYIDKQLSG..LVLqyad.igkaNSLEEYYHSTRKS...........kDSDKDKIVKIQDNLRKQIVK.RLKD...................---SDEFKRIDK...KELIQ..........................SDLAEFIK---.--.PAEDRAL.......IAEFKNFTTYFTGFNENRQNMYS.DK......AISTAIAYRLIHENLPKFIDNIETFDRIAGITE-L---YD..........------..--...--QTSSD......AEIFRLEHFSETL......SQKQIDAYNSVMG---------R---YNMLINEYNQ.THKQ.---SR...LPKFKMLYKQI.............................
E0S4L0_BUTPB/48-276 ................ERLKPVIDEGIKDIARDTLKN..CEL.........-SFEKLYEHFL--............SGDKKAYAKESERLKKEIVK.TLIKn.................lPEGIGKISEINS...AKYLN..........................GVLYDFIDKTH.KD.SEEKQNIl....sdILETKGYLALFSKFLTSRITTL-.--......--EQSMPKRVI-ENFEIYAANIPKMQDALERGA-------..........------..--...VSFAIEY......ESICSVDYYNQIL......SQEDIDSYNRLISGIMDEDGAKE-KGINQTISEKNI.KIKS.EHLEEk.pFRILKQLHKQI.............................
A0A2W4J069_9BACT/66-354 ................KKIKPFLDKLHTIFINESLKD..LKL.........-DFGNTETKFL--............EWQKENDKTKKDKLKEEIFG.KNGKggifgkl....rndinkkfEKNGKNWKDLYE...KKLTVtdekgkekkikikgegykillsdtnlDILSDIFSEEKeGE.NVLIENIkgekvnlFKSFKGFTTYFSNFNNSRENFYK.DD......GKAGRIATRIIDENLIFFLKNKKNFDEKFKNENYFSIEMN..........KVLENF..G-...----ENL......NDFFSLEFYNKCF......TGTQIEYYNQIIGELNSVINSKKQADYSKHIQDKKEkKDTE.FKKQN...YPLFRELYKQI.............................
A0A4Y9J6K2_9LACT/44-212 ..............ey--MQSLFDDDFKKLIDETLAL..ISL.........D--QDLLTEVF--............SEDTSIKERASEQLKNYIKS.FFDT...................------SSPLFS...PDKHL..........................----KLLE---.-Q.SYPTDDT.......IRLFKGFSTYFKKFFDTRKRIFS.EI......T-HGTIAYRLIDENLVIFKKNIDKFNMLPDELKQQL----..........------..--...-------......-------------......------------------------------------.----.-----...-----------lsigghkinalhlyssyltsynivkyrfy
A0A328EL15_9BACT/48-304 ................EKVKPYFNKIHQEFINFALRN..PNFd.......fSQFEEKYLNWL-K............DKKNKDLLKEKESIDKIFLE.KIGKlfensvkdflkengfesivKEEDQNLKFFRR...KEIFEvl......................qeKYGSELETQMV.NK.DGEIKSI.......FNGWEKWLGYFDKFFNTRDNFYK.TD......GTSTAIATRIIKDNLQIFLENTVVFDKIKNKEINF-----..........---SEV..EK...-IFSIDV......NLFFEINNFNNYF......LQDGIDSYNKIIGGETLENGE-KLKGLNEIINKYRQ.DTG-.---EK...IPYFKKLQKQI.............................
A0A1Q2MH85_9BACT/51-308 ................KKMKRILDDYHKEFIEEVLNDdiF-T........aNEMESAFEVYRKYmas......kndDKLKKEITEIFTDLRKKIAK.AFENks..............keyCLYKGDFSKL--...--INEkktgkdkgpg.....klwywlkakadAGVNEFGD-GQ.TF.EQAEEA-.......LAKFNNFSTYFTGFNQNRDNIYT.DA......EQQTAISYRVINENMTRYFDNCIRYSSIENKYPEL-----..........--V---..--...-KQLEPL......SGKFAPGNYKDYL......SQTAIDIYNEAVG---HKSDDINAKGINQFINEYRQ.RNSI.-KGRE...LPIMSVLYKQI.............................
A0A388TJE5_9BACT/50-277 ................KEVKKIIDEYHKEFIARVLSG.vTNL.........KNLRNFYNLYKTSke.......kqdTGFDKKFENAQKLLRKEIVD.VFKK...................---DEQYQKLFK...KELIQ..........................ELLPEFIS---.-K.DIPKEKL.......VEGFQRWTTYFKGFNENRQNMYS.DE......DKATAIAYRIVNENLPKFIDNLKVYKDIKSKIK-------..........------..--...--TTAKS......DQVFSLEYFVHVL......TQYGIDEYNAVIGGIPAEAGKEKIKGLNEDINLYNQ.KQDD.-KKNR...LPKFKQLYKQI.............................
A0A091FHB8_9DELT/49-289 ................KKVKNIIDEYHKDFIEKSLNG..LKL.........DGLEEYKTLYLKQe.........kdDKDKKAFDKEKENLRKQIAN.AFRN...................---NEKFKTLFA...KELIK..........................NDLMSFACEED.KK.N------.......VKEFEAFTTYFTGFHQNRANMYV.AD......EKRTAIASRLIHENLPKFIDNIKIFEKMKKEAPELLSPFN..........QTLKDM..KD...VIKGTTL......EEIFSLDYFNKTL......TQSGIDIYNSVIGGRTPEEGKTKIKGLNEYINTDFN.QKQT.DKKKR...QPKFKQLYKQI.............................
A0A840SFS7_9SPIR/49-300 ................KAVKKIIDNYHKYFIDDVLKN..ASFt.......wTKLEEAIKEYNKN............RNDDSVVENEQKKLREEILK.LFTS...................---DKRYKALTAatpKDLFD..........................TILPEWFGENS.NP.DLNKTA-.......LKTFQKFTSYFTGFQENRKNVYS.AE......PIPTAVPYRIVNDNFPKFLQNISIFKTIQEKCPQV---ID..........DVEKEL..SS...YLGKEKL......ADIFTLESFNKYLgqggkeNQRGIDFYNQIIGGIAEKEGEQNLRGINQFLNLYWQ.QNPE.FAKEN..rRIKMVPLYKQI.............................
A0A328EET9_9BACT/165-394 ..kengykilteagil---------------------..---.........KVLKKIFENETEI............KNLVKENSKAIEMMENKFIF.YLKKienekdf....swwasintGENEKNFDKNQA...KKYLE..........................EILEKIYKKDL.KE.IQ-KQVLd.....vINNLNDFWTYFSAFNNNRENYYS.SE......NKSTAVANRIVNENFITFIGNINNLEKIDISLS-------..........------..--...----NQE......DEIFKIENYNKYL......SQEGIDEYNEIIGGKKDEKGVRIEDGINQRLNEYSQ.KNNK.-EKI-...--QLKPLYKQI.............................
D7JGI7_9BACT/48-295 ...............v-KVKKIIDKYHKCLIDEALSG..FTFdteadgrsnNSLSEYYLYYNLKk.........rnEQEQKTFKTIQNNLRKQIVN.KLTQ...................---SEKYKRIDK...KELIT..........................TDLPDFLT---.-N.ESEKEL-.......VEKFKNFTTYFTEFHKNRKNMYS.KE......EKSTAIAFRLINENLPKFVDNIAAFEKVVSSPL--AEKIN..........ALYEDF..KE...YLNVEEI......SRVFRLDYYDELL......TQKQIDLYNAIVGGRTEEDNKIQIKGLNQYINEYNQ.QQTD.-RSNR...LPKLKPLYKQI.............................
A0A0A7LCY1_9ARCH/48-285 ................KILKEAIDEYHKKFIDEHLTN..MSLd.......wNSLKQISEKYYKSr..........eEKDKKVFLSEQKRMRQEIVS.EFKK...................---DDRFKDLFS...KKLFS..........................-ELLKEEIYKK.GN.HQEIDA-.......LKSFDKFSGYFIGLHENRKNMYS.DG......DEITAISNRIVNENFPKFLDNLQKYQEARKKYPEWIIKAE..........SAL---..--...VAHNIKM......DEVFSLEYFNKVL......NQEGIQRYNLALGGYVTKSGEKMM-GLNDALNLAHQ.SEKS.SKGRI...--HMTPLFKQI.............................
A0A2W4IMZ0_9BACT/56-296 ................QAIKPLLDELHHQFISESLQE..LPEq......nwSDFVSFYQDYQQNkkrkadldektiKTLDEDFKTRTGAFRKAIGE.AFAAtaeqrk......anpaycnEKGKAFLSQKSY...KILTE..........................QGILSVLEQKY.SD.QSEKLDL.......IRRFGNFFTYFTGFNQNRENYYS.TE......EKSTAVAYRTINQNLLTFANNCELFEALQ-VLD-------..........------..--...--LSAQE......QKIFTPDSYSDYL......VQEGIQHYNEQIA------------SIKSKINLYIQ.QHKT.----K...LPQPKELYKQI.............................
D8E0G1_PREBR/57-300 ................KKVKKIIDEYHKAFIEKSLSN..FELkyqs.edklDSLEEYLMYYSMKr.........ieKTEKDKFAKIQDNLRKQIAD.HLKG...................---DESYKTIFS...KDLIR..........................KNLPDFVK---.-S.D-EERTL.......IKEFKDFTTYFKGFYENRENMYS.AE......DKSTAISHRIIHENLPKFVDNINAFSKIILIPE-LREKLN..........QIYQDF..EE...YLNVESI......DEIFHLDYFSMVM......TQKQIEVYNAIIGGKSTNDK--KIQGLNEYINLYNQ.KHKD.---CK...LPKLKLLFKQI.............................
A0A073IR12_9BACT/49-291 ................KSVTKLIDDYHRKFIHETLDP..AHFd.......wNPLAEALIQSG--............SKNNKALPAEQKEMREKIIS.MFTS...................---QAVYKKLFK...KELFS..........................ELLPEMIKSEL.VS.DLEKQAQl....daVKSFDKFSTYFTGFHENRKNIYS.KK......DTSTSIAFRIVHQNFPKFLANVRAYTLIKERAPEV---ID..........KAQKEL..SG...ILGGKTL......DDIFSIESFNNVL......TQDKIDYYNQIIGGVSGKAGDKKLRGVNEFSNLYRQ.QHPE.VASLR...I-KMVPLYKQI.............................
#=GC seq_cons .................clKpllDcYH+pFIccsLss..hpl.........spLpchhphatpp...........pcppcKphcphpcpLRKpIsp.hhps......................cttapplhp...KcLlp..........................phL.cahp.t..tt.p.pcps........lppFppFoTYFsuFacNRcNhYo.sc......spuTAIuaRllpENhs+FlcNlphFcclppph......hp..........ph.tph..pt.....tsppl......sclFslchaNpsL......oQpGIDhYNpllGGhstppsp.chpGlNchINhhpQ.pppp..ttpp...l.ph+.LYKQI.............................
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