#=GF ID   RE_LlaMI
#=GF AC   PF09562.14
#=GF DE   LlaMI restriction endonuclease
#=GF AU   Coggill P;0000-0001-5731-1588
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   25.30 249.60;
#=GF NC   24.80 24.50;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   16144727
#=GF RT   In vitro expression of the restriction endonucleases LlaMI and
#=GF RT   ScrFI isolated from Lactococcus lactis M19 and UC503. 
#=GF RA   Szatmari G, Hua NM, Vzdornov D, Daigle F, Smoragiewicz W,
#=GF RA   Mamet-Bratley MD, Karska-Wysocki B; 
#=GF RL   J Biotechnol. 2006;121:144-153.
#=GF RN   [2]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019063;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes the LlaMI (recognises and cleaves CC^NGG)
#=GF CC   restriction endonuclease.
#=GF SQ   9
#=GS L8MZ19_9CYAN/16-256      AC L8MZ19.1
#=GS A0A1S9CFV4_9FIRM/14-267  AC A0A1S9CFV4.1
#=GS A0A059XRI9_9MOLU/24-274  AC A0A059XRI9.1
#=GS A0A385C8R2_9GAMM/14-258  AC A0A385C8R2.1
#=GS K9Y9J9_HALP7/1-245       AC K9Y9J9.1
#=GS A0A241VLP7_9GAMM/17-261  AC A0A241VLP7.1
#=GS A0A162D5M2_9BACI/15-268  AC A0A162D5M2.1
#=GS A0A380NL38_9FIRM/16-283  AC A0A380NL38.1
#=GS A0A3M0A0J9_9BACT/15-271  AC A0A3M0A0J9.1
L8MZ19_9CYAN/16-256                 .....VRGRKPDTSN.INQDHDGKAGHWLEHQMGIKINNKTEADLFGYEMKNQTTSGKITFGDWSADYYIFKDYKYFTS..GNTGV-NRDC.FMQIF.GTYKLDK.GRYSWSGEVTPKIKNF.NRYGQKLIITENK..............DITAIYSYDQDSRQNKKDIIPVNMQINDLILARW..............TSNSMKKRVESKFNDKGWFKCLQNSLGVYTNIQFGKPITFESWIDLVAEGVVFFDSGMYQG....NNRPYSQWRALNNF.WDSLIIETY....
A0A1S9CFV4_9FIRM/14-267             .....VKGKCADTSS.RNVNHDGWEGHWLEQQFGIEPNSNNGADLFGYELKKETS-SKTSFGDWSANRYIFKTGSYFQYfeGDTFKDRQNS.FCQIF.GKPNPHKnNRYSWSGSSCPKINSF.NEVGQKLVIDDNG..............DIVAIYCYTQDTRLNKYSIVPIAFQQEDLELARWfgkss....psnnkGDKCLKLKLEDKFNDAGWFTIKKDGNGRYKQLCFGEPINFDRWLNLIKEGTVFFDSGMYQG....NSRPYSLWRANNKF.WDSLITEIY....
A0A059XRI9_9MOLU/24-274             svldf------DIDNrINK-------HWLEQKFGLNYNGECICSDVGYELKIE-SEKMINFGDWTPNYYIYNQTDYLEIfpGNTPAERRVS.FLLMFaGDFDRN-.NRYYWNGENCIQTKCS.NYCGLILRVEDNS..............DISIIYNFSEDKRINKYEVVDFRLQKENVILAQWfgrkntkvkrngifNGRSLQSRFEDKYEGKGFCVVKSDHQGYYRSIKFGYKLTFRDWVQQVEEGNVIYSCEMNAE....NHRTYARWESANNIyWDRVA----niei
A0A385C8R2_9GAMM/14-258             ...vl--GKRADSSQ.YNTNHDGKVGHWLEKQMGIKPNAKAEADLMGFEMKNQ-TSIKTTFGDWSPTYFIFNDPHIIQWntGENALTRRNKyFLPTF.GKPNEDKdNRLSWSGSAIPKINQR.NQYGCILKVTAHN..............HIEIQYSYSFDNRTHKSTLVPEEFKKDDLVIARW..............SADKMRQRVNQKFNQNGWFRCKTDDSGKYVAIEFGEPLSFEKWIRLVKQGVIFFDSGMYES....NRRPYSHWRASNSL.WDALVVRSY....
K9Y9J9_HALP7/1-245                  .....MRGLKATTTN.INQKHDGAKGHWLETQMGISHNNTNKADLLGYEMKTGTSSGKISFGDWAADYYIFDNEDFFDV..SETRIVRRDQ.FIKVF.GKFNQTK.NRYSWSGEVCPTYYNRrTNSGQMINISPTN..............DVLIEYNHSEDFRNDNE--IPSYFQKDNLILAKW..............DAKSLRKKVEKKFNQKGWFKCFINEEGQYTSIGFGNPITFEIWIKLLKEGKIFFDSGMYADpnkpNQRFYSQWRAITKV.WDDLIKETY....
A0A241VLP7_9GAMM/17-261             ....v-YGKKADVSG.MNSKHDGNKGHWLERQMGITHNASNAPDLLGFEMKNQTTS-KTTFGDWSPSYFIFNDKEIIPRekGIRAVDRRDThFLTVW.GQPNVEKeNRLSWSGKPIPKIDQW.NDFGCILLVNQNN..............DIEIVYDYQRDLRPNKTAIVPEFYRNAPIAIAKW..............DAAKLAKKVNDKFNQKGWFTCKTNALGVYEKICFGNPITFEDWIYLVKQGIVFYDSGMYFG....NARPYAQWRASNNY.WNSLILRE-y...
A0A162D5M2_9BACI/15-268             .....VKGRRPDTTG.ANIRHDGRQGHWLERQFGINANGNNEADLFGYELKNETTS-KTTFGDWSANRYIFKTGEYVNSfdGNTAPERQDS.FCGIF.GKPNQLKaGRCSWSGSPCPTIRGY.NDFGQVLIIDNNK..............DIVALYSYSKDMRINKSQIVPAELQQENLEIARWfgeys....ptprqTDKCLKTKLEDKFNDAGWFTCKKGPDGTYQKICFGEPMTYDNWLKLVETGIVFFDSGMYQG....NKRPYSQWRANNSY.WDSLITECY....
A0A380NL38_9FIRM/16-283             .....VKGQVPDVTG.RNERHDGKEGNWLEEQFGKSPDADNHADFYGYELKNETTS-KTSFGDWSANRYIYKKSCYSHLfdGKTPTQRQDS.FCRIF.GAPNPDKnNRYSWSGRPVPKINKY.NSFGQILKIVEPNeswgtpfdtpirefDILAVYSFSKDMRENKDFIIPKPLQQENLIIAHWfgles....lsikrGDKCLKQKLEDKFNDMGWFTCKTDLNGKYDRICFGAPFNYNSWLELIRRGIVFFDSGMHEG....NIRPYSQWRASNQF.WDSLIIETY....
A0A3M0A0J9_9BACT/15-271             .....VKGKKPNIKT.SNINHDGKYGHWLELQFGLKANDVNEPDLLGYELKSD-TKAVTSFGDWSANMYIFNNEKYKEIfqGQTNLKRRDK.FLTIF.GMKNISKlSRFSWSGLSCPKINHF.NSFGQKLLICENK..............DIIVVYSFSKDMRVEKEQIVPRELQQEDLILAIWygekfp.anykfkyNEKTLKNKVEDKFNKQGWFTCKKNSEGEYTKICFGPPIDYNLWLEKVKLGIVYFDSGMHTG....NSRPYQQWRAKNEF.WDSMINEEY....
#=GC seq_cons                       .....h+G++sDsos.hNppHDGptGHWLEpQhGIphNusNcADLhGYEhKspTTS.KToFGDWSAshYIFpstcYhph.pGpTshpRRDs.FhplF.Gp.N.sK.NRaSWSGpssPKIppa.NpaGQhLhIspNs..............DIhhlYsaScDhR.NKppIVPtthQp-sLllA+W..............ss+sL+pKlEDKFNppGWFsCKpsspGpYppIsFGpPloF-pWlcLV+pGlVFFDSGMYpG....NpRPYSQWRAsNpa.WDSLIhEpY....
//