#=GF ID   RTX_C
#=GF AC   PF08339.14
#=GF DE   RTX C-terminal domain
#=GF AU   Fenech M;0000-0001-7933-4617
#=GF SE   Pfam-B_2178 (release 18.0)
#=GF GA   30.20 30.20;
#=GF TC   30.50 30.70;
#=GF NC   29.80 29.60;
#=GF BM   hmmbuild HMM.ann SEED.ann
#=GF SM   hmmsearch -Z 75585367 -E 1000 --cpu 4 HMM pfamseq
#=GF TP   Family
#=GF RN   [1]
#=GF RM   8800842
#=GF RT   Biological effects of RTX toxins: the possible role of
#=GF RT   lipopolysaccharide. 
#=GF RA   Czuprynski CJ, Welch RA; 
#=GF RL   Trends Microbiol 1995;3:480-483.
#=GF DR   INTERPRO; IPR013550;
#=GF DR   SO; 0100021; polypeptide_conserved_region;
#=GF CC   This family describes the C-terminal region of various bacterial
#=GF CC   haemolysins and leukotoxins, which belong to the RTX family of
#=GF CC   toxins. These are produced by various Gram negative bacteria,
#=GF CC   such as E. coli (Swiss:P09983) and Actinobacillus
#=GF CC   pleuropneumoniae (Swiss:P15377). RTX toxins may interact with
#=GF CC   lipopolysaccharide (LPS) to functionally impair and eventually
#=GF CC   kill leukocytes [1]. This region is found in association with
#=GF CC   the RTX N-terminal domain (Pfam:PF02382) and multiple
#=GF CC   hemolysin-type calcium-binding repeats (Pfam:PF00353).
#=GF SQ   13
#=GS Q46716_ECO57/854-998       AC Q46716.2
#=GS F5S905_KINKI/813-944       AC F5S905.1
#=GS M4RAK6_BIBTR/809-940       AC M4RAK6.1
#=GS A3N0W6_ACTP2/810-940       AC A3N0W6.1
#=GS A3N292_ACTP2/868-993       AC A3N292.1
#=GS A0A084A6G7_9GAMM/23-141    AC A0A084A6G7.1
#=GS A0A238HI88_9NEIS/824-955   AC A0A238HI88.1
#=GS A0A3S4XCH7_MANHA/807-938   AC A0A3S4XCH7.1
#=GS A0A859PPD0_9ENTR/126-223   AC A0A859PPD0.1
#=GS A0A380TL94_9PAST/810-940   AC A0A380TL94.1
#=GS C0AY19_9GAMM/155-298       AC C0AY19.1
#=GS A0A380TW60_9PAST/885-1006  AC A0A380TW60.1
#=GS A0A066UM22_9GAMM/784-916   AC A0A066UM22.1
Q46716_ECO57/854-998                  ........HLSDISFDDIAFKRVGNDLIMNKaingvlsfneSNDVNGITFKNWFA....------KDASGADNHLVEVItDKDGREI---KVDKIPhnNNER.SG.YIKASNIA----.SEKNMVNITSVANDINKIISSVSGFDSgderlaslynlslhQNNTHSTTLTTTV................................................
F5S905_KINKI/813-944                  ........AFADADLSELTIERTAQGIMIKR..........NDGSGSINMAEWYK....TLSRPNYHGNATDDKIEQII.GKNGDYITSEQIDKLL..KDKQ.TG.TITSAQLQQLAQeNKSKSIDSGNLASTLNKLIESMASFGS..............RGATASNYLQPAH................................................
M4RAK6_BIBTR/809-940                  ........SFSDSNLKDLTFEKVNHHLVIT-..........NTKQEKVTIQNWFReaefAKTIQNYVATR-DDKIEEII.GQNGERITSKQVDELI..-EKG.NG.KIAQSELTKVVD.NYQLLKYSRDASNSLDKLISSASAFTS..............SNDSRNVLASPTS................................................
A3N0W6_ACTP2/810-940                  ........AFSDVNLKDLTFKKVDSSLEII-..........NQKGEKVRIGNWFLeddlASTVANYKATN-DRKIEEII.GKGGERITSEQVDKLI..-KEG.NN.QISAEALSKVVN.DYNTSKDRQNVSNSLAKLISSVGSFTS..............SSDFRNNL-----gtyv............................................
A3N292_ACTP2/868-993                  .......l-LSDLSFKDVGFIRIGDDLLVNKriggtlyyheDYNGNALTIKDWFK....----EGKEGQN--NKIEKIV.DKDGAYVLSQYLTELT..-A--.--.------------.---------------------------..............-------------pgrginyfngleeklyygegynalpqlrkdieqiisstgaltgehgqv
A0A084A6G7_9GAMM/23-141               kevtaemv----------GYRRESNHLIITV..........GKQGAQVTINNYFA....------GAAYRTINRFEFAD.GTVWQDI--RKTDRFV..SDTTaTT.KITARQLT-TEQ.NLVSADQSAAIASQVNSLISAMATFAP..............QGSSTSI------ipdd............................................
A0A238HI88_9NEIS/824-955              ........AFADADLSELTIERTAQGIMIKR..........NDGSGSINMAEWYK....TLSRQNYHGNATDDKIEQII.GKNGDYITSEQIDKLL..KDKQ.TG.TITSAQLQQLAQeNKSKSIDSGNLASTLNKLIESMASFGS..............RGATASNYLQPAH................................................
A0A3S4XCH7_MANHA/807-938              ........SFSDSNLKDLTFEKVKHNLVIT-..........NSKKEKVTIQDWFReadfAKEVRNYKATK-DEKIEEII.GQNGERITSKQVDDLI..-AKG.NG.KITQDELSKVVD.NYELLKHSKNVTNSLDKLISSASAFTS..............SNDSRNVLVAPTS................................................
A0A859PPD0_9ENTR/126-223              .......q-FNDAAFSDLWFTKKNANLMINE..........KNSEDSVELMNWFS....T------TADK--NKIIH--.TADGYDVTSIQVQELI..EAMS.TF.SATHSNLT-LVE.QQTEFMQSFNTSSYL------------..............-------------ssd.............................................
A0A380TL94_9PAST/810-940              ........AFSDVNLKDLTFKKVDSSLEII-..........NQKGEKVRIGNWFLeddlASTVANYKATN-DRKIEEII.GKGGERITSEQVDKLI..-KEG.NN.QISAEALSKVVN.DYNTSKDRQNVSNSLAKLISSVGSFTS..............SSDFRNNL-----gtyv............................................
C0AY19_9GAMM/155-298                  .....gll---NIDFKNVVFKQEGDDLVMYKaen...naisIGNKNGITFKNWFK....----KDQKGAY-NYKIEQLF.DKDGRVITAESLENAL..KDQS.KN.RLNYVNGYNALS.RYADKNNLNPLNNEINKIILSAGNFDT..............NKE----------kpaaasllvssnnginiasna...........................
A0A380TW60_9PAST/885-1006             .......y-LSDFSFDRLLVEKVDDNLVLRSn.......esSHNNGVLTIKDWFK....-------EGNKYNHKIEQIV.DKNGRKLTAENLGTYF..KNAP.--.--KADNLLNYATkEDQNESNLSSLKTELGKIITNAGNFGVa............kQGN----------tginta..........................................
A0A066UM22_9GAMM/784-916              ........AFADANLSELTIERTQEGILIKL..........NDNSGSINVSNWYI....ASKLVNYHGHKTDNKIEHLI.GKDGTYITSEQIDSLL..ENKQ.VGeKITSQQLQELANkNKSQEISVSDIASSLNKLIGSMALFGT..............ENPVSSNTLQPTT................................................
#=GC seq_cons                         ........tFuDsshc-LsFc+ssssLlIp...........sssssslslpNWFp....s....shcusp.DsKIEcII.GKsGccITScQlDcLl..pscs.ss.pIouspLpplsp.shspthsppslussLsKLIsShusFso..............pss.tssh.....................................................
//