#=GF ID RE_AspBHI_N
#=GF AC PF18062.5
#=GF DE Restriction endonuclease AspBHI N-terminal
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF AU Smart A;0000-0002-6965-5633
#=GF SE ECOD:EUF03979
#=GF GA 27.00 27.00;
#=GF TC 27.40 33.00;
#=GF NC 25.70 26.80;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF CL CL0178
#=GF RN [1]
#=GF RM 24604015
#=GF RT Structure and mutagenesis of the DNA modification-dependent
#=GF RT restriction endonuclease AspBHI.
#=GF RA Horton JR, Nugent RL, Li A, Mabuchi MY, Fomenkov A, Cohen-Karni
#=GF RA D, Griggs RM, Zhang X, Wilson GG, Zheng Y, Xu SY, Cheng X;
#=GF RL Sci Rep. 2014;4:4246.
#=GF DR INTERPRO; IPR041409;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This is the N-terminal domain found in modification-dependent
#=GF CC restriction endonuclease proteins such as AspBHI, which can be
#=GF CC found in Azoarcus sp. AspBHI is a homo-tetrameric protein that
#=GF CC recognizes 5-methylcytosine in the double-strand DNA sequence
#=GF CC context of (C/T) (C/G) (5mC) nucleotide (C/G) and cleaves the
#=GF CC two strands at a fixed distance (N12/N16) 3 to the modified
#=GF CC cytosine. The N-terminal domain is responsible for
#=GF CC DNA-recognition and resembles an SRA-like 5-methylcytosine
#=GF CC binding domain in structure and function [1].
#=GF SQ 129
#=GS A0A519ECY1_9SPHN/26-213 AC A0A519ECY1.1
#=GS A0A545UDY6_9GAMM/19-209 AC A0A545UDY6.1
#=GS M0MC44_9EURY/1-109 AC M0MC44.1
#=GS A0A6M0H348_9CLOT/24-210 AC A0A6M0H348.1
#=GS A0A2T0Q2Z9_9ACTN/32-224 AC A0A2T0Q2Z9.1
#=GS A0A4R4S2H9_9ACTN/43-180 AC A0A4R4S2H9.1
#=GS A0A7I7RXX3_9MYCO/29-216 AC A0A7I7RXX3.1
#=GS A0A2T1HMI0_9HYPH/26-213 AC A0A2T1HMI0.1
#=GS A0A268JT00_9BACI/44-237 AC A0A268JT00.1
#=GS A0A895YPM5_9ACTN/40-234 AC A0A895YPM5.1
#=GS A0A1G6JBJ2_NIADE/12-172 AC A0A1G6JBJ2.1
#=GS A0A5C6TSY3_9SPHN/25-211 AC A0A5C6TSY3.1
#=GS A0A1H4DWJ6_9FIRM/31-223 AC A0A1H4DWJ6.1
#=GS A0A1Q2D2B2_9ACTN/40-238 AC A0A1Q2D2B2.1
#=GS A0A365GVA7_9ACTN/50-241 AC A0A365GVA7.1
#=GS A0A4Q9KGZ5_9ACTN/30-217 AC A0A4Q9KGZ5.1
#=GS Q8P4X5_XANCP/39-223 AC Q8P4X5.1
#=GS A0A1H9N1A4_9ACTN/36-231 AC A0A1H9N1A4.1
#=GS A0A6G6WW37_9HYPH/27-216 AC A0A6G6WW37.1
#=GS A0A4R0HDH5_9ACTN/27-216 AC A0A4R0HDH5.1
#=GS A0A6B3FUU4_9ACTN/34-230 AC A0A6B3FUU4.1
#=GS A0A1V4AYL1_9PAST/25-210 AC A0A1V4AYL1.1
#=GS A0A6P0CL26_9RHOB/17-95 AC A0A6P0CL26.1
#=GS A0A369UQL7_9GAMM/25-211 AC A0A369UQL7.1
#=GS A0A7D6ZFL9_9NOCA/26-217 AC A0A7D6ZFL9.1
#=GS A0A3N0HXL9_9FIRM/33-231 AC A0A3N0HXL9.1
#=GS L7KLY3_9ACTN/53-173 AC L7KLY3.1
#=GS A0A1S1V481_9FIRM/24-228 AC A0A1S1V481.1
#=GS A0A4R1PKY5_9FIRM/28-212 AC A0A4R1PKY5.1
#=GS A0A6B0GSL0_9EURY/16-201 AC A0A6B0GSL0.1
#=GS A0A448MWR1_9ACTN/36-224 AC A0A448MWR1.1
#=GS A0A0X3RZ78_9ACTN/1-180 AC A0A0X3RZ78.1
#=GS A0A840WAT1_9ACTN/30-218 AC A0A840WAT1.1
#=GS A0A7J9SDQ6_9EURY/22-201 AC A0A7J9SDQ6.1
#=GS A0A240AU78_SERFI/22-211 AC A0A240AU78.1
#=GS J7L5C2_NOCAA/35-227 AC J7L5C2.1
#=GS W5WDC6_9PSEU/44-184 AC W5WDC6.1
#=GS A0A1I0RC05_9FIRM/32-229 AC A0A1I0RC05.1
#=GS A0A0D8D479_9GAMM/22-212 AC A0A0D8D479.1
#=GS A0A3N7CDT0_9BURK/26-210 AC A0A3N7CDT0.1
#=GS A0A7D5E2H1_9EURY/16-201 AC A0A7D5E2H1.1
#=GS A0A4D6HE59_9EURY/16-201 AC A0A4D6HE59.1
#=GS A8H9C2_SHEPA/36-232 AC A8H9C2.1
#=GS A0A1I6QTM0_9PSEU/44-229 AC A0A1I6QTM0.1
#=GS M1Y2R7_NATM8/16-201 AC M1Y2R7.1
#=GS A0A3N2R1K1_9GAMM/19-209 AC A0A3N2R1K1.1
#=GS A0A850P6T1_9PROT/27-214 AC A0A850P6T1.1
#=GS A0A1Q4W6Z0_9ACTN/47-241 AC A0A1Q4W6Z0.1
#=GS U2YXB9_9EURY/16-201 AC U2YXB9.1
#=GS A0A1H9BNG4_9ACTN/1-78 AC A0A1H9BNG4.1
#=GS R5ZMT6_9CLOT/34-229 AC R5ZMT6.1
#=GS A0A7K2Z1E4_9ACTN/35-228 AC A0A7K2Z1E4.1
#=GS A0A4R3Z8J8_9FIRM/35-153 AC A0A4R3Z8J8.1
#=GS A0A445N5F3_STRNE/32-224 AC A0A445N5F3.1
#=GS A0A6V8L582_9ACTN/39-237 AC A0A6V8L582.1
#=GS A0A2H5AUA9_9ACTN/1-180 AC A0A2H5AUA9.1
#=GS A0A7Y9YF14_9ACTN/12-202 AC A0A7Y9YF14.1
#=GS A0A7K3DVM1_9ACTN/1-180 AC A0A7K3DVM1.1
#=GS E4NSD1_HALBP/16-201 AC E4NSD1.1
#=GS A0A2S7KNC9_9FLAO/26-212 AC A0A2S7KNC9.1
#=GS A0A6A9SWU3_9EURY/16-201 AC A0A6A9SWU3.1
#=GS I4F1M3_9ACTN/27-219 AC I4F1M3.1
#=GS A0A163UQU4_9HYPH/27-213 AC A0A163UQU4.1
#=GS A0A6P0HIK6_9ACTN/57-253 AC A0A6P0HIK6.1
#=GS A0A255HBM0_9ACTN/28-217 AC A0A255HBM0.1
#=GS A0A515KS79_9BRAD/32-219 AC A0A515KS79.1
#=GS A0A0A5GHS6_9BACI/24-146 AC A0A0A5GHS6.1
#=GS A0A388SEL3_9BURK/25-214 AC A0A388SEL3.1
#=GS A1K2B7_AZOSB/26-209 AC A1K2B7.1
#=GS A0A897MXS0_9EURY/16-201 AC A0A897MXS0.1
#=GS A0A0M8Y2X2_9ACTN/30-219 AC A0A0M8Y2X2.1
#=GS D5EQ08_CORAD/15-212 AC D5EQ08.1
#=GS A0A1C2FXM7_9GAMM/22-211 AC A0A1C2FXM7.1
#=GS A0A162MYC7_9FIRM/26-212 AC A0A162MYC7.1
#=GS A0A0R2BCA9_SECCO/47-235 AC A0A0R2BCA9.1
#=GS A0A1C4JIJ2_9ACTN/33-225 AC A0A1C4JIJ2.1
#=GS A0A2N9JBZ9_9ACTN/105-293 AC A0A2N9JBZ9.1
#=GS A0A0L0K1A4_9ACTN/36-230 AC A0A0L0K1A4.1
#=GS A0A4R7TCZ5_9ACTN/33-230 AC A0A4R7TCZ5.1
#=GS A0A5N5VB29_MYCPH/58-256 AC A0A5N5VB29.1
#=GS A0A6F8Y5G6_9ACTN/43-241 AC A0A6F8Y5G6.1
#=GS B5CRW0_9FIRM/25-212 AC B5CRW0.1
#=GS Q5ZW53_LEGPH/25-214 AC Q5ZW53.1
#=GS G2GC47_9ACTN/34-230 AC G2GC47.1
#=GS A0A3G2L9Z7_9FLAO/41-227 AC A0A3G2L9Z7.1
#=GS A0A1Q2CUY2_9ACTN/26-214 AC A0A1Q2CUY2.1
#=GS A0A5N0UXA4_9PSEU/35-226 AC A0A5N0UXA4.1
#=GS A0A3R6IIH0_9FIRM/24-216 AC A0A3R6IIH0.1
#=GS A0A0F8AYJ6_9EURY/17-203 AC A0A0F8AYJ6.1
#=GS A0A0X3W4D5_9ACTN/35-230 AC A0A0X3W4D5.1
#=GS D9XJL6_9ACTN/32-223 AC D9XJL6.1
#=GS U6FQA5_LACHE/1-116 AC U6FQA5.1
#=GS A0A231GTI6_9NOCA/34-226 AC A0A231GTI6.1
#=GS A0A4Q5IUU6_9ACTN/28-216 AC A0A4Q5IUU6.1
#=GS A0A830FNC8_9EURY/16-201 AC A0A830FNC8.1
#=GS A0A0Q5VAZ8_9CAUL/26-213 AC A0A0Q5VAZ8.1
#=GS A0A0A5G2I7_9BACI/1-80 AC A0A0A5G2I7.1
#=GS A0A1H5SR69_9EURY/17-203 AC A0A1H5SR69.1
#=GS A0A0V8JFZ9_9BACI/16-202 AC A0A0V8JFZ9.1
#=GS I6XRE8_ARAPF/36-224 AC I6XRE8.1
#=GS A0A7Y0B1Z0_9ACTN/14-208 AC A0A7Y0B1Z0.1
#=GS A0A5C4MMX8_9RHOB/25-211 AC A0A5C4MMX8.1
#=GS A0A2S8VT80_9CAUL/13-206 AC A0A2S8VT80.1
#=GS A0A4S2T7H5_9ACTN/35-230 AC A0A4S2T7H5.1
#=GS E6WTF1_PSEUU/44-230 AC E6WTF1.1
#=GS G2MPQ2_9EURY/19-204 AC G2MPQ2.1
#=GS A0A7K0DV39_9NOCA/29-218 AC A0A7K0DV39.1
#=GS D9T010_MICAI/33-225 AC D9T010.1
#=GS A0A0W1RFI7_9EURY/18-213 AC A0A0W1RFI7.1
#=GS A0A248YWP5_9ACTN/40-231 AC A0A248YWP5.1
#=GS Q1LSI6_CUPMC/1-172 AC Q1LSI6.1
#=GS A0A7K2KL34_9ACTN/14-208 AC A0A7K2KL34.1
#=GS A0A255GIX1_9ACTN/32-221 AC A0A255GIX1.1
#=GS A0A1G9S7N4_ALLAB/35-226 AC A0A1G9S7N4.1
#=GS A0A7Z0IKS1_9ACTN/44-243 AC A0A7Z0IKS1.1
#=GS A0A846XL83_9NOCA/29-218 AC A0A846XL83.1
#=GS K6V919_9ACTN/28-218 AC K6V919.1
#=GS A0A1E7NBL8_KITAU/37-228 AC A0A1E7NBL8.1
#=GS A0A2Z5K4C8_9ACTN/1-188 AC A0A2Z5K4C8.1
#=GS A0A7W7LXU6_9ACTN/32-226 AC A0A7W7LXU6.1
#=GS C4IFW2_CLOBU/23-209 AC C4IFW2.1
#=GS A0A0X3RWS3_9ACTN/34-132 AC A0A0X3RWS3.1
#=GS A0A550HFT5_9ACTN/32-224 AC A0A550HFT5.1
#=GS W5WCV0_9PSEU/1-57 AC W5WCV0.1
#=GS A0A0A2TWT6_9BACI/16-209 AC A0A0A2TWT6.1
#=GS A0A4Y9NKG1_9ACTN/75-263 AC A0A4Y9NKG1.1
#=GS A0A8J7YMX1_9EURY/16-201 AC A0A8J7YMX1.1
#=GS A0A1H7WG04_9FIRM/24-216 AC A0A1H7WG04.1
#=GS A0A4R4ZQU7_9ACTN/29-218 AC A0A4R4ZQU7.1
A0A519ECY1_9SPHN/26-213 .........................lk--NVAGEPLSKLT.......G...............TGNQGGFRFC...........GP..NA.......APKLVVLYS.....TLTEADWPDALDEETGLFTYYGDNRKPGYEL....HDRKsgRGGNQILRRA...FELAHg.gEA..ERRQVAPFLVFAK......G...E..-G....R..D..AV..FKGLAVPGAAHLDASSDLVAVWKS..V..EGQRFQNYRATFTI...L...ALD....VVPRAWLAELLQ.....GVT.......DGPACPAVWRQWVKTGK.....................
A0A545UDY6_9GAMM/19-209 ..........................n-GNTSDDPLPSLL.......G...............VDNGAGFRHL...........GK..RPd....ieTLKLLVLKS.....TFKDPDWPDKLNTESGLFTYYGDNKSIR-EI....HDTP..RQGNLILRNL...FEARH..qTR..SLEHFPPILLFGG......T...G..EY....W..D..VR..FLGLAVPGAQRLGPDDDLTAIWRStgA..ENLRFQNYRAIFTV...L...DVP....VVKRKWIDDIKN.....GNA......aNSKYAPTVWLDWVKNR-k....................
M0MC44_9EURY/1-109 ..........................m-------------.......-...............----------...........--..--.......-PAALVLVSndsgiSQQDDPLEDTLAINTGHISYWGDAKASNP--....-YDE..FIQNRKIKSA...FESAT...AG..QREEVPPILVFRK......P...E..SG....-..V..VE..FCGLCVPNHLE-------VRSYYT..A..SGTQVPNY------...-...---....------------.....---.......-----------------.....................
A0A6M0H348_9CLOT/24-210 ..........................n-GNMSDEVLSKLM.......K...............CENSCGFRKK...........GS..LKd.....kKLKYVVLYS.....NGNNGDWNDDFDITTDEFIYYGDQNKPNKSL....WDTP..KKGNEILRRI...FDMLK...KG..EKINIPPFFIFVK......H...R..KR....-..D..VV..FKGLAVPGSYNKNIEKCLEVVTIK..N..NDGYIKNYRATFTI...L...NEK....NISRKWLYDLEN.....NLG......lISEFAPLEWKNWINN--kc...................
A0A2T0Q2Z9_9ACTN/32-224 ..........................q-RNAGDDPISKLI......pG...............VGNQGGFRHR...........GS..PAk.....gTVRLSVLYT.....TGGEIDWPDYLDLETGTFTYYGDNRTPGRDL....HDTP..RSGNMLLRDA...FAASHgdpAE..RGAGVPPFLLFQK.....aS...T..AG....R..A..VR..FRGLLAPGGPNLTSDDELAAIWRS..T..AGHRFQNYRARFTV...L...DEA....RISRSWIQHVLA.....GGD......tLEGDCPAAWRDWVERR-t....................
A0A4R4S2H9_9ACTN/43-180 ....rlimnrgidhparvsapdgqrrp-------------.......-...............----------...........--..--.......---VILLRSnplqaGSSKTPWDDEIDLKRGKVVYYGDHRASTTVP....LGGT..-RGNGTLLLT...AEAHRsdrPE..IRATAVPLLIFRS......V...E..HN....R..Q..--..TKGYLEFCGLGVID----------..-..--------------...-...---....------------.....---.......-----------------kvyarkaggpnhqenis....
A0A7I7RXX3_9MYCO/29-216 .........................qg--HAGDDAIGKLL.......P...............VGNQGGFRPK...........GSviKD.......AVRLVALYT.....SGAEVDWPDHIDPTTGDFTYYGDNRKPGKDL....HDTP..RGGNLLLRSI...FAASRa.gAD..DRQKVPPLFLFEK......V...S..-G....R..D..VI..FRGLLAPGSPRLTSDEELVAIWRT..T..RDLRFQNYRSHFTV...L...QTP....VVRREWIDEIVA.....GDP.......LGGACPPEWRNWVKAR-i....................
A0A2T1HMI0_9HYPH/26-213 .........................ik--NVAGEPLARLT.......G...............TGNQGGFRYC...........GP..NS.......VPKLVVLYS.....TMAEADWPDGLDEEAGLFTYYGDNRKPGYEL....HDRRsgRGGNQILRRA...FQLAHg.dEA..DRALVPPFLIFAK......G...E..-G....R..D..AI..FKGLAVPGAAHLDPSSDLIAVWKL..A..EGQRFQNYKATFTV...L...NLD....VVPRGWLTELQS.....GNR.......LGSACPSIWREWVRTGK.....................
A0A268JT00_9BACI/44-237 ................kegynlplles-------------.......G...............INKVAAINGP...........DE..IR.......TPAILISSSph.kiGSSDTPWQDYFDPDNGHIRYYGDNKTPGKS-....PELA..-TGNKRLLEA...YDVQNsldIS..VRQSAIPILFFKR......V...N..YK....-..-..GR..AKGNVMFQGYGIVERAERVTQYDL..K..TNKYFSNYVFDFAV...F...SLEsedeIFNWDWINKRRDps.lsLEE.......TISSAPKSWTNWIKAG-q....................
A0A895YPM5_9ACTN/40-234 ........klmlerginpsalvagpgd-------------.......-...............----------...........-E..HR.......RPVILIRSSpw.kaGQASNPWHDEFDLDHGYVRYYGDHKPDTAGL....PGTT..-AGNRAMREA...WELHAsigQP..RRAASPPLLLFRSa...tvV...Q..HG....-..R..RL..VKGHVEFCGVAIIERLEHVVQRDP..V..SGRGFPNLAFDLVV...L...DLAdsgeRLDMRWIADRRNpalslAE-.......TERHAPASWRRWAAEG-k....................
A0A1G6JBJ2_NIADE/12-172 .........................ap--NLSSEPISKLL.......P...............VGNQAGIRFS...........GT..AA.......TPELVVLYT.....TLKDKDWPDEVID--NKLIYFGDNKSPGKEI....HDLP..--GNQALRSI...FNNFY...--..LKGEYPLILLFSK......G...N..EG....F..D..RV..FQGVLAPGYDGLNEMEDLVAVWKT..R..GGIRFQNYKAVFTI...L...PIE....VLNRKNIESVKH.....A--.......-----------------k....................
A0A5C6TSY3_9SPHN/25-211 ........................rgg---AGDDPLPRLV.......G...............VSTGGGFRYR...........GR..ID.......RLELVVLTS.....NKRDPDWPDALDRETGVYTYYGDNKVPGRAL....HATP..RFGNALLQRI...FEDANa.gEE..GRQKVPPVLVFTS......A...G..EW....R..D..VI..FLGLAVPGVAGQRPAEDLVAVWRT..R..DESRFQNYRARFTI...L...RTE....SVARSWIQSIIA.....GQS.......DASLAPPVWTTWVETG-r....................
A0A1H4DWJ6_9FIRM/31-223 ......................kggya-----DDVLTVML......hN...............CRNTGGFRIP...........HR..AD......gSIPYIGLHL.....CGFEPSWPDDFNVETGILTYYGDNRKGGNEV....EKTD..IGGNKLLHQM...FDNLSe.gGA..KLKNIPPVLVFQN......T...G..IE....R..D..VR..FLGLAVPGVKDVHEDVFFSTVWRT.nK..DGVRFPNYVAKFTI...L...DIEd..eIIHREWLETLMT....dPEN.......SDKYAPKAWKTFQKKG-l....................
A0A1Q2D2B2_9ACTN/40-238 dhlnirkvmleaginapaltvasdgpr-------------.......-...............----------...........--..--.......RSLIAIRSSpw.kaGHETNPWHDEFDLDHGHVRYFGDHKPTTTGA....PGAT..-RGNAMLLDA...MRLHAgttRE..ERLLAPPLLLFRSv....sV...H..RG....G..R..QI..QKGHVEFCGAAIIERLEHVVQRDP..A..TGKSFPNIALDLAVvsdL...TVD....GIDLRWLDDRRDpl.lsAEE.......SLKHAPQRWKDWIAKG-r....................
A0A365GVA7_9ACTN/50-241 ......................glptv---------QLES.......G...............IDGPAAIKAP...........EG..RR.......RPAVLIRSSpw.kaGSEQTPWHDVFDMDDGHLRYFGDHKFTTDKP....LGRT..-PGNKALLEE...FAHHLggsPA..DRARAAPLLLFRS......V...T..RG....G..K..--..PKGHVEFCGLGVLERAERVL-QRD..R..EARTFVNYVFDITI...L...DLNdeedRLPWQWIAARRD.....GSTal...daTQELAPAVWHRWIQEGQ.....................
A0A4Q9KGZ5_9ACTN/30-217 .........................rg--HAGDDAIGRLL.......P...............VGNQGGFRFN...........GSvaSR.......TVKLVVLYT.....SGAEVDWPDHIDPTTGDFTYYGDNRKPGKDL....HDTP..RSGNELLRQM...FAASRa.dAI..ERQEVPPVFLFER......V...S..-G....R..D..VR..FRGLLAPGSPRLTSDEELVAIWRT..T..RQLRFQNYRSHFTV...L...KTP....RISRAWIDEILA.....GDP.......LGPACPPEWRVWVKG--ri...................
Q8P4X5_XANCP/39-223 .......pslqlerrinapsvtraidg-------------.......-...............----------...........--..-D.......RVAVVLLASnehkrGSMENPWHDTLAPDEGFARYFGDNRTPDV-D....PGTA..-IGNRTLLRQ...FEFHTspdQG..KRERAAPVLLFRS......T...K..KG....-..F..KE..FSGLALIVGAR------RVTQFSE..K..NGGFFTNYLFDLAV...L...SLTeedeSLAMLWIHDRRD.....PSRac...gvANAMAPKAWQRWVKF--gs...................
A0A1H9N1A4_9ACTN/36-231 ...............hspglkrallea-------------.......G...............INGMAKVSTP...........DG..IR.......RPTILIRSSpw.kaGTEQTPWHDVFDMDNGHVRYFGDHKASTTAE....PGKT..-IGNAALLDA...FVKHQghtPE..ERVSAVPLLLFRA......V...S..RS....G..K..--..VKGHVEFCGLGVIERAERLVQWSG..S..EHTTFTNYVYDIAL...I...DLTdeddKVSWEWIDSRRN.....KSVsd...vaTLEFAPRAWREWVKYG-n....................
A0A6G6WW37_9HYPH/27-216 .......................gqlv-----GEALSRLL......pG...............IGNRGGFRAA...........GR..GE.......RKSLVILYT.....SGEDPDWPDNLDTSTGKFSYFGDNKSPGHEL....HDTR..RGGNMILRRA...FDNLHg.tPP..DRASIPPFLVFQKy...atP...I..SS....R..S..VQ..FKGLAIPGFPGLTSNADLVAVWKT..T..EGKRFQNYQAVFTV...L...DVA....VVPRAWLADVAA.....GSP.......MSANAPGTWTEWVRTG-r....................
A0A4R0HDH5_9ACTN/27-216 .........................ag--SAADDALARLL.......P...............VGNQGGFRPK...........GS..PRd.....gTARLVALYT.....SGTEVDWPDILDPRTGVFTYFGDNRRPGREL....HQTQ..RSGNLLLRDA...FALGHg.tLN..DRRAVPPFLLFHR......A...M..PG....R..S..VA..FNGLLAPGAASLSSDDDLVAVWRS..T..GGQRFQNYRARFTV...L...DAG....HIPRAWINDVLA.....GRA......yESEHCPAVWKAWVDG--rv...................
A0A6B3FUU4_9ACTN/34-230 ...............thssghkralle------------A.......G...............INGMAKVSTP...........DG..IR.......RPAILIRSSpw.kaGTEQTPWHDVFDMDNGHVRYFGDHKAGSSVP....PGTT..-TGNAALLDA...FTDHQgrtAD..ERAAATPLLLFRA......V...P..RN....G..-..-K..PKGHVAFCGLGVIERTERLVQWGG..R..EHTPFVNYVYDIAL...I...DLTseddTVDWEWIGARRDkgvshAQ-.......ALDLAPRAWREWVKHG-s....................
A0A1V4AYL1_9PAST/25-210 .........................ng--NISDEVLTKLM.......N...............VQNSGGFRFK...........NVlnSK.......DKAYIVLYT.....SNEDIDWPDTLEQEMGKFKYYGDNKSPGYKV....--DS..KKGNLILENI...FNEK-...--..DRNKIPPIFIFMK......KptiT..SN....R..S..VK..FLGLAVPEDYHLGRDNSLKAIWRT..S..NGERFINYEAHFTI...L...NTK....SISKEWLNCLVD.....GDY......lNKEYAPKAWIKYVKEG-l....................
A0A6P0CL26_9RHOB/17-95 .......................gvkf----EDDELLRWLnt..sagS...............IANSGGIRFKdpasggsvdpeTG..RA.......VPAFFVLITrd.maAQHHNPWEDVVDEVSGNIYYWG---------....----..----------...-----...--..-------------......-...-..--....-..-..--..------------------------..-..--------------...-...---....------------.....---.......-----------------.....................
A0A369UQL7_9GAMM/25-211 ........................qgg---AGDDPLPKLT.......G...............VSSGGGFRYR...........GS..VD.......QLELLVLTS.....SKSDPDWPDTLDAESGIYTYYGDNKVSGRSL....DKTP..RFGNEILKRI...FEDAEs.gLQ..GRKRIPPILVFSK......A...G..KR....R..D..VT..FRGIAVPGVNGQGHSEDLVAIWRT..S..RGERFLNYRAHFTI...L...RSE....KVTRNWIDSIIA.....GRP.......NANLAPKEWLTWIKTG-r....................
A0A7D6ZFL9_9NOCA/26-217 .........................qg--HTGDDALARLA.......P...............VGNLGGFRYN...........GSpaRN.......EVRMVVLFT.....SGNESDWPDVLDPQTGIFTYYGDNRKPGQPD...lHDTP..RSGNLLLRNA...FEATHa.tEA..ERAKVPPFLLFEK......A...A..PG....R..S..AQ..FRGLLAPGAEVLSTDDDLVAIWRS..K..SGQRFQNYRAKFTV...L...NTG....KVERAWIDDLAN.....GVPp.....vKSVHCPESWKAWVKS--cs...................
A0A3N0HXL9_9FIRM/33-231 .........................sk--NISSEPFHKLI......pK...............CENSGGFRKK...........LR..EDg....sgKYAYIILYT.....TMEELEWPDYLDKETGIFRYYGDNRKPGRTL....TDTK..KKGNLILENV...FSLLN..sGE..SLEDMPPFLIFRKfdkgsnI...G..HA....R..N..VQ..FLGLAAPGNPKISPDKDLVSFWRT..M..GDNRFQNYESYFTI...L...DTGd..ePISRKWIESLIY.....DHK......nNFRYAPKAWKKFIQQGK.....................
L7KLY3_9ACTN/53-173 ..elsrpkvlleaginapaevvdcdgf-------------.......-...............----------...........--..RR.......RPLIAIRSSpw.kaGSSVTPWHDEFDLDHGHIRYFGDHKPTTLGL....PGST..-RGNRLLLET...AKLHAgtsTD..ERAAAPPLLVFRA......I...T..VY....R..D..--..------------------------..-..--------------...-...---....------------.....---.......-----------------gravhkgl.............
A0A1S1V481_9FIRM/24-228 .......................nksp---TKDDPLSKIFriegcrrG...............IGNQGGFRKA...........LK..ERegkpvsgKVAFVVIVD.....SGKQEEWPNSFDEDSGIFTYYGDNRIPNNDI....FKTK..NLGNKFLYEI...FRKSYg.tPD..ERAEIPPIFIFKS......T...G..NG....C..D..KR..FIGLAVPGVTGKSFEECLERRAFE..T..DEGNFENFVAQFTV...M...DTSk..eVINREWLKEIKL.....KES......lISYYEPAQWTKYIING-i....................
A0A4R1PKY5_9FIRM/28-212 .........................sg--NLRDDVLSKLL.......G...............CGNAGGFRFL...........GK..GP.......DYKLVVLFT.....TDNDPDWPDLLDPHTGLFVYYGDNKSPGHDA....GSK-..-KGNKLLETI...YNRLHa.qTA..ERRLIPPVFVFSR......G...I..EG....H..D..VV..FRGLAVPGAEGMGTAEDLVALWRT..S..GSSRFQNYKAVLSI...L...DVP....VIPRAWINDIQA.....GNP.......LSRNCPAVWKSWSEGG-v....................
A0A6B0GSL0_9EURY/16-201 .........................sf--RNADDQFLRWIrgs.ldsG...............IKNTGGIRGL...........SA..DHs.....dTPAALVLVSndtgvSQHDDPWEDTLAVNAGYISYWGDAKAGNP--....YDES..-AYNRQIKTA...FDRAA...AG..QREDAPPVLVFRK......P...E..SG....-..V..VE..FCGLGVPDHFE-------VRSYRD..D..AGVQVPNYLFHFSI...L...NTQ....SVPVSWLHDRAR.....MND.......-DGHAPDVWQHWVET--ae...................
A0A448MWR1_9ACTN/36-224 ..........................a-KNAGDDPIGKLV.......P...............VGNQGGFRFA...........GS..VRr.....gGVKLMVLYT.....SGGEVDWPDHLDPTTGDFTYYGDNRRPGREL....HDTP..RGGNLLLRSM...FEDAHd.sAE..SRRRVPPILLFEK......T...G..HG....R..D..VR..FRGLLVPGSSRLRSDEELVAIWRT..T..LNQRFQNYRAHFTV...L...RTH....KVTRRWIDSVLD.....GDP.......LGPGCPKEWKAWVRSR-i....................
A0A0X3RZ78_9ACTN/1-180 ........................mak-------------.......-...............------VTTS...........DG..TR.......RPAILIRSSpw.kaGTEQTPWHDVFDMDNGHVRYFGDHKAGLSAT....PGTT..-TGNAALLDA...FTGHQghtLE..ERAIAAPLLLFRA......V...S..QN....G..K..--..PKGHVEFCGVGIVERTERLVQWGG..R..EHTTFVNYVYDIAL...I...DLTsegdAVTWDWIEARRDk..gtS-Ha.....qALELAPRAWREWVKHG-s....................
A0A840WAT1_9ACTN/30-218 .........................sg--NSGDDPIARIA.......K...............VGNQGGFRMM...........GS..PRk.....gTVKLAVLYS.....STQEPDWPDDLDVQTGRFTYYGDNRRPGLDL....HQTP..RGGNLLLRDV...FAAASg.sAD..ERDRIPPFLLFQK......A...G..RG....R..D..VR..FRGLLAPGAAGLSSDDELVALWRS..T..RGQRFQNYRAIFTV...L...DTA....RVTRSWINELAE.....GKT.......TGPHAPDVWLSWVKAR-h....................
A0A7J9SDQ6_9EURY/22-201 .........tneyrgwlnapldggvsy-------------.......-...............----RGIEAL...........RN..PHt.....gTCEFIILYSss.ttSTSHDPWEDIINLEDGIAYYWGDSKAGDGPD....PLSR..-RGNRLVKEQ...YCSTY..aQN..NRDEAPPVL-FQK......E...R..VG....-..W..VT..FKGCCIIDGLN--------ITRHR..D..EGETVVNYRIDLEI...L...DTD....TVDLEWIHRKSR.....TGY.......-DAGGPEAWDHWVKTG-t....................
A0A240AU78_SERFI/22-211 ..........................n-GNASDDPLPQLL.......S...............VDNGAGFRHL...........GK..RPn....vdTLKLLVLKT.....NLSDSSWPDMIDKENGTFIYYGDNRKPGD-I....HKTN..RQGNLILKNL...FNEAS..sNK..SSVHFPPIFVFSN......S...G..VY....R..D..VV..FLGLAVPGAIGLSPDDDLIAVWRK.sE..EGNRFQNYRAIFTI...L...DIP....KITRQWIKDIQL.....GNA......vNSIYAPKPWLDWVNSR-k....................
J7L5C2_NOCAA/35-227 ..........................h-SSAYGEQVQLEK.......G...............INGTAGITAV...........DG..SR.......RPAILIRSSpw.ksGTVETPWKDHFEVEDGYVRYYGDHKASTEVA....LGRT..-PGNAAMLEA...FDHH-...RV..PSAYAPPLLLFRA......V...P..RN....G..-..-K..QKGYVEFCGLGVIERVEKVEQQGG..Q..AKDSFINYAYDIAL...L...DLTpendSVAWEWIEARRNka.ysAEE.......TLEWAPKSWRHWVENGT.....................
W5WDC6_9PSEU/44-184 ..........................a-GNSSDDALHGLL.......G...............VGNQGGFRYQ...........GS..VRd.....dAVRVIVLYT.....TGQDPYWPDRIDLSTGTVTYFGDNKTPGRLL....HDTP..RQGNEVLRRI...FDRAHg.sAA..DRERVPPVLVFAK......A...G..QY....R..D..VV..FRGLAD------------------..-..--------------...-...---....------------.....---.......-----------------rvhracplaktwwrsggsptt
A0A1I0RC05_9FIRM/32-229 ..........thvdgfnntfsfqrgih-------------.......-...............--SIRSVTGP...........DG..KS.......RCPVIIISSspykaGSDDTPWQDKYEPDRGYVRYYGDNKSSSTNP....DKDG..NHSLLTLKRV...YDSGN..rEE..RLLNAVPIVFFER......T...T..VN....G..-..-R..VKGNLKFHGYGIVEKAELVTQYDT..K..KNEYFSNYLFHFCV...F...SMKedceCFDWNWIAKRCDs..slTNE......eTNYFAPKAWKKWVDGGK.....................
A0A0D8D479_9GAMM/22-212 ..........................n-GNASDDPLPKLL.......G...............VDNQAGFRHL...........GK..RPe....leTLKMIVLKS.....SFKEPDWPDFLDTETGIFTYYGDRRSPG-EL....HDTP..RQGNKILSNL...FQETH..tPQ..LKDHFPPIFVFGN......T...G..VY....R..D..VR..FIGLAVPGAENIGQDDDLVALWRAtgS..NNIRFQNYRAKFTI...L...DVS....TVSRLWIKDIQS.....GKN......lLSENAPKPWVDWVLKR-k....................
A0A3N7CDT0_9BURK/26-210 ......................erggi-----ADPLVPLA.......G...............VSRQGGFRYR...........GS..KE.......RPTLLVLTS.....NLAEPEWPDQLDETTGTFTYYGDNRHPGRLL....HDTP..RFGNQLLRQI...FDWSH...LG..QRHLVPPILVFTT......E...A..SG....R..T..FR..FRGLAVPGSPALAATEDLVALWKT..S..EGQRFQNYKAVFTI...L...DEA....VIARSWIHAAGR.....GDA.......SAAAAPGAWKAWMASG-g....................
A0A7D5E2H1_9EURY/16-201 .........................sf--RNADDQFLRWIrgp.lssG...............IKNVGGIRDL...........GA..DRa.....dTPAALVLVSndsgvSQHEDPWEDTLAVNRGEIHYWGDAKMDNP--....YDES..-SQNRKITDA...FDDTA...SG..HREEVPPVLVFRK......P...E..SG....-..V..VE..FCGLCAPDHFE-------VRSYQD..G..SGTQIPNYLFHFSV...L...NTE....AVPVSWLHDRAQ.....MND.......-DRSASDVWRHWVETG-e....................
A0A4D6HE59_9EURY/16-201 ........................syr---NPDDQFLRWIrgs.ldsG...............IKNTGGIRDL...........GA..DRs.....eIPAALVLISndsgiSQHDDPWEDTLAVNAGYISYWGDAKADNP--....YDDS..-PNNQKIKSA...FDRAA...AG..QREEVPPVLVFRK......P...E..SG....-..V..VE..FCGLCVPDRFE-------VCSYQD..D..TGTQIPNYLFHFSV...L...NTQ....SVPVAWLHDRAQ.....MND.......-NDRAPAVWQRWVETG-d....................
A8H9C2_SHEPA/36-232 .........................tk--HSEANNLQLEK.......G...............INPSAKIKTN...........SG..EL......vRSAILVSSSpn.kkGSIETPWEDFYDVDNGHIRYFGDNKEPGKDP....ATA-..-PGNKALLEA...FRLAHshsAE..ERALTPPILFFKR......A...V..IN....G..V..--..AKGYPQFYGLGIINSVELVTQWDN..K..LARTFTNYAFDFTV...L...CIAseheEFEWDWINSRRK....kGFSl....siTNKASPKSWRQWLIEG-s....................
A0A1I6QTM0_9PSEU/44-229 ..................leaginpma-------------.......-...............--------KV...........DG..GR.......RPAVLIRSSpw.kaGSEETPWRDVFDLDNGHIRYFGDHKHSSAGD....PGNS..-PGNAALLAA...FDLHCaptAA..ERASAPPLLVFRS......V...S..RN....-..-..KQ..PKGHVEFCGVGIIERAERVVQWSGsgT..DRRTFTNYVYDLAL...L...DLTaeneQVEWDWITARRTha.tsCSE.......ALELAPSAWKQWVDNG-s....................
M1Y2R7_NATM8/16-201 ........................swr---NDDDQFLRWLrga.lsaG...............IKNTGGIRDL...........SF..EDs.....dEPAALVLVSnddgvSQHEDPWQDSLSVSSGHIEYWGDAKADLA--....YDES..-IQNEKIKTA...FERAA...RG..DRSAVPPVLIFRK......P...E..PG....-..V..VQ..FCGLCVPVSFE-------VATYYD..D..SGARIPNYRFNFAV...L...NTP....RVPVSWLHERAE.....RHS.......-DASAPSEWTEWTSSG-v....................
A0A3N2R1K1_9GAMM/19-209 ..........................n-GNASDDPLPRLL.......G...............VDSGAGFRHL...........GK..RPg....idTLKLLALVT.....NFNDPDWPDYLDTESGLFTYYGDNKEAR-GI....HDTP..RQGNQILRNL...FDARH..sPI..SFEHFPVVLLFGG......T...G..DY....R..D..MR..FMGLAVPGAQNLGSDDDLVAIWRS..KgpNNFRFQNYKSIFTI...L...DVP....VITRKWLDDIKA.....GKA......vSSRHAPKPWLDWVSGR-k....................
A0A850P6T1_9PROT/27-214 .........................vk--NVAGEPLAPLT.......G...............TGNQGGFRYC...........GP..NK.......APKLVVLYS.....TLAEPNWPDALDEENGVFVYYGDNRKPGYEL....HDRKagRGGNQILRQS...FELAHa.gRE..GRIKVPPFLVFAK......G...E..-G....R..D..AV..FKGLAVPGAAHLDPSNDLVAVWKS..V..DGQRFQNYRAVFTI...L...KLD....VVPRAWITELQR.....GEA.......LGASCPAVWRQWIATG-k....................
A0A1Q4W6Z0_9ACTN/47-241 ..................spgrpraql-----------EK.......G...............INPMAKVKTV...........AG..LR.......RPAVMIRSSpw.kaGSEQTPWHDVFDVDNGHVRYFGDHKPETMKP....VGGT..-TGNAALLEA...FDSHQaptPE..GRAAAAPLLLFRS......V...P..HN....-..-..GR..DKGQVQFCGAALIERAERVVQWGG..A..TKTTFTNYVFDLAV...I...DLTeeddKLSWDWITARRDpg.rsD-A......eILKLAPAAWRGWVKHG-h....................
U2YXB9_9EURY/16-201 .........................sf--RNADDQFLRWIrgp.lssG...............IKNTGGIRDL...........GA..DRs.....dTPAALVLVSndggvSQHDDPWEDTLAVNAGYISYWGDAKADNP--....YDES..-AQNRKIKHA...FDDAA...AG..RREDVPPVLVFRK......P...E..SG....-..V..VE..FCGLCVPDHLE-------IHAYQA..D..DGAQVPNYRFHFSI...L...NTE....AVPVTWLQGRAQ.....QND.......-DSAGPDVWQRWVQTG-e....................
A0A1H9BNG4_9ACTN/1-78 ...........................-------------.......-...............----------...........--..--.......---------.....-------------------------------....----..----------...-----...--..-------------......-...-..--....-..-..MR..FRGLLAPGGPNMAPDDELVAIWRT..T..GGRRFQNYRARFTV...L...DHA....RVSRTWLQHVLE.....GGH......pLEGGCPPAWGTWVVG--ra...................
R5ZMT6_9CLOT/34-229 ...............kvknfdstftfq------------K.......G...............IHSVKVINTS...........DG..KS.......RCPVIIVSSsphkaGSEYAPWKDYYDTDHGYIKYYGDNKDGNS-I....PSDK..-VGNKELLKLlpkFQSED..sDI..RKNEAVPIVFFERvn..ydN...R..AK....G..N..LK..FQGFGVLDSAK--------LITQA..N..KGEEFSNYLFEFAI...F...SMAneneEFDWDWIAKRCDsn.ltTEE.......TNKYAPKAWKDWVKTG-n....................
A0A7K2Z1E4_9ACTN/35-228 ...............ntpgekralles-------------.......G...............INGIAVVKAI...........DG..PR.......RPAVLIRSSpw.kaGTVETPWHDRFGDDGATLRYFGDHKPGEKQS....VGAT..-KGNATLLAA...WGRQLalvVA..DRRRAEPLLIFSS......V...P..YE....-..-..GR..QKGQVRFDGVGLIENVERVEQGGG..P..DAGTFPNYAYDMSL...I...SLEd..nRMDWNWIVARRN.....PTVsl...dqALKAAPPAWQEWVEQG-r....................
A0A4R3Z8J8_9FIRM/35-153 .........................kg--NHSSEVLSKLM.......K...............VGNTGGMRPK...........NN..KY......kNTAYIVLNI.....THDNNAWEDYIDYKKEEVIYYGDNAKSED-L....FETK..HKGNRNLKFL...FDNI-...-D..NPDNQFPLFLFERd....aE...C..VN....R..D..FK..YIGLVIP-----------------..-..--------------...-...---....------------.....---.......-----------------si...................
A0A445N5F3_STRNE/32-224 .........................ng--NTGDDPMSNLI......pG...............VGNQGGFRYA...........GS..PAk.....gTVRLAVLCT.....SGGEVDWPDHLDVQTGTFTYYGDNKTPGRSL....HDTP..RSGNILLRDA...FAASHgtaAE..RASGVPPFFLFEK.....aG...A..SG....R..S..VR..FRGLLAPGGPTMTSDDELAAIWRA..T..AGQRFQNYRSHFTV...L...DHD....RIPRSWIQHVLM.....GGD......pLGGSCPDVWRTWGE---grv..................
A0A6V8L582_9ACTN/39-237 .................dlrrpklmle------------R.......G...............INAAAAVSAP...........DG..PR.......RPVIAIRSSpw.kaGHASNPWHDEFDLDHGHVRYYGDHKPTTVGL....PGAT..-AGNRALLEA...WSLHAgtsKR..ERSLAPPLLLFRSs....tV...N..QG....G..R..SI..VKGHVEFCGVAIIERLEHVVQRDP..A..SGRSFPNIVLDLAV...L...DLAeagdTIDLRWIDDRRNet.ltVTQ.......TARHAPASWNVWVAQG-r....................
A0A2H5AUA9_9ACTN/1-180 ........................mak-------------.......-...............------ITAA...........AG..VR.......RPAVMIRSSpw.kaGSEQTPWHDVFDLDNGHVRYFGDHKFDTAKP....LGST..-TGNAALLEV...FDGHQaptAA..GRAAAAPLLLFRS......V...S..RN....G..K..--..VKGHVEFCGVGLIERAERVVQWAG..R..ARTTFTNYVFDLAV...I...DLAaegdKLDWEWITARRV.....ASRsd...aeVLELAPTAWREWVKRG-h....................
A0A7Y9YF14_9ACTN/12-202 ......mleaginspaevigpdggrra-------------.......-...............----------...........--..--.......--LIAIRSSpw.kaGHETNPWHDEFDLDHGHVRYFGDHKPGTVGL....PGAT..-KGNRLLLEA...ARLHAgtsRD..ERLLAPPLLLFRS......V...T..VH....RegR..AI..VKGHVEFCGAAIIERLEHVVQRDP..E..TGRSFPNLALDLAV...VsggEVD....GIDLRWIDDRRDpq.ltAEQ.......ALRDAPESWARWVKQG-r....................
A0A7K3DVM1_9ACTN/1-180 .........................ma-------------.......-...............-----KVRTS...........DG..DR.......RPVILIRSSpw.kaGSEQTPWHDVFDMDNGHVRYFGDHKATTTVA....PGKT..-TGNAALLDA...FTRHQghtPE..ERATAVPLLLFRA......V...K..RS....-..-..GR..DKGHVEFCGLGVIERAERLVQWGG..S..DHTTFTNYVYDIAL...I...DLTaeddKVAWAWIDSRRDkt.vaD-A......eTLELAPLAWREWVKHG-h....................
E4NSD1_HALBP/16-201 .........................sy--RNSDDQFLRWIrgp.ldsG...............IKNTGGIRDL...........GA..DRs.....eTPAALVLVSndsgiSQHDDPWEDTLAVNAGYISYWGDAKASNP--....YDES..-TQNQKIKAA...FDNAA...AG..RRENVPPVLVFRK......P...E..SG....-..V..VD..FCGLCVPDHFE-------VHAYQA..D..DGTQVPNYQFHFSI...L...NTN....AVPVTWLHDRAR.....QND.......-DSEAPDVWQHWVQTG-e....................
A0A2S7KNC9_9FLAO/26-212 ..........................k-GNAGDDPISKIL.......K...............CGNQAGFRYT...........GT..AKl.....mNFNYIVLYS.....SMDDPDWPDMLDLRSGLFIYYGDNKKPGHEL....HDTS..RKGNLILKHY...FGLLT...SN..DYTSIPPFFVFTK......A...G..KS....R..D..VV..FRGLAVPGAQNLEITDNLVAIWKS..Q..KGERFQNYKAIFTI...L...DIP....IITREWIDDLNQ.....GNT.......FTKNTPLPYLNWANKN-r....................
A0A6A9SWU3_9EURY/16-201 .........................sf--RNSDDQFLRWIrgp.ldsG...............IKNTGGIRAL...........GA..DRs.....dTPAALVLVSndvgvSQHDDPWEDTLAVNAGYVSYWGDAKATNP--....YDES..-VKNQKIKAA...FDRAA...AG..QREDVPPVLVFRK......P...E..SG....-..V..VE..FCGLCVPDHFE-------SRSYQD..G..SGTRVPNYLFHFSI...L...NTQ....SIPVSWLHDRTT.....MND.......-DGRAPDVWTRWVETG-e....................
I4F1M3_9ACTN/27-219 .........................ag--HAGDDPLAVLL.......P...............VGNQGGFRYA...........GS..PAq.....gTVRLVVLYT.....SGVNPDWPDVLDPTTGSFTYYGDNRQPGRDL....HDTP..RRGNGILRAA...FDGAHg.gTV..GRATVPPFLLFER.....aS...T..TS....R..A..VR..FRGLLAPGSPSAPPDEHLSAIWRS..R..EGLRFQNYRALFTV...L...DER....TVTRAWLEELLGp..gpLKT.......TGPGSPPAWRNWVEG--dv...................
A0A163UQU4_9HYPH/27-213 ..........................k-GNAGDEPLPPLV.......S...............VSNNGGFRYR...........GN..LD.......ALELVALTS.....TLKDPDWPDMLNPETGIFTYYGDNKRPGRPL....HETP..RNGNELLRRI...FESAHa.gPD..GRRRVPPIFIFTS......T...G..EG....R..D..YR..FRGLAVPGSISLSSSEDLVAIWKV..A..EGARFQNYRARFTI...L...DAP....IISRSWINDIIA.....GSA.......YTENAPKAWRDWVEKG-n....................
A0A6P0HIK6_9ACTN/57-253 .......ngrpkvmleaginapsevfg-------------.......-...............---------S...........DG..QR.......RPLVAIRSSpw.kaGHESNPWHDEFDLDHGHVRYFGDHKPSTVGL....PGAT..-KGNRLLLEA...ARLHAgttRQ..ERLLAPPLLLFRS......T...TvyRG....G..R..AI..VKGHVEFCGAAIIERLEHVVQRDP..E..TGKSFPNIALDLAV...VagrEID....GIDMRWIDDRRDpd.ldSET.......ALRYAPDSWVRWVKEG-r....................
A0A255HBM0_9ACTN/28-217 .........................ag--NAGDDPISKLI......pG...............VGNMGGFRSI...........GS..IRg.....qGVKLVVLYT.....SGEDTDWPDSIDPVTGDFTYYGDNKKPGSGL....HDTP..RKGNLLLRQV...FELTHg.gPE..DRVKVPPFLLFQK......T...A..DG....R..N..VL..FRGLLAPGSSRLTAEEELVAVWRT..T..RELRFQNYRAHFTV...L...NVD....PVSREWIDEVRA.....GNP.......LGPHAPKAWKRWVRG--rv...................
A0A515KS79_9BRAD/32-219 .........................rg--NMGDDPLPRLL.......R...............MDSLGGFRKR...........GS..VA......gKLQMLVLTS.....SMADTDWPDSLDRETGVFTYYGDNKKPGQEL....HKTG..RDGNLILQKI...FNAARs.gVE..GRREVPPTFLFAN......A...G..TW....R..D..MI..FLGLAVPGASDLDASEELVAIWRT..A..GGQRFQNYRARFTV...L...NVP....TITRTWLDSLIA.....GKP.......EDELAPEAWQTWIKTG-r....................
A0A0A5GHS6_9BACI/24-146 .......................kgnp---AADDPLTKLFrldgyikS...............VGNRGGFRKS...........RK..ESggk.vkdQLAYTVIFS.....TGKVDEWPDLLNEKKGTFTYYGDNKTPNNNH....LDTK..QRGNVLLKDV...FEKAYk.sKD..ERREIPPMFIFES......T...-..--....-..-..--..------------------------..-..--------------...-...---....------------.....---.......-----------------vdrl.................
A0A388SEL3_9BURK/25-214 ........................pnl----AGEVITKLV......pG...............CPNLGGFRKV...........YN..QRt.....kRIAYIVLYT.....SMCELAWPDFLDTETGVLRYYGDNRKAGRSL....LDTR..GKGNLLLQEV...FGELH...AG..DRSEIPPFLIFKR......H...G..TG....R..D..MR..FLGLAAPGAAGLPPDRDLTAHWRT..V..DGERFQNYEAYFTI...L...DTGs..qPVSKAWLRALWH.....GDP......dSLRLAPRAWRDFVREG-r....................
A1K2B7_AZOSB/26-209 .......................ergg----MADPLVPLV.......G...............VSRQGGFRYR...........GT..RE.......RPTLLVLTS.....NLAEPEWPDQLDETTGTFIYYGDNRHPGRLL....HDTP..RFGNQLLRQI...FDWAH...LG..QRHLVPPILVFTT......E...A..TG....R..T..FR..FRGLAVPGSPALAATEDLVALWKT..T..EGQRFQNYKAVFTI...L...DEA....VIPRAWVHAVGR.....GET.......-SGLAPVAWNAWLSAG-g....................
A0A897MXS0_9EURY/16-201 .........................sy--RNSNDQFLRWIrgp.ldtG...............IKNTGGIRDL...........GA..DRs.....eTPAALVLVSndsgiSQHDDPWEDTLAVNAGYISYWGDAKATNP--....YDES..-AQNQKIKAA...FDNAA...AG..WREEVPPVLVFRK......P...E..SG....-..V..VE..FCGLCVPDHFE-------VHAYQA..D..DGTQVPNYQFHFSI...L...NTN....AVPVTWLHDRAQ.....RND.......-DSEAPGVWQQWVQTG-e....................
A0A0M8Y2X2_9ACTN/30-219 .........................ag--HSGDDPIARIV......pK...............VGNQGGFRTV...........GSpwKK.......TVKLAVLYS.....SGREPDWPDRLDVQTGRFMYYGDNRHPGHDL....HDTQ..RGGNCLLRDT...FSTALg.tAG..DRARIPPFLLFQK......V...G..KG....R..D..VR..FRGLLAPGADDLSSEDELVALWRS..T..RGQRFQNYRAAFTV...L...DTA....IVTRAWIKELSE.....GLT.......TGPNAPAAWLAWVKAR-q....................
D5EQ08_CORAD/15-212 ......................trrip----EDEFINWLDte...giT...............IGTTGGIRSKrfnn..laigpSE..SP.......LPAVLVLVTrq.fsHQYHNPWEDLVDYSTGQIFYWGDAKFNKDRS...kKHNH..FRGNKILESM...YDRIL...EQ..NLRKLPPILHFVK......D...K..KG....-..Y..VK..FSGLCAMEKLD--------ITWYE..D..RGNPIKNFRARLAI...L...DIE....EVELSWLNSRAL.....SEEv....ecIDENAPKVWKDYITGN-t....................
A0A1C2FXM7_9GAMM/22-211 .........................ng--NSFDDPLPKLL.......D...............VDNGAGFRHL...........GQ..RPe....vkTLKLLVLKT.....SFSDTNWPDALDGENGTFVYYGDKRVPGD-L....HQTP..RQGNLILRNL...FDEAH..qHQ..QSSAFPPILLFGN......A...G..TY....R..D..VR..FIGLAVLGATGMGADDDLVAVWRT.tD..DGVRFQNYKATLTV...L...DVP....VVSRAWVKDIQA.....GDA......iSSPHAPKAWLDWVGGR-k....................
A0A162MYC7_9FIRM/26-212 .........................dv--NVKGDPISKLL.......G...............CGNLGGFRYL...........GS..TDp.....fELKYVVLYS.....SLLDPDWPDSLDNQTGIFTYFGDNKDPGNQL....HRTR..KKGNYILKEC...FNMLH...NS..KLDKIPPFFIFTK......G...T..KG....R..D..VV..FRGVAVPGAKNLTSFDDLVAIWKI..K..GQERFQNYRAIFTI...L...DID....KVTRNWIKDLQN.....GNI.......ITHNTPKAFKEWVEKG-i....................
A0A0R2BCA9_SECCO/47-235 ........sknfisenkldrkknnlht-------------.......S...............TGTNGGFRMVnlap...qskrSN..ST.......EHAFLVITSa...eKAKANIWSDDFDSGNHLLTYHGDNKASQN-I....FNTP..KKGNFYLDEI...FSEN-...FA..QSTQAFPILYFKL......F...A..DN....-..R..VE..YMGLAYPIPNG---------LKSI..R..EKNNIPNYEAKFYI...D...QTT....SIKKEWLTHLKE.....GKS......aKNSIVPQSWSNFIH---lk...................
A0A1C4JIJ2_9ACTN/33-225 .........................sg--HSGDDALARLL......pG...............TGNQGGFRCA...........GS..PAk.....gTVRLAILYT.....SGGEVDWPDYLDTETGTFTYYGDNKTPGKSL....HKTP..RNGNVLLRDV...FEHSHgtaRD..RGTKVPPFLLFEK.....aR...A..RG....R..A..VR..FRGLLAPGGPTLTSDDELAAIWRS..S..GGKRFQNYRSRFTV...L...DAE....RISRNWISHVLD.....GGD......vLRGGCPEVWETWVQSR-i....................
A0A2N9JBZ9_9ACTN/105-293 .........................ag--NAGDDPIARLV.......P...............VGNQGGFRFK...........GS..PRr.....gTVRLAVLYT.....SGVEVDWPDHIDPTTGDFTYYGDNRTPGHDL....HDTR..RGGNLLLRDI...FAASRs.tPE..ARRAVPPILLFQS......A...G..SG....R..D..AI..FRGLLAPGSPRLASDEELVAIWRT..T..KEMRFQNYRAHFTV...L...KTP....VVPRAWLEQILA.....GEP.......LGSSCPGEWRKWVQG--ri...................
A0A0L0K1A4_9ACTN/36-230 ................apghkralles-------------.......G...............INGMAKVPVG...........GR..QR.......RPAILIRSSpw.kaGSEQTPWHDVFDMDNGHVRYFGDHKAGVTKL....PGAT..-TGNAALLDA...FTEHQaptPE..ERAGAAPLLLFRA......V...S..RN....G..K..--..VKGFVEFCGLGVIERAERIVQWAG..H..EHTTFTNYVYDIAL...I...DLAaendQVDWDWITARRSpv.vsDQE.......TLAKAPRAWREWVKRG-h....................
A0A4R7TCZ5_9ACTN/33-230 ..................vthspdqkr--------VLLEA.......G...............INGVARLSCV...........DG..VR.......RPAVLIRSSpw.kaGSEQTPWHDVFDMDNGHVRYFGDHKAGVTVP....PGAT..-KGNAWLLEA...FSEHQahtPA..ERAAAAPLFLFRS......V...S..ID....G..-..-K..PKGHVEFCGLGLVERAERLVQWSG..S..GHTTFVNYVYDIAL...L...DLSaeadQVSWNWIDARRD.....SSKtv...aqALNLAPVSWREWVRRG-n....................
A0A5N5VB29_MYCPH/58-256 ...............ehlgrnkvmlea-------------.......G...............INAPAEVTGP...........DG..PR.......RPLIAIRSSpw.kaGHETNPWHDEFDLDHGHVRYFGDHKPSTVGL....PGAT..-QGNRLLLDA...ARLHAgttRE..ERLLAPPLLIFRA......V...T..VH....RdgK..AV..VKGHVEFCGAALIERLEHVVQRDP..E..TGRSFPNLSVDLAV...IsggEAD....GIDFRWVDDRRNpe.ltAEE.......ALRYAPPTWARWVKQG-r....................
A0A6F8Y5G6_9ACTN/43-241 ..............aahgrklmleagi-------------.......-...............-NAAAIVETA...........DG..PR.......RPVISLRSSpw.kaGHATNPWHDEFDLDHGHVRYYGDHKPSTMGL....PGAT..-AGNRALLDA...WTLHAatdPR..GRLQAPPLLIYRS......I...T..VN....R..D..GRslVKGHIEFCGAAIIERLEHVVQRDP..E..SGRSFPNLVLDLAV...I...DLVdtgdALDMRWIDDRRNpe.ldAER.......AARHAPASWRRWIRDGK.....................
B5CRW0_9FIRM/25-212 .........................at--NLNGDVLSKLM.......S...............VGTQGGFRPV...........NI..RNq....kgKAAYIVLES.....TNKHPDWLDNIDYESGIIQYYGDNREPGREL....HDSK..RGGNKVLRDV...FEMLQ...DN..RRQEIPPFFYFES......E...E..-G....R..N..RR..FLGLLVPGSDKFKLEELLVAIWRM..K..NGERYQNYKAVFTI...L...DVA....SVSRGWLEDLLS.....GNG......yQSDFAPKEWKKWIDKG-v....................
Q5ZW53_LEGPH/25-214 ..........................s-GNASDDPISKII......kG...............IGNMGGFRSA...........GQ..GI.......FKKLIVLYT.....NMEDGDWPDSIDTSKGQFIYYGDNKHPGHDI....HDTP..RQGNATLKML...FDSTHn.eKD..ARRIVPPIFIFVKy...ptA...S..SS....R..S..VQ..FKGVAVPGYPGLSATDDLIAVWKT..T..NGQRFQNYRAIFTI...L...NIP....MVSRKWINSLFD.....PFG.......-QDNSLNPFYQWKISGK.....................
G2GC47_9ACTN/34-230 ...............thssghkralle------------A.......G...............INGMAKVSTP...........DG..IR.......RPAILIRSSpw.kaGTEQTPWHDVFDMDNGHVRYFGDHKAGSSVP....PGTT..-TGNAALLDA...FTDHQgrtAD..ERAAATPLLLFRA......V...P..RN....G..-..-K..PKGHVAFCGLGVIERTERLVQWGG..R..EHTPFVNYVYDIAL...I...DLTseddTVDWEWIGARRDegvshAQ-.......ALNLAPRAWREWVKHG-s....................
A0A3G2L9Z7_9FLAO/41-227 ...........ainlfrpmfwfknkne-------------.......-...............----------...........--..--.......ICPAIILSSnpllkNKERKPWEDEINIEKSRVHYFGDNKTPGKHPleslPKEP..QTGNQKMVSM...AENYLsndRA..KRIEAPPIIIFQH......C...K..VG....R..Q..--..SKGYRKFIGVG-YLYNYQLIQQKT..T..EGKFFANYCYDIKL...I...DLEn..nQFDWSWIYDRKSw..npTKN.......NNLKAPESWKRWMEHG-h....................
A0A1Q2CUY2_9ACTN/26-214 .........................ag--TSADDPLASLL.......P...............VGNQGGFRYK...........GS..PAq.....gTVQLLVLYT.....SGTETDWPDTIDPETGDFTYYGDNRQAGSLL....HETR..RKGNLLLRDI...FEWSRg.gPE..DRERIPVILLFEK......S...G..RG....R..A..VR..FRGLLVPGSPRLTSEEELVAIWRT..T..RDHRFQNYRAHFTI...L...NEA....VVSRAWIDQILA.....GDP.......LGRDCPGAWRRWVQAR-i....................
A0A5N0UXA4_9PSEU/35-226 .........................sg--HAGDDPIAKLL......pG...............VGNQGGFRYV...........GS..QRe.....gDVRLAVLYT.....TGDQPDWPDSLDLQTGLFTYYGDNRAAGREL....HNTS..RRGNLLLRDV...FSDSHg.tPE..QRKKVPPFLLFEK.....aT...T..QG....R..G..VR..FRGLLAPGGPALTPDDELQAIWRT..T..GRERFQNYRARFTV...L...DCA....TVPRTWIQGVSA.....GLD......pLAGDCPREWASWVRGR-a....................
A0A3R6IIH0_9FIRM/24-216 .........................ap--NMSSEPFHKLI......pG...............CENAGGVRKK...........FR..EDg....sgKYAYVVLYT.....SMEELEWPDYLDEETGIFRYYGDNREPGREL....TDTK..KKGNKILEMA...FSLLN..eGK..NLEDMPPFLIFKK......T...G..TG....R..D..IQ..FLGLAVPGNPKISPDRDLVAFWRT..V..KENRFQNYEAYFTV...L...DTGe..kPIYRKWIESLIY.....DHE......nNLKYAPEAWVRFVKQG-r....................
A0A0F8AYJ6_9EURY/17-203 ........................ssd---PEKDEFQGWLngp.idnG...............IRNSGGIRAI...........VN..STt.....gEREFLVFVSsq.erGGPQNPWEDVINREEGIVRYWGDAKARDNPN....PENA..-NGNSWVKND...YCETY..aQD..ARKDAPPVLLFEK......P...R..SG....-..E..VT..FQGVCILTEIS--------IERYK..D..GDDTVVNYLFNLAI...L...DVD....TVDLEWIHRKSR.....TGV.......-DVGGPDAWNEWVDSG-r....................
A0A0X3W4D5_9ACTN/35-230 ................dapghkkalle------------A.......G...............INGMAKVSAG...........GR..QR.......RPAILIRSSpw.kaGSEQTPWHDVFDLDNGHVRYFGDHKAGVSKP....PGTT..-TGNAALLDA...FGAHQaptPE..ARAGAAPLLLFRA......V...S..RD....-..-..GK..VKGFVEFCGLGVIERAERIVQWAG..H..EHTTFTNYVYDIAL...I...DLTtendQVDWDWITARRT.....STVsd...qdSLAKAPRAWQEWVRRG-h....................
D9XJL6_9ACTN/32-223 .........................sg--HTGDDPMSKII......kG...............IGNQGGFRYA...........GS..PAl.....gTVKLAVLYT.....SGGEVDWPDYLDVETGTFTYYGDNRRPGQSL....HETP..RSGNILLRDA...FAASHg.tPA..DRSKVPPFFLFEK.....aA...A..RG....R..S..VL..FRGLLAPGGPNLTSDDELAAIWRA..T..DGRRFQNYRARFTV...L...EVD....RVPRAWIQHLLN.....GGD......pLDGECPDAWRTWTESR-v....................
U6FQA5_LACHE/1-116 .......................mldq-------------.......-...............----------...........--..--.......---------.....-------------------------------....----..----------...FKISHdpnSE..VRATAVPIIFFET......R...K..QG....-..E..RI..FHGYGVIKNVK------LVTQYTGsgA..DKAYFSNYLFTFCV...F...SMKkeqeGFDWSWIEARKQ.....AAKdknflslANALAPKEWKFWIRTG-d....................
A0A231GTI6_9NOCA/34-226 .......................qghi----GDEPIARLL......rG...............AGNQGGFRPI...........GSvlKK.......SVRAAVLYT.....TGEVIDWPDNLDPQTGIFTYYGDNQKPGRAD...lHDTS..RRGNLLLRDT...FEAVHa.nAA..ARALVPPFLLFEK......A...A..PG....S..A..VR..FRGLLAPGAATLGADDDLTAIWRS..K..NGRRFQNYRAKFSV...L...NTG....RVTRAWIDDLHA.....GTAp.....tKSPHCPGSWRAWVESR-t....................
A0A4Q5IUU6_9ACTN/28-216 .........................rg--NRGDDPIAKLL.......P...............VGNAGGFRFV...........GS..PTa.....gTVRALALYT.....SNADADWPDRLDAATGTFSYYGDNKAPGRQL....HDTP..RKGNLFLSLA...FALVS...EGvlGRRQVPPILLFAK......G...G..RG....A..D..VH..FRGLLVPSSPLVPVDEQLVAIWRS..A..GDQRFQNYRATFSV...L...DVP....CVSREWITAVVS.....GED.......PVRLAPPAWEKWVRTG-v....................
A0A830FNC8_9EURY/16-201 ........................syr---NPDDQFLRWIrgp.ldsG...............IKNTGGIRDL...........GA..DRs.....dTPAALVLVSndsgiSQHDDPWEDTLAVNAGYVSYWGDAKADNP--....YDES..-AQNRKIKHA...FDDAA...AG..RREDVPPVLVFRK......P...E..SG....-..V..VE..FCGLCVPDHLE-------VRAYRA..D..DGTQIPNYRFHFSI...L...NTE....AVPVTWLHERAR.....QND.......-DSAAPDVWQQWVQTG-e....................
A0A0Q5VAZ8_9CAUL/26-213 .........................lk--NVAGEPLSKLT.......G...............TGNQGGFRFC...........GP..NA.......APKLVVLYS.....TLTEADWPDALDEETGLFTYYGDNRKPGYEL....HDRKsgRGGNQILRRA...FELAHg.gEA..ERRQVAPFLVFAK......G...D..-G....R..D..AV..FKGLAVPGAAHLDASSDLVAIWKS..V..EGQRFQNYRATFTI...L...ALN....LVPRAWLAELLQ.....GVT.......DGPACPAVWRQWVKTGK.....................
A0A0A5G2I7_9BACI/1-80 ..........................m-------------.......-...............----------...........--..--.......---------.....-------------------------------....----..----------...-----...--..-------------......-...-..--....-..N..VQ..FKGIAVPGLKGKGKEDSLQLKSFG..E..SPNKFRNFEAHFTI...L...NEH....VVEKDWLYNLKD.....YEG......dSLESAPKEWISYVESG-p....................
A0A1H5SR69_9EURY/17-203 .....................srdlet------NEFLRWLngp.ldgG...............VNFGRGIAQL...........KQ..PGt.....dECEFLVFYSsd.ggSKSPDPWEDIINLEDGIVHYWGDSKAGDGPD....PSQ-..RDGNQIVKQQ...YCETY..aKN..NREEAPPVLLFVK......E...E..SG....-..W..VT..FNGLCIISGLE--------IGRHN..H..DGETVVNYRISLDI...L...DID....AVDLEWIHRKAR.....TGV.......-DVGGPEAWDHWVETG-t....................
A0A0V8JFZ9_9BACI/16-202 ..........................n-DNASHDPISKLL.......K...............CENMGGFRIS...........GS..KKt.....sSYKLCALYT.....DLINPDWPDMIEKETGKFFYYGDNRKPVKEL....HETP..KGGNRLLRFV...FDQLH...LG..NRKAIPPFFVFTK......S...G..RR....R..D..MI..FQGIAVPGHQDVNENDDLVAIWKL..K..EGRRFQNYKSVFTI...L...DVA....TISQTWINDLHQ.....GNA.......FTPNASKEWINWVLEGK.....................
I6XRE8_ARAPF/36-224 ..........................a-KNAGDDPIGKLV.......P...............VGNQGGFRFA...........GS..VRr.....gGVKLMVLYT.....SGGEVDWPDHLDPTTGDFTYYGDNRRPGREL....HDTP..RGGNLLLRSM...FEDAHd.sAE..SRRRVPPILLFEK......T...G..HG....R..D..VR..FRGLLVPGSSRLRSDEELVAIWRT..T..LNQRFQNYRAHFTV...L...RTH....KVTRRWIDSVLD.....GDP.......LGPGCPKEWKAWVRSR-i....................
A0A7Y0B1Z0_9ACTN/14-208 ....................taserla-------QIQLSK.......G...............INPIAKVKAP...........GG..LR.......RPCILIRSSpw.kaGTAETPWHDVFDLDNGRILYFGDHRVDHTVP....VGTT..-QGNAVLLEA...LEEHQglaAE..QRALAVPLLVFAA......V...S..RN....-..-..KT..PKGYVEFCGVAVIDRAE--QIEQQ..A..TGTSFPNYRYELSL...L...DLSaendQVDWAWIEARGNpe.lsTAD.......ALQLAPRSWRQWVEQG-h....................
A0A5C4MMX8_9RHOB/25-211 ..........................q-GNAGDDPLGPLL.......K...............VSNSGGFRYR...........GK..MD.......RFSLIVLTT.....GMADPDWPDRIDRETGILTYYGDNKVAGQAL....HATP..RRGNEILRRL...FEDAHg.gVE..GRRKVPPILVFAT......T...R..SW....R..D..VE..FLGLVVPGTSDLQVSEDLVAVWHT..S..AERRFQNYRARFTV...L...DTG....SIPRRWIDDIIS.....GAD.......PVAKAPSAWHLWRETG-q....................
A0A2S8VT80_9CAUL/13-206 ................legspraller-------------.......G...............INPIASLKTV...........AG..LR.......RPAILISSSph.rvGSVQTPWHDVFDADNGHIRYFGDAKTPGQDP....ATA-..-PGNKALLEA...YAVHSaiePA..ERAAATPIVFYRR......T...T..VN....G..V..--..QKGYLTFQGYGVIERVERLTQFDP..R..RNASFANYVYDFAV...L...AQSaeheLFDWGWINARRDps.ltTAQ.......TQALAPAAWRNWIANG-p....................
A0A4S2T7H5_9ACTN/35-230 ...............dapghkralles-------------.......G...............INGMAKVSAG...........GR..LR.......RPAILVRSSpw.kaGSEQTPWHDVFDMDNGHVRYFGDHKAGLTKP....PGTT..-TGNAALLDA...FAEHQaptPE..ERSGAAPLLLFRA......V...S..RN....-..-..GR..VKGYVEFCGLGVIERAERIVQWAG..H..EHTTFTNYVYDIAL...L...DLAtendQVDWDWITARRSpv.vsDQE.......TLAKAPRAWREWVKRG-h....................
E6WTF1_PSEUU/44-230 ......................glasl---------QLEK.......G...............INSPSATRAV...........DG..ER.......LAAVLLQSSvh.krGSIENPWHDTLAPDEGFARYFGDNKTPDVD-....PGLA..-NGNRTLLRQ...FELHTspdRA..KRERAAPMLLFRS......T...Q..KG....-..L..KE..FAGLGLIVGAK------RVTQFSE..K..NGGFFTNYLFDLAI...L...SLTeedeSLAMLWIRDRRDpt.laA-P......iANAMAPKSWQAWVKF--gs...................
G2MPQ2_9EURY/19-204 .........................sf--RNAEDQFLRWIrgp.ldsG...............IKNTGGIRDL...........GA..DRs.....eTPAALVLVSndagiSQHDDPWEDTLAVNAGYVSYWGDAKNDLR--....YDES..-AQNRKIKDA...FDRSA...SG..QREEVPPVLVFRK......P...E..SG....-..V..VE..FCGLCVPDHFE-------VRTYQD..D..SGEQIPNYRFHFSI...L...NTQ....VVPVSWLHKRAQ.....TND.......-DDQAPEVWKRWVRGG-e....................
A0A7K0DV39_9NOCA/29-218 .......................pgrs-----VDPLSRML.......R...............VGVQGGIRGR...........GQ..LSr.....gIARLVALYS.....TRNEPDWPDFLDERTGTLTYFGDNRDPARDL....LDTN..LYGNLIFKNS...FAAAAg.nVS..DRAGVPPFFYFER.....vS...D..KG....P..I..VR..FRGLAVPGAPNGPELGDLVEIVIE..G..KRGIVRNYRARFTI...L...DTP....HVSRQWIDALIA.....GKS......tLSDGCPAAWRKWVENS-e....................
D9T010_MICAI/33-225 ..................igtrvlles-------------.......G...............INPVRSIGAQ...........GR..QR.......RPVIALRSSpw.kaGGEDTPWHDVFDLDHGHVRYFGDHKVSTDGP....LGST..-TGNKALLEA...WPQHRgstPE..TRAAAPPLLLFRS......V...S..VG....R..A..--..LKGYIEFCGVAVLDRLEHVVQRDP..S..TGQSFANYAFDLTV...L...SLAeeaeAIDWRWIDDRRDpg.lsLQE.......THRHAPRSWRRWVEHG-d....................
A0A0W1RFI7_9EURY/18-213 ........................ynt---SDEDEFNSWL.......ShpipedesdlpylkgMRALRNFSET...........QK..TG.......EYATFILVS.....SDQDETYPDEIDLENGEIRYWGDAKYSVKRGt..rSKDR..FYGNRRLKPH...FDTVK...ES..GRDVAAPILFFER......K...E..SG....-..Y..VT..FDGVCVLKAVT----PDRNRESTD..D..GVVWTPNYRYHLSV...L...DIP....EISLEWIYNRAT.....ADS.......-DAGAPDAWTEWKQSE-s....................
A0A248YWP5_9ACTN/40-231 mleaginpaamvggpdgqrrpvislrs-------------.......-...............----------...........--..--.......--------Spw.kaGHASNPWHDEFDLDHGHVRYYGDHKPTTVGL....PGAT..-VGNRALLDA...WALHAatdPR..RRRQAPPLLLYRS......V...T..VR....R..NgrNL..VKGHIEFCGVAVIERLEHVVQRDP..E..TGRSFPNLVLDLAV...I...DLAdtgdALDLRWIDDRRD.....PSLdc...vqADRHAPDAWSRWVRDG-r....................
Q1LSI6_CUPMC/1-172 ...........................-------------.......-...............---MGGFRVT...........GR..GE.......QKSWVVLFT.....TGEDKDWPDTLDLSTGKFVYFGDNKTPGHEL....HETR..-GGNKVLRYS...FERLHa.aVN..PRADVAPFLVFKKy...plA...H..GA....R..S..VQ..FKGLAVPGFPSLSSTEDLVAVWKS..S..EGQRFQNYRAVFTI...L...NAP....VLSRAWINDLKA.....GDL.......NSSNAPRAWRQWRESGK.....................
A0A7K2KL34_9ACTN/14-208 ....................taserla-------QIQLSK.......G...............INPNAKIKAP...........GG..LR.......RPCILIRSSpw.kaGTAETPWHDVFDLDNGRILYFGDHRVDHTVP....VGTT..-QGNAVLLEA...LEEHQgltAE..QRALAVPLLVFAA......V...T..RNktpkG..Y..VE..FCGVAVIDHAE--------QIEQQ..A..KGISFPNYRYELSV...L...DLSaeddRVDWAWIEARGNpe.lsTAD.......ALRLAPRSWRQWVEQG-r....................
A0A255GIX1_9ACTN/32-221 .........................rg--NVGDEPIARII......pG...............VGNQGGFRSL...........GS..ISr.....gDVRLVVLYT.....SGEDTNWPDTLDPVTGDFTYYGDNKKPGAAL....HDTP..RRGNLLLREV...FQLTHg.gPG..DRLQVPPFLLFEK......G...A..QG....R..D..VI..FRGLLAPGSSRLTAEEELVAVWRT..T..RDKRFQNYRSHFTV...L...NVA....SVTRSWLTEIAN.....GNI.......NGPHAPKAWTRWVRG--rv...................
A0A1G9S7N4_ALLAB/35-226 ........................sgh---VGDDPIAKLL......pG...............VGNQGGFRYV...........GS..PRr.....gKVNLVVLYT.....TGDQPDWPDALDLQTGLFTYYGDNRTPGHEL....HETS..RAGNLLLRDV...FNASHg.tPE..QRQAVPPFLLFEK.....aS...T..RG....R..G..VR..FRGLLAPGGPALTPDDELQAVWRT..T..RRQRFQNYRARFTV...L...DCA....VIPRTWLRHVTG.....GGD......pLTGDCPREWVSWVRGR-a....................
A0A7Z0IKS1_9ACTN/44-243 ....................spgisar--------IQLER.......G...............INTPAEITAP...........DA..RR.......RPVILLRSSpg.kaGSATTPWEDVFDLDHGHARYFGDHKASTVGP....IGAT..-QGNRALLDA...WQLHGssaRA..DRVLAPPILLMRG......V...S..VM....RdgK..RV..DKGHLEFCGVAVIERLEYIVQRDP..Q..TARTFPNLAVDLAV...I...KLDettdELDFRWIDDRRDge.ltAEQ.......ANAKGPASWRRWVDQGK.....................
A0A846XL83_9NOCA/29-218 ........................kgt---AGDDALGRLL.......P...............VGLQGGFRPR...........GS..VRk.....kRVRLVALYT.....AGTEPDWPDHLDPETGIFTYYGDNRRSGSDL....HHTK..RSGNLLLRDV...FEATHg.lPE..ERAVVPPFLCFEK......A...A..PG....R..S..VR..FRGLLAPGTETMTSDEDLSAIWRH..T..KGARFQNYRATFTV...L...DVG....IVQRRWLSSVLA.....GEP......tTGPGCPEPWREWVEGR-v....................
K6V919_9ACTN/28-218 .........................qg--HAGDDPLARLL.......P...............VGNQGGFRFN...........GS..PRk.....gEVSIAVLYT.....SGTEIDWPDNLDPQTGLFEYFGDNRHSGQEL....HNTR..RGGNILLRDV...FAHAHg.sPA..DRERVPPFLLFEK......A...E..PG....R..A..VR..FRGLLVPGGASLTSDDELTAIWRS..T..GRLRFQNYRAFFTV...L...DVG....TVTRSWIQAILD.....GNAp.....aSAAGCPGEWAAWVKGR-a....................
A0A1E7NBL8_KITAU/37-228 .........................ng--NTGDDPIAKLL......rG...............VGNQGGFRYV...........GSplRG.......DVRLVVLYT.....TGDQPDWPDALDPQTGAFTYYGDNRTPGHEL....HGTS..RKGNLLLRDI...FAASHe.tPE..QRRRIPPFLLFEK.....aA...A..KG....R..D..VR..FRGLLAPGGPALTSDDELAAVWRT..T..AGRRFQNYRARFTV...L...NQA....VVSRGWIDHLRS.....GGD......pLSGGCPSAWRTWVHTR-s....................
A0A2Z5K4C8_9ACTN/1-188 .......................mlea-------------.......G...............INGMAKVRTP...........DG..ER.......RPVILIRSSpw.kaGTEQTPWHDVFDMDNGHVRYFGDHKATTTAA....PGKT..-NGNAALLDA...FTGHQghtPE..ERATAVPLLLFRA......V...S..RN....G..K..--..VKGHVEFCGLGVIERAERLVQWGG..S..DHTTFTNYVYDIAL...I...DLTaeddKVAWAWIDSRRDktvpdT-E.......TLELAPRAWREWVKHG-n....................
A0A7W7LXU6_9ACTN/32-226 ......yvtasdtlpqiqlskginpia-------------.......-...............-------RSK...........GG..QR.......RPAILIRSSpw.kaGTAETPWHDVFDLDNGRVRYFGDHRADHTVP....VGST..-QGNAVLLEA...FAEQQasnPE..HRARAVPLLVFAA......V...S..RN....-..-..KT..PKGYVQFCGLAVIERAELIE--QE..T..DGKPFPNYRYDMTL...L...DLSkeddRVDWAWIERRGDtw.rtAVD.......VLNHAPHSWLEWVQHG-h....................
C4IFW2_CLOBU/23-209 .........................ng--NIGDEPISKLM.......N...............CENSSGIRKK...........GH..LTd.....eKLKYVILYM.....TGKHKHWQDKYDKDSDVLIYYGDQNKADKDI....FDTP..KKGNIVLNRT...FEYLN...KG..MRDKICPFFVFEK......E...S..-G....R..D..VR..FLGVAIPGNKNYEAKKCLQVVENN..T..EKGKVTNYKAIFTI...L...NVE....RIDRRWLLDLDN.....LRG......iESDYVPLQWKEWVYNE-e....................
A0A0X3RWS3_9ACTN/34-132 ...............thtpghrralle------------A.......G...............INAMAHVKTA...........DG..ER.......RPAVLIRSSpw.kaGTEQTPWHDVFDLDNGHVRYFGDHKAGLSGP....PGST..-RGNAALLDA...FDGHQ...E-..-------------......-...-..--....-..-..--..------------------------..-..--------------...-...---....------------.....---.......-----------------ptpeagpr.............
A0A550HFT5_9ACTN/32-224 ..........................n-GNSGDDPIARLI......rG...............VGNQGGFRYK...........GS..PTk.....qTVRLAVLYT.....TGADVDWPDHLDTDTGTFTYYGDNKRPGQDL....HGTP..RGGNVLLRDA...FAASHgaeTD..RLTGVPPFLLFEK.....aA...G..SG....R..A..VR..FRGLLVPGGPALSPDDELAAIWRA..T..SGQRFQNYRARFTV...L...DYA....RISRTWLQHLLT.....GGN......pLEGGCPPVWASWVKGR-a....................
W5WCV0_9PSEU/1-57 ..........................m-------------.......-...............----------...........--..--.......---------.....-------------------------------....----..----------...-----...--..-------------......-...-..--....-..-..--..-------------------AIWRV..A..DDSRFQNYRAILTL...Q...DTA....EVPRTWLDSVLN.....GKI.......LTEECPSAWLRWVQTG-v....................
A0A0A2TWT6_9BACI/16-209 .........................st--NNISDQFLRWIni..ngsG...............MRNTPGIRPL...........KY..VNkl..lddVPAYIILVTnd.ksSGEKNPWDDIVDFSSGEILYWGDAKCHIEKR....-YNE..FEGNKKLEII...YDKIL...EN..KSEHVPPILHFSK......P...R..KG....-..I..VR..FNGLCILDKLE--------LTWYIdgT..TSLPIKNYRCHLKI...L...DVE....EVDINWLHDRAK.....GHDi....sqIDNNAPKVWKDYKRG--ri...................
A0A4Y9NKG1_9ACTN/75-263 ......aginapaltvapdgqrravig-------------.......-...............----------...........--..--.......-----IRSSpw.kaGHATNPWHDEFDLDHGYVRYFGDHKPNSPGL....PGTT..-TGNRTLFEA...LASHAspdPA..LRRLAPPLLLFRSi....tV...R..RE....G..R..TL..VKGHIEFCGVAVIDRLENIIQRDP..E..TQRGFPNIALDLAV...I...SLAdsgdTLDLRWIDDRRNpa.ltGDE.......AMRHAPASWRRWVAEG-p....................
A0A8J7YMX1_9EURY/16-201 ........................swr---DEDDQFLRWIrgp.lsaG...............IKNTGGIRDL...........SF..EDs.....sETAALILVSnddgvSQHADPWKDALDVSGGHIEYWGDAKAGVA--....YDES..-VQNQKIAQA...FERAA...RG..NRSAVPPVLMFRK......P...E..PG....-..V..VQ..FCGLCVPVRFE-------VGTYYD..D..DGTQIPNYRFHFAI...L...NVP....KVPVSWLHERAL.....HRS.......-DAAAPSEWTEWVSSGT.....................
A0A1H7WG04_9FIRM/24-216 .........................sg--NAGDEPLPRLI......pR...............CEASGGFRKK...........LR..EDd....sgKYAYVVLYT.....TMSELEWPDYLDEETGVFRYYGDNRHPGKEL....TDTK..KKGNAVLEMV...FALLN..eGC..HLDDMPPFFIFKK......A...G..EG....R..D..AQ..FLGLAAPGNPQISPDKDLVAFWRT..V..KEKRFQNYEAYFTV...L...NTGk..tPISRQWIESLIY.....DHE......nNLQYAPEVWKKFLREG-r....................
A0A4R4ZQU7_9ACTN/29-218 .........................ag--SAADDALARLL.......P...............VGNQGGFRPR...........GS..VRs.....eSVRLVALYT.....SGTEADWPDVLDTQTGVFTYFGDNRRPGREL....HETQ..RDGNLLLRDV...FAFGHg.tFV..DRRKVPPFLLFHK......A...I..PG....R..S..VA..FIGLLVPGAESLPSDDDLVAVWRT..T..GGRRFQNYRARFTV...L...DVG....RVTRAWINDVIA.....GNG......yESVHCPAVWKAWVDER-v....................
#=GC seq_cons .........................tt.....t-.h.hhh.......s...............lss.uGhRhh...........us...c.......pstlllLhS.....utpcssW.DhlDhcsGhhpYaGDsKtsspth....hsss...tGNthLpcs...Fsttps.sst..pRtpsPPlLlFcp......s...s..pu....t..s..sp..F+Glss.suhsl..pt-hlshacs..s..psppFpNYphcFol...L...chs....tlshpWIpshts.....ups........sttAPpsWppWVcpG.p....................
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