#=GF ID RSS_P20
#=GF AC PF11757.12
#=GF DE Suppressor of RNA silencing P21-like N-terminal domain
#=GF AU Mistry J;0000-0003-2479-5322
#=GF AU Coggill P;0000-0001-5731-1588
#=GF AU El-Gebali S;0000-0003-1378-5495
#=GF SE Pfam-B_1073 (release 23.0)
#=GF GA 25.00 25.00;
#=GF TC 25.10 74.00;
#=GF NC 24.90 24.20;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch -E 1000 -Z 75585367 --cpu 4 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 12642093
#=GF RT Suppressor of RNA silencing encoded by Beet yellows virus.
#=GF RA Reed JC, Kasschau KD, Prokhnevsky AI, Gopinath K, Pogue GP,
#=GF RA Carrington JC, Dolja VV;
#=GF RL Virology. 2003;306:203-209.
#=GF DR INTERPRO; IPR021742;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC This domain can be found at the N-terminal region of is a large
#=GF CC family of putative suppressors of RNA silencing proteins,
#=GF CC P20-P25, from ssRNA positive-strand viruses such as
#=GF CC Closterovirus, Potyvirus and Cucumovirus families. RNA silencing
#=GF CC is one of the major mechanisms of defence against viruses, and,
#=GF CC in response, some viruses have evolved or acquired functions for
#=GF CC suppression of RNA silencing. These counter-defencive viral
#=GF CC proteins with RNA silencing suppressor (RSS) activity were
#=GF CC originally discovered in the members of plant virus genera
#=GF CC Potyvirus and Cucumovirus. Each of the conserved blocks of amino
#=GF CC acids found in P21-like proteins corresponds to a
#=GF CC computer-predicted alpha-helix, with the most C-terminal element
#=GF CC being 42 residues long. This suggests conservation of the
#=GF CC predominantly alpha-helical secondary structure in the P21-like
#=GF CC proteins. C-terminal domain entry found under Pfam:PF11479.
#=GF SQ 12
#=GS P21_BYVU/1-93 AC Q08545.1
#=GS Q5G7F9_9CLOS/1-94 AC Q5G7F9.1
#=GS A0MBX2_9CLOS/1-94 AC A0MBX2.1
#=GS C6GFK6_9CLOS/1-94 AC C6GFK6.1
#=GS Q66244_9CLOS/1-92 AC Q66244.1
#=GS A0A0K1HRT6_9CLOS/1-92 AC A0A0K1HRT6.1
#=GS V5IV74_9CLOS/1-92 AC V5IV74.1
#=GS Q0GK46_9CLOS/1-91 AC Q0GK46.1
#=GS Q8BEP1_9CLOS/1-89 AC Q8BEP1.1
#=GS Q49IG5_9CLOS/1-89 AC Q49IG5.1
#=GS A0A385HW53_9CLOS/1-91 AC A0A385HW53.1
#=GS A0A0A0P4U4_9CLOS/1-94 AC A0A0A0P4U4.1
P21_BYVU/1-93 MKFFLKDGETSRALSRSESLLRRVKELGTNSQQSEISECVDE.FNELASFNHLLVTVEHREWMEQHPNQSS-KLRVPSRIGEMLKEIRAFLKVRV.
Q5G7F9_9CLOS/1-94 MKLYFRVAYYESLVTEATNLLTRVRNRDENHDRAALNKWILD.FTDLAARVQCIKSDVNDAKREESAHDINTKVALLQTFEQRLAEARDVLRLIV.
A0MBX2_9CLOS/1-94 MRACFSIDDMINTISYVTICVAQIRRTDVTHSGDTLNPLIRA.LNDSIGTLTAMKLDANTTKLCGYYSEASNKLKHCATVEELIREWLFGCRRI-l
C6GFK6_9CLOS/1-94 MKLYISIYEYIALVSEISRLLDLVSECVSGVTYDKFKEFRYR.FVHLTMLIPSLKSDLNDSLRDEGFSMQSEKKEQLVLFEKTCSDVQSKLRRM-i
Q66244_9CLOS/1-92 MRAYFSVNDYISLLAKVSAVVERL--CDPSVTLAEVMDEIND.FNSFLALVHSMKSDMNGDHQDGHHEMGEHKSRLLCNIEAKLRVLLDIIRRRF.
A0A0K1HRT6_9CLOS/1-92 MKLYIQVKFYESYLKLITDLLEAI--NASNSSNEKLVEWVTD.FTDLCSRLQALKSDVNDAKREESANNLTRKANILKLAGDNLASIRDELRKRV.
V5IV74_9CLOS/1-92 MKFFLTTSDRNAAVSRAESVLREVNALSESSEASVVAARINE.FNELVKFSQLLNTVEQRERSETQNSLSTNSHGN--SLSGLLKEIRSSLKVHV.
Q0GK46_9CLOS/1-91 MRGYYDVQAFKDLNNHYVSCIHVVGAVERRTD--GLKQHCLE.FNNSLAIKAALKCDANSDVMSRKNSAKE-KLEILTEIDANCAILLKLLRKKV.
Q8BEP1_9CLOS/1-89 MRVIVSPYEAEDILTRSTEMLRNI--DSGALD---TRECIKA.FSTLTRDLHCAKASYQWCVDTGLCQRDCAEKRLIDTVESNLRLAHPLIREKV.
Q49IG5_9CLOS/1-89 MRVIVSPYEAEDILKKSTDILRDI---DSGVL--NTKECIKV.FSTITRDLHCAKASYQWGVDTGLYQRDCAEKRLIDTVESNIRLAQPLVRQKV.
A0A385HW53_9CLOS/1-91 MKLYINVGYYKTYLKMVVSLLTTI--ESTSETDIDVNKWIED.FTDLATRIQALKSDVNDAKREENECDINKKAHLLEQAEEKLARIRDELRK--l
A0A0A0P4U4_9CLOS/1-94 MKLYFSLNEYATYLAEICQLSQDMDFTSTEVT-IPLLDELRLrFTNLTMKIPSLKSDLNDCLRDDSIEMYTKKREKLVAFEKTCSEVQTKFRSV-i
#=GC seq_cons M+hahslt-hpshlscssslLcpl..psssss..tlpchlpc.FssLsthlpslKoDhNsshp-pphpttspKtcllsphEpplpplpshlRphh.
//
