#=GF ID RTX
#=GF AC PF02382.19
#=GF DE N-terminal domain in RTX protein
#=GF AU Mian N;0000-0003-4284-4749
#=GF AU Bateman A;0000-0002-6982-4660
#=GF SE Pfam-B_833 (release 5.2)
#=GF GA 26.80 26.80;
#=GF TC 27.90 27.70;
#=GF NC 26.70 26.40;
#=GF BM hmmbuild HMM.ann SEED.ann
#=GF SM hmmsearch --cpu 4 -Z 75585367 -E 1000 HMM pfamseq
#=GF TP Domain
#=GF RN [1]
#=GF RM 9628576
#=GF RT Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an
#=GF RT enterohemorrhagic Escherichia coli O157:H7 derived from Sakai
#=GF RT outbreak.
#=GF RA Makino K, Ishii K, Yasunaga T, Hattori M, Yokoyama K, Yutsudo
#=GF RA CH, Kubota Y, Yamaichi Y, Iida T, Yamamoto K, Honda T, Han CG,
#=GF RA Ohtsubo E, Kasamatsu M, Hayashi T, Kuhara S, Shinagawa H;
#=GF RL DNA Res 1998;5:1-9.
#=GF RN [2]
#=GF RM 30405113
#=GF RT Cytotoxic activity of Kingella kingae RtxA toxin depends on
#=GF RT post-translational acylation of lysine residues and cholesterol
#=GF RT binding.
#=GF RA Osickova A, Balashova N, Masin J, Sulc M, Roderova J, Wald T,
#=GF RA Brown AC, Koufos E, Chang EH, Giannakakis A, Lally ET, Osicka R;
#=GF RL Emerg Microbes Infect. 2018;7:178.
#=GF DR INTERPRO; IPR018504;
#=GF DR TC; 1.C.11;
#=GF DR SO; 0000417; polypeptide_domain;
#=GF CC The RTX family of bacterial toxins are a group of cytolysins and
#=GF CC cytotoxins that have RTX (Repeat in ToXin repeats) Pfam:PF00353.
#=GF CC This is a hydrophobic pore-forming domain found at the
#=GF CC N-terminal of these proteins [2].
#=GF SQ 23
#=GS C0AY17_9GAMM/133-358 AC C0AY17.1
#=GS CYAA_BORPE/588-896 AC P0DKX7.1
#=GS A0A5B0DWI5_9HYPH/458-633 AC A0A5B0DWI5.1
#=GS Q46716_ECO57/278-586 AC Q46716.2
#=GS A0A3S4XCH7_MANHA/283-589 AC A0A3S4XCH7.1
#=GS A0A5B0E4H1_9HYPH/489-668 AC A0A5B0E4H1.1
#=GS A0A380TW60_9PAST/299-607 AC A0A380TW60.1
#=GS A3N292_ACTP2/288-596 AC A3N292.1
#=GS A0A5B0E0T2_9HYPH/486-664 AC A0A5B0E0T2.1
#=GS A0A5B0E0B9_9HYPH/420-622 AC A0A5B0E0B9.1
#=GS A0A5R8KKD4_9BACT/7-149 AC A0A5R8KKD4.1
#=GS A0A5B0DZM7_9HYPH/237-409 AC A0A5B0DZM7.1
#=GS M4RAK6_BIBTR/285-591 AC M4RAK6.1
#=GS A0A380MT91_9GAMM/418-739 AC A0A380MT91.1
#=GS A3N0W6_ACTP2/288-592 AC A3N0W6.1
#=GS A0A238HI88_9NEIS/298-604 AC A0A238HI88.1
#=GS F5S905_KINKI/287-593 AC F5S905.1
#=GS A0A066UM22_9GAMM/265-571 AC A0A066UM22.1
#=GS J2LL45_9BURK/504-842 AC J2LL45.1
#=GS A0A640VVZ5_9RHOB/566-877 AC A0A640VVZ5.1
#=GS A0A380TL94_9PAST/288-592 AC A0A380TL94.1
#=GS E3BKQ9_9VIBR/744-1065 AC E3BKQ9.1
#=GS A4ES15_9RHOB/402-709 AC A4ES15.1
C0AY17_9GAMM/133-358 .....................LAQRVAQGL........STTAASAGLI---....................ASAVSLAISPLSFLAISDQFKRANQIEEYAQRFKKLGYEGDSLLAAFRKETGAIDAALTTISTVLNSVSAGVSAAATASLVGAPISALVGAVSGIITGILEASKQSMFEHVANKMANTI--....AEWEKKHG-KNYFENGYDARHSAFL..EDNFELLSKYSKEHSTELSILITQQHWDDL.IGELAGVT..K..NG..ARV.FSGKAYVDYYKEG.......KHLEK-------------------------...---------------------..------.-.-----------........-------------.---------ki....
CYAA_BORPE/588-896 .....................LALAAARGV........TSGLQVAGASAGA...................aAGALAAALSPMEIYGLVQQSHYADQLDKLAQESSAYGYEGDALLAQLYRDKTAAEGAVAGVSAVLSTVGAAVSIAAAASVVGAPVAVVTSLLTGALNGILRGVQQPIIEKLANDYARKI--....---DELGGPQAYFEKNLQARHEQLAnsDGLRKMLADLQAGWNASSVIGVQTTEISKS.ALELAAIT..G..NA..DNL.KSVDVFVDRFVQG.......-----ERVAGQPVVLDVAAGGIDIASRKG-...ERPALTFITPLAAPGEEQRRR..TKTGKS.E.FTTFVEIVGKQ.......dRWRIRDGAADTTI.DLAKVVSQ-l.....
A0A5B0DWI5_9HYPH/458-633 ...........ileeylpktg---------........-------------....................-------------------------------------------------------------------------------------------------------------------------....--SSKEKAINLFWSDGFDSREKEVQ..HEYVMLLRQMSSKVESKRVIAVTGQELRTD.MAMVSALL..GgaFA..NGV.NSNRNY---FYDS.......QKLTPNE----NGMIGRGLDGIAINLESSA...TEQYFLFLTPVMVTTDKERYE..TSVGKT.TiYGTKLP-ETPH........RMVITDGASATTA.DVRNFA---ssa...
Q46716_ECO57/278-586 .....................LAQRMAQGL........STTAASAGLI---....................TSAVMLAISPLSFLAAADKFERAKQLESYSERFKKLNYEGDALLAAFHKETGAIDAALTTINTVLSSVSAGVSAASSASLIGAPISMLVSALTGTISGILEASKQAMFEHVAEKFAARI--....NEWEKEHG-KNYFENGYDARHAAFL..EDSLSLLADFSRQHAVERAVAITQQHWDEK.IGELAGIT..R..NA..DRS.QSGKAYINYLENG.......GLLEAQPKEFTQQVFDPQKGTIDLSTGNV-...-SSVLTFITPTFTPGEEVRER..KQSGKY.E.YMTSLIVNGKD........TWSVKGIKNHKGVyDYSKLIQ--fv....
A0A3S4XCH7_MANHA/283-589 .....................LAQRVAAGL........SSTGPVAALI---....................ASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASVTAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKI--....VEWEKNNHGKNYFENGYDARYLANL..QDNMKFLLNLNKELQAERVIAITQQQWDNN.IGDLAGIS..R..LG..EKV.LSGKAYVDAFEEG.......KHLKADK----LVQLDSANGIIDVSNSGKA...KTQHILFRTPLLTPGTEHRER..VQTGKY.E.YITKLNINRVD........SWKITDGAASSTF.DLTNVVQRI......
A0A5B0E4H1_9HYPH/489-668 .....tilkdylgragadgtv---------........-------------....................-------------------------------------------------------------------------------------------------------------------------....-----ESAVQDFWNDGFDTREKQAQ..QGYIDSMKALAASTEVKRVVAVTGQELRAD.MAQVAGITggK..IA..QGV.KSGVNYMY-VEDGs....saKPSK-NGLYGQSLVSD----IIDINS--GA...SSQYFTMLTPLMRVTDESRAS..AVAGKNtR.YGSSLPRAGDK........AMEIVDGASHTTA.DVRN-----fas...
A0A380TW60_9PAST/299-607 .....................LAQRLAAGL........STTGPAAALI---....................ASSISLAISPLAFLRVADNFNRSKEIGEFAERFKKLGYDGDKLLSEFYHEAGTIDASITTISTALSAIAAGTAAASAGALVGAPITLLVTGITGLISGILEFSKQPMLDHVASKIGNKI--....DEWEKKY-GKNYFENGYDARHKAFL..EDSFSLLSSFNKQYETERAVLITQQRWDEY.IGELAGIT..G..KG..DKL.SSGKAYVEYFQEG.......KLLEKKPDDFSKVVFDPTKGEIDISNSQT-...-STLLKFVTPLLTPGTESRER..TQTGKY.E.YITKLVVKGKD........KWVVNGVKDKGAVyDYTNLIQH-a.....
A3N292_ACTP2/288-596 .....................IAQRVAAGL........STTAATGGLI---....................GSVVALAISPLSFLNVADKFERAKQLEQYSERFKKFGYEGDSLLASFYRETGAIEAALTTINSVLSAASAGVGAAATGSLVGAPVAALVSAITGIISGILDASKQAIFERVATKLANKI--....DEWEKKHG-KNYFENGYDARHSAFL..EDTFELLSQYNKEYSVERVVAITQQRWDVN.IGELAGIT..R..KG..ADA.KSGKAYVDFFEEG.......KLLEKDPDRFDKKVFDPLEGKIDLSSINK-...-TTLLKFITPVFTAGEEIRER..KQTGKY.E.YMTELFVKGKE........KWVVTGVQSHNAIyDYTNLIQ--la....
A0A5B0E0T2_9HYPH/486-664 ....nllarlginaadgeaav---------........-------------....................-------------------------------------------------------------------------------------------------------------------------....-----TAAVKEFLNEGFDSREIIAQ..RGHVDAIQRIAATTDAKRVVAVTGQETRSDmATFLAATG..G..VF.lANA.SSNRNFIYDSADQ.......-TIKANGLIGQRLGSD----VIDISSKAE-...-SQYFLFLTPAMPISGEERDM..LSSGKK.R.TS-KASLVADT........LFTIVDGATNTVA.NAANVASQ-a.....
A0A5B0E0B9_9HYPH/420-622 ............satpvinlf---------........-------------....................---------------------------------------------------------------------------------------------SAMFGMLDTSKRSADRILADYGVTDL-S....DSEAVSQAARKFMIDGLDARERAVQ..ADYIAALKRIAASTETKRIIAVTGQELRAD.QAAVAALL..G..TAfvKEI.NSSRHYFYDLSDQ.......TRK-----DNGLVATASASNSISIDS--TA...DSQYFLFLTPIMPVTPEERAE..TISGKS.V.KNSLVPLQTLP........GFELMDGAASTVA.DIRK-----fasf..
A0A5R8KKD4_9BACT/7-149 .......aelehdqnldpitg---------........-------------....................------------------------------------------------------EPSSHPVGTGVGALGGGLTGAAIG-AVGGPVGIVIGAAAGSVAGGLMGKNVAESQDPTDRAVEAISPeseeSHWQQQCGNEAYFDPQYNFADYAPA..YRLGYETKELQRTSSFEDLEGILKGRWQE-.--------..-..--..---.-------------.......------------------------------...---------------------..------.-.-----------........-------------.---------akgds.
A0A5B0DZM7_9HYPH/237-409 .....anhilssygitsgssa---------........-------------....................-------------------------------------------------------------------------------------------------------------------------....--EDIARAKAQFWGDGFDSREKGLR..DGYVAAMRKIADTTEAKRVIAITGQELRSD.QATIAGFT..G..LI..PD-.NSNRNYMYVLEGG.......------K--NDRLVLTSD--KIDVTSN--A...QSQYVAFLSPVMPISGEERQT..LIDGKQ.T.THGLKRPTKVD........VMHLIDGNSDTTF.DPRNI----atl...
M4RAK6_BIBTR/285-591 .....................LAQRVAAGL........SSTGPVAALI---....................ASTVALAISPLSFAGIADKFDRAKSLENYAERFKKLGYEGDSLLAEYQHGTGTIDASVTAINTALAAIAGGVSAAAAGSVVASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKI--....VEWEKNNGGKNYFENGYDARYLANL..QDNMKFLLNLNKELQAERVIAITQQQWDSN.IGDLAGIS..R..LG..EKV.LSGKAYVDAFEEG.......QHLKADK----LVQLDSAKGIIDVSNTGEA...KTQHILFRTPLLTPGTEKRER..VQTGKY.E.YITKLHINRVD........SWQIKDGAASSTF.DLTNVVQRI......
A0A380MT91_9GAMM/418-739 vavgldvglksvgtvatsvsv---------........------------IgdsiakilgtttilpqigaaVSGLALAASPLEIKGLIDENVHVKEVNKLGDETQIFGYEGDKILADLLHEKFVLNTAYTATDIALNITTTAISTAAAASVVGAPVAAVVGVVRGVIGGILAAVKQPSLEVIADRYAQKI--....---RDYGDVTAFFNTNKEALLNQFYqtDAVRDSFKQLQNFYKVDSVITLDGAASSST.AMELAAHT..K..LI..DQM.NKANNYAQLIRDG.......EINKDD--SAKYLTMDSLTGVLTIN---TP...KDSLIKFNSPLFTPGAEESTR..KQVGKN.A.YYTDLMINGPD........KHTIIDGDSSN--.---------ifisn.
A3N0W6_ACTP2/288-592 .....................LAQRVASGL........SSTGPVAALI---....................ASTVALAVSPLSFLNVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGLITTILEYSKQAMFEHVANKVHDRI--....VEWEKKH-NKNYFEQGYDSRHLADL..QDNMKFLINLNKELQAERVVAITQQRWDNQ.IGDLAAIS..R..RT..DKI.SSGKAYVDAFEEG.......QHQSYDS----SVQLDNKNGIINISNTNR-...KTQSVLFRTPLLTPGEENRER..IQEGKN.S.YITKLHIQRVD........SWTVTDGDASSSV.DFTNVVQRI......
A0A238HI88_9NEIS/298-604 .....................LAQRAAAGL........STTGAVASLI---....................TASIMLAISPLAFMNAADKFKNASLIDEFAKQFKKFGYDGDSLLAEYQRGAGTIEASLTAINTALGAVSAGVSAAAVGSVVGSPVALLVAGVTGLISGILEASKQAMFESVANRLQSKI--....LAWEKENGGKNYFENGYDARHAHYL..ERNLKLLSELNKELQAERVIAITQQRWDAN.IGELAGIT..K..LG..DRV.SSGKAYADAFEDG.......KKLDGAS----NVTVDTRTGVVDISNANGK...KTQALHFTSPLLTAGTETRER..VQNGKY.S.YINQLKFNRVK........SWTVKDGEANSRL.DFSKVIQHV......
F5S905_KINKI/287-593 .....................LAQRAAAGL........STTGAVASLI---....................TASIMLAISPLAFMNAADKFKNASLIDEFAKQFKKFGYDGDSLLAEYQRGAGTIEASLTAINTALGAVSAGVSAAAVGSVVGSPVALLVAGVTGLISGILEASKQAMFESVANRLQSKI--....LAWEKENGGKNYFENGYDARHAHYL..ERNLKLLSELNKELQAERVIAITQQRWDAN.IGELAGIT..K..LG..DRI.SSGKAYADAFEDG.......KKLDGAS----NVTVDTRTGVVDISNANGK...KTQALHFTSPLLTAGTETRER..VQNGKY.S.YINQLKFNRVK........SWTVKDGEANSRL.DFSKVIQHV......
A0A066UM22_9GAMM/265-571 .....................LAQRVAAGL........STTGAVAALI---....................TSSIMLAISPLAFVNAVDKFNHANALDEFAQQFQKFGYDGDHLLAEYQRGVGTIEASLTTINTALGAVSAGVSAAAVGSAVGAPIALLVAGVTGLISGILEASKQAMFESVANRLQGRI--....LEWEKQNGGQNYFDKGYDSRYAAYL..ANNLQFLSELNKELEAERVIAITQQRWDNN.IGELAGIT..K..LG..EKV.ESGKAYVDAFEDG.......KKVEAGV----NITLDAKTGIVDISNSDSK...KTQALHFTSPLLSAGNESRER..ISNGKY.S.YINKLKFERVK........NWQITDGDASSKL.DFSKVIQRI......
J2LL45_9BURK/504-842 .....................LAQVVGRGIayplvpdaASFSGATRLVRHRslmgp..........mgltfTAGAMLALSPLEIYALAKQSEYATDLDKLASG----GYAGHGLLADFYREKNGVQAGIFATSAILDIVSSLAVAACVVSGVGAPIAIPLGLVVTGISAVFRAAEYAFIEKMAEKAVQKIYAy.vdPKDSSRKGPQAYFENSLNAQNKSLSdsAMLTDYLAKLQG--NYGSVVWVDTQTMSPQ.AMELAALI..R..NT..TDL.VTAKAYIERFSNG.......-----ISRPTASLRIDAETGELNLDNDGTAklgSTQLLTFLNPLLAPGKETRKK..GHVGGK.T.SSTSLTLTDANgtaytigkGWTINDGNASSTM.DLTNVVTKV......
A0A640VVZ5_9RHOB/566-877 ..maamaaegalaatamlshs------AKA........LSFATKGVPVAGA....................VVTLLSVLDPVSWQRFDAAKDYIDHL-----RETDDGTETNGLLADRLEDTYDKEVAHYAAATAVDAAFGIASIGIAATGVGAPVAVAVALVGAAISTIIRLTEGNTWQREADKLADEMRS....LPNGDQQTIAQFFEKQLDTRWEAIA..AENEERFDRILDK-NFDSIIGLGSQSFTDA.DASLAIQS..D..TI..SEMgKTAKHYGTEYLGQ.......-----GNWDHQSVTLDESAAQIDLPNGGAD...KAVYLTFMAPLMLAVEEVYTRpmFNFGKG.G.GTTT---TYVS........GWTITDGTTK---.---------ytessq
A0A380TL94_9PAST/288-592 .....................LAQRVASGL........SSTGPVAALI---....................ASTVALAVSPLSFLNVADKFKQADLIKSYSERFQKLGYDGDRLLADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGLITTILEYSKQAMFEHVANKVHDRI--....VEWEKKH-NKNYFEQGYDSRHLADL..QDNMKFLINLNKELQAERVVAITQQRWDNQ.IGDLAAIS..R..RT..DKI.SSGKAYVDAFEEG.......QHQSYDS----SVQLDNKNGIINISNTNR-...KTQSVLFRTPLLTPGEENRER..IQEGKN.S.YITKLHIQRVD........SWTVTDGDASSSV.DFTNVVQRI......
E3BKQ9_9VIBR/744-1065 .....................LAMGLTVGVltakaaitGTTVSSAVPVLGI....................VASLASAINPVQWAAFEQSKDHINDVDAKTDESSDAYETSAQYLTELLEDIHGTEVGFYSASTAVGVLGGIGTTAAAATGVGAPVALVIAGITAGLQGMLEGLKQVHLDNVAEDMAEKIRA....F----NEGVAGFFDQSFEHSTDKAL..SDFVDDAKHFIEK-GYDSVSGLGSVQMTAS.DLELAGLS..G..VG..GEL.KQTQKHFSGFIEK.......ADLETGEWNREEIKIDASQGVIERTNVNGAatgKDNMLTFVTPMAAAGNENIST..EHVSKN.R.YETTINISNLK........GWTIKDGGDNTTF.DLDNIVTKA......
A4ES15_9RHOB/402-709 .....................LAVTAGSKA........ATVLGKAVPIIGA....................IGSVIGAINPVKWAEFEQKQDRIDAI-------RDSGTYSSGLLGDLLQESKTAEAAFYGTTTALDVTTGVTAGVLAATGVGAPISAAVGLIGGAISAIVGAFEQVALEAIADRYADKIRT....DAEGNPQTVEAFFKGSFDQKQERIK..EHYTEFFEEFIAENDVDRVLALGGQGLDAT.DIELAAIS..K..TS..GELnKTARNYVETFTTNgwqpgshALSPSSGFETNVIQLDKAHG----------...SKSFLTFTTPLFAAGTEDISR..RETGKN.E.YQTTLRIKDLS........GWEIRDHGVNETTfNMSKVVSS-a.....
#=GC seq_cons .....................LA.thutGl........uossssus.l.......................suslhhAlSPltahshspp.ppsp.lpphupp.pchGY-GctLLAph.+tttsh-uuhtshsTsLssluuusuuAusuohVGuPluhlVuslsGhIouILchsKQshhEplAs+hts+I.......t.ccppuscsYF-sGaDuRctuhh..pc.hchLpclscphps-RVlAlTpQchcss.hu-LAulo..+..hu..scl.pSu+sYsptFp-G.......ph.p.st....pltlDstpGhI-lsstst....pophltFhTPLhssGsEpRpR..hpsGK..p.YhTpL.lptsc........sWplpDGsusosh.Dhspllp........
//
