#=GF ID   RE_NgoPII
#=GF AC   PF09521.14
#=GF DE   NgoPII restriction endonuclease
#=GF AU   Bateman A;0000-0002-6982-4660
#=GF SE   Bateman A
#=GF GA   25.00 25.00;
#=GF TC   32.80 38.40;
#=GF NC   22.40 18.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 --cpu 4 -E 1000 HMM pfamseq
#=GF TP   Family
#=GF CL   CL0236
#=GF RN   [1]
#=GF RM   22638584
#=GF RT   Sequence, structure and functional diversity of PD-(D/E)XK
#=GF RT   phosphodiesterase superfamily.
#=GF RA   Steczkiewicz K, Muszewska A, Knizewski L, Rychlewski L, Ginalski
#=GF RA   K;
#=GF RL   Nucleic Acids Res. 2012;40:7016-7045.
#=GF DR   INTERPRO; IPR019046;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family includes the NgoPII (recognises and cleaves GG^CC)
#=GF CC   restriction endonuclease.
#=GF SQ   53
#=GS A0A139NAB8_9STRE/3-264   AC A0A139NAB8.1
#=GS A0A2B2C9F5_9BACI/7-271   AC A0A2B2C9F5.1
#=GS A0A1Z4RSD4_9CHRO/2-267   AC A0A1Z4RSD4.1
#=GS A0A2T1F904_9CYAN/2-270   AC A0A2T1F904.1
#=GS A0A5C7AK03_9FLAO/2-263   AC A0A5C7AK03.1
#=GS A0A4Y9IXW1_9BACT/3-266   AC A0A4Y9IXW1.1
#=GS A0A2T1CGT8_9CYAN/2-55    AC A0A2T1CGT8.1
#=GS A0A5Q0UJ82_9ARCH/2-274   AC A0A5Q0UJ82.1
#=GS G8X6Y9_FLACA/2-263       AC G8X6Y9.1
#=GS A0A2S7XPC3_9GAMM/1-260   AC A0A2S7XPC3.1
#=GS A8MHW4_ALKOO/3-264       AC A8MHW4.1
#=GS A0A1T0C7N0_9GAMM/6-266   AC A0A1T0C7N0.1
#=GS A0A1H3HHD9_9FLAO/2-262   AC A0A1H3HHD9.1
#=GS A0A166ESV4_9EURY/1-59    AC A0A166ESV4.1
#=GS D5ERM8_PRER2/4-268       AC D5ERM8.1
#=GS A0A1G6KNM7_9GAMM/3-263   AC A0A1G6KNM7.1
#=GS A0A5B8XCH1_9RICK/3-263   AC A0A5B8XCH1.1
#=GS V7PW33_9BACT/3-264       AC V7PW33.1
#=GS A0A6N8UBM8_9FLAO/2-258   AC A0A6N8UBM8.1
#=GS K9RKZ4_9CYAN/2-259       AC K9RKZ4.1
#=GS A0A0L0QQ08_VIRPA/7-274   AC A0A0L0QQ08.1
#=GS V9H9F6_9NEIS/2-265       AC V9H9F6.1
#=GS A0A1B8PLE0_MORNO/2-262   AC A0A1B8PLE0.1
#=GS D5VBE5_MORCB/1-47        AC D5VBE5.1
#=GS A0A3G2GAW9_9FLAO/2-262   AC A0A3G2GAW9.1
#=GS C9MNU9_9BACT/2-264       AC C9MNU9.1
#=GS A0A087MZP8_9BACI/5-273   AC A0A087MZP8.1
#=GS K9VY48_9CYAN/2-266       AC K9VY48.1
#=GS A0A3N4WJ91_9PAST/1-261   AC A0A3N4WJ91.1
#=GS K0C131_CYCSP/2-261       AC K0C131.1
#=GS A6EU95_9BACT/2-262       AC A6EU95.1
#=GS D1B3R6_SULD5/2-265       AC D1B3R6.1
#=GS F0S2I4_DESTD/6-276       AC F0S2I4.1
#=GS A0A345GVL5_9FLAO/2-261   AC A0A345GVL5.1
#=GS A0A8J7Z1W7_9CYAN/12-274  AC A0A8J7Z1W7.1
#=GS A0A286EDP7_9NEIS/1-260   AC A0A286EDP7.1
#=GS A0A316EDV0_9BACT/2-235   AC A0A316EDV0.1
#=GS A0A2T1C852_9CYAN/2-267   AC A0A2T1C852.1
#=GS A0A376BLN2_9NEIS/1-260   AC A0A376BLN2.1
#=GS A0A2M9A3N0_9BACT/2-262   AC A0A2M9A3N0.1
#=GS A0A1G7BJM1_9FLAO/2-260   AC A0A1G7BJM1.1
#=GS I4AHT4_BERLS/2-262       AC I4AHT4.1
#=GS A0A099XQ01_9FLAO/2-262   AC A0A099XQ01.1
#=GS I3CCM7_9GAMM/2-265       AC I3CCM7.1
#=GS A0A1X7MFT8_9GAMM/2-264   AC A0A1X7MFT8.1
#=GS A0A556UCI9_9LACO/5-275   AC A0A556UCI9.1
#=GS A0A2H1EBK2_9FLAO/2-262   AC A0A2H1EBK2.1
#=GS A0A1Z4J0S1_9CYAN/2-263   AC A0A1Z4J0S1.1
#=GS A0A0K8MDE4_9PROT/11-116  AC A0A0K8MDE4.1
#=GS A0A2T1EGY6_9CHRO/2-264   AC A0A2T1EGY6.1
#=GS D2EGA9_PARA4/2-273       AC D2EGA9.1
#=GS A0A0H4IT76_NEIG1/3-153   AC A0A0H4IT76.1
#=GS A0A1V3TQH4_9PAST/1-259   AC A0A1V3TQH4.1
A0A139NAB8_9STRE/3-264              ..........................ANILTAVINIIKSHN.S.NLQEIYIGS..NR..ANSMGDALEKYIVDSFA.D.TILE.DDESARILKVNQVFSYL.GNDSNPPDAMLKGG.AAIETKK.IES..R.N.S.QLQLNSSSPKSKL..YVDDSRLKQAA..REAE....EWSEKDFIYSIGFVKDRQ.......LRELALIDASVYCADKTVYQDIFEKIKYGIS...S.I...PNVNF....SPTQELGRVNKIDPLGITSLRIRGMWLLDNPFTV..FKY..I...YTP..VE..EA...DFNLFALVSSQHFDNFNNKD--ELLS.LAnnTCNLSILDVKVK................
A0A2B2C9F5_9BACI/7-271              ..........................TNVLVALKNILDRNS.S.ILTPIFRSN..GS..ANAAGDSLEFFVKDMFC.T.GASQyQYEHEKMRKYNEYLSWT.GNSSNFPDFIIKGG.AGVEPKK.LNN..Q.SyS.SLALNSSYPKDYI..YPDSQNLPRDI..NE-E....EWVRKEVIYVTGNLNTQNn.....kLLSLWFAYGNTMVADRSTYLNLIDEIRDAVA...S.T...-NATL....IASKELARAKGIDPLKLSNLRVRGMYELEHPHKV..FSD..Y...ITR..DDipSD...ASKIFVVMLISDYIALEEQP-DFSTH.LA..SGKLKITEI---yip.............
A0A1Z4RSD4_9CHRO/2-267              .........................v-DILQGISNLVAHPL.P.NLLDHYQSKsnNR..INAVRDALEEYVKDLFA.N.TIDE.TNLERKLIKYEQVFSWQ.GGKNNPPDLIIRSG.DAIEVKK.ISS..L.N.S.QIALNSSFPKHKL..FINNLMISSSS..RKCE....NWIEKDLIYAIGVIPNKQ.......LKLLWLIYGDCYAASQDYYDRIKNTIATGIS...T.I...QNVTF....SQTKELNRVNKVDPLQITYLRIRAMWGMQNPLDV..YNY..L...NLY..EP..DS...TFQVIAIMRENKYLSFPKSSIHNLES.CVssNRELTIDIKS--ik..............
A0A2T1F904_9CYAN/2-270              ..........................TNILQAIATIINNPI.P.DLLSYYKSQgnNR..IKAMGDALKYFVKDAFA.N.TIDE.PELS-KPEKYDEVFSWIrGNQSNPPNLMIRNG.DAIEVYK.IQS..S.K.G.SIQLNSSYPKSKL..FYNNPQITLAC..RDCE....TWTEKDIIYAIGVTSKDNtk...enLKTLWLIYGDCYAASKEYYEGIKDQIASGIN...A.I...SDVEF....SETEELGRVNKVDPLSITSLRIRPMWLINNPSTV..FDY..V..dTGY..DP..LK...NFQIIAIMKESKYLSFPLDSRTTIES.IS..VPGFNINTQSIK................
A0A5C7AK03_9FLAO/2-263              .........................i-NILDAIYNIAQREE.L.EIKDITFGN..NR..ANNMGEGLEAFIKDSFA.N.MFDE.PDKNLRNIKYKQVFSFQ.GSKRNPPDLMLKSG.PAIEVKK.IES..L.T.T.ELQLNSSHPKQVL..KSDSSFITKKC..VECE....EWTEKEFIYVIGHIPKNTn.....rLSSLWFVYGDIYAASEETYISLKNDIATTID...E.I...PDIEF....SETNEIGRVNKVDPLGITNLRIRGMWLLQPPFKV..FDY..I...HNY..EP..GK...RFQCFALIPLTKYNNFPESSINRLAE.--..TEGVTISDVNV-n...............
A0A4Y9IXW1_9BACT/3-266              .........................g-NILTAIQAIVNRSS.L.KVAENRQENiqNR..ANQMGAALEDYVKDAFA.N.CLGQ.DYQSIR-QAHNETFSYI.GNNTNPPDAILTNS.DAIEIKK.IKT..I.G.AaQLQLNSSYPKNKL..RRDNPKICKAC..RDCE...eDWEEKDMLYVVGAVENEE.......LQDIFFVYGDLYCDTHEIYEKVENAIKDGIK...L.I...EEVTV....AETGELARINKVDHLGISDLRVRGMWLIDTPFQL..FKD..L...TKE..IK..GY...TFKLTALIPKYKYDEFENTD--EFEK.FC.mKNRVSISDQKI-a...............
A0A2T1CGT8_9CYAN/2-55               ..........................TDILRAITTLVNHPI.P.NLLDYYRSKsqNR..INAIGDALEEYIKDIFA.K.IINY.-----------------.--------------.-------.---..-.-.-.-------------..-----------..----....------------------.......-------------------------------...-.-...-----....----------------------------------..---..-...---..--..--...--------------------------.--..------------kmr.............
A0A5Q0UJ82_9ARCH/2-274              .........................v-NILDALLNYAEMDD.R.DMSEIYSSS..NR..INRVGDRLEYFTMDLFC.G.SFDI.ETKDEKEKKYSKHFSWL.GNKNHPPDFMIENG.EAFEVKK.TTS..K.A.G.SIQLNSSHPHQKL..KSSNERITNSC..QKCEdhlgGWNEKELVYILGRVPRGEd.....nLDFIWMVYGDCWAAPEQVYENLSNKLSKKTS...QaV...GELDYgdlsSQTNEIGKVHDADPLGRTKLRIRGMWTMSHPANY..FSQ..HienYKH..KI..EE...KQPLFAVMKKSKYQEIPEDKIKAIEE.--..QENIKYQEI---qa..............
G8X6Y9_FLACA/2-263                  ..........................TNILDAIYNISLIQD.L.SIDEIIFGN..NR..ANNMGEGLESFIKDSFA.N.TFNE.DNNRILSEKYSVFFSYE.GSKNNPPDLMIKNG.DALEIKK.VES..L.T.S.ELQLNSSHPKSKL..YSSSPLINKHC..KNCE....IWDEKDFIYTIGHIPNGTk.....kLSSLWFVYGSIYSADEEIYLSIKNELAKSLE...E.N...QNLHF....SVTNEIGRLNFVDPLKITNLRIRGMWLLQPPFKV..FKD..Y...YEY..KK..ES...NFQCFAFIPNDKYISFPIESRNKVEN.--..SNNIKIENIKVK................
A0A2S7XPC3_9GAMM/1-260              .........................m-NVLQFLVRCASLPT.M.SLSAVSSGN..NR..INNVGDALEKFVKDVFA.N.AVNV.TAQN-SNLAYSVTFSYC.GNKNNPPDVMIKGG.DAIEIKK.IES..P.R.A.RIALNSSYPKDKI..YSNSEMLTLAC..RNCE....KWTEKDMLYVIGYVKNSD.......IKCLWLVYGDCFIANKEIYERLKNKISTGVN...E.I...PDIKF....TETNELGKVKKIDPLGVTDLRIRGMWHIDNPMTI..FEH..F...ENY..DQ..SS...EFKLVCIMQKSKFETMPAEDIYSIES.ES..SAF---------ftrnesir........
A8MHW4_ALKOO/3-264                  ..........................TNIIRAIINLVNTPV.V.ELKEYADSH..NR..VNSMGGALEEYIKDIFA.G.TVGE.IDEKKRLLKIQECFSYL.GNQNNPPDSMLWGG.DAIEVKK.IES..K.D.A.QLALNSSYPKAKL..FSNSKMIKKAC..RACE....DWTVKDMIYTVGVVKDSK.......LSSLCMVYGIDYAADAETYEQIKEVIKDGVE...S.I...NGVEF....AETKELGRVNRVDPLGITYLRVRGMWGIENPFKV..FNY..V...YER..DS..SK...NFNFMALINNEKYDTLEYTD--ELEK.LVgvKEGLELKEVNIK................
A0A1T0C7N0_9GAMM/6-266              ..........................ANIINAIVNLLNNPI.V.DLKTIYIGK..NR..INNVGDALERYVQDLFI.N.GFDL.NDNI-RNQKVSEHFSYL.GNTSNPPDMMLKGD.DAIEVKK.IQS..K.N.A.ALALNSSHPKSTL..RADNPMLTVSC..KEAE....AWQEKDMLYVVGVVGNEC.......LTSLCFVYGVDYAAAHEVYETVKQRIKSGVE...T.I...EGVEF....HPTNELGKIKRIDPLGITNLRVRGMWHIENPFRV..FEY..V...YQR..NY..DH...QFNFMTIINNKKWQSLDNRQ-DLIDK.IN.tIETANISDIHIK................
A0A1H3HHD9_9FLAO/2-262              ..........................TNILEAIYNIVNHKN.F.AIREFYSGR..NR..ANSMGEALENYIKDAFA.D.TFDS.EDEQSRLKTYNEEFSWL.GSQNNPPDIMIKGG.DAIEVKK.TQS..A.N.S.SLALNSSYPKTDL..RHTSPMITSEC..RDCE....EWTVKDLIYCVGHTSDTN.......IKSLWMVYGSSYAAKHETYQRIKTTISDGIK...T.I...PDVVF....ADTKELGRVNQVDPLGITNLRIRGMWQIENPRKV..FNY..L...HEP..TD..KD...-FELVCIIPLEKYNSFPNESKSKLEG.IT..EKGFSIEDKQIK................
A0A166ESV4_9EURY/1-59               ..........................---------------.-.---------..--..-----------------.-.----.-----------------.--------------.-------.---..-.-.-.-------------..-----------..----....------------------.......-------------------------------...-.-...-----....------------------------MWGIEHPLDV..YSY..L...FKE..ES..DK...EFSIYGLMRKGKYDSFSDEDRKIIEN.--..DKDISIEEVKVK................
D5ERM8_PRER2/4-268                  .........................y-NIITAIINIIKDNR.R.VIGNSPNSN..NR..LHSLGEPLEEYIKDAFS.N.SLGL.SGVD-KTRKRAEALSYG.GGKNNPPDAVLKRG.AAIEVKK.VES..I.G.N.-INLNSSYPKSHL..FKNDSKISKAC..REIEn..gDWDVKDIIYAIGCVEKKKn.....nLKSLALVYGSVYCASKECYENVFNSVKQSIE...E.S...SELDL....EETKELAHINAVDPLRITFFRARGMWGISHPFKVgsFAD..I...YRY..DE..SN...-FELMAIIPSDKYNSFENID--ELSE.LSqrIDNLTIEDTFV-q...............
A0A1G6KNM7_9GAMM/3-263              ..........................ANVINAMLNLIEHPI.T.DLQSNYVAK..NR..ANGMGEALERYVQDLFI.N.GFNL.DEMT-RLKRIEEHFSYI.GNDSNPPDAMLKGG.DAIEIKK.TES..R.N.A.DIALNSSYPKAKL..NIDHPMLTAGC..KVAE....SWHEKDMLYAIGTVAKNT.......LESLVFVYGEDYAADEATYQAVKTRIKQGVE...T.I...EGIEF....TPTKELGKINRIDPLGITYLRVRGMWGIQNPYKV..FNY..V...YQR..DF..SN...KFNFMAVINAEKWSSFENTEQ-LVTL.IK.nTANASITDIEIK................
A0A5B8XCH1_9RICK/3-263              ..........................TDILQGIKNLIDNEL.N.GIEKYENSS..YKigINNMGSKFENFMKDAFC.N.SFQS.NEI-AKMSMYNEYFSYL.GNQNNPPDLIVRGG.DAFEIKK.IES..K.D.G.DIALNSSFPKDKL..YRNSNMITVAC..KSCE...aNWNEKDICYIIGSIKDKK.......IQSIWFVYGDCYSANPEIYTILKHKITNSIE...E.L...-GIEL....SATNEIARINNVDPLGITYLRVRGIWGIKHPSKV..FEY..I...ATK..SS..KP...--HIKAIMLKEKFELFDENSRNELSKkCS..IKEVKIQD----pnn.............
V7PW33_9BACT/3-264                  ..........................TNLLKAIRNIIANPS.N.DLLSQYRSL..NR..MNSMGEALEFYVKDIFC.D.SLKE.DNSD-KGKIYSEYFSYL.GNQNNPPDIIIKNG.DAIEVKKhIGA..R.A.S.GLALNSSYPKDYL..YADSPMITTAC..RGCE....NWEKKDLLYVIGSIVDSK.......IKSLWFVYGDCYAASREIYEKIKDAISDGVN...S.L...PDIEF....GETNELGRVNKVDPLGITDLRIRGMWAIKHPNKV..FDY..I...SEI..SN..EA...DFKVNAIMLSSKYNSFPESDRKELES.LI..SHNLIINDIKIK................
A0A6N8UBM8_9FLAO/2-258              .........................m-NILEALVNIAENKD.Y.EINEYTQGN..NR..AQNMGEALEEYIFDAFS.N.SFHI.KDNEKRINEHQKTFSFL.GSKNKIPDAILRNG.HALEVKK.STS..E.S.T.-IQLNSSYPKHTL..KSCDTRIKSSA..LICEd..kPWEEKEMIYCFGYIPKGSk.....hIKSLWFVYGRVFCDLPEVYEEIIDNIRVNLN...D.D...-----....YEGNELGGATGIDSLNITRLRVRGMWVIDHPQKV..FSN..L...IKD..WN..NT...KFEVKALIPKSIFNNFPEDSKNKISK.--..-SQFTIEEVEV-t...............
K9RKZ4_9CYAN/2-259                  ..........................ADILQAIKAIIDNTI.P.DIVSYSQGK..NR..INSAGDALEDFIKDIFS.E.ALKD.SDLTLKNKKYSEAFSYI.GNQNNPPDIILKNG.DAIEVKK.IES..L.K.S.SIALNSSYPKSKL..YFDEPMITNSC..RNCE....DWQEKDIIYAIGVVKEKK.......LQLLWLIYGDCYAADREIYQRIRNKINSGIT...E.I...PNVEF....SETKELGRVNKVDPLGITYLRIRGMWGIKNPVVV..YDY..L...FEN..LD..IN...TFKLIVVMKEEKYLSFPYEKRMLLEG.IS..NQNFTIR-----k...............
A0A0L0QQ08_VIRPA/7-274              ..........................TNVLIALRNILERNS.N.KMPKVLNHKnsNR..INSAGDLLEYFVKDAFC.SySFNY.EMAGDKLKEYQKVFSYL.GNSNNPPDFVIKHG.AAVEVKK.IEG..T.NpN.GIALNSSFPKDYL..HSNDLRIKKEC..RECEneygGWAKKDMIYAVGNVKNKK.......LSSLWLIYGDCFCADKETYEKISNAIKDGVS...S.I...PEVEF....GETKELGRVNRVDPLGITYLRIRGMWGIEHPSSI..FRS..L...INL..DK..VK...-THVYVLMRKETFDSIEDKP--NLNK.YV.eNNNLQMKNVTI-p...............
V9H9F6_9NEIS/2-265                  ..........................SNIINAIYNLVTDFE.N.NFNRENHGL..NR..ANQMGEALEEWVKDLFA.N.TLHT.QNEQQRLARLSETFSYL.GNQNNPPDMILKNG.DAIEVKK.VIG..K.D.A.TLALNSSYPKDKL..LASSPLLTQEC..RNCE...pNWREKDIIYVVGVVPKNQ......pLQSLCMVYGVDYAANHMIYERIRHTIVTGIQ...Q.I...PDVEF....TETNELAKVKKIDPLGITDLRVRGMWSIANPFKV..FNY..L...YQR..DF..ER...PFNLMCLINLEKYQSFNNTE--DIEQ.LVgqVPDFSIADVMIK................
A0A1B8PLE0_MORNO/2-262              ..........................ANIINAIIHLIQYPI.I.DLQESYLGK..NR..INNVGDALEHYVQDLFL.G.DFDL.DAND-RNVKISECFSYF.GNSSNPPDMMLKGG.DAIEVKK.IES..R.N.S.DLALNSSYPKAKL..LSDNPMLNKAC..KNAE....CWMVKDMLYVVGIVDNGR.......LNALTFIYGDDCCAEQEIYETVKNRIKTGVE...M.I...QNVEF....TPTKELGKIKRIDPLGITNLRVRGMWHIENPFKV..FDY..V...YQR..NF..NH...QFNFMAIINDQKWQSFSNTD-ELIKL.IN.kTPNTSLIDIKVK................
D5VBE5_MORCB/1-47                   .........................m-NIINAIFNIVTDFS.Y.ELTRDLHGL..NR..ANQMGGALEEWVKDIFA.K.----.-----------------.--------------.-------.---..-.-.-.-------------..-----------..----....------------------.......-------------------------------...-.-...-----....----------------------------------..---..-...---..--..--...--------------------------.--..------------ly..............
A0A3G2GAW9_9FLAO/2-262              ..........................TNILEAIVNIAQNPI.Y.TIRSLYSGR..NR..VNNIGEALETFVKDAFV.N.SIQT.EDELEKMRRYSEEFSWL.GNQNHPPDIMIKGG.DAIEVKK.TQS..A.N.S.DLALNSSYPKSTV..QSISKLITQSC..RTCE....DWTEKDLIYCVGHTTDDS.......IKSLWMVYGNIYAASHETYQIIKQKITEGIN...E.I...PNVEL....AETNELGRVNRVDPLGITNLRIRGMWQIQNPRRV..FNY..L...HTP..SS..SI...-FELVAIIPTSKYESFPSESKTKLET.LG..NVNLTTENVQVK................
C9MNU9_9BACT/2-264                  .........................g-NILTAITAIVGNSL.ElSGNALGEIQ..NR..VNQMGAALEDYVKNAFA.D.CIGK.DQRT-INSLRNSTFSYL.GNNTNPPDAMLKGS.DAIEIKK.VES..A.K.N.TLQFNSSYPKNKL..SSGNPKISVKC..KNCE....EWNTKDMIYVVGHVEESI.......LHNIFFVYGDVYCDAHNVYENVENTIKECVQ...S.L...DGIES....SETRELGRVNKVDHLGISSLRVRGMWVIASPFKQ..FEY..L...YED..KA..KEegySFRLIAIIPVDKYDTFKNKS--DFET.--..------------fcmdhavvvndedi..
A0A087MZP8_9BACI/5-273              ..........................TNLLVALRNILERNS.S.ILTPLFRSN..GS..ANVAGDSLEYFVKDMFC.T.GASQyQMENEKMRIYNQYLSWT.GDSKHFPDFIIKNG.AGVEPKK.VNG..KsK.G.NIALNSSYPKDYI..YPDSQNIPNTT..LLIEd..dNWDKKDIIYAVGNLDSTNn.....kLLSLWLVNGNTFIANRKVYENLITEIREAIS...K.-...TNATL....QDSKELARAIGIDPLNHANLRVRGMYELKHPEAI..FGT..Y...ISDivLP..KE...STRIYVVMLKDDLVKLELENEDLN--.--..------------edlctyynqkrlfrkd
K9VY48_9CYAN/2-266                  ..........................TNILQAINTIINNPI.P.DLVSYYQSKsqNK..INAIGEALEEFIKDVFA.D.TISE.TDTIKKSKKYEQVFSHQ.GSQNNPPDLMIKNG.DAIEVKK.INK..I.G.S.GIALNSSYPTAKL..YQDSPMITADC..RNCE....TWTEKDIIYAIGCTPEQK.......LRLLWFVYGDCYAASKETYKRISQQIAIGVN...Q.I...PNVVF....SKTKELGKVNQVDPLKITDLRIRGMWSIKNPLKV..YKY..I..nLDY..DN..SS...QFQLNVVMRQTKYLSFPEKERIKLES.LS..KPGFSIADNKIK................
A0A3N4WJ91_9PAST/1-261              .........................m-NLINAIINLINNPI.T.ELVTHYQSN..NR..ANQAGDALEEYVKDLFA.N.TFNL.PEIE-RLEKRAEIFSYL.GNNSNPPDIMLKNG.DAIEVKK.IKN..N.N.S.YLALNSSYPKSKL..LANSSMISNAC..RNAE....NWTEKDLMYIVGIVDNSH.......LKHLSIVYGDDYCATEDCYSKIKSTIKNGVE...S.I...PGVEF....SFTKELGRINKIDPLGITYLRVRGMWGIENPWNV..FNY..I...YTR..SF..SN...NFNFMAIINEQKWNSFNNTQ-DLLEL.VN.dNDNLNIIDIKIK................
K0C131_CYCSP/2-261                  ..........................SNIIKAIINIANEPI.V.QLRDSYTSR..NT..INNIGQALEAYMQDAFA.N.TISE.PSPQKRNERINEVFSYL.GNQNNPPDIILKDG.DAIEVKK.IQS..K.G.A.AIALNSSYPKSKL..HSDDSKITDAC..RDCE....DWTAKDIIYAIGVTSDQN.......LKHLWLVYGDCYAASREIYTRIGKTIKEGVK...E.I...EDIEF....SETKELGRVNRVDPLGITNLRIRGMWHIDNPLKV..YKD..Y...YEA..NE..TK...TFSLACIIREDKFLSFNSSDIDSLYS.--..HNDIAIKDIEIK................
A6EU95_9BACT/2-262                  ..........................TNILEAIYNIVNHKN.F.AIREFYSGR..NR..ANSMGEALENYIKDAFA.D.TFDS.DDEQSRLKTYNQEFSWL.GSQNNPPDIMIKGG.DAIEVKK.TQS..A.N.S.SLALNSSYPKTDL..RHTSPMITSEC..RDCE....EWTVKDLIYCVGHTSDTN.......IKSLWMVYGSSYAAKHETYQRIKTTISDGIK...T.I...PDVVF....ADTKELGRVNQVDPLGITNLRIRGMWQIENPRKV..FNY..L...HEP..TD..KD...-FELVCIIPLEKYNSFPNESKSKLEG.IT..EKGFSIEDKQIK................
D1B3R6_SULD5/2-265                  ..........................TNILSAFRTIISNYQ.T.NVQHVTNGS..NR..ANNMGDGLEAFIKDAFA.N.TFNE.TNEQTKLEVFSRIYSYS.GNKNNPPDLILQNS.DAIEIKK.LES..A.S.T.AIALNSSYPKAKL..FSNSTMITTAC..RTCE....AWSEKDMLYAIGNVPKTTn.....qLKSLWLVYGDCFCADKEVYERIQQTISSGIT...S.I...PNVEF....TQTNELGKVKKVDPLGITDLRIRGMWHIENPTKI..FNY..L...YHY..DE..TA...TFQLICLMKKEKYEALPLEDRNAIEN.LS..NLHVTLSDIRIK................
F0S2I4_DESTD/6-276                  iidfivnlssyikafgyglpsidvsv---------------.-.-------YR..SR..VNSSGEALEHFVRDMFA.G.TYNL.ESESEKIKIFSEVFSYL.GNQNNPPDLMIKGG.DAVEVKK.IESdgL.R.K.KIPLNSSYPKNKL..YRTDPRITNSC..RKAE....DWEEKDLIYSIGVVKRML.......IHRLYMIYGDLYAADKEVYERCFNVIKKAVK...H.SltdIGLEM....KKTKELAKIDRVDPLGITDLRIRGMWNILSPKGT..FGD..In.gIEE..FK..DE...NNKVLILLRKEKLQRILQETEEEI--.--..------------lekyfelreegfire.
A0A345GVL5_9FLAO/2-261              ..........................TNILIAIKNLVENPV.I.DIKSYYQGR..NR..ANSVGGALETYIKDIFA.N.TINS.SEGE-SLTEYEKHFSYL.GNQNNPPDLMIKNG.DAIEVKK.IQS..P.G.S.TLALNSSFPKAKL..YSDSPMITKSC..RDCE....DWKVKDIIYAVGYTSDDK.......INWLWLVYGDCYAADKSIYQRIKNKITEGIT...E.I...SDVEF....TETKELGKVKKVDPLGITDLRIRGMWHIANPNKV..FQY..I...NDN..EG..AA...-FKLRVLMTRDKFNSFSKIDRENLES.LK..Q--VKMKSVKIKnp..............
A0A8J7Z1W7_9CYAN/12-274             ..........................TNVLKAIKHLVENPV.F.DVVNYYRSN..NK..INAAGDALELFVKDIFA.G.ILDN.QNEDEKLATYERVYSYF.GNASNPPDLMIIGG.DAIEVKK.LIS..D.S.A.SIALNSSYPSAKL..FSDSLMITKTC..RICE....VWSERDLIYAIGSVNQEK.......LSSLWLVYGDCYAASREVYEKIKQKIAKGVS...E.I...QGVEF....SATKELGRVNKVDPLGITNLRIRGMWQIDHPRKV..YQY..L...NIP..DQ..RN..aALKVFALMREEKYLSFPFEDRRWLET.AE..TSNLTIADVKIK................
A0A286EDP7_9NEIS/1-260              .........................m-NIINAIIHIVQNPV.N.ELVAHYQNR..NR..ANLAGDALENYIKDVFS.G.TFHL.SENE-RIQRHSEVFSYL.GNHSNPPDMMLKNG.DAIEVKK.IES..P.N.S.ALALNSSYPKAKL..LVNSNMISTAC..RNAE....NWEVKDLIYAVGVVNKQN......eLKHLCMVYGEDYCADEECYLKIKSTIKTGVE...S.I...VGVEF....AETNELGRVNKIDPLGVTYLRVRGMWGIENPWAV..FNY..V...YQR..DL..TK...NFNFMCIINDEKWQQFHNTD--ELLK.LQ..NDNLIITDIKIK................
A0A316EDV0_9BACT/2-235              ..........................SNLLKALKLIIDNPI.I.QVKNYYTGR..NR..ANSVGEALENYVKDIFA.N.SFDL.SEIE-RIEKLNKIFSYL.GNQNNPPDIILRNG.DAIETKK.VQS..G.N.S.DLALNSSFPKAQL..FADDLLLKDEA..RNGE....KWNVKDIIYIIGHTSDTD.......IKHLWFVYGDCFAAKKEVYERIKTTIADGIK...S.I...PDVEF....AKTNELGRVNRVDPLGITNLRIRGMWTLQNPSKV..FSY..L...DCI..DV..NS...RFQVNCILKNR---------------.--..------------ev..............
A0A2T1C852_9CYAN/2-267              ..........................TDILQAIATLVNRPI.P.NLLDYYRSKsqNR..INAVGDALEEYIKDIFA.D.TIDE.TNLDLKNNKYNQVFSWQ.GSQNNPPDLIIRNG.DALEVKK.IGT..I.G.S.QIALNSFFPKAKL..FSNDLMISSDC..RNCE....TWTAKDLVYAIGVTSHQK.......LNLLWLIYGDCYAASQEYYTRIKNTIATGIS...A.I...DDVNF....SQTKELGRVNKVDPLEITYLRIRGMWGIQNPLSA..YNY..L...NLY..DA..NA...TFQLIAIVKETKYLSFPTVSRNTLEA.LVscDRELIINI----qnik............
A0A376BLN2_9NEIS/1-260              .........................m-NIINAIITLVQNPV.T.ELVSHYQNR..NR..ANQAGDALEQYIKDVFS.G.SLNL.SETE-RIQRHSEVFSYL.GNNSNPPDMMLKNG.DAIEVKK.IES..P.N.S.ALALNSSYPKAKL..FAHSNMISTAC..RHAE....NWQEKDLIYAVGVVNKQN......qLKQLCMVYGEDYCADEECYLRIKSTIKQGVE...N.I...SGVEF....AETNELGRVNRIDPLGVTYLRVRGMWGIDNPWSV..FHY..V...YQK..DT..RK...AFNFMCLINENKWQSLPNTQ--DLLN.LQ..NNNLIISDIQIK................
A0A2M9A3N0_9BACT/2-262              ..........................SNIIDAIINLVNYKN.N.SLLENTAGN..NR..ANNSGDGLEEYVKDLFA.G.TFDI.EGAQ-RLEKIGETFSYL.GNNSNPPDAMLREG.DAIEVKK.IET..P.N.S.ALALNSSYPKNKL..FASSSMISQAC..KNAE....AWKSKDIMYIVGFVQSNR.......LKQLSIVYGMDYCADESCYLRIKNTIKESVE...S.I...PSIEF....AESRELGHINKVDPLGITYMRVRGMWGIENPWKV..FSY..V...YNR..TF..NS...NFSFVCIINDEKWATFANTS--SLLN.LAttERSLNISNIRIK................
A0A1G7BJM1_9FLAO/2-260              ..........................TNILEAIVNIVQNPI.N.EIKSHYTSK..NR..VNNVGEALECFVKDAFA.N.CIHE.EIEE-RLEKYNEVFSWL.GNQNHPPDIMIKGG.DAIEVKK.TQS..L.K.S.DLALNSSYPKSTL..KSDSLMITKSC..KNCE....KWTEKDLIYCVGHTTDNS.......VKSLWFVYGEIYAAEHETYEIIKNKITQGIN...E.I...PNVEL....SETKELGRVNRVDPLGITNLRIRGMWQIQNPRKV..FEY..I...YDS..NS..EL...SFELVAIIPTRKYNNFPIDSINKIEN.--..IDYLDIKDVKVK................
I4AHT4_BERLS/2-262                  ..........................TNILEAIYAIIQNPI.F.EIKSFYTGR..NR..ANSVGDALENYIKDAFA.N.SFHI.NDEKERMKLFNENFSWL.GSQNNPPDIMIKGG.DAIEVKK.TQT..A.N.T.NLALNSSYPKSNI..NSSSPMITQSC..KNCE....EWTEKDLIYCVGHTTDTT.......LKSLWMVYGNIYAAGHETYERIKNTISEGID...T.I...PNVEF....AETKELGRVNKVDALGITNLRIRGMWQIQNPRKV..FSY..L...HIP..TE..KK...-FELICIIPTSNYNSFDKSSKNKIES.IN..KVGFTIQDEKVK................
A0A099XQ01_9FLAO/2-262              ..........................TNILEAIYNIANHQD.F.EIKSLYSGR..NR..ANNIGEALEKYIKDAFA.G.TLGV.TDELQRIQTFNQEFSWL.GSQNNPPDIMIKGG.DAIEVKK.TQS..A.N.T.SLALNSSYPKTDL..RSTSPMITKEC..KECE....DWTVKDLIYCVGHTTDTN.......VKSLWMVYGNSYAAKHETYQRIKTTISEGIE...T.I...PDVVF....ADTKELGRVNQVDPLGITNLRIRGMWQIENPRKV..FNY..L...HEP..TN..KD...-FELVCIIPTEKYNSFPNDSITKLEG.IT..QSGFSIEDKQIK................
I3CCM7_9GAMM/2-265                  ..........................TNLIIALKNLIQNPI.T.DLNSFYQGS..NR..ANSMGDALETYIKDIFC.N.SLHL.SDTE-KDKLYSQNFSYI.GNQNNPPDIIIKGG.DAIEVKK.IES..I.S.S.AIALNSSYPKSKL..FRNDSRITNAC..KECEg.avSWEQKDIIYIIGVAPKST.......LKALWFVYGDCYAAESEIYHRVANKISQGIS...E.I...SGVEL....VATNELAKVKKVDPLGITDLRVRGMWHIENPIKV..FQH..I...ASI..TE..LH...QLTVHTILLEEKYNTFPQSDREQLEQ.LQ..SEHFTIRNVAI-r...............
A0A1X7MFT8_9GAMM/2-264              ..........................TNILEAIVNIANLPN.L.SVKKLTFGN..NR..ATNVGDGLEEFIKDVFS.G.NNTV.SDYAVKDSNYKKTFSYE.GSKTTPPDLMMKDG.DAIEVKK.TES..L.K.S.ELQLNSSHPKAKL..FATSPLINSYC..KDCE....SWTEKDIIYAIGYIPKGTk.....tLSSLWMIYGSIYAADEKVYTDLKDIVTTSLE...S.I...ENLNF....SETKELGRVNFVDPLKITNMRVRGMWLLKPPVNV..FNY..V...YAY..DL..DL...KFQLIAIVPVEKYITFPEENITKIES.L-..KNTVKIIDVDIK................
A0A556UCI9_9LACO/5-275              ..........................TNVIIALKNILDHNS.T.RLTPIYKSN..GS..VNATGDNLEFFVKDMFCkE.AMQY.SYEDQKQKEYMKYLSWT.GDSSHFPDLIVQGG.VGVESKK.LNN.dS.K.S.TIALNSSYPKDYItrYTQNYPLNSLYfePDVD....NLNKKPVIYAIGNLNTNKkdyldnqLISLWFVYGNTIVPNSNYYKNIIKGIRDSIK...N.V..nSNIKI....EDSKELARVKGVDKLSRTNMRVRGMYELEHPAKI..FES..Y...VKS..FKvpKG...KSKIFVVILQSDLDEIKRDM------.--..------------edkwdilsnelni...
A0A2H1EBK2_9FLAO/2-262              ..........................TNILESIYNIVSFPE.R.KLKSIYSGS..NR..ANSMGDALENYIKDSFA.N.TFQT.EDEKDRMKIFNQKFSWL.GSQNNPPDIMIKGG.DAIEVKK.TQS..A.G.S.SLALNSSYPKADI..HANSPMITKEC..KECE....DWTTKDLIYCVGHTTDSE.......LKSLWLVYGNVYAAKHETYQRIRNTISDGIK...T.I...SDVVF....SETKELGRVNKVDPLGITNLRIRGMWQIENPRKV..FSY..L...HKT..GG..NE...-FEVVCIIPISKYDSFPMESKQKIKS.II..DKKFSIDDVDVK................
A0A1Z4J0S1_9CYAN/2-263              .........................a-DLLKAIKTIVDNPI.P.DLVSYYQGK..NR..INSIGDALECFVKDIFA.E.TLSQ.SDQALKNERYSEVFSYI.GNQNNPPDLILKNG.DAIEVKK.IES..L.K.A.SIALNSSYPKSKL..YYDSPLLTKHC..RQCE....DWQEKDIIYVIGVPKDRK.......LKLLWFIYGDCYAADREIYERIAKKISSGIR...E.I...KDVEF....SDTRELGRVNKVDPLGITDLRIRGMWGITNPIFV..YDY..I...FQY..EE..TN...NLQVVVIMKEDKYLSFYSETRKEIEG.IS..NVNFKHQNVNI-r...............
A0A0K8MDE4_9PROT/11-116             ..................kfgdihed---------------.-.---------..--..-----------------.-.----.-----------------.--------------.-------.---..-.-.-.-------------..-----------..----....------------------.......----------------------KRKITNSIQ...E.F...-GIEL....SETNEIAKIKKIDPLGITDLRVRGMWHIKHPSKV..FQY..I...TTK..QS..KP...--HIKALMLTSKFESFEMGIRKQIATkCN..LQNVKIQN----pnn.............
A0A2T1EGY6_9CHRO/2-264              ..........................TNILQAVRVIVNSKI.P.DVASFYRSQ..NR..INAVGDALEAFVKDIFA.N.TVSE.TDASSKYEAYSKLFSYS.GNANNLPDLMIKGG.DAVEVKK.VGL..G.T.G.KIALNSSYPSAKL..FFDSPMITSTC..RNCE....SWTEKDIIYATGCFANNK.......LEILWLIYGECYAASRETYEKIKNKISQGVS...E.I...SSVEF....SVTKELGRVNKIDPLGITDLRIRGMWQIENPRNV..YNY..I..dIDY..KL..NK...SFRLFILIQETKYLSFPIEDRKQLES.LN..NPDLVIKNIKIK................
D2EGA9_PARA4/2-273                  ..........................TNIITAAVGIINAYKnK.KVFSTNKGAygTS..INNWGAYLEDFIAAAFS.G.SLLI.NDIKKRQELKEKAFCYS.GSQNLPPDLMLRNGgPAIEVKK.HAS..D.T.G.GLSLNSSPPRQTL..RKEDKRIASAA..RTAE....YWEERKIIYAIGTIPGSNn.....iIKSIQLVYGDCFAASHEFYDKVEGIIREQLEgagS.E...SPVEK....YEGNELGRMNAVDPLKATYLRVRGMWEIKNPLRI..FKEegI...ADY..SL..SK...GFTLLAMAKKAEFGKLSKESPEALAK.LK..-TYADIKDIKI-i...............
A0A0H4IT76_NEIG1/3-153              .............aclqkpakmrkng---------------.-.---------..--..-----------------.-.----.-----------------.--------------.-------.---..-.-.-.-------------..-----------..----....--KRKTLSIIVGVVDKKK......nLKHLAMVYGIDYCADAECYLKIKNQIKEGIG...N.I...GGIQF....AETKELGRVNRIDPLNITYLRVRGMWGIENPWFV..FNY..I...YQR..NM..EK...SFNFMAIINEDKWNSFNNTD--KLLA.IQ..DSKLAISDIKIK................
A0A1V3TQH4_9PAST/1-259              .........................m-NIINAIINLVNNPV.N.ELVTDYQGR..NR..ANSAGGALEEYVKDLFT.N.SFHL.SETK-RIKKWSEAFSYL.GNNNNPPDAMLRNG.DAIEVKK.IES..N.S.S.ALALNSSYPKSKL..FVNNSMLSTAC..RNAE....NWTEKDLIYVTGVVNNSH.......LSHLAMVYGEDYCATEECYLRIKSTIKAGVE...S.I...DGVEF....SETKELGRVNSVDPLGITYLRVRGMWGIENPWTV..FDY..V...YQR..DF..SR...SFNFMAIINEEKWHSFTNTA--ELLC.LQ..NEQLKISNIEIK................
#=GC seq_cons                       ..........................sNILpAIhsllpps....pltshapup..NR..hNshG-ALEpalKDhFu.s.ohs..sspp.+.ppaschFSal.GNpsNPPDhhlKsG.DAIEVKK.lpS..h.s.u.slALNSSYPKscL..hsssshIopsC..+pCE....sWpcKDlIYslGhlscpp.......LppLWhVYGssYsAscEsYpcI+spIppGlp...p.I...ssl-F....u-TpELGRVN+VDPLGITsLRlRGMWtIcNPhcV..FsY..l...hph..st..pp...pFplhsll.ppKapoFspps.pplpp.l...ppphpIpslpl.................
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